Effect of perceived stress on cytokine production in healthy college students.
Identifieur interne : 000456 ( PubMed/Curation ); précédent : 000455; suivant : 000457Effect of perceived stress on cytokine production in healthy college students.
Auteurs : Vorachai Sribanditmongkol [Israël] ; Jeremy L. Neal [États-Unis] ; Thelma E. Patrick [États-Unis] ; Laura A. Szalacha [États-Unis] ; Donna O. Mccarthy [États-Unis]Source :
- Western journal of nursing research [ 1552-8456 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Cytokines (immunologie), Cytokines (sang), Facteur de nécrose tumorale alpha (sang), Femelle, Humains, Interleukine-1 bêta (sang), Interleukine-6 (sang), Mâle, Personnel militaire, Stress psychologique (), Stress psychologique (physiopathologie), Stress psychologique (psychologie), Stress psychologique (sang), Universités, Études transversales, Étudiants (psychologie).
- MESH :
- immunologie : Cytokines.
- physiopathologie : Stress psychologique.
- psychologie : Stress psychologique, Étudiants.
- sang : Cytokines, Facteur de nécrose tumorale alpha, Interleukine-1 bêta, Interleukine-6, Stress psychologique.
- Adolescent, Adulte, Femelle, Humains, Mâle, Personnel militaire, Stress psychologique, Universités, Études transversales.
English descriptors
- KwdEn :
- Adolescent, Adult, Cross-Sectional Studies, Cytokines (blood), Cytokines (immunology), Female, Humans, Interleukin-1beta (blood), Interleukin-6 (blood), Male, Military Personnel, Stress, Psychological (blood), Stress, Psychological (complications), Stress, Psychological (physiopathology), Stress, Psychological (psychology), Students (psychology), Tumor Necrosis Factor-alpha (blood), Universities.
- MESH :
- chemical , blood : Cytokines, Interleukin-1beta, Interleukin-6, Tumor Necrosis Factor-alpha.
- chemical , immunology : Cytokines.
- blood : Stress, Psychological.
- complications : Stress, Psychological.
- physiopathology : Stress, Psychological.
- psychology : Stress, Psychological, Students.
- Adolescent, Adult, Cross-Sectional Studies, Female, Humans, Male, Military Personnel, Universities.
Abstract
Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis. The purpose of this study was to determine whether psychological stress increases ex vivo cytokine production or decreases glucocorticoid sensitivity (GCS) of peripheral blood leukocytes from healthy college students. A convenience sample of Reserve Officer Training Corps (ROTC) students completed the Perceived Stress Scale (PSS). Whole blood was incubated in the presence of influenza vaccine and dexamethasone to evaluate production of interleukin-6 (IL-6), interleukin-1-beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). Multiple regression models controlling for age, gender, and grade point average revealed a negative relationship between PSS and GCS for vaccine-stimulated production of IL-1β, IL-6, and TNF-α. These data increase our understanding of the complex relationship between chronic stress and immune function.
DOI: 10.1177/0193945914545658
PubMed: 25125502
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Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis. The purpose of this study was to determine whether psychological stress increases ex vivo cytokine production or decreases glucocorticoid sensitivity (GCS) of peripheral blood leukocytes from healthy college students. A convenience sample of Reserve Officer Training Corps (ROTC) students completed the Perceived Stress Scale (PSS). Whole blood was incubated in the presence of influenza vaccine and dexamethasone to evaluate production of interleukin-6 (IL-6), interleukin-1-beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). Multiple regression models controlling for age, gender, and grade point average revealed a negative relationship between PSS and GCS for vaccine-stimulated production of IL-1β, IL-6, and TNF-α. These data increase our understanding of the complex relationship between chronic stress and immune function. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25125502</PMID><DateCompleted><Year>2016</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2015</Year><Month>02</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1552-8456</ISSN><JournalIssue CitedMedium="Internet"><Volume>37</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Western journal of nursing research</Title><ISOAbbreviation>West J Nurs Res</ISOAbbreviation></Journal><ArticleTitle>Effect of perceived stress on cytokine production in healthy college students.</ArticleTitle><Pagination><MedlinePgn>481-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/0193945914545658</ELocationID><Abstract><AbstractText>Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis. The purpose of this study was to determine whether psychological stress increases ex vivo cytokine production or decreases glucocorticoid sensitivity (GCS) of peripheral blood leukocytes from healthy college students. A convenience sample of Reserve Officer Training Corps (ROTC) students completed the Perceived Stress Scale (PSS). Whole blood was incubated in the presence of influenza vaccine and dexamethasone to evaluate production of interleukin-6 (IL-6), interleukin-1-beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). Multiple regression models controlling for age, gender, and grade point average revealed a negative relationship between PSS and GCS for vaccine-stimulated production of IL-1β, IL-6, and TNF-α. These data increase our understanding of the complex relationship between chronic stress and immune function. </AbstractText><CopyrightInformation>© The Author(s) 2014.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sribanditmongkol</LastName><ForeName>Vorachai</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Naval Medical Center Portsmouth, VA, USA Vorachai.Sribanditmongkol@med.navy.mil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neal</LastName><ForeName>Jeremy L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>The Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patrick</LastName><ForeName>Thelma E</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>The Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szalacha</LastName><ForeName>Laura A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>The Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Donna O</ForeName><Initials>DO</Initials><AffiliationInfo><Affiliation>Marquette University, Milwaukee, WI, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>West J Nurs Res</MedlineTA><NlmUniqueID>7905435</NlmUniqueID><ISSNLinking>0193-9459</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>N</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>West J Nurs Res. 2015 Apr;37(4):495-7</RefSource><PMID Version="1">25472444</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>West J Nurs Res. 2015 Apr;37(4):494</RefSource><PMID Version="1">25720649</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008889" MajorTopicYN="N">Military Personnel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013334" MajorTopicYN="N">Students</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014495" MajorTopicYN="N">Universities</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">cytokines</Keyword><Keyword MajorTopicYN="N">glucocorticoid sensitivity</Keyword><Keyword MajorTopicYN="N">influenza</Keyword><Keyword MajorTopicYN="N">stress</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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