Role of early stress in the individual differences in host response to viral infection.
Identifieur interne : 000862 ( PubMed/Corpus ); précédent : 000861; suivant : 000863Role of early stress in the individual differences in host response to viral infection.
Auteurs : Ronit Avitsur ; John Hunzeker ; John F. SheridanSource :
- Brain, behavior, and immunity [ 0889-1591 ] ; 2006.
English descriptors
- KwdEn :
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Corticosterone (blood), Cytokines (genetics), Cytokines (immunology), Cytokines (metabolism), Humans, Hypothalamo-Hypophyseal System (immunology), Influenza A virus (immunology), Lung (immunology), Lung (metabolism), Male, Maternal Deprivation, Mice, Mice, Inbred C57BL, Neurosecretory Systems (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (metabolism), Pituitary-Adrenal System (immunology), RNA, Messenger (analysis), Stress, Psychological (immunology), Stress, Psychological (metabolism).
- MESH :
- chemical , analysis : RNA, Messenger.
- chemical , blood : Corticosterone.
- chemical , genetics : Cytokines.
- chemical , immunology : Cytokines.
- chemical , metabolism : Cytokines.
- immunology : Hypothalamo-Hypophyseal System, Influenza A virus, Lung, Neurosecretory Systems, Orthomyxoviridae Infections, Pituitary-Adrenal System, Stress, Psychological.
- metabolism : Lung, Orthomyxoviridae Infections, Stress, Psychological.
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Humans, Male, Maternal Deprivation, Mice, Mice, Inbred C57BL.
Abstract
Early negative life events, especially during the neonatal period, resulted in long lasting, irreversible effects on well being. The goal of the following study was to examine the lifelong effects of neonatal stress on the response to an influenza viral infection. Mouse pups were repeatedly separated from their dams between postnatal days 1-14 (maternal separation, MSP). As adults, these mice were infected with influenza A/PR8 virus and lung cytokine and plasma corticosterone responses to the viral infection were measured. The results indicated that MSP augmented several aspects of the response to infection. First, infection-induced lung proinflammatory cytokine (interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-alpha) mRNA expression was higher in MSP mice compared to controls. In addition, MSP augmented infection-induced lung IL-12 and interferon (IFN)-gamma, but had no effect on IL-18 mRNA. Interestingly, MSP-induced increase in IL-1, TNF-alpha and IFN-gamma mRNA expression was evident in females, but not in males. These findings suggest that MSP disrupted the regulation of innate resistance resulting in enhanced cytokine responses in the lungs during an infectious challenge. These changes in host response to the viral infection were accompanied by an increase in viral replication in lungs of MSP mice. Interestingly, influenza-induced corticosterone secretion was blunted in MSP mice, suggesting that the increase in immune reactivity to the virus was due to lack of glucocorticoid feedback control. These data demonstrate that neonatal stress has implications for host resistance to infection throughout life. Thus, long lasting effects of negative life events on health and disease may be the basis for the individual differences in host susceptibility to infection.
DOI: 10.1016/j.bbi.2005.09.006
PubMed: 16289758
Links to Exploration step
pubmed:16289758Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of early stress in the individual differences in host response to viral infection.</title><author><name sortKey="Avitsur, Ronit" sort="Avitsur, Ronit" uniqKey="Avitsur R" first="Ronit" last="Avitsur">Ronit Avitsur</name><affiliation><nlm:affiliation>Section of Oral Biology, Ohio State University, Columbus, OH, USA. avitsur@mta.ac.il</nlm:affiliation></affiliation></author><author><name sortKey="Hunzeker, John" sort="Hunzeker, John" uniqKey="Hunzeker J" first="John" last="Hunzeker">John Hunzeker</name></author><author><name sortKey="Sheridan, John F" sort="Sheridan, John F" uniqKey="Sheridan J" first="John F" last="Sheridan">John F. Sheridan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16289758</idno><idno type="pmid">16289758</idno><idno type="doi">10.1016/j.bbi.2005.09.006</idno><idno type="wicri:Area/PubMed/Corpus">000862</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000862</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Role of early stress in the individual differences in host response to viral infection.</title><author><name sortKey="Avitsur, Ronit" sort="Avitsur, Ronit" uniqKey="Avitsur R" first="Ronit" last="Avitsur">Ronit Avitsur</name><affiliation><nlm:affiliation>Section of Oral Biology, Ohio State University, Columbus, OH, USA. avitsur@mta.ac.il</nlm:affiliation></affiliation></author><author><name sortKey="Hunzeker, John" sort="Hunzeker, John" uniqKey="Hunzeker J" first="John" last="Hunzeker">John Hunzeker</name></author><author><name sortKey="Sheridan, John F" sort="Sheridan, John F" uniqKey="Sheridan J" first="John F" last="Sheridan">John F. Sheridan</name></author></analytic><series><title level="j">Brain, behavior, and immunity</title><idno type="ISSN">0889-1591</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Analysis of Variance</term><term>Animals</term><term>Animals, Newborn</term><term>Corticosterone (blood)</term><term>Cytokines (genetics)</term><term>Cytokines (immunology)</term><term>Cytokines (metabolism)</term><term>Humans</term><term>Hypothalamo-Hypophyseal System (immunology)</term><term>Influenza A virus (immunology)</term><term>Lung (immunology)</term><term>Lung (metabolism)</term><term>Male</term><term>Maternal Deprivation</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Neurosecretory Systems (immunology)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (metabolism)</term><term>Pituitary-Adrenal System (immunology)</term><term>RNA, Messenger (analysis)</term><term>Stress, Psychological (immunology)</term><term>Stress, Psychological (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Corticosterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Influenza A virus</term><term>Lung</term><term>Neurosecretory Systems</term><term>Orthomyxoviridae Infections</term><term>Pituitary-Adrenal System</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term><term>Orthomyxoviridae Infections</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Analysis of Variance</term><term>Animals</term><term>Animals, Newborn</term><term>Humans</term><term>Male</term><term>Maternal Deprivation</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Early negative life events, especially during the neonatal period, resulted in long lasting, irreversible effects on well being. The goal of the following study was to examine the lifelong effects of neonatal stress on the response to an influenza viral infection. Mouse pups were repeatedly separated from their dams between postnatal days 1-14 (maternal separation, MSP). As adults, these mice were infected with influenza A/PR8 virus and lung cytokine and plasma corticosterone responses to the viral infection were measured. The results indicated that MSP augmented several aspects of the response to infection. First, infection-induced lung proinflammatory cytokine (interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-alpha) mRNA expression was higher in MSP mice compared to controls. In addition, MSP augmented infection-induced lung IL-12 and interferon (IFN)-gamma, but had no effect on IL-18 mRNA. Interestingly, MSP-induced increase in IL-1, TNF-alpha and IFN-gamma mRNA expression was evident in females, but not in males. These findings suggest that MSP disrupted the regulation of innate resistance resulting in enhanced cytokine responses in the lungs during an infectious challenge. These changes in host response to the viral infection were accompanied by an increase in viral replication in lungs of MSP mice. Interestingly, influenza-induced corticosterone secretion was blunted in MSP mice, suggesting that the increase in immune reactivity to the virus was due to lack of glucocorticoid feedback control. These data demonstrate that neonatal stress has implications for host resistance to infection throughout life. Thus, long lasting effects of negative life events on health and disease may be the basis for the individual differences in host susceptibility to infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16289758</PMID><DateCompleted><Year>2006</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0889-1591</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>4</Issue><PubDate><Year>2006</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Brain, behavior, and immunity</Title><ISOAbbreviation>Brain Behav. Immun.</ISOAbbreviation></Journal><ArticleTitle>Role of early stress in the individual differences in host response to viral infection.</ArticleTitle><Pagination><MedlinePgn>339-48</MedlinePgn></Pagination><Abstract><AbstractText>Early negative life events, especially during the neonatal period, resulted in long lasting, irreversible effects on well being. The goal of the following study was to examine the lifelong effects of neonatal stress on the response to an influenza viral infection. Mouse pups were repeatedly separated from their dams between postnatal days 1-14 (maternal separation, MSP). As adults, these mice were infected with influenza A/PR8 virus and lung cytokine and plasma corticosterone responses to the viral infection were measured. The results indicated that MSP augmented several aspects of the response to infection. First, infection-induced lung proinflammatory cytokine (interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-alpha) mRNA expression was higher in MSP mice compared to controls. In addition, MSP augmented infection-induced lung IL-12 and interferon (IFN)-gamma, but had no effect on IL-18 mRNA. Interestingly, MSP-induced increase in IL-1, TNF-alpha and IFN-gamma mRNA expression was evident in females, but not in males. These findings suggest that MSP disrupted the regulation of innate resistance resulting in enhanced cytokine responses in the lungs during an infectious challenge. These changes in host response to the viral infection were accompanied by an increase in viral replication in lungs of MSP mice. Interestingly, influenza-induced corticosterone secretion was blunted in MSP mice, suggesting that the increase in immune reactivity to the virus was due to lack of glucocorticoid feedback control. These data demonstrate that neonatal stress has implications for host resistance to infection throughout life. Thus, long lasting effects of negative life events on health and disease may be the basis for the individual differences in host susceptibility to infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Avitsur</LastName><ForeName>Ronit</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Section of Oral Biology, Ohio State University, Columbus, OH, USA. avitsur@mta.ac.il</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunzeker</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sheridan</LastName><ForeName>John F</ForeName><Initials>JF</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 MH046801</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>11</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Behav Immun</MedlineTA><NlmUniqueID>8800478</NlmUniqueID><ISSNLinking>0889-1591</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>W980KJ009P</RegistryNumber><NameOfSubstance UI="D003345">Corticosterone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000831" MajorTopicYN="N">Animals, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003345" MajorTopicYN="N">Corticosterone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008426" MajorTopicYN="N">Maternal Deprivation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009490" MajorTopicYN="N">Neurosecretory Systems</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>07</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>09</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>09</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>11</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>8</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>11</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16289758</ArticleId><ArticleId IdType="pii">S0889-1591(05)00183-2</ArticleId><ArticleId IdType="doi">10.1016/j.bbi.2005.09.006</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000862 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000862 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:16289758
|texte= Role of early stress in the individual differences in host response to viral infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:16289758" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |