COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?
Identifieur interne : 000386 ( Pmc/Checkpoint ); précédent : 000385; suivant : 000387COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?
Auteurs : Giovanni Novi [Italie] ; Malgorzata Mikulska [Italie] ; Federica Briano [Italie] ; Federica Toscanini [Italie] ; Francesco Tazza [Italie] ; Antonio Uccelli [Italie] ; Matilde Inglese [Italie]Source :
- Multiple Sclerosis and Related Disorders [ 2211-0348 ] ; 2020.
Abstract
A MS patient treated with ocrelizumab healed from COVID-19 without consequences Immunosuppression might have played favorable role This report supports the use of immunosuppressants in serious COVID-19 c
Url:
DOI: 10.1016/j.msard.2020.102120
PubMed: 32315980
PubMed Central: 7156942
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7156942Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?</title><author><name sortKey="Novi, Giovanni" sort="Novi, Giovanni" uniqKey="Novi G" first="Giovanni" last="Novi">Giovanni Novi</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Neuroscience, Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Mikulska, Malgorzata" sort="Mikulska, Malgorzata" uniqKey="Mikulska M" first="Malgorzata" last="Mikulska">Malgorzata Mikulska</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Health Sciences (DISSAL), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences (DISSAL), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Briano, Federica" sort="Briano, Federica" uniqKey="Briano F" first="Federica" last="Briano">Federica Briano</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Health Sciences (DISSAL), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences (DISSAL), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Toscanini, Federica" sort="Toscanini, Federica" uniqKey="Toscanini F" first="Federica" last="Toscanini">Federica Toscanini</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Tazza, Francesco" sort="Tazza, Francesco" uniqKey="Tazza F" first="Francesco" last="Tazza">Francesco Tazza</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Uccelli, Antonio" sort="Uccelli, Antonio" uniqKey="Uccelli A" first="Antonio" last="Uccelli">Antonio Uccelli</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Inglese, Matilde" sort="Inglese, Matilde" uniqKey="Inglese M" first="Matilde" last="Inglese">Matilde Inglese</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32315980</idno><idno type="pmc">7156942</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156942</idno><idno type="RBID">PMC:7156942</idno><idno type="doi">10.1016/j.msard.2020.102120</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000621</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000621</idno><idno type="wicri:Area/Pmc/Curation">000621</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000621</idno><idno type="wicri:Area/Pmc/Checkpoint">000386</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000386</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?</title><author><name sortKey="Novi, Giovanni" sort="Novi, Giovanni" uniqKey="Novi G" first="Giovanni" last="Novi">Giovanni Novi</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Neuroscience, Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Mikulska, Malgorzata" sort="Mikulska, Malgorzata" uniqKey="Mikulska M" first="Malgorzata" last="Mikulska">Malgorzata Mikulska</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Health Sciences (DISSAL), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences (DISSAL), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Briano, Federica" sort="Briano, Federica" uniqKey="Briano F" first="Federica" last="Briano">Federica Briano</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Department of Health Sciences (DISSAL), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences (DISSAL), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Toscanini, Federica" sort="Toscanini, Federica" uniqKey="Toscanini F" first="Federica" last="Toscanini">Federica Toscanini</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Tazza, Francesco" sort="Tazza, Francesco" uniqKey="Tazza F" first="Francesco" last="Tazza">Francesco Tazza</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Uccelli, Antonio" sort="Uccelli, Antonio" uniqKey="Uccelli A" first="Antonio" last="Uccelli">Antonio Uccelli</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Inglese, Matilde" sort="Inglese, Matilde" uniqKey="Inglese M" first="Matilde" last="Inglese">Matilde Inglese</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Ospedale Policlinico San Martino, IRCCS, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Policlinico San Martino, IRCCS, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author></analytic><series><title level="j">Multiple Sclerosis and Related Disorders</title><idno type="ISSN">2211-0348</idno><idno type="eISSN">2211-0356</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0002">A MS patient treated with ocrelizumab healed from COVID-19 without consequences</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0003">Immunosuppression might have played favorable role</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0004">This report supports the use of immunosuppressants in serious COVID-19 c</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Guan, W" uniqKey="Guan W">W. Guan</name></author><author><name sortKey="Ni, Z" uniqKey="Ni Z">Z. Ni</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name></author><author><name sortKey="Liang, W" uniqKey="Liang W">W. Liang</name></author><author><name sortKey="Ou, C" uniqKey="Ou C">C. Ou</name></author><author><name sortKey="He, J" uniqKey="He J">J. He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, C" uniqKey="Wu C">C. Wu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Cai, Y" uniqKey="Cai Y">Y. Cai</name></author><author><name sortKey="Xia, J" uniqKey="Xia J">J. Xia</name></author><author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name></author><author><name sortKey="Xu, S" uniqKey="Xu S">S. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehta, P" uniqKey="Mehta P">P. Mehta</name></author><author><name sortKey="Mcauley, D F" uniqKey="Mcauley D">D.F. McAuley</name></author><author><name sortKey="Brown, M" uniqKey="Brown M">M. Brown</name></author><author><name sortKey="Sanchez, E" uniqKey="Sanchez E">E. Sanchez</name></author><author><name sortKey="Tattersall, R S" uniqKey="Tattersall R">R.S. Tattersall</name></author><author><name sortKey="Manson, J J" uniqKey="Manson J">J.J. Manson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mult Scler Relat Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mult Scler Relat Disord</journal-id><journal-title-group><journal-title>Multiple Sclerosis and Related Disorders</journal-title></journal-title-group><issn pub-type="ppub">2211-0348</issn><issn pub-type="epub">2211-0356</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32315980</article-id><article-id pub-id-type="pmc">7156942</article-id><article-id pub-id-type="publisher-id">S2211-0348(20)30197-8</article-id><article-id pub-id-type="doi">10.1016/j.msard.2020.102120</article-id><article-id pub-id-type="publisher-id">102120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0001"><name><surname>Novi</surname><given-names>Giovanni</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0002"><name><surname>Mikulska</surname><given-names>Malgorzata</given-names></name><xref rid="aff0002" ref-type="aff">b</xref><xref rid="aff0003" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au0003"><name><surname>Briano</surname><given-names>Federica</given-names></name><xref rid="aff0002" ref-type="aff">b</xref><xref rid="aff0003" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au0004"><name><surname>Toscanini</surname><given-names>Federica</given-names></name><xref rid="aff0003" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au0005"><name><surname>Tazza</surname><given-names>Francesco</given-names></name><xref rid="aff0003" ref-type="aff">c</xref><xref rid="aff0004" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="au0006"><name><surname>Uccelli</surname><given-names>Antonio</given-names></name><xref rid="aff0003" ref-type="aff">c</xref><xref rid="aff0004" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="au0007"><name><surname>Inglese</surname><given-names>Matilde</given-names></name><email>m.inglese@unige.it</email><xref rid="aff0003" ref-type="aff">c</xref><xref rid="aff0004" ref-type="aff">d</xref><xref rid="cor0001" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0001"><label>a</label>Department of Neuroscience, Ospedale Policlinico San Martino, IRCCS, Genova, Italy</aff><aff id="aff0002"><label>b</label>Department of Health Sciences (DISSAL), University of Genova, Genova, Italy</aff><aff id="aff0003"><label>c</label>Ospedale Policlinico San Martino, IRCCS, Genova, Italy</aff><aff id="aff0004"><label>d</label>Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy</aff><author-notes><corresp id="cor0001"><label>⁎</label>Corresponding author: Matilde Inglese, M.D. Ph.D., Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy <email>m.inglese@unige.it</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>7</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>15</day><month>4</month><year>2020</year></pub-date><volume>42</volume><fpage>102120</fpage><lpage>102120</lpage><history><date date-type="received"><day>7</day><month>4</month><year>2020</year></date><date date-type="accepted"><day>9</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0001"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0002">A MS patient treated with ocrelizumab healed from COVID-19 without consequences</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0003">Immunosuppression might have played favorable role</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0004">This report supports the use of immunosuppressants in serious COVID-19 c</p></list-item></list></p></abstract><abstract id="abs0002"><sec><title>Background</title><p>Coronavirus disease 19 (COVID-19) is a novel disease entity that is spreading throughout the world. It has been speculated that patients with comorbidities and elderly patients could be at high risk for respiratory insufficiency and death. Immunosuppression could expose infected patients to even higher risks of disease complications due to dampened immune response. However, it has been speculated that overactive immune response could drive clinical deterioration and, based on this hypothesis, several immunosuppressants are currently being tested as potential treatment for COVID-19.</p></sec><sec><title>Methods</title><p>In this paper we report on a patient that has been treated with ocrelizumab (a B-cell depleting monoclonal antibody) for primary progressive multiple sclerosis who developed COVID-19.</p></sec><sec><title>Results</title><p>Despite complete B cell depletion, patient symptoms abated few days after hospitalization, and he was discharged to home-quarantine. Phone interview follow-up confirmed that, after 14 days, no new symptoms occurred.</p></sec><sec><title>Discussion</title><p>This report supports the putative role of immunosuppressive therapy in COVID-19 affected patients.</p></sec></abstract></article-meta></front></pmc><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Novi, Giovanni" sort="Novi, Giovanni" uniqKey="Novi G" first="Giovanni" last="Novi">Giovanni Novi</name></noRegion><name sortKey="Briano, Federica" sort="Briano, Federica" uniqKey="Briano F" first="Federica" last="Briano">Federica Briano</name><name sortKey="Briano, Federica" sort="Briano, Federica" uniqKey="Briano F" first="Federica" last="Briano">Federica Briano</name><name sortKey="Inglese, Matilde" sort="Inglese, Matilde" uniqKey="Inglese M" first="Matilde" last="Inglese">Matilde Inglese</name><name sortKey="Inglese, Matilde" sort="Inglese, Matilde" uniqKey="Inglese M" first="Matilde" last="Inglese">Matilde Inglese</name><name sortKey="Mikulska, Malgorzata" sort="Mikulska, Malgorzata" uniqKey="Mikulska M" first="Malgorzata" last="Mikulska">Malgorzata Mikulska</name><name sortKey="Mikulska, Malgorzata" sort="Mikulska, Malgorzata" uniqKey="Mikulska M" first="Malgorzata" last="Mikulska">Malgorzata Mikulska</name><name sortKey="Tazza, Francesco" sort="Tazza, Francesco" uniqKey="Tazza F" first="Francesco" last="Tazza">Francesco Tazza</name><name sortKey="Tazza, Francesco" sort="Tazza, Francesco" uniqKey="Tazza F" first="Francesco" last="Tazza">Francesco Tazza</name><name sortKey="Toscanini, Federica" sort="Toscanini, Federica" uniqKey="Toscanini F" first="Federica" last="Toscanini">Federica Toscanini</name><name sortKey="Uccelli, Antonio" sort="Uccelli, Antonio" uniqKey="Uccelli A" first="Antonio" last="Uccelli">Antonio Uccelli</name><name sortKey="Uccelli, Antonio" sort="Uccelli, Antonio" uniqKey="Uccelli A" first="Antonio" last="Uccelli">Antonio Uccelli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/TocilizumabV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000386 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000386 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= TocilizumabV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:7156942
|texte= COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:32315980" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a TocilizumabV1
| This area was generated with Dilib version V0.6.34. |  |