Serum uric acid levels correlate with benign paroxysmal positional vertigo.
Identifieur interne : 000178 ( Main/Exploration ); précédent : 000177; suivant : 000179Serum uric acid levels correlate with benign paroxysmal positional vertigo.
Auteurs : A. Celikbilek [Turquie] ; Z K Gencer ; L. Saydam ; G. Zararsiz ; N. Tanik ; M. OzkirisSource :
- European journal of neurology [ 1468-1331 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Uric Acid.
- blood : Vertigo.
- Adult, Area Under Curve, Benign Paroxysmal Positional Vertigo, Female, Humans, Male, ROC Curve, Sensitivity and Specificity.
Abstract
BACKGROUND AND PURPOSE
Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect the quality of life. In this study, we aimed to assess the possible relations between serum uric acid (SUA) levels and BPPV.
METHODS
Fifty patients with BPPV, and 40 age- and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio-vestibular test battery including the Dix-Hallpike maneuver and supine roll test for posterior semicircular canal (PSC) and horizontal semicircular canal, respectively. Routine hematological and biochemical analyses were performed in both groups. In the BPPV group, measurements of SUA levels were repeated 1 month after the vertigo attack.
RESULTS
The lipid profiles and SUA levels were higher in patients with BPPV than detected in controls (P < 0.05 and P < 0.001, respectively). Albumin and SUA values were independently associated with BPPV in multiple logistic regression models (P < 0.05 and P < 0.001, respectively). A cutoff value of 4 for SUA level with a sensitivity of 0.72 (0.58-0.84) and a specificity of 0.60 (0.43-0.75) was obtained in the receiver operating characteristic analyses. There was a significant decrement in SUA level 1 month after the vertigo attack compared with the values obtained during the attack (P < 0.001). Among the most involved type of BPPV (PSC BPPV), the right side was affected in 26 patients (57.8%) and the left side in 19 patients (42.2%). SUA levels did not differ statistically in patients with PSC BPPV for either the right or left sides (P > 0.05).
CONCLUSIONS
Elevated SUA is positively correlated with BPPV, requiring further efforts to clarify the exact mechanism.
DOI: 10.1111/ene.12248
PubMed: 23952220
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum uric acid levels correlate with benign paroxysmal positional vertigo.</title><author><name sortKey="Celikbilek, A" sort="Celikbilek, A" uniqKey="Celikbilek A" first="A" last="Celikbilek">A. Celikbilek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Medical School, Bozok University, Yozgat, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Neurology, Medical School, Bozok University, Yozgat</wicri:regionArea><wicri:noRegion>Yozgat</wicri:noRegion></affiliation></author><author><name sortKey="Gencer, Z K" sort="Gencer, Z K" uniqKey="Gencer Z" first="Z K" last="Gencer">Z K Gencer</name></author><author><name sortKey="Saydam, L" sort="Saydam, L" uniqKey="Saydam L" first="L" last="Saydam">L. Saydam</name></author><author><name sortKey="Zararsiz, G" sort="Zararsiz, G" uniqKey="Zararsiz G" first="G" last="Zararsiz">G. Zararsiz</name></author><author><name sortKey="Tanik, N" sort="Tanik, N" uniqKey="Tanik N" first="N" last="Tanik">N. Tanik</name></author><author><name sortKey="Ozkiris, M" sort="Ozkiris, M" uniqKey="Ozkiris M" first="M" last="Ozkiris">M. Ozkiris</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23952220</idno><idno type="pmid">23952220</idno><idno type="doi">10.1111/ene.12248</idno><idno type="wicri:Area/Main/Corpus">000195</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000195</idno><idno type="wicri:Area/Main/Curation">000195</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000195</idno><idno type="wicri:Area/Main/Exploration">000195</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serum uric acid levels correlate with benign paroxysmal positional vertigo.</title><author><name sortKey="Celikbilek, A" sort="Celikbilek, A" uniqKey="Celikbilek A" first="A" last="Celikbilek">A. Celikbilek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Medical School, Bozok University, Yozgat, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Neurology, Medical School, Bozok University, Yozgat</wicri:regionArea><wicri:noRegion>Yozgat</wicri:noRegion></affiliation></author><author><name sortKey="Gencer, Z K" sort="Gencer, Z K" uniqKey="Gencer Z" first="Z K" last="Gencer">Z K Gencer</name></author><author><name sortKey="Saydam, L" sort="Saydam, L" uniqKey="Saydam L" first="L" last="Saydam">L. Saydam</name></author><author><name sortKey="Zararsiz, G" sort="Zararsiz, G" uniqKey="Zararsiz G" first="G" last="Zararsiz">G. Zararsiz</name></author><author><name sortKey="Tanik, N" sort="Tanik, N" uniqKey="Tanik N" first="N" last="Tanik">N. Tanik</name></author><author><name sortKey="Ozkiris, M" sort="Ozkiris, M" uniqKey="Ozkiris M" first="M" last="Ozkiris">M. Ozkiris</name></author></analytic><series><title level="j">European journal of neurology</title><idno type="eISSN">1468-1331</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Area Under Curve (MeSH)</term><term>Benign Paroxysmal Positional Vertigo (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>ROC Curve (MeSH)</term><term>Sensitivity and Specificity (MeSH)</term><term>Uric Acid (blood)</term><term>Vertigo (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide urique (sang)</term><term>Adulte (MeSH)</term><term>Aire sous la courbe (MeSH)</term><term>Courbe ROC (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Sensibilité et spécificité (MeSH)</term><term>Vertige (sang)</term><term>Vertige positionnel paroxystique bénin (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Uric Acid</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Vertigo</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Acide urique</term><term>Vertige</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Area Under Curve</term><term>Benign Paroxysmal Positional Vertigo</term><term>Female</term><term>Humans</term><term>Male</term><term>ROC Curve</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Aire sous la courbe</term><term>Courbe ROC</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sensibilité et spécificité</term><term>Vertige positionnel paroxystique bénin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND AND PURPOSE</b></p><p>Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect the quality of life. In this study, we aimed to assess the possible relations between serum uric acid (SUA) levels and BPPV.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Fifty patients with BPPV, and 40 age- and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio-vestibular test battery including the Dix-Hallpike maneuver and supine roll test for posterior semicircular canal (PSC) and horizontal semicircular canal, respectively. Routine hematological and biochemical analyses were performed in both groups. In the BPPV group, measurements of SUA levels were repeated 1 month after the vertigo attack.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The lipid profiles and SUA levels were higher in patients with BPPV than detected in controls (P < 0.05 and P < 0.001, respectively). Albumin and SUA values were independently associated with BPPV in multiple logistic regression models (P < 0.05 and P < 0.001, respectively). A cutoff value of 4 for SUA level with a sensitivity of 0.72 (0.58-0.84) and a specificity of 0.60 (0.43-0.75) was obtained in the receiver operating characteristic analyses. There was a significant decrement in SUA level 1 month after the vertigo attack compared with the values obtained during the attack (P < 0.001). Among the most involved type of BPPV (PSC BPPV), the right side was affected in 26 patients (57.8%) and the left side in 19 patients (42.2%). SUA levels did not differ statistically in patients with PSC BPPV for either the right or left sides (P > 0.05).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Elevated SUA is positively correlated with BPPV, requiring further efforts to clarify the exact mechanism.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23952220</PMID><DateCompleted><Year>2014</Year><Month>10</Month><Day>21</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-1331</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>European journal of neurology</Title><ISOAbbreviation>Eur J Neurol</ISOAbbreviation></Journal><ArticleTitle>Serum uric acid levels correlate with benign paroxysmal positional vertigo.</ArticleTitle><Pagination><MedlinePgn>79-85</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ene.12248</ELocationID><Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect the quality of life. In this study, we aimed to assess the possible relations between serum uric acid (SUA) levels and BPPV.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fifty patients with BPPV, and 40 age- and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio-vestibular test battery including the Dix-Hallpike maneuver and supine roll test for posterior semicircular canal (PSC) and horizontal semicircular canal, respectively. Routine hematological and biochemical analyses were performed in both groups. In the BPPV group, measurements of SUA levels were repeated 1 month after the vertigo attack.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The lipid profiles and SUA levels were higher in patients with BPPV than detected in controls (P < 0.05 and P < 0.001, respectively). Albumin and SUA values were independently associated with BPPV in multiple logistic regression models (P < 0.05 and P < 0.001, respectively). A cutoff value of 4 for SUA level with a sensitivity of 0.72 (0.58-0.84) and a specificity of 0.60 (0.43-0.75) was obtained in the receiver operating characteristic analyses. There was a significant decrement in SUA level 1 month after the vertigo attack compared with the values obtained during the attack (P < 0.001). Among the most involved type of BPPV (PSC BPPV), the right side was affected in 26 patients (57.8%) and the left side in 19 patients (42.2%). SUA levels did not differ statistically in patients with PSC BPPV for either the right or left sides (P > 0.05).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Elevated SUA is positively correlated with BPPV, requiring further efforts to clarify the exact mechanism.</AbstractText><CopyrightInformation>© 2013 The Author(s) European Journal of Neurology © 2013 EFNS.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Celikbilek</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical School, Bozok University, Yozgat, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gencer</LastName><ForeName>Z K</ForeName><Initials>ZK</Initials></Author><Author ValidYN="Y"><LastName>Saydam</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Zararsiz</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Tanik</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Ozkiris</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Neurol</MedlineTA><NlmUniqueID>9506311</NlmUniqueID><ISSNLinking>1351-5101</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>268B43MJ25</RegistryNumber><NameOfSubstance UI="D014527">Uric Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065635" MajorTopicYN="N">Benign Paroxysmal Positional Vertigo</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012372" MajorTopicYN="N">ROC Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014527" MajorTopicYN="N">Uric Acid</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014717" MajorTopicYN="N">Vertigo</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">benign paroxysmal positional vertigo</Keyword><Keyword MajorTopicYN="N">uric acid</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>05</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>07</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23952220</ArticleId><ArticleId IdType="doi">10.1111/ene.12248</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Turquie</li></country></list><tree><noCountry><name sortKey="Gencer, Z K" sort="Gencer, Z K" uniqKey="Gencer Z" first="Z K" last="Gencer">Z K Gencer</name><name sortKey="Ozkiris, M" sort="Ozkiris, M" uniqKey="Ozkiris M" first="M" last="Ozkiris">M. Ozkiris</name><name sortKey="Saydam, L" sort="Saydam, L" uniqKey="Saydam L" first="L" last="Saydam">L. Saydam</name><name sortKey="Tanik, N" sort="Tanik, N" uniqKey="Tanik N" first="N" last="Tanik">N. Tanik</name><name sortKey="Zararsiz, G" sort="Zararsiz, G" uniqKey="Zararsiz G" first="G" last="Zararsiz">G. Zararsiz</name></noCountry><country name="Turquie"><noRegion><name sortKey="Celikbilek, A" sort="Celikbilek, A" uniqKey="Celikbilek A" first="A" last="Celikbilek">A. Celikbilek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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