Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.
Identifieur interne : 000943 ( PubMed/Corpus ); précédent : 000942; suivant : 000944Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.
Auteurs : Judith R. Turnlund ; Robert A. Jacob ; Carl L. Keen ; J J Strain ; Darshan S. Kelley ; Joseph M. Domek ; William R. Keyes ; Jodi L. Ensunsa ; Jens Lykkesfeldt ; James CoulterSource :
- The American journal of clinical nutrition [ 0002-9165 ] ; 2004.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Copper.
- chemical , blood : Benzylamine Oxidase.
- chemical , metabolism : Ceruloplasmin, Copper, Superoxide Dismutase.
- chemical , pharmacology : Copper.
- drug effects : Immune System.
- Adult, Diet, Humans, Male, Nutritional Status.
Abstract
Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown.
DOI: 10.1093/ajcn/79.6.1037
PubMed: 15159234
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pubmed:15159234Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.</title><author><name sortKey="Turnlund, Judith R" sort="Turnlund, Judith R" uniqKey="Turnlund J" first="Judith R" last="Turnlund">Judith R. Turnlund</name><affiliation><nlm:affiliation>US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA. jturnlun@whnrc.usda.gov</nlm:affiliation></affiliation></author><author><name sortKey="Jacob, Robert A" sort="Jacob, Robert A" uniqKey="Jacob R" first="Robert A" last="Jacob">Robert A. Jacob</name></author><author><name sortKey="Keen, Carl L" sort="Keen, Carl L" uniqKey="Keen C" first="Carl L" last="Keen">Carl L. Keen</name></author><author><name sortKey="Strain, J J" sort="Strain, J J" uniqKey="Strain J" first="J J" last="Strain">J J Strain</name></author><author><name sortKey="Kelley, Darshan S" sort="Kelley, Darshan S" uniqKey="Kelley D" first="Darshan S" last="Kelley">Darshan S. Kelley</name></author><author><name sortKey="Domek, Joseph M" sort="Domek, Joseph M" uniqKey="Domek J" first="Joseph M" last="Domek">Joseph M. Domek</name></author><author><name sortKey="Keyes, William R" sort="Keyes, William R" uniqKey="Keyes W" first="William R" last="Keyes">William R. Keyes</name></author><author><name sortKey="Ensunsa, Jodi L" sort="Ensunsa, Jodi L" uniqKey="Ensunsa J" first="Jodi L" last="Ensunsa">Jodi L. Ensunsa</name></author><author><name sortKey="Lykkesfeldt, Jens" sort="Lykkesfeldt, Jens" uniqKey="Lykkesfeldt J" first="Jens" last="Lykkesfeldt">Jens Lykkesfeldt</name></author><author><name sortKey="Coulter, James" sort="Coulter, James" uniqKey="Coulter J" first="James" last="Coulter">James Coulter</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15159234</idno><idno type="pmid">15159234</idno><idno type="doi">10.1093/ajcn/79.6.1037</idno><idno type="wicri:Area/PubMed/Corpus">000943</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000943</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.</title><author><name sortKey="Turnlund, Judith R" sort="Turnlund, Judith R" uniqKey="Turnlund J" first="Judith R" last="Turnlund">Judith R. Turnlund</name><affiliation><nlm:affiliation>US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA. jturnlun@whnrc.usda.gov</nlm:affiliation></affiliation></author><author><name sortKey="Jacob, Robert A" sort="Jacob, Robert A" uniqKey="Jacob R" first="Robert A" last="Jacob">Robert A. Jacob</name></author><author><name sortKey="Keen, Carl L" sort="Keen, Carl L" uniqKey="Keen C" first="Carl L" last="Keen">Carl L. Keen</name></author><author><name sortKey="Strain, J J" sort="Strain, J J" uniqKey="Strain J" first="J J" last="Strain">J J Strain</name></author><author><name sortKey="Kelley, Darshan S" sort="Kelley, Darshan S" uniqKey="Kelley D" first="Darshan S" last="Kelley">Darshan S. Kelley</name></author><author><name sortKey="Domek, Joseph M" sort="Domek, Joseph M" uniqKey="Domek J" first="Joseph M" last="Domek">Joseph M. Domek</name></author><author><name sortKey="Keyes, William R" sort="Keyes, William R" uniqKey="Keyes W" first="William R" last="Keyes">William R. Keyes</name></author><author><name sortKey="Ensunsa, Jodi L" sort="Ensunsa, Jodi L" uniqKey="Ensunsa J" first="Jodi L" last="Ensunsa">Jodi L. Ensunsa</name></author><author><name sortKey="Lykkesfeldt, Jens" sort="Lykkesfeldt, Jens" uniqKey="Lykkesfeldt J" first="Jens" last="Lykkesfeldt">Jens Lykkesfeldt</name></author><author><name sortKey="Coulter, James" sort="Coulter, James" uniqKey="Coulter J" first="James" last="Coulter">James Coulter</name></author></analytic><series><title level="j">The American journal of clinical nutrition</title><idno type="ISSN">0002-9165</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Benzylamine Oxidase (blood)</term><term>Ceruloplasmin (metabolism)</term><term>Copper (administration & dosage)</term><term>Copper (metabolism)</term><term>Copper (pharmacology)</term><term>Diet</term><term>Humans</term><term>Immune System (drug effects)</term><term>Male</term><term>Nutritional Status</term><term>Superoxide Dismutase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Copper</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Benzylamine Oxidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Ceruloplasmin</term><term>Copper</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Copper</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immune System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Diet</term><term>Humans</term><term>Male</term><term>Nutritional Status</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15159234</PMID><DateCompleted><Year>2004</Year><Month>06</Month><Day>15</Day></DateCompleted><DateRevised><Year>2018</Year><Month>03</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9165</ISSN><JournalIssue CitedMedium="Print"><Volume>79</Volume><Issue>6</Issue><PubDate><Year>2004</Year><Month>Jun</Month></PubDate></JournalIssue><Title>The American journal of clinical nutrition</Title><ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation></Journal><ArticleTitle>Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.</ArticleTitle><Pagination><MedlinePgn>1037-44</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">A study was conducted in men to determine the effect of long-term high copper intake on indexes of copper status, oxidant damage, and immune function.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Nine men were confined to a metabolic research unit (MRU) for 18 d and were fed a 3-d rotating menu providing an average of 1.6 mg Cu/d. The men continued the study under free-living conditions for 129 d and supplemented their usual diets with 7 mg Cu/d. The men then returned to the MRU for 18 d of the same diet as during the first period, except that copper intake was 7.8 mg/d. Plasma copper, ceruloplasmin activity, ceruloplasmin protein, plasma malondialdehyde, benzylamine oxidase activity, erythrocyte superoxide dismutase, hair copper, urinary copper, and urinary thiobarbituric acid-reactive substances were measured during each MRU period.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Ceruloplasmin activity, benzylamine oxidase, and superoxide dismutase were significantly higher at the end of the second MRU period than at the end of the first. Urinary copper excretion, hair copper concentrations, and urinary thiobarbituric acid-reactive substances were significantly higher during the second MRU period than during the first. Polymorphonuclear cell count, the percentage of white blood cells, lymphocyte count, and interleukin 2R were affected by copper supplementation. Antibody titer for the Beijing strain of influenza virus was significantly lower in supplemented subjects after immunization than in unsupplemented control subjects.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Under highly controlled conditions, long-term high copper intake results in increases in some indexes of copper status, alters an index of oxidant stress, and affects several indexes of immune function. The physiologic implications of these changes are unknown.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Turnlund</LastName><ForeName>Judith R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA. jturnlun@whnrc.usda.gov</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacob</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Keen</LastName><ForeName>Carl L</ForeName><Initials>CL</Initials></Author><Author ValidYN="Y"><LastName>Strain</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Kelley</LastName><ForeName>Darshan S</ForeName><Initials>DS</Initials></Author><Author ValidYN="Y"><LastName>Domek</LastName><ForeName>Joseph M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Keyes</LastName><ForeName>William R</ForeName><Initials>WR</Initials></Author><Author ValidYN="Y"><LastName>Ensunsa</LastName><ForeName>Jodi L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Lykkesfeldt</LastName><ForeName>Jens</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Coulter</LastName><ForeName>James</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Clin Nutr</MedlineTA><NlmUniqueID>0376027</NlmUniqueID><ISSNLinking>0002-9165</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>789U1901C5</RegistryNumber><NameOfSubstance UI="D003300">Copper</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.16.3.1</RegistryNumber><NameOfSubstance UI="D002570">Ceruloplasmin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.4.3.-</RegistryNumber><NameOfSubstance UI="D001595">Benzylamine Oxidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001595" MajorTopicYN="N">Benzylamine Oxidase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002570" MajorTopicYN="N">Ceruloplasmin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003300" MajorTopicYN="N">Copper</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="Y">Diet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007107" MajorTopicYN="N">Immune System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009752" MajorTopicYN="N">Nutritional Status</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>5</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>6</Month><Day>16</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>5</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15159234</ArticleId><ArticleId IdType="doi">10.1093/ajcn/79.6.1037</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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