Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.
Identifieur interne : 001C60 ( PubMed/Checkpoint ); précédent : 001C59; suivant : 001C61Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.
Auteurs : Natasja St Hr Gudmann [Danemark] ; Peter Junker [Danemark] ; Pernille Juhl [Danemark] ; Christian Schneider Thudium [Danemark] ; Anne Sofie Siebuhr [Danemark] ; Inger Byrjalsen [Danemark] ; Morten Asser Karsdal [Danemark] ; Anne Christine Bay-Jensen [Danemark]Source :
- Clinical and experimental rheumatology [ 0392-856X ]
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Anticorps monoclonaux humanisés (usage thérapeutique), Antirhumatismaux (usage thérapeutique), Association de médicaments, Collagène de type IV (sang), Femelle, Humains, Indice de gravité médicale, Marqueurs biologiques (sang), Membrane synoviale (), Membrane synoviale (imagerie diagnostique), Membrane synoviale (métabolisme), Mâle, Méthode en double aveugle, Méthotrexate (usage thérapeutique), Polyarthrite rhumatoïde (imagerie diagnostique), Polyarthrite rhumatoïde (sang), Polyarthrite rhumatoïde (traitement médicamenteux), Résultat thérapeutique.
- MESH :
- imagerie diagnostique : Membrane synoviale, Polyarthrite rhumatoïde.
- métabolisme : Membrane synoviale.
- sang : Collagène de type IV, Marqueurs biologiques, Polyarthrite rhumatoïde.
- traitement médicamenteux : Polyarthrite rhumatoïde.
- usage thérapeutique : Anticorps monoclonaux humanisés, Antirhumatismaux, Méthotrexate.
- Adulte d'âge moyen, Association de médicaments, Femelle, Humains, Indice de gravité médicale, Membrane synoviale, Mâle, Méthode en double aveugle, Résultat thérapeutique.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Humanized (therapeutic use), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (blood), Arthritis, Rheumatoid (diagnostic imaging), Arthritis, Rheumatoid (drug therapy), Biomarkers (blood), Collagen Type IV (blood), Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Methotrexate (therapeutic use), Middle Aged, Severity of Illness Index, Synovial Membrane (diagnostic imaging), Synovial Membrane (drug effects), Synovial Membrane (metabolism), Treatment Outcome.
- MESH :
- chemical , blood : Biomarkers, Collagen Type IV.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate.
- blood : Arthritis, Rheumatoid.
- diagnostic imaging : Arthritis, Rheumatoid, Synovial Membrane.
- drug effects : Synovial Membrane.
- drug therapy : Arthritis, Rheumatoid.
- metabolism : Synovial Membrane.
- Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Severity of Illness Index, Treatment Outcome.
Abstract
The expanding spectrum of targeted therapies for rheumatoid arthritis (RA) implies a need for development of precision tools for disease assessment reflecting pathobiologic processes. Type IV collagen is an abundant protein of basement membranes, but is also present in the intercellular matrix of the synovial lining layer. We aimed to investigate the association of type IV collagen turnover with RA disease activity, response to IL-6 inhibition and radiographic progression.
PubMed: 29745884
Affiliations:
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pubmed:29745884Le document en format XML
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sortKey="Gudmann, Natasja St Hr" sort="Gudmann, Natasja St Hr" uniqKey="Gudmann N" first="Natasja St Hr" last="Gudmann">Natasja St Hr Gudmann</name><affiliation wicri:level="1"><nlm:affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark. nsg@nordicbio.com.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Biomarkers and Research, Nordic Bioscience, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Juhl, Pernille" sort="Juhl, Pernille" uniqKey="Juhl P" first="Pernille" last="Juhl">Pernille Juhl</name><affiliation wicri:level="1"><nlm:affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Biomarkers and Research, Nordic Bioscience, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Thudium, Christian Schneider" sort="Thudium, Christian Schneider" uniqKey="Thudium C" first="Christian Schneider" last="Thudium">Christian Schneider Thudium</name><affiliation wicri:level="1"><nlm:affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Biomarkers and Research, Nordic Bioscience, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Siebuhr, Anne Sofie" sort="Siebuhr, Anne Sofie" uniqKey="Siebuhr A" first="Anne Sofie" last="Siebuhr">Anne Sofie Siebuhr</name><affiliation wicri:level="1"><nlm:affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Biomarkers and Research, Nordic Bioscience, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Byrjalsen, Inger" sort="Byrjalsen, Inger" uniqKey="Byrjalsen I" first="Inger" last="Byrjalsen">Inger Byrjalsen</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Development, Nordic Bioscience, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Development, Nordic Bioscience, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Karsdal, Morten Asser" sort="Karsdal, Morten Asser" uniqKey="Karsdal M" first="Morten Asser" last="Karsdal">Morten Asser Karsdal</name><affiliation wicri:level="1"><nlm:affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Biomarkers and Research, Nordic Bioscience, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Bay Jensen, Anne Christine" sort="Bay Jensen, Anne Christine" uniqKey="Bay Jensen A" first="Anne Christine" last="Bay-Jensen">Anne Christine Bay-Jensen</name><affiliation wicri:level="1"><nlm:affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Biomarkers and Research, Nordic Bioscience, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical and experimental rheumatology</title><idno type="ISSN">0392-856X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (blood)</term><term>Arthritis, Rheumatoid (diagnostic imaging)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Biomarkers (blood)</term><term>Collagen Type IV (blood)</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Methotrexate (therapeutic use)</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Synovial Membrane (diagnostic imaging)</term><term>Synovial Membrane (drug effects)</term><term>Synovial Membrane (metabolism)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Antirhumatismaux (usage thérapeutique)</term><term>Association de médicaments</term><term>Collagène de type IV (sang)</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Marqueurs biologiques (sang)</term><term>Membrane synoviale ()</term><term>Membrane synoviale (imagerie diagnostique)</term><term>Membrane synoviale (métabolisme)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Méthotrexate (usage thérapeutique)</term><term>Polyarthrite rhumatoïde (imagerie diagnostique)</term><term>Polyarthrite rhumatoïde (sang)</term><term>Polyarthrite rhumatoïde (traitement médicamenteux)</term><term>Résultat thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Collagen Type IV</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antirheumatic Agents</term><term>Methotrexate</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Membrane synoviale</term><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Membrane synoviale</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Collagène de type IV</term><term>Marqueurs biologiques</term><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term><term>Antirhumatismaux</term><term>Méthotrexate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Membrane synoviale</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The expanding spectrum of targeted therapies for rheumatoid arthritis (RA) implies a need for development of precision tools for disease assessment reflecting pathobiologic processes. Type IV collagen is an abundant protein of basement membranes, but is also present in the intercellular matrix of the synovial lining layer. We aimed to investigate the association of type IV collagen turnover with RA disease activity, response to IL-6 inhibition and radiographic progression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29745884</PMID><DateCompleted><Year>2019</Year><Month>01</Month><Day>07</Day></DateCompleted><DateRevised><Year>2019</Year><Month>01</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0392-856X</ISSN><JournalIssue CitedMedium="Print"><Volume>36</Volume><Issue>5</Issue><PubDate><MedlineDate>2018 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Clinical and experimental rheumatology</Title><ISOAbbreviation>Clin. Exp. Rheumatol.</ISOAbbreviation></Journal><ArticleTitle>Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.</ArticleTitle><Pagination><MedlinePgn>829-835</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The expanding spectrum of targeted therapies for rheumatoid arthritis (RA) implies a need for development of precision tools for disease assessment reflecting pathobiologic processes. Type IV collagen is an abundant protein of basement membranes, but is also present in the intercellular matrix of the synovial lining layer. We aimed to investigate the association of type IV collagen turnover with RA disease activity, response to IL-6 inhibition and radiographic progression.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">C4M, a serologic marker of type IV collagen metabolism, was measured at baseline and at follow-up in serum samples of RA patients participating in the phase III studies LITHE (n=687) and RADIATE (n=217). Both were double-blinded, placebo-controlled clinical trials testing the safety and efficacy of 4 and 8 mg/kg tocilizumab (TCZ) in combination with methotrexate (MTX) vs. MTX plus placebo. Associations with disease activity, radiographic severity and ACR response were investigated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Baseline C4M correlated significantly with clinical disease parameters in both study populations, including DAS28, HAQ score and VASpain (all p<0.00001). C4M at baseline correlated significantly with change in JSN (p=0.001) and Sharp score (p=0.00002) at 52 weeks. TCZ lowered C4M by 11-40% in a dose dependent manner. The likelihood of achieving an ACR20 response by week 16 was associated with C4M suppression exceeding the median decrease at week 4 (p<0.0001).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Type IV collagen remodelling was associated with disease activity and radiographic progression in RA and was persistently and dose-dependently suppressed by TCZ. These findings indicate that C4M may serve as a plausible biologic marker of destructive synovitis growth in RA.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gudmann</LastName><ForeName>Natasja Stæhr</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark. nsg@nordicbio.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Junker</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Juhl</LastName><ForeName>Pernille</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thudium</LastName><ForeName>Christian Schneider</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siebuhr</LastName><ForeName>Anne Sofie</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Byrjalsen</LastName><ForeName>Inger</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Clinical Development, Nordic Bioscience, Herlev, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karsdal</LastName><ForeName>Morten Asser</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bay-Jensen</LastName><ForeName>Anne Christine</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>05</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Clin Exp Rheumatol</MedlineTA><NlmUniqueID>8308521</NlmUniqueID><ISSNLinking>0392-856X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024141">Collagen Type IV</NameOfSubstance></Chemical><Chemical><RegistryNumber>I031V2H011</RegistryNumber><NameOfSubstance UI="C502936">tocilizumab</NameOfSubstance></Chemical><Chemical><RegistryNumber>YL5FZ2Y5U1</RegistryNumber><NameOfSubstance UI="D008727">Methotrexate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D061067" MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018501" MajorTopicYN="N">Antirheumatic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001172" MajorTopicYN="N">Arthritis, Rheumatoid</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024141" MajorTopicYN="N">Collagen Type IV</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008727" MajorTopicYN="N">Methotrexate</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013583" MajorTopicYN="N">Synovial Membrane</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>10</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>01</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>5</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>5</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29745884</ArticleId><ArticleId IdType="pii">12293</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Gudmann, Natasja St Hr" sort="Gudmann, Natasja St Hr" uniqKey="Gudmann N" first="Natasja St Hr" last="Gudmann">Natasja St Hr Gudmann</name></noRegion><name sortKey="Bay Jensen, Anne Christine" sort="Bay Jensen, Anne Christine" uniqKey="Bay Jensen A" first="Anne Christine" last="Bay-Jensen">Anne Christine Bay-Jensen</name><name sortKey="Byrjalsen, Inger" sort="Byrjalsen, Inger" uniqKey="Byrjalsen I" first="Inger" last="Byrjalsen">Inger Byrjalsen</name><name sortKey="Juhl, Pernille" sort="Juhl, Pernille" uniqKey="Juhl P" first="Pernille" last="Juhl">Pernille Juhl</name><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><name sortKey="Karsdal, Morten Asser" sort="Karsdal, Morten Asser" uniqKey="Karsdal M" first="Morten Asser" last="Karsdal">Morten Asser Karsdal</name><name sortKey="Siebuhr, Anne Sofie" sort="Siebuhr, Anne Sofie" uniqKey="Siebuhr A" first="Anne Sofie" last="Siebuhr">Anne Sofie Siebuhr</name><name 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