Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults.
Identifieur interne : 000A54 ( PubMed/Curation ); précédent : 000A53; suivant : 000A55Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults.
Auteurs : W B Malarkey [États-Unis] ; H. Wu ; J T Cacioppo ; K L Malarkey ; K M Poehlmann ; R. Glaser ; J K Kiecolt-GlaserSource :
- Endocrine [ 1355-008X ] ; 1996.
Abstract
"Pituitary" peptides are produced in both endocrine and immune cells. Acute and chronic stress can alter pituitary peptide secretion and might also influence neuroendocrine gene expression in human immune cells. We reasoned that, in Alzheimer caregivers, the chronic stress of caregiving would impact on the sympathetic-adrenal-medullary and hypothalamicpituitary-adrenal axis possibly leading to alterations in GH mRNA in their peripheral blood mononuclear cells (PBMCs). Therefore, we evaluated 10 caregivers and 10 controls subjects using a math and speech stress protocol to determine their neuroendocrine profile and to evaluate any relationship with mononuclear cell GH mRNA levels simultaneously acquired and then evaluated by a quantitative competitive RT-PCR technique. We found a significant (p<.0001) decrease 50% in GH mRNA levels in cells from caregivers. Plasma ACTH and norepinephrine levels were negatively correlated with GH mRNA levels, suggesting their possible role in the down-regulation of mononuclear cell GH gene expression. These observations support the hypothesis that experiences associated with caregiving alter the brain's autonomic nervous system and neuroendocrine control of the hypothalamic-pituitary axis. These and perhaps other influences may then produce altered GH gene expression in mononuclear cells of chronically stressed individuals. It is tempting to speculate that the decreased GH mRNA that we found in these chronically stressed caregivers was partially responsible for their poor response to influenza vaccine and their delayed wound healing.
DOI: 10.1007/BF02738653
PubMed: 21153091
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults.</title><author><name sortKey="Malarkey, W B" sort="Malarkey, W B" uniqKey="Malarkey W" first="W B" last="Malarkey">W B Malarkey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, Malarkey%crcvax.decnet@gate.hosp.ohiostate.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH</wicri:regionArea></affiliation></author><author><name sortKey="Wu, H" sort="Wu, H" uniqKey="Wu H" first="H" last="Wu">H. Wu</name></author><author><name sortKey="Cacioppo, J T" sort="Cacioppo, J T" uniqKey="Cacioppo J" first="J T" last="Cacioppo">J T Cacioppo</name></author><author><name sortKey="Malarkey, K L" sort="Malarkey, K L" uniqKey="Malarkey K" first="K L" last="Malarkey">K L Malarkey</name></author><author><name sortKey="Poehlmann, K M" sort="Poehlmann, K M" uniqKey="Poehlmann K" first="K M" last="Poehlmann">K M Poehlmann</name></author><author><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name></author><author><name sortKey="Kiecolt Glaser, J K" sort="Kiecolt Glaser, J K" uniqKey="Kiecolt Glaser J" first="J K" last="Kiecolt-Glaser">J K Kiecolt-Glaser</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:21153091</idno><idno type="pmid">21153091</idno><idno type="doi">10.1007/BF02738653</idno><idno type="wicri:Area/PubMed/Corpus">000A57</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A57</idno><idno type="wicri:Area/PubMed/Curation">000A54</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults.</title><author><name sortKey="Malarkey, W B" sort="Malarkey, W B" uniqKey="Malarkey W" first="W B" last="Malarkey">W B Malarkey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, Malarkey%crcvax.decnet@gate.hosp.ohiostate.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH</wicri:regionArea></affiliation></author><author><name sortKey="Wu, H" sort="Wu, H" uniqKey="Wu H" first="H" last="Wu">H. Wu</name></author><author><name sortKey="Cacioppo, J T" sort="Cacioppo, J T" uniqKey="Cacioppo J" first="J T" last="Cacioppo">J T Cacioppo</name></author><author><name sortKey="Malarkey, K L" sort="Malarkey, K L" uniqKey="Malarkey K" first="K L" last="Malarkey">K L Malarkey</name></author><author><name sortKey="Poehlmann, K M" sort="Poehlmann, K M" uniqKey="Poehlmann K" first="K M" last="Poehlmann">K M Poehlmann</name></author><author><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name></author><author><name sortKey="Kiecolt Glaser, J K" sort="Kiecolt Glaser, J K" uniqKey="Kiecolt Glaser J" first="J K" last="Kiecolt-Glaser">J K Kiecolt-Glaser</name></author></analytic><series><title level="j">Endocrine</title><idno type="ISSN">1355-008X</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">"Pituitary" peptides are produced in both endocrine and immune cells. Acute and chronic stress can alter pituitary peptide secretion and might also influence neuroendocrine gene expression in human immune cells. We reasoned that, in Alzheimer caregivers, the chronic stress of caregiving would impact on the sympathetic-adrenal-medullary and hypothalamicpituitary-adrenal axis possibly leading to alterations in GH mRNA in their peripheral blood mononuclear cells (PBMCs). Therefore, we evaluated 10 caregivers and 10 controls subjects using a math and speech stress protocol to determine their neuroendocrine profile and to evaluate any relationship with mononuclear cell GH mRNA levels simultaneously acquired and then evaluated by a quantitative competitive RT-PCR technique. We found a significant (p<.0001) decrease 50% in GH mRNA levels in cells from caregivers. Plasma ACTH and norepinephrine levels were negatively correlated with GH mRNA levels, suggesting their possible role in the down-regulation of mononuclear cell GH gene expression. These observations support the hypothesis that experiences associated with caregiving alter the brain's autonomic nervous system and neuroendocrine control of the hypothalamic-pituitary axis. These and perhaps other influences may then produce altered GH gene expression in mononuclear cells of chronically stressed individuals. It is tempting to speculate that the decreased GH mRNA that we found in these chronically stressed caregivers was partially responsible for their poor response to influenza vaccine and their delayed wound healing.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">21153091</PMID><DateCompleted><Year>2012</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1355-008X</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>1</Issue><PubDate><Year>1996</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Endocrine</Title><ISOAbbreviation>Endocrine</ISOAbbreviation></Journal><ArticleTitle>Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults.</ArticleTitle><Pagination><MedlinePgn>33-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/BF02738653</ELocationID><Abstract><AbstractText>"Pituitary" peptides are produced in both endocrine and immune cells. Acute and chronic stress can alter pituitary peptide secretion and might also influence neuroendocrine gene expression in human immune cells. We reasoned that, in Alzheimer caregivers, the chronic stress of caregiving would impact on the sympathetic-adrenal-medullary and hypothalamicpituitary-adrenal axis possibly leading to alterations in GH mRNA in their peripheral blood mononuclear cells (PBMCs). Therefore, we evaluated 10 caregivers and 10 controls subjects using a math and speech stress protocol to determine their neuroendocrine profile and to evaluate any relationship with mononuclear cell GH mRNA levels simultaneously acquired and then evaluated by a quantitative competitive RT-PCR technique. We found a significant (p<.0001) decrease 50% in GH mRNA levels in cells from caregivers. Plasma ACTH and norepinephrine levels were negatively correlated with GH mRNA levels, suggesting their possible role in the down-regulation of mononuclear cell GH gene expression. These observations support the hypothesis that experiences associated with caregiving alter the brain's autonomic nervous system and neuroendocrine control of the hypothalamic-pituitary axis. These and perhaps other influences may then produce altered GH gene expression in mononuclear cells of chronically stressed individuals. It is tempting to speculate that the decreased GH mRNA that we found in these chronically stressed caregivers was partially responsible for their poor response to influenza vaccine and their delayed wound healing.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Malarkey</LastName><ForeName>W B</ForeName><Initials>WB</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, Malarkey%crcvax.decnet@gate.hosp.ohiostate.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Cacioppo</LastName><ForeName>J T</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Malarkey</LastName><ForeName>K L</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Poehlmann</LastName><ForeName>K M</ForeName><Initials>KM</Initials></Author><Author ValidYN="Y"><LastName>Glaser</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Kiecolt-Glaser</LastName><ForeName>J K</ForeName><Initials>JK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Endocrine</MedlineTA><NlmUniqueID>9434444</NlmUniqueID><ISSNLinking>1355-008X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>1996</Year><Month>03</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>1996</Year><Month>05</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>1996</Year><Month>05</Month><Day>02</Day></PubMedPubDate><PubMedPubDate 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