Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.
Identifieur interne : 000A21 ( PubMed/Corpus ); précédent : 000A20; suivant : 000A22Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.
Auteurs : M. Mileva ; L. Tancheva ; R. Bakalova ; A. Galabov ; V. Savov ; S. RibarovSource :
- Toxicology letters [ 0378-4274 ] ; 2000.
English descriptors
- KwdEn :
- Aminopyrine N-Demethylase (antagonists & inhibitors), Aminopyrine N-Demethylase (metabolism), Aniline Hydroxylase (antagonists & inhibitors), Aniline Hydroxylase (metabolism), Animals, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System (metabolism), Dipyrone (metabolism), Dose-Response Relationship, Drug, Ethylmorphine-N-Demethylase (antagonists & inhibitors), Ethylmorphine-N-Demethylase (metabolism), Influenza A virus (metabolism), Lipid Peroxidation (drug effects), Liver (drug effects), Liver (enzymology), Liver (virology), Male, Mice, NADPH-Ferrihemoprotein Reductase (metabolism), Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (enzymology), Oxidative Stress (drug effects), Thiobarbituric Acid Reactive Substances (metabolism), Vitamin E (pharmacology).
- MESH :
- chemical , antagonists & inhibitors : Aminopyrine N-Demethylase, Aniline Hydroxylase, Ethylmorphine-N-Demethylase.
- chemical , metabolism : Aminopyrine N-Demethylase, Aniline Hydroxylase, Cytochrome P-450 Enzyme System, Dipyrone, Ethylmorphine-N-Demethylase, NADPH-Ferrihemoprotein Reductase, Thiobarbituric Acid Reactive Substances.
- drug effects : Lipid Peroxidation, Liver, Oxidative Stress.
- drug therapy : Orthomyxoviridae Infections.
- enzymology : Liver, Orthomyxoviridae Infections.
- metabolism : Influenza A virus.
- chemical , pharmacology : Vitamin E.
- virology : Liver.
- Animals, Cytochrome P-450 Enzyme Inhibitors, Dose-Response Relationship, Drug, Male, Mice.
Abstract
Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP. H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.
DOI: 10.1016/s0378-4274(99)00265-9
PubMed: 10713467
Links to Exploration step
pubmed:10713467Le document en format XML
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<author><name sortKey="Mileva, M" sort="Mileva, M" uniqKey="Mileva M" first="M" last="Mileva">M. Mileva</name>
<affiliation><nlm:affiliation>Department of Medical Physics and Biophysics, Medical University, 2 Zdrave Str., Sofia, Bulgaria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tancheva, L" sort="Tancheva, L" uniqKey="Tancheva L" first="L" last="Tancheva">L. Tancheva</name>
</author>
<author><name sortKey="Bakalova, R" sort="Bakalova, R" uniqKey="Bakalova R" first="R" last="Bakalova">R. Bakalova</name>
</author>
<author><name sortKey="Galabov, A" sort="Galabov, A" uniqKey="Galabov A" first="A" last="Galabov">A. Galabov</name>
</author>
<author><name sortKey="Savov, V" sort="Savov, V" uniqKey="Savov V" first="V" last="Savov">V. Savov</name>
</author>
<author><name sortKey="Ribarov, S" sort="Ribarov, S" uniqKey="Ribarov S" first="S" last="Ribarov">S. Ribarov</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.</title>
<author><name sortKey="Mileva, M" sort="Mileva, M" uniqKey="Mileva M" first="M" last="Mileva">M. Mileva</name>
<affiliation><nlm:affiliation>Department of Medical Physics and Biophysics, Medical University, 2 Zdrave Str., Sofia, Bulgaria.</nlm:affiliation>
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<author><name sortKey="Tancheva, L" sort="Tancheva, L" uniqKey="Tancheva L" first="L" last="Tancheva">L. Tancheva</name>
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<author><name sortKey="Bakalova, R" sort="Bakalova, R" uniqKey="Bakalova R" first="R" last="Bakalova">R. Bakalova</name>
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<author><name sortKey="Galabov, A" sort="Galabov, A" uniqKey="Galabov A" first="A" last="Galabov">A. Galabov</name>
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<author><name sortKey="Savov, V" sort="Savov, V" uniqKey="Savov V" first="V" last="Savov">V. Savov</name>
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<author><name sortKey="Ribarov, S" sort="Ribarov, S" uniqKey="Ribarov S" first="S" last="Ribarov">S. Ribarov</name>
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<series><title level="j">Toxicology letters</title>
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<imprint><date when="2000" type="published">2000</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminopyrine N-Demethylase (antagonists & inhibitors)</term>
<term>Aminopyrine N-Demethylase (metabolism)</term>
<term>Aniline Hydroxylase (antagonists & inhibitors)</term>
<term>Aniline Hydroxylase (metabolism)</term>
<term>Animals</term>
<term>Cytochrome P-450 Enzyme Inhibitors</term>
<term>Cytochrome P-450 Enzyme System (metabolism)</term>
<term>Dipyrone (metabolism)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Ethylmorphine-N-Demethylase (antagonists & inhibitors)</term>
<term>Ethylmorphine-N-Demethylase (metabolism)</term>
<term>Influenza A virus (metabolism)</term>
<term>Lipid Peroxidation (drug effects)</term>
<term>Liver (drug effects)</term>
<term>Liver (enzymology)</term>
<term>Liver (virology)</term>
<term>Male</term>
<term>Mice</term>
<term>NADPH-Ferrihemoprotein Reductase (metabolism)</term>
<term>Orthomyxoviridae Infections (drug therapy)</term>
<term>Orthomyxoviridae Infections (enzymology)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Thiobarbituric Acid Reactive Substances (metabolism)</term>
<term>Vitamin E (pharmacology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Aminopyrine N-Demethylase</term>
<term>Aniline Hydroxylase</term>
<term>Ethylmorphine-N-Demethylase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aminopyrine N-Demethylase</term>
<term>Aniline Hydroxylase</term>
<term>Cytochrome P-450 Enzyme System</term>
<term>Dipyrone</term>
<term>Ethylmorphine-N-Demethylase</term>
<term>NADPH-Ferrihemoprotein Reductase</term>
<term>Thiobarbituric Acid Reactive Substances</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lipid Peroxidation</term>
<term>Liver</term>
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Liver</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Vitamin E</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cytochrome P-450 Enzyme Inhibitors</term>
<term>Dose-Response Relationship, Drug</term>
<term>Male</term>
<term>Mice</term>
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<front><div type="abstract" xml:lang="en">Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP. H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.</div>
</front>
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<Title>Toxicology letters</Title>
<ISOAbbreviation>Toxicol. Lett.</ISOAbbreviation>
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<ArticleTitle>Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.</ArticleTitle>
<Pagination><MedlinePgn>39-45</MedlinePgn>
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<Abstract><AbstractText>Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP. H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mileva</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medical Physics and Biophysics, Medical University, 2 Zdrave Str., Sofia, Bulgaria.</Affiliation>
</AffiliationInfo>
</Author>
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<Chemical><RegistryNumber>6429L0L52Y</RegistryNumber>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014810" MajorTopicYN="N">Vitamin E</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
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