| Ident. | Authors (with country if any) | Title |
|---|
| 000298 (2020) |
Yoshikazu Nakaoka ; Mitsuaki Isobe ; Yoshiya Tanaka ; Tomonori Ishii ; Seido Ooka ; Hiroaki Niiro [Japon] ; Naoto Tamura ; Shogo Banno ; Hajime Yoshifuji [Japon] ; Yasushi Sakata ; Atsushi Kawakami ; Tatsuya Atsumi ; Shunsuke Furuta ; Hitoshi Kohsaka ; Katsuya Suzuki ; Ryoki Hara ; Yasuhiro Maejima ; Hiroshi Tsukamoto ; Yoshinari Takasaki ; Katsuhisa Yamashita ; Norihiro Okada ; Shinji Yamakido ; Syuji Takei ; Shumpei Yokota [Japon] ; Norihiro Nishimoto [Japon] | Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: final results of the randomized controlled phase 3 TAKT study. |
| 000D72 (2019) |
Shuji Asai [Japon] ; Masatoshi Hayashi [Japon] ; Masahiro Hanabayashi [Japon] ; Yasuhide Kanayama [Japon] ; Toki Takemoto [Japon] ; Yuichiro Yabe [Japon] ; Tomone Shioura [Japon] ; Hisato Ishikawa [Japon] ; Yutaka Yoshioka [Japon] ; Takefumi Kato [Japon] ; Yuji Hirano [Japon] ; Takayoshi Fujibayashi [Japon] ; Yosuke Hattori [Japon] ; Tomonori Kobayakawa [Japon] ; Masahiko Ando [Japon] ; Yachiyo Kuwatsuka [Japon] ; Nobunori Takahashi [Japon] ; Takuya Matsumoto [Japon] ; Nobuyuki Asai [Japon] ; Yasumori Sobue [Japon] ; Tsuyoshi Nishiume [Japon] ; Mochihito Suzuki [Japon] ; Naoki Ishiguro [Japon] ; Toshihisa Kojima [Japon] | Discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab: An interventional study. |
| 001731 (2017) |
Kei Ishibashi [Japon, Allemagne] ; Tobias Haber [Allemagne] ; Ines Breuksch [Allemagne] ; Susanne Gebhard [Allemagne] ; Takashi Sugino [Japon] ; Hitoshi Kubo [Japon] ; Junya Hata [Japon] ; Tomoyuki Koguchi [Japon] ; Michihiro Yabe [Japon] ; Masao Kataoka [Japon] ; Soichiro Ogawa [Japon] ; Hiroyuki Hiraki [Japon] ; Tomohiko Yanagida [Japon] ; Nobuhiro Haga [Japon] ; Joachim W. Thüroff [Allemagne] ; Dirk Prawitt [Allemagne] ; Walburgis Brenner [Allemagne] ; Yoshiyuki Kojima [Japon] | Overriding TKI resistance of renal cell carcinoma by combination therapy with IL-6 receptor blockade |
| 001A82 (2016) |
Yasufumi Masaki [Japon] ; Hiroshi Kawabata [Japon] ; Kazue Takai [Japon] ; Masaru Kojima [Japon] ; Norifumi Tsukamoto [Japon] ; Yasuhito Ishigaki [Japon] ; Nozomu Kurose [Japon] ; Makoto Ide [Japon] ; Jun Murakami [Japon] ; Kenji Nara [Japon] ; Hiroshi Yamamoto [Japon] ; Yoko Ozawa [Japon] ; Hidekazu Takahashi [Japon] ; Katsuhiro Miura [Japon] ; Tsutomu Miyauchi [Japon] ; Shinichirou Yoshida [Japon] ; Akihito Momoi [Japon] ; Nobuyasu Awano [Japon] ; Soichiro Ikushima [Japon] ; Yasunori Ohta [Japon] ; Natsue Furuta [Japon] ; Shino Fujimoto [Japon] ; Haruka Kawanami [Japon] ; Tomoyuki Sakai [Japon] ; Takafumi Kawanami [Japon] ; Yoshimasa Fujita [Japon] ; Toshihiro Fukushima [Japon] ; Shigeo Nakamura [Japon] ; Tomohiro Kinoshita [Japon] ; Sadao Aoki [Japon] | Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version. |
| 001B46 (2016) |
Toshihisa Kojima [Japon] ; Nobunori Takahashi ; Koji Funahashi ; Shuji Asai ; Kenya Terabe ; Atsushi Kaneko [Japon] ; Yuji Hirano [Japon] ; Masatoshi Hayashi [Japon] ; Hiroyuki Miyake [Japon] ; Takeshi Oguchi [Japon] ; Hideki Takagi [Japon] ; Yasuhide Kanayama [Japon] ; Yuichiro Yabe [Japon] ; Tsuyoshi Watanabe [Japon] ; Takayoshi Fujibayashi [Japon] ; Tomone Shioura [Japon] ; Takayasu Ito [Japon] ; Yutaka Yoshioka [Japon] ; Hisato Ishikawa [Japon] ; Nobuyuki Asai ; Toki Takemoto ; Masayo Kojima [Japon] ; Naoki Ishiguro | Improved safety of biologic therapy for rheumatoid arthritis over the 8-year period since implementation in Japan: long-term results from a multicenter observational cohort study. |
| 001D00 (2016) |
Tomo Nozawa [Japon] ; Masaaki Mori [Japon] ; Kenichi Nishimura [Japon] ; Nodoka Sakurai [Japon] ; Masako Kikuchi [Japon] ; Ryoki Hara [Japon] ; Shumpei Yokota [Japon] | Usefulness of two interferon‐γ release assays for rheumatic disease |
| 001D18 (2016) |
Tomoyuki Igawa [Japon] ; Kenta Haraya [Singapour] ; Kunihiro Hattori [Japon] | Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation |
| 002120 (2015) |
Daiki Mochizuki [États-Unis] ; April Adams [États-Unis] ; Kristy A. Warner [États-Unis] ; Zhaocheng Zhang [États-Unis] ; Alexander T. Pearson [États-Unis] ; Kiyoshi Misawa [Japon] ; Scott A. Mclean [États-Unis] ; Gregory T. Wolf [États-Unis] ; Jacques E. Nör [États-Unis] | Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma. |
| 002506 (2014) |
Keisuke Tanaka [Japon] ; Misato Hashizume ; Masahiko Mihara ; Hiroto Yoshida ; Miho Suzuki ; Yoshihiro Matsumoto | Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. |
| 002736 (2013) |
Otoya Ueda [Japon] ; Hiromi Tateishi ; Yoshinobu Higuchi ; Etsuko Fujii ; Atsuhiko Kato ; Yosuke Kawase ; Naoko A. Wada ; Takanori Tachibe ; Mami Kakefuda ; Chisato Goto ; Makoto Kawaharada ; Shin Shimaoka ; Kunihiro Hattori ; Kou-Ichi Jishage | Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor. |
| 002903 (2013) |
Takayuki Sakurai [Japon] ; Ryo Takai [Japon] ; Heinrich Bürgin [Suisse] ; Akifumi Shioda [Japon] ; Yuichiro Sakamoto [Japon] ; Jun Amano [Japon] ; Hans Peter Grimm [Suisse] ; Wolfgang F. Richter [Suisse] ; Yoshinobu Higuchi [Japon] ; Shuichi Chiba [Japon] ; Akinori Kawamura [Japon] ; Masami Suzuki [Japon] ; Lutz Müller [Suisse] | The Effects of Interleukin‐6 Signal Blockade on Immune System, Reproductive and Skeletal Development in Juvenile Mice |
| 003610 (2012) |
Takayuki Sakurai [Japon] ; Ryo Takai [Japon] ; Heinrich Bürgin [Suisse] ; Kana Ishihara [Japon] ; Yuichiro Sakamoto [Japon] ; Jun Amano [Japon] ; Yoshinobu Higuchi [Japon] ; Shuichi Chiba [Japon] ; Thomas Singer [Suisse] ; Akinori Kawamura [Japon] ; Masami Suzuki [Japon] ; Lutz Müller [Suisse] | The Effects of Interleukin‐6 Signal Blockade on Fertility, Embryo‐fetal Development, and Immunization In vivo |
| 003866 (2011) |
Masahiko Mihara [Japon] ; Yoshiyuki Ohsugi [Japon] ; Tadamitsu Kishimoto [Japon] | Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis. |
| 003C74 (2010) |
Tomoyuki Igawa [Japon] ; Shinya Ishii ; Tatsuhiko Tachibana ; Atsuhiko Maeda ; Yoshinobu Higuchi ; Shin Shimaoka ; Chifumi Moriyama ; Tomoyuki Watanabe ; Ryoko Takubo ; Yoshiaki Doi ; Tetsuya Wakabayashi ; Akira Hayasaka ; Shoujiro Kadono ; Takuya Miyazaki ; Kenta Haraya ; Yasuo Sekimori ; Tetsuo Kojima ; Yoshiaki Nabuchi ; Yoshinori Aso ; Yoshiki Kawabe ; Kunihiro Hattori | Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization. |
| 003D00 (2010) |
Misato Hashizume [Japon] ; Hiroto Yoshida [Japon] ; Nobuo Koike [Japon] ; Miho Suzuki [Japon] ; Masahiko Mihara [Japon] | Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor |
| 003D83 (2010) |
Hiroto Yoshida [Japon] ; Misato Hashizume [Japon] ; Masahiko Mihara [Japon] | IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis |
| 003E75 (2010) |
Tomoyuki Igawa [Japon] ; Shinya Ishii [Japon] ; Tatsuhiko Tachibana [Japon] ; Atsuhiko Maeda [Japon] ; Yoshinobu Higuchi [Japon] ; Shin Shimaoka [Japon] ; Chifumi Moriyama [Japon] ; Tomoyuki Watanabe [Japon] ; Ryoko Takubo [Japon] ; Yoshiaki Doi [Japon] ; Tetsuya Wakabayashi [Japon] ; Akira Hayasaka [Japon] ; Shoujiro Kadono [Japon] ; Takuya Miyazaki [Japon] ; Kenta Haraya [Japon] ; Yasuo Sekimori [Japon] ; Tetsuo Kojima [Japon] ; Yoshiaki Nabuchi [Japon] ; Yoshinori Aso [Japon] ; Yoshiki Kawabe [Japon] ; Kunihiro Hattori | Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization |
| 003F71 (2009) |
Misato Hashizume [Japon] ; Yasushi Uchiyama [Japon] ; Naoto Horai [Japon] ; Naohisa Tomosugi [Japon] ; Masahiko Mihara [Japon] | Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production |
| 003F97 (2009) |
Misato Hashizume [Japon] ; Naohiko Hayakawa [Japon] ; Miho Suzuki [Japon] ; Masahiko Mihara [Japon] | IL-6/sIL-6R trans-signalling, but not TNF-α induced angiogenesis in a HUVEC and synovial cell co-culture system |
| 004003 (2009) |
Masahiko Mihara [Japon] ; Yoshiyuki Ohsugi [Japon] ; Tadamitsu Kishimoto | Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti‐interluekin‐6 receptor antibody |
| 004019 (2009) |
Miho Suzuki [Japon] ; Misato Hashizume [Japon] ; Hiroto Yoshida [Japon] ; Masahiko Mihara [Japon] | Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule |
