Ghrelin-reactive immunoglobulins and anxiety, depression and stress-induced cortisol response in adolescents. The TRAILS study.
Identifieur interne : 000441 ( PubMed/Curation ); précédent : 000440; suivant : 000442Ghrelin-reactive immunoglobulins and anxiety, depression and stress-induced cortisol response in adolescents. The TRAILS study.
Auteurs : Marie François [France] ; Johanna M. Schaefer [Pays-Bas] ; Christine Bole-Feysot [France] ; Pierre Déchelotte [France] ; Frank C. Verhulst [Pays-Bas] ; Sergueï O. Fetissov [France]Source :
- Progress in neuro-psychopharmacology & biological psychiatry [ 1878-4216 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Ghréline, Grippe humaine, Simplexvirus.
- métabolisme : Anxiété, Dépression, Hydrocortisone, Salive, Stress psychologique.
- sang : Immunoglobulines.
- Adolescent, Facteurs sexuels, Femelle, Humains, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Immunoglobulins.
- chemical , immunology : Ghrelin.
- immunology : Influenza, Human, Simplexvirus.
- metabolism : Anxiety, Depression, Hydrocortisone, Saliva, Stress, Psychological.
- Adolescent, Female, Humans, Male, Sex Factors.
Abstract
Ghrelin, a hunger hormone, has been implicated in the regulation of stress-response, anxiety and depression. Ghrelin-reactive immunoglobulins (Ig) were recently identified in healthy and obese humans showing abilities to increase ghrelin's stability and orexigenic effects. Here we studied if ghrelin-reactive Ig are associated with anxiety and depression and with the stress-induced cortisol response in a general population of adolescents. Furthermore, to test the possible infectious origin of ghrelin-reactive Ig, their levels were compared with serum IgG against common viruses.
DOI: 10.1016/j.pnpbp.2014.12.011
PubMed: 25562566
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The TRAILS study.</title><author><name sortKey="Francois, Marie" sort="Francois, Marie" uniqKey="Francois M" first="Marie" last="François">Marie François</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183</wicri:regionArea></affiliation></author><author><name sortKey="Schaefer, Johanna M" sort="Schaefer, Johanna M" uniqKey="Schaefer J" first="Johanna M" last="Schaefer">Johanna M. Schaefer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Child and Adolescent Psychiatry & Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Child and Adolescent Psychiatry & Psychology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Bole Feysot, Christine" sort="Bole Feysot, Christine" uniqKey="Bole Feysot C" first="Christine" last="Bole-Feysot">Christine Bole-Feysot</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183</wicri:regionArea></affiliation></author><author><name sortKey="Dechelotte, Pierre" sort="Dechelotte, Pierre" uniqKey="Dechelotte P" first="Pierre" last="Déchelotte">Pierre Déchelotte</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183</wicri:regionArea></affiliation></author><author><name sortKey="Verhulst, Frank C" sort="Verhulst, Frank C" uniqKey="Verhulst F" first="Frank C" last="Verhulst">Frank C. Verhulst</name><affiliation wicri:level="1"><nlm:affiliation>Department of Child and Adolescent Psychiatry & Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Child and Adolescent Psychiatry & Psychology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Fetissov, Serguei O" sort="Fetissov, Serguei O" uniqKey="Fetissov S" first="Sergueï O" last="Fetissov">Sergueï O. Fetissov</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France. Electronic address: Serguei.Fetissov@univ-rouen.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183</wicri:regionArea></affiliation></author></analytic><series><title level="j">Progress in neuro-psychopharmacology & biological psychiatry</title><idno type="eISSN">1878-4216</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Anxiety (metabolism)</term><term>Depression (metabolism)</term><term>Female</term><term>Ghrelin (immunology)</term><term>Humans</term><term>Hydrocortisone (metabolism)</term><term>Immunoglobulins (blood)</term><term>Influenza, Human (immunology)</term><term>Male</term><term>Saliva (metabolism)</term><term>Sex Factors</term><term>Simplexvirus (immunology)</term><term>Stress, Psychological (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Anxiété (métabolisme)</term><term>Dépression (métabolisme)</term><term>Facteurs sexuels</term><term>Femelle</term><term>Ghréline (immunologie)</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Hydrocortisone (métabolisme)</term><term>Immunoglobulines (sang)</term><term>Mâle</term><term>Salive (métabolisme)</term><term>Simplexvirus (immunologie)</term><term>Stress psychologique (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Ghrelin</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Ghréline</term><term>Grippe humaine</term><term>Simplexvirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term><term>Simplexvirus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Hydrocortisone</term><term>Saliva</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anxiété</term><term>Dépression</term><term>Hydrocortisone</term><term>Salive</term><term>Stress psychologique</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobulines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Female</term><term>Humans</term><term>Male</term><term>Sex Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Facteurs sexuels</term><term>Femelle</term><term>Humains</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ghrelin, a hunger hormone, has been implicated in the regulation of stress-response, anxiety and depression. Ghrelin-reactive immunoglobulins (Ig) were recently identified in healthy and obese humans showing abilities to increase ghrelin's stability and orexigenic effects. Here we studied if ghrelin-reactive Ig are associated with anxiety and depression and with the stress-induced cortisol response in a general population of adolescents. Furthermore, to test the possible infectious origin of ghrelin-reactive Ig, their levels were compared with serum IgG against common viruses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25562566</PMID><DateCompleted><Year>2015</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2018</Year><Month>05</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-4216</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><PubDate><Year>2015</Year><Month>Jun</Month><Day>03</Day></PubDate></JournalIssue><Title>Progress in neuro-psychopharmacology & biological psychiatry</Title><ISOAbbreviation>Prog. Neuropsychopharmacol. Biol. Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Ghrelin-reactive immunoglobulins and anxiety, depression and stress-induced cortisol response in adolescents. The TRAILS study.</ArticleTitle><Pagination><MedlinePgn>1-7</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0278-5846(14)00248-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.pnpbp.2014.12.011</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Ghrelin, a hunger hormone, has been implicated in the regulation of stress-response, anxiety and depression. Ghrelin-reactive immunoglobulins (Ig) were recently identified in healthy and obese humans showing abilities to increase ghrelin's stability and orexigenic effects. Here we studied if ghrelin-reactive Ig are associated with anxiety and depression and with the stress-induced cortisol response in a general population of adolescents. Furthermore, to test the possible infectious origin of ghrelin-reactive Ig, their levels were compared with serum IgG against common viruses.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We measured ghrelin-reactive IgM, IgG and IgA in serum samples of 1199 adolescents from the Dutch TRAILS study and tested their associations with 1) anxiety and depression symptoms assessed with the Youth Self-Report, 2) stress-induced salivary cortisol levels and 3) IgG against human herpesvirus 1, 2, 4 and 6 and Influenza A and B viruses.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Ghrelin-reactive IgM and IgG correlated positively with levels of antibodies against Influenza A virus. Ghrelin-reactive IgM correlated negatively with antibodies against Influenza B virus. Ghrelin-reactive IgM correlated positively with anxiety scores in girls and ghrelin-reactive IgG correlated with stress-induced cortisol secretion, but these associations were weak and not significant after correction for multiple testing.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These data indicate that production of ghrelin-reactive autoantibodies could be influenced by viral infections. Serum levels of ghrelin-reactive autoantibodies probably do not play a role in regulating anxiety, depression and the stress-response in adolescents from the general population.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>François</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schaefer</LastName><ForeName>Johanna M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry & Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bole-Feysot</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Déchelotte</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verhulst</LastName><ForeName>Frank C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry & Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fetissov</LastName><ForeName>Sergueï O</ForeName><Initials>SO</Initials><AffiliationInfo><Affiliation>Nutrition, Gut and Brain Laboratory, Inserm UMR1073, Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76183, France. Electronic address: Serguei.Fetissov@univ-rouen.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Prog Neuropsychopharmacol Biol Psychiatry</MedlineTA><NlmUniqueID>8211617</NlmUniqueID><ISSNLinking>0278-5846</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054439">Ghrelin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007136">Immunoglobulins</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054439" MajorTopicYN="N">Ghrelin</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007136" MajorTopicYN="N">Immunoglobulins</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018139" MajorTopicYN="N">Simplexvirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anxiety</Keyword><Keyword MajorTopicYN="N">Autoantibodies</Keyword><Keyword MajorTopicYN="N">Depression</Keyword><Keyword MajorTopicYN="N">Infection</Keyword><Keyword MajorTopicYN="N">Molecular mimicry</Keyword><Keyword MajorTopicYN="N">Peptide hormones</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>12</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25562566</ArticleId><ArticleId IdType="pii">S0278-5846(14)00248-6</ArticleId><ArticleId IdType="doi">10.1016/j.pnpbp.2014.12.011</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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