Effect of the Miaoyao Fanggan sachet-derived isorhamnetin on TLR2/4 and NKp46 expression in mice.
Identifieur interne : 000553 ( PubMed/Curation ); précédent : 000552; suivant : 000554Effect of the Miaoyao Fanggan sachet-derived isorhamnetin on TLR2/4 and NKp46 expression in mice.
Auteurs : Hui Wang [République populaire de Chine] ; Quan Zhang ; Ming Liang Cheng ; Li Ma ; Qing Zhi Meng ; Liang Duan ; Yun Chen ; Jia Wu Tan ; Man Chen ; Ting Ting Liang ; Guo Jun Li ; Jun Li LiSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Animaux, Antigènes Ly (métabolisme), Basse température, Immunité innée (), Immunosuppression thérapeutique, Mâle, Médicaments issus de plantes chinoises (administration et posologie), Quercétine (administration et posologie), Quercétine (analogues et dérivés), Récepteur de type Toll-2 (génétique), Récepteur de type Toll-2 (métabolisme), Récepteur de type Toll-4 (génétique), Récepteur de type Toll-4 (métabolisme), Récepteur-1 de déclenchement de cytotoxicité naturelle (métabolisme), Souris, Stress physiologique (physiologie).
- MESH :
- administration et posologie : Médicaments issus de plantes chinoises, Quercétine.
- analogues et dérivés : Quercétine.
- génétique : Récepteur de type Toll-2, Récepteur de type Toll-4.
- métabolisme : ARN messager, Antigènes Ly, Récepteur de type Toll-2, Récepteur de type Toll-4, Récepteur-1 de déclenchement de cytotoxicité naturelle.
- physiologie : Stress physiologique.
- Animaux, Basse température, Immunité innée, Immunosuppression thérapeutique, Mâle, Souris.
English descriptors
- KwdEn :
- Animals, Antigens, Ly (metabolism), Cold Temperature, Drugs, Chinese Herbal (administration & dosage), Immunity, Innate (drug effects), Immunosuppression, Male, Mice, Natural Cytotoxicity Triggering Receptor 1 (metabolism), Quercetin (administration & dosage), Quercetin (analogs & derivatives), RNA, Messenger (metabolism), Stress, Physiological (physiology), Toll-Like Receptor 2 (genetics), Toll-Like Receptor 2 (metabolism), Toll-Like Receptor 4 (genetics), Toll-Like Receptor 4 (metabolism).
- MESH :
- chemical , administration & dosage : Drugs, Chinese Herbal, Quercetin.
- chemical , analogs & derivatives : Quercetin.
- chemical , genetics : Toll-Like Receptor 2, Toll-Like Receptor 4.
- chemical , metabolism : Antigens, Ly, Natural Cytotoxicity Triggering Receptor 1, RNA, Messenger, Toll-Like Receptor 2, Toll-Like Receptor 4.
- drug effects : Immunity, Innate.
- physiology : Stress, Physiological.
- Animals, Cold Temperature, Immunosuppression, Male, Mice.
Abstract
Miaoyao Fanggan Sachets (MFS) has long been used as a folk medicine for the prevention of influenza in Southeast of Guizhou Province, China. However, the precise immunological mechanisms by which MFS confers protection have not been defined.
DOI: 10.1016/j.jep.2012.08.040
PubMed: 22974546
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uniqKey="Chen Y" first="Yun" last="Chen">Yun Chen</name></author><author><name sortKey="Tan, Jia Wu" sort="Tan, Jia Wu" uniqKey="Tan J" first="Jia Wu" last="Tan">Jia Wu Tan</name></author><author><name sortKey="Chen, Man" sort="Chen, Man" uniqKey="Chen M" first="Man" last="Chen">Man Chen</name></author><author><name sortKey="Liang, Ting Ting" sort="Liang, Ting Ting" uniqKey="Liang T" first="Ting Ting" last="Liang">Ting Ting Liang</name></author><author><name sortKey="Li, Guo Jun" sort="Li, Guo Jun" uniqKey="Li G" first="Guo Jun" last="Li">Guo Jun Li</name></author><author><name sortKey="Li, Jun Li" sort="Li, Jun Li" uniqKey="Li J" first="Jun Li" last="Li">Jun Li Li</name></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Ly (metabolism)</term><term>Cold Temperature</term><term>Drugs, Chinese Herbal (administration & dosage)</term><term>Immunity, Innate (drug effects)</term><term>Immunosuppression</term><term>Male</term><term>Mice</term><term>Natural Cytotoxicity Triggering Receptor 1 (metabolism)</term><term>Quercetin (administration & dosage)</term><term>Quercetin (analogs & derivatives)</term><term>RNA, Messenger (metabolism)</term><term>Stress, Physiological (physiology)</term><term>Toll-Like Receptor 2 (genetics)</term><term>Toll-Like Receptor 2 (metabolism)</term><term>Toll-Like Receptor 4 (genetics)</term><term>Toll-Like Receptor 4 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (métabolisme)</term><term>Animaux</term><term>Antigènes Ly (métabolisme)</term><term>Basse température</term><term>Immunité innée ()</term><term>Immunosuppression thérapeutique</term><term>Mâle</term><term>Médicaments issus de plantes chinoises (administration et posologie)</term><term>Quercétine (administration et posologie)</term><term>Quercétine (analogues et dérivés)</term><term>Récepteur de type Toll-2 (génétique)</term><term>Récepteur de type Toll-2 (métabolisme)</term><term>Récepteur de type Toll-4 (génétique)</term><term>Récepteur de type Toll-4 (métabolisme)</term><term>Récepteur-1 de déclenchement de cytotoxicité naturelle (métabolisme)</term><term>Souris</term><term>Stress physiologique (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Drugs, Chinese Herbal</term><term>Quercetin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Quercetin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Toll-Like Receptor 2</term><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Ly</term><term>Natural Cytotoxicity Triggering Receptor 1</term><term>RNA, Messenger</term><term>Toll-Like Receptor 2</term><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Médicaments issus de plantes chinoises</term><term>Quercétine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Quercétine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunity, Innate</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Récepteur de type Toll-2</term><term>Récepteur de type Toll-4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Antigènes Ly</term><term>Récepteur de type Toll-2</term><term>Récepteur de type Toll-4</term><term>Récepteur-1 de déclenchement de cytotoxicité naturelle</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Stress physiologique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cold Temperature</term><term>Immunosuppression</term><term>Male</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Immunité innée</term><term>Immunosuppression thérapeutique</term><term>Mâle</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Miaoyao Fanggan Sachets (MFS) has long been used as a folk medicine for the prevention of influenza in Southeast of Guizhou Province, China. However, the precise immunological mechanisms by which MFS confers protection have not been defined.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22974546</PMID><DateCompleted><Year>2013</Year><Month>03</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN><JournalIssue CitedMedium="Internet"><Volume>144</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Oct</Month><Day>31</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Effect of the Miaoyao Fanggan sachet-derived isorhamnetin on TLR2/4 and NKp46 expression in mice.</ArticleTitle><Pagination><MedlinePgn>138-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2012.08.040</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-8741(12)00565-X</ELocationID><Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE" NlmCategory="BACKGROUND">Miaoyao Fanggan Sachets (MFS) has long been used as a folk medicine for the prevention of influenza in Southeast of Guizhou Province, China. However, the precise immunological mechanisms by which MFS confers protection have not been defined.</AbstractText><AbstractText Label="STUDY AIM" NlmCategory="OBJECTIVE">To explore the effects of MFS on innate immune system responses using a cold stress-induced immune impairment model as a means of examining MFS-mediated influenza prevention. We investigated the effects of MFS on toll-like receptor 2 and 4 (TLR2/4) gene and protein expression levels and on the percentage of NKp46(+) cells present in serum. No overt toxicity was observed following continuous administration of MFS at high doses.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Kunming male mice (n=40) were randomly divided into 4 groups consisting of the continuous inhalation Sachet group, Yu-Ping-Feng powder (YPF-P) gavage positive control group, discontinuous inhalation MFS group and untreated controls. After 4 weeks, mice were sacrificed and lungs harvested. The expression of toll-like receptors 2 and 4 (TLR2/4) gene and protein levels was assessed using real-time polymerase chain reaction (RT-PCR) and Western blot analyses, respectively. An additional 60 Kunming mice were randomly divided into 6 groups comprised of a blank control group, continuous MFS inhalation group, an immune-compromised continuous MFS inhalation group, an immuno-compromised group, an immune-compromised MFS discontinuous inhalation group and an immune-compromised positive control group. Immune suppression was induced by cold stress (4 °C/4 h daily for 3 days) and mice were treated with MFS or YPF-P before cold stress treatments. Immuno-compromised mice were treated with MFS continuously or intermittently, or treated with YPF-P. Blood samples were collected and examined for natural killer cells based on positive NKp46 staining. The isorhamnetin associated with MFS-induced immune modulation was obtained from 'wo ga le' which is considered to be a major component of MFS, and analyzed by HPLC.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mice continuously inhaling MFS showed a moderate increase in TLR2/4 mRNA and protein levels compared to mice in the control and discontinuous inhalation groups. MFS significantly increased the TLR2/4 expression in a dose-dependent manner. Furthermore, there was also a slightly significant increase in the number of NKp46(+) cells in the continuous inhalation group compared to controls and discontinuous inhalation group. Pretreatment with MFS partially prevented cold stress-induced inhibition of NKp46(+) cells. HPLC analysis of the 'wo ga le' associated with immune function identified the major component to be isorhamnetin.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Taken together, these data suggested that MFS significantly enhanced TLR2/4 expression levels and the number of NKp46(+) cells in mice and moderately affected innate immune responses associated with protection against influenza, suggesting that isorhamnetin in the MFS enhanced innate immune potency. The use of MFS for the prevention of various respiratory tract infections can be attributed to its antimicrobial properties. In a pilot study, a large quantity (40 g) was administered over a prolonged period did not produce apparent toxicity.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Quan</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Ming Liang</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Li</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Qing Zhi</ForeName><Initials>QZ</Initials></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Liang</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yun</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Jia Wu</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Man</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Ting Ting</ForeName><Initials>TT</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Guo Jun</ForeName><Initials>GJ</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jun Li</ForeName><Initials>JL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>09</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>J Ethnopharmacol</MedlineTA><NlmUniqueID>7903310</NlmUniqueID><ISSNLinking>0378-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000950">Antigens, Ly</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055627">Natural Cytotoxicity Triggering Receptor 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C118384">Ncr1 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C493486">Tlr2 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C493487">Tlr4 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051195">Toll-Like Receptor 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>07X3IB4R4Z</RegistryNumber><NameOfSubstance UI="C047368">3-methylquercetin</NameOfSubstance></Chemical><Chemical><RegistryNumber>9IKM0I5T1E</RegistryNumber><NameOfSubstance UI="D011794">Quercetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000950" MajorTopicYN="N">Antigens, Ly</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003080" MajorTopicYN="N">Cold Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055627" MajorTopicYN="N">Natural Cytotoxicity Triggering Receptor 1</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011794" MajorTopicYN="N">Quercetin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051195" MajorTopicYN="N">Toll-Like Receptor 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22974546</ArticleId><ArticleId 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