Mobile phone base station radiation does not affect neoplastic transformation in BALB/3T3 cells.
Identifieur interne : 000794 ( PubMed/Curation ); précédent : 000793; suivant : 000795Mobile phone base station radiation does not affect neoplastic transformation in BALB/3T3 cells.
Auteurs : H. Hirose [Japon] ; T. Suhara ; N. Kaji ; N. Sakuma ; M. Sekijima ; T. Nojima ; J. MiyakoshiSource :
- Bioelectromagnetics [ 1521-186X ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
- effets des radiations : Transformation cellulaire néoplasique.
- toxicité : 1,2-Dihydro-méthyl-benzo[j]acéanthrylène, Cancérogènes.
- Animaux, Cellules 3T3, Ondes hertziennes, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- MESH :
- chemical , toxicity : Carcinogens, Methylcholanthrene.
- radiation effects : Cell Transformation, Neoplastic.
- 3T3 Cells, Animals, Cell Phone, Mice, Mice, Inbred BALB C, Radio Waves.
Abstract
A large-scale in vitro study focusing on low-level radiofrequency (RF) fields from mobile radio base stations employing the International Mobile Telecommunication 2000 (IMT-2000) cellular system was conducted to test the hypothesis that modulated RF fields affect malignant transformation or other cellular stress responses. Our group previously reported that DNA strand breaks were not induced in human cells exposed to 2.1425 GHz Wideband Code Division Multiple Access (W-CDMA) radiation up to 800 mW/kg from mobile radio base stations employing the IMT-2000 cellular system. In the current study, BALB/3T3 cells were continuously exposed to 2.1425 GHz W-CDMA RF fields at specific absorption rates (SARs) of 80 and 800 mW/kg for 6 weeks and malignant cell transformation was assessed. In addition, 3-methylcholanthrene (MCA)-treated cells were exposed to RF fields in a similar fashion, to assess for effects on tumor promotion. Finally, the effect of RF fields on tumor co-promotion was assessed in BALB/3T3 cells initiated with MCA and co-exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA). At the end of the incubation period, transformation dishes were fixed, stained with Giemsa, and scored for morphologically transformed foci. No significant differences in transformation frequency were observed between the test groups exposed to RF signals and the sham-exposed negative controls in the non-, MCA-, or MCA plus TPA-treated cells. Our studies found no evidence to support the hypothesis that RF fields may affect malignant transformation. Our results suggest that exposure to low-level RF radiation of up to 800 mW/kg does not induce cell transformation, which causes tumor formation.
DOI: 10.1002/bem.20362
PubMed: 17694516
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000797
Links to Exploration step
pubmed:17694516Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mobile phone base station radiation does not affect neoplastic transformation in BALB/3T3 cells.</title><author><name sortKey="Hirose, H" sort="Hirose, H" uniqKey="Hirose H" first="H" last="Hirose">H. Hirose</name><affiliation wicri:level="1"><nlm:affiliation>Research Division for Advanced Technology, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd., Kamisu, Japan. h-hirose@ankaken.co.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Research Division for Advanced Technology, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd., Kamisu</wicri:regionArea></affiliation></author><author><name sortKey="Suhara, T" sort="Suhara, T" uniqKey="Suhara T" first="T" last="Suhara">T. Suhara</name></author><author><name sortKey="Kaji, N" sort="Kaji, N" uniqKey="Kaji N" first="N" last="Kaji">N. Kaji</name></author><author><name sortKey="Sakuma, N" sort="Sakuma, N" uniqKey="Sakuma N" first="N" last="Sakuma">N. Sakuma</name></author><author><name sortKey="Sekijima, M" sort="Sekijima, M" uniqKey="Sekijima M" first="M" last="Sekijima">M. Sekijima</name></author><author><name sortKey="Nojima, T" sort="Nojima, T" uniqKey="Nojima T" first="T" last="Nojima">T. Nojima</name></author><author><name sortKey="Miyakoshi, J" sort="Miyakoshi, J" uniqKey="Miyakoshi J" first="J" last="Miyakoshi">J. Miyakoshi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:17694516</idno><idno type="pmid">17694516</idno><idno type="doi">10.1002/bem.20362</idno><idno type="wicri:Area/PubMed/Corpus">000797</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000797</idno><idno type="wicri:Area/PubMed/Curation">000794</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000794</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mobile phone base station radiation does not affect neoplastic transformation in BALB/3T3 cells.</title><author><name sortKey="Hirose, H" sort="Hirose, H" uniqKey="Hirose H" first="H" last="Hirose">H. Hirose</name><affiliation wicri:level="1"><nlm:affiliation>Research Division for Advanced Technology, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd., Kamisu, Japan. h-hirose@ankaken.co.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Research Division for Advanced Technology, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd., Kamisu</wicri:regionArea></affiliation></author><author><name sortKey="Suhara, T" sort="Suhara, T" uniqKey="Suhara T" first="T" last="Suhara">T. Suhara</name></author><author><name sortKey="Kaji, N" sort="Kaji, N" uniqKey="Kaji N" first="N" last="Kaji">N. Kaji</name></author><author><name sortKey="Sakuma, N" sort="Sakuma, N" uniqKey="Sakuma N" first="N" last="Sakuma">N. Sakuma</name></author><author><name sortKey="Sekijima, M" sort="Sekijima, M" uniqKey="Sekijima M" first="M" last="Sekijima">M. Sekijima</name></author><author><name sortKey="Nojima, T" sort="Nojima, T" uniqKey="Nojima T" first="T" last="Nojima">T. Nojima</name></author><author><name sortKey="Miyakoshi, J" sort="Miyakoshi, J" uniqKey="Miyakoshi J" first="J" last="Miyakoshi">J. Miyakoshi</name></author></analytic><series><title level="j">Bioelectromagnetics</title><idno type="eISSN">1521-186X</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3T3 Cells</term><term>Animals</term><term>Carcinogens (toxicity)</term><term>Cell Phone</term><term>Cell Transformation, Neoplastic (radiation effects)</term><term>Methylcholanthrene (toxicity)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Radio Waves</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>1,2-Dihydro-méthyl-benzo[j]acéanthrylène (toxicité)</term><term>Animaux</term><term>Cancérogènes (toxicité)</term><term>Cellules 3T3</term><term>Ondes hertziennes</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Transformation cellulaire néoplasique (effets des radiations)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Carcinogens</term><term>Methylcholanthrene</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Transformation cellulaire néoplasique</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cell Transformation, Neoplastic</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>1,2-Dihydro-méthyl-benzo[j]acéanthrylène</term><term>Cancérogènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>3T3 Cells</term><term>Animals</term><term>Cell Phone</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Radio Waves</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules 3T3</term><term>Ondes hertziennes</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A large-scale in vitro study focusing on low-level radiofrequency (RF) fields from mobile radio base stations employing the International Mobile Telecommunication 2000 (IMT-2000) cellular system was conducted to test the hypothesis that modulated RF fields affect malignant transformation or other cellular stress responses. Our group previously reported that DNA strand breaks were not induced in human cells exposed to 2.1425 GHz Wideband Code Division Multiple Access (W-CDMA) radiation up to 800 mW/kg from mobile radio base stations employing the IMT-2000 cellular system. In the current study, BALB/3T3 cells were continuously exposed to 2.1425 GHz W-CDMA RF fields at specific absorption rates (SARs) of 80 and 800 mW/kg for 6 weeks and malignant cell transformation was assessed. In addition, 3-methylcholanthrene (MCA)-treated cells were exposed to RF fields in a similar fashion, to assess for effects on tumor promotion. Finally, the effect of RF fields on tumor co-promotion was assessed in BALB/3T3 cells initiated with MCA and co-exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA). At the end of the incubation period, transformation dishes were fixed, stained with Giemsa, and scored for morphologically transformed foci. No significant differences in transformation frequency were observed between the test groups exposed to RF signals and the sham-exposed negative controls in the non-, MCA-, or MCA plus TPA-treated cells. Our studies found no evidence to support the hypothesis that RF fields may affect malignant transformation. Our results suggest that exposure to low-level RF radiation of up to 800 mW/kg does not induce cell transformation, which causes tumor formation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17694516</PMID><DateCompleted><Year>2008</Year><Month>01</Month><Day>16</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1521-186X</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>1</Issue><PubDate><Year>2008</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Bioelectromagnetics</Title><ISOAbbreviation>Bioelectromagnetics</ISOAbbreviation></Journal><ArticleTitle>Mobile phone base station radiation does not affect neoplastic transformation in BALB/3T3 cells.</ArticleTitle><Pagination><MedlinePgn>55-64</MedlinePgn></Pagination><Abstract><AbstractText>A large-scale in vitro study focusing on low-level radiofrequency (RF) fields from mobile radio base stations employing the International Mobile Telecommunication 2000 (IMT-2000) cellular system was conducted to test the hypothesis that modulated RF fields affect malignant transformation or other cellular stress responses. Our group previously reported that DNA strand breaks were not induced in human cells exposed to 2.1425 GHz Wideband Code Division Multiple Access (W-CDMA) radiation up to 800 mW/kg from mobile radio base stations employing the IMT-2000 cellular system. In the current study, BALB/3T3 cells were continuously exposed to 2.1425 GHz W-CDMA RF fields at specific absorption rates (SARs) of 80 and 800 mW/kg for 6 weeks and malignant cell transformation was assessed. In addition, 3-methylcholanthrene (MCA)-treated cells were exposed to RF fields in a similar fashion, to assess for effects on tumor promotion. Finally, the effect of RF fields on tumor co-promotion was assessed in BALB/3T3 cells initiated with MCA and co-exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA). At the end of the incubation period, transformation dishes were fixed, stained with Giemsa, and scored for morphologically transformed foci. No significant differences in transformation frequency were observed between the test groups exposed to RF signals and the sham-exposed negative controls in the non-, MCA-, or MCA plus TPA-treated cells. Our studies found no evidence to support the hypothesis that RF fields may affect malignant transformation. Our results suggest that exposure to low-level RF radiation of up to 800 mW/kg does not induce cell transformation, which causes tumor formation.</AbstractText><CopyrightInformation>(c) 2007 Wiley-Liss, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hirose</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Research Division for Advanced Technology, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd., Kamisu, Japan. h-hirose@ankaken.co.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suhara</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Kaji</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Sakuma</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Sekijima</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nojima</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Miyakoshi</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Bioelectromagnetics</MedlineTA><NlmUniqueID>8008281</NlmUniqueID><ISSNLinking>0197-8462</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002273">Carcinogens</NameOfSubstance></Chemical><Chemical><RegistryNumber>56-49-5</RegistryNumber><NameOfSubstance UI="D008748">Methylcholanthrene</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016475" MajorTopicYN="N">3T3 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002273" MajorTopicYN="N">Carcinogens</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D040421" MajorTopicYN="Y">Cell Phone</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002471" MajorTopicYN="N">Cell Transformation, Neoplastic</DescriptorName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008748" MajorTopicYN="N">Methylcholanthrene</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011846" MajorTopicYN="Y">Radio Waves</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>1</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17694516</ArticleId><ArticleId IdType="doi">10.1002/bem.20362</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000794 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000794 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:17694516
|texte= Mobile phone base station radiation does not affect neoplastic transformation in BALB/3T3 cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:17694516" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |