| Ident. | Authors (with country if any) | Title |
|---|
| 000000 (2005) |
Masahiko Mihara [Japon] ; Keiko Kasutani [Japon] ; Makoto Okazaki [Japon] ; Akito Nakamura [Japon] ; Shigeto Kawai [Japon] ; Masamichi Sugimoto [Japon] ; Yoshihiro Matsumoto [Japon] ; Yoshiyuki Ohsugi [Japon] | Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family |
| 000001 (2005) |
Norihiro Nishimoto [Japon] | Clinical studies in patients with Castleman's disease, Crohn's disease, and rheumatoid arthritis in Japan |
| 000002 (2005) |
Shumpei Yokota [Japon] ; Takako Miyamae [Japon] ; Tomoyuki Imagawa [Japon] ; Shigeki Katakura [Japon] ; Rumiko Kurosawa [Japon] ; Masaaki Mori [Japon] | Clinical study of tocilizumab in children with systemic-onset juvenile idiopathic arthritis |
| 000004 (2006) |
R. N. Maini [Royaume-Uni] ; P. C. Taylor [Royaume-Uni] ; J. Szechinski [Pologne] ; K. Pavelka [République tchèque] ; J. Bröll [Autriche] ; G. Balint [Hongrie] ; P. Emery [Royaume-Uni] ; F. Raemen [Belgique] ; J. Petersen [Danemark] ; J. Smolen [Autriche] ; D. Thomson [Royaume-Uni] ; T. Kishimoto [Japon] | Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in european patients with rheumatoid arthritis who had an incomplete response to methotrexate |
| 000005 (2006) |
Yasuaki Okuda [Japon] ; Kiyoshi Takasugi [Japon] | Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis |
| 000006 (2007) |
Naoko Yoshio-Hoshino [Japon] ; Yasuo Adachi [Japon] ; Chieko Aoki [Japon] ; Alexander Pereboev [États-Unis] ; David T. Curiel [États-Unis] ; Norihiro Nishimoto [Japon] | Establishment of a new lnterleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor |
| 000009 (2007) |
Junya Kanda [Japon] ; Hiroshi Kawabata [Japon] ; Yuhei Yamaji [Japon] ; Tatsuo Ichinohe [Japon] ; Takayuki Ishikawa [Japon] ; Toshihiro Tamura [Japon] ; Yutaka Furukawa [Japon] ; Takeshi Kimura [Japon] ; Toru Kita [Japon] ; Takashi Uchiyama [Japon] | Reversible cardiomyopathy associated with multicentric castleman disease : Successful treatment with tocilizumab, an anti-interleukin 6 receptor antibody |
| 000010 (2007) |
Norihiro Nishimoto [Japon] ; Jun Hashimoto [Japon] ; Nobuyuki Miyasaka [Japon] ; Kazuhiko Yamamoto [Japon] ; Shinichi Kawai [Japon] ; Tsutomu Takeuchi [Japon] ; Norikazu Murata [Japon] ; Désirée Van Der Heijde [Pays-Bas] ; Tadamitsu Kishimoto [Japon] | Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAL) : evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab |
| 000013 (2008) |
N. Nishimoto [Japon] ; T. Kishimoto [Japon] | Humanized Antihuman IL-6 Receptor Antibody, Tocilizumab |
| 000014 (2008) |
Tim Bongartz [États-Unis] ; Shumpei Yokota [Japon] ; Tomoyuki Imagawa [Japon] ; Masaaki Mori [Japon] ; Takako Miyamae [Japon] ; Yukoh Aihara [Japon] ; Shuji Takei [Japon] ; Naomi Iwata [Japon] ; Hiroaki Umebayashi [Japon] ; Takuji Murata [Japon] ; Mari Miyoshi [Japon] ; Minako Tomiita [Japon] ; Norihiro Nishimoto [Japon] ; Tadamitsu Kishimoto [Japon] | Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis : a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Commentary |
| 000017 (2008) |
Norihiro Nishimoto [Japon] ; Hideko Nakahara [Japon] ; Naoko Yoshio-Hoshino [Japon] ; Toru Mima [Japon] | Successful Treatment of a Patient With Takayasu Arteritis Using a Humanized Anti-Interleukin-6 Receptor Antibody |
| 000018 (2008) |
Yasuo Adachi [Japon] ; Naoko Yoshio-Hoshino [Japon] ; Norihiro Nishimoto [Japon] | The Blockade of IL-6 Signaling in Rational Drug Design |
| 000019 (2008) |
Atsuhiko Kato [Japon] ; Saori Matsuo [Japon] ; Hirotake Takai [Japon] ; Yasushi Uchiyama [Japon] ; Masahiko Mihara [Japon] ; Masami Suzuki [Japon] | Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model |
| 000020 (2008) |
Atsushi Taga [Japon] ; Soichiro Kita [Japon] ; Kaori Nishiura [Japon] ; Tomonori Hayashi [Japon] ; Mitsuhiro Kinoshita [Japon] ; Atsushi Sato [Japon] ; Kentaro Suzuki [Japon] ; Shuji Kodama [Japon] ; Kazuaki Kakehi [Japon] | Analysis of an antibody pharmaceutical, tocilizumab, by capillary electrophoresis using a carboxylated capillary |
| 000021 (2008) |
Yasuo Adachi [Japon] ; Naoko Yoshio-Hoshino [Japon] ; Norihiro Nishimoto [Japon] | Gene therapy for Multiple Myeloma |
| 000022 (2008) |
Yasushi Uchiyama [Japon] ; Hiroto Yoshida [Japon] ; Nobuo Koike [Japon] ; Naohiko Hayakawa [Japon] ; Atsuko Sugita [Japon] ; Takashi Nishimura [Japon] ; Masahiko Mihara [Japon] | Anti-IL-6 receptor antibody increases blood IL-6 level via the blockade of IL-6 clearance, but not via the induction of IL-6 production |
| 000025 (2008) |
M. Hashizume [Japon] ; N. Hayakawa [Japon] ; M. Mihara [Japon] | IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-α and IL-17 |
| 000028 (2008) |
Norihiro Nishimoto [Japon] ; Kimio Terao [Japon] ; Toru Mima [Japon] ; Hideko Nakahara [Japon] ; Nobuhiro Takagi [Japon] ; Takahiro Kakehi [Japon] | Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease |
| 000030 (2009) |
M. Kawai [Japon] ; K. Hagihara [Japon] ; T. Hirano [Japon] ; Y. Shima [Japon] ; Y. Kuwahara [Japon] ; J. Arimitsu [Japon] ; M. Narazaki [Japon] ; A. Ogata [Japon] ; I. Kawase [Japon] ; T. Kishimoto [Japon] ; T. Tanaka [Japon] | Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis |
| 000031 (2009) |
M. Hirao [Japon] ; J. Hashimoto [Japon] ; H. Tsuboi [Japon] ; A. Nampei [Japon] ; H. Nakahara [Japon] ; N. Yoshio [Japon] ; T. Mima [Japon] ; H. Yoshikawa [Japon] ; N. Nishimoto [Japon] | Laboratory and febrile features after joint surgery in patients with rheumatoid arthritis treated with tocilizumab |
| 000034 (2009) |
Kyoko Taniguchi [Japon] ; Chihiro Shimazaki [Japon] ; Yoshiko Fujimoto [Japon] ; Kazuho Shimura [Japon] ; Hitoji Uchiyama [Japon] ; Yosuke Matsumoto [Japon] ; Junya Kuroda [Japon] ; Shigeo Horiike [Japon] ; Masafumi Taniwaki [Japon] | Tocilizumab is effective for pulmonary hypertension associated with multicentric Castleman's disease |
