Glycemic Variability in Diabetes Increases the Severity of Influenza.
Identifieur interne : 000129 ( PubMed/Curation ); précédent : 000128; suivant : 000130Glycemic Variability in Diabetes Increases the Severity of Influenza.
Auteurs : Rebecca J. Marshall [Australie] ; Pornthida Armart [Australie] ; Katina D. Hulme [Australie] ; Keng Yih Chew [Australie] ; Alexandra C. Brown [Australie] ; Philip M. Hansbro [Australie] ; Conor J. Bloxham [Australie] ; Melanie Flint [Australie] ; Katharina Ronacher [Australie] ; Helle Bielefeldt-Ohmann [Australie] ; Linda A. Gallo [Australie] ; Kirsty R. Short [Australie]Source :
- mBio [ 2150-7511 ] ; 2020.
Abstract
People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this susceptibility are poorly understood. In healthy individuals, small and short-lived postprandial peaks in blood glucose levels occur. In diabetes mellitus, these fluctuations become greater and more frequent. This glycemic variability is associated with oxidative stress and hyperinflammation. However, the contribution of glycemic variability to the pathogenesis of influenza A virus (IAV) has not been explored. Here, we used an in vitro model of the pulmonary epithelial-endothelial barrier and novel murine models to investigate the role of glycemic variability in influenza severity. In vitro, a history of glycemic variability significantly increased influenza-driven cell death and destruction of the epithelial-endothelial barrier. In vivo, influenza virus-infected mice with a history of glycemic variability lost significantly more body weight than mice with constant blood glucose levels. This increased disease severity was associated with markers of oxidative stress and hyperinflammation both in vitro and in vivo Together, these results provide the first indication that glycemic variability may help drive the increased risk of severe influenza in people with diabetes mellitus.IMPORTANCE Every winter, people with diabetes are at increased risk of severe influenza. At present, the mechanisms that cause this increased susceptibility are unclear. Here, we show that the fluctuations in blood glucose levels common in people with diabetes are associated with severe influenza. These data suggest that glycemic stability could become a greater clinical priority for patients with diabetes during outbreaks of influenza.
DOI: 10.1128/mBio.02841-19
PubMed: 32209691
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<front><div type="abstract" xml:lang="en">People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this susceptibility are poorly understood. In healthy individuals, small and short-lived postprandial peaks in blood glucose levels occur. In diabetes mellitus, these fluctuations become greater and more frequent. This glycemic variability is associated with oxidative stress and hyperinflammation. However, the contribution of glycemic variability to the pathogenesis of influenza A virus (IAV) has not been explored. Here, we used an <i>in vitro</i>
model of the pulmonary epithelial-endothelial barrier and novel murine models to investigate the role of glycemic variability in influenza severity. <i>In vitro</i>
, a history of glycemic variability significantly increased influenza-driven cell death and destruction of the epithelial-endothelial barrier. <i>In vivo</i>
, influenza virus-infected mice with a history of glycemic variability lost significantly more body weight than mice with constant blood glucose levels. This increased disease severity was associated with markers of oxidative stress and hyperinflammation both <i>in vitro</i>
and <i>in vivo</i>
Together, these results provide the first indication that glycemic variability may help drive the increased risk of severe influenza in people with diabetes mellitus.<b>IMPORTANCE</b>
Every winter, people with diabetes are at increased risk of severe influenza. At present, the mechanisms that cause this increased susceptibility are unclear. Here, we show that the fluctuations in blood glucose levels common in people with diabetes are associated with severe influenza. These data suggest that glycemic stability could become a greater clinical priority for patients with diabetes during outbreaks of influenza.</div>
</front>
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<Abstract><AbstractText>People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this susceptibility are poorly understood. In healthy individuals, small and short-lived postprandial peaks in blood glucose levels occur. In diabetes mellitus, these fluctuations become greater and more frequent. This glycemic variability is associated with oxidative stress and hyperinflammation. However, the contribution of glycemic variability to the pathogenesis of influenza A virus (IAV) has not been explored. Here, we used an <i>in vitro</i>
model of the pulmonary epithelial-endothelial barrier and novel murine models to investigate the role of glycemic variability in influenza severity. <i>In vitro</i>
, a history of glycemic variability significantly increased influenza-driven cell death and destruction of the epithelial-endothelial barrier. <i>In vivo</i>
, influenza virus-infected mice with a history of glycemic variability lost significantly more body weight than mice with constant blood glucose levels. This increased disease severity was associated with markers of oxidative stress and hyperinflammation both <i>in vitro</i>
and <i>in vivo</i>
Together, these results provide the first indication that glycemic variability may help drive the increased risk of severe influenza in people with diabetes mellitus.<b>IMPORTANCE</b>
Every winter, people with diabetes are at increased risk of severe influenza. At present, the mechanisms that cause this increased susceptibility are unclear. Here, we show that the fluctuations in blood glucose levels common in people with diabetes are associated with severe influenza. These data suggest that glycemic stability could become a greater clinical priority for patients with diabetes during outbreaks of influenza.</AbstractText>
<CopyrightInformation>Copyright © 2020 Marshall et al.</CopyrightInformation>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>The University of Newcastle, Callaghan, NSW, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Technology Sydney, Faculty of Science, Ultimo, NSW, Australia.</Affiliation>
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<ReferenceList><Reference><Citation>Virology. 2013 Sep;444(1-2):301-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23876457</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2012;7(8):e42588</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22870337</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Sci (Lond). 2011 Dec;121(12):555-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21729007</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Vis Exp. 2011 Apr 14;(50):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21525841</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2016 Sep 8;166(6):1512-1525.e12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27610573</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Microbiol. 2014 Dec 02;5:653</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25520707</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Vaccine Immunol. 2011 Mar;18(3):469-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21209157</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Mol Sci. 2014 Oct 13;15(10):18381-406</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25314300</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur Respir J. 1997 Jul;10(7):1535-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9230243</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Microbiol. 2017 May 22;8:861</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28588558</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Vaccine. 2017 Sep 12;35(38):5095-5101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28807608</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28252317</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2011 Jul 2;378(9785):31-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21705069</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Euro Surveill. 2010 Dec 09;15(49):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21163179</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Trends Pharmacol Sci. 2012 Jan;33(1):3-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21962460</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Diabetes Investig. 2016 May;7(3):297-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27330713</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2012;7(3):e32947</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22396801</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes Care. 2010 Jul;33(7):1491-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20587722</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2008 Aug 01;4(8):e1000115</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18670648</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Diabetes. 2018 Mar;10(3):186-187</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29091343</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes Care. 2003 Feb;26(2):510-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12547890</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes. 2014 May;63(5):1748-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24458354</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur Respir J. 2016 Mar;47(3):954-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26743480</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Exp Med. 2008 Sep 29;205(10):2409-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18809715</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetologia. 1995 Jun;38(6):672-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7672488</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Jan;14(1):57-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24239327</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Crit Care. 2013 Mar 06;17(2):305</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23470218</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2275-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16888238</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell. 2011 Sep 16;146(6):980-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21925319</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1998 Aug;72(8):6884-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9658139</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Respir Cell Mol Biol. 2017 Nov;57(5):536-546</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28613916</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2014 Oct 10;9(10):e108844</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25303153</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes. 2003 Nov;52(11):2795-804</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14578299</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Vaccine. 2010 Mar 24;28(15):2775-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20117261</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E924-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11595647</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Endocrinol. 2015;2015:406394</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26366172</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2010 Aug 12;6(8):e1001039</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20711359</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes. 2005 Nov;54(11):3103-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16249432</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27162351</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAMA. 2006 Apr 12;295(14):1681-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16609090</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes Res Clin Pract. 2018 May;139:253-261</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29501829</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes. 1999 Apr;48(4):870-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10102706</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes. 2008 May;57(5):1349-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18299315</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Endocrinol. 2015 Dec;55(3):169-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26464382</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS One. 2016 Feb 24;11(2):e0149864</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26910342</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Exp Ther Med. 2012 Jan;3(1):76-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22969848</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2019 Oct 22;220(11):1859-1860</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31283821</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabetes Res Clin Pract. 2011 Feb;91(2):e40-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21035886</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2007 Jul 6;358(3):679-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17506980</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Exp Dermatol. 2010 Jan;35(1):78-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19594769</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Physiol. 2012 May 22;3:146</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22661953</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2008 Oct 9;359(15):1577-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18784090</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Microb Pathog. 2017 Dec;113:233-241</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29066377</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2001 Sep 1;167(5):2595-601</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11509600</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
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