Methylprednisolone infusion for life-threatening H1N1-virus infection.
Identifieur interne : 000680 ( PubMed/Corpus ); précédent : 000679; suivant : 000681Methylprednisolone infusion for life-threatening H1N1-virus infection.
Auteurs : Marco Confalonieri ; Rossella Cifaldi ; Lorella Dreas ; Marino Viviani ; Marco Biolo ; Marco GabrielliSource :
- Therapeutic advances in respiratory disease [ 1753-4666 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Antiviral Agents (therapeutic use), Bronchoalveolar Lavage (methods), Combined Modality Therapy, Extracorporeal Membrane Oxygenation, Female, Glucocorticoids (administration & dosage), Glucocorticoids (therapeutic use), Humans, Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (diagnosis), Influenza, Human (therapy), Influenza, Human (virology), Male, Methylprednisolone (administration & dosage), Methylprednisolone (therapeutic use), Middle Aged, Oseltamivir (therapeutic use), Respiration, Artificial (methods), Severity of Illness Index, Treatment Outcome, Young Adult.
- MESH :
- chemical , administration & dosage : Glucocorticoids, Methylprednisolone.
- chemical , therapeutic use : Antiviral Agents, Glucocorticoids, Methylprednisolone, Oseltamivir.
- diagnosis : Influenza, Human.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- methods : Bronchoalveolar Lavage, Respiration, Artificial.
- therapy : Influenza, Human.
- virology : Influenza, Human.
- Adult, Aged, Combined Modality Therapy, Extracorporeal Membrane Oxygenation, Female, Humans, Male, Middle Aged, Severity of Illness Index, Treatment Outcome, Young Adult.
Abstract
During winter 2009 we treated with prolonged corticosteroid infusion eight consecutive patients affected by H1N1-virus infection and severe pneumonia. The most severe patient was a previously healthy 30-year-old man admitted to hospital because of bilateral pneumonia and severe acute respiratory failure.
DOI: 10.1177/1753465810376951
PubMed: 20639272
Links to Exploration step
pubmed:20639272Le document en format XML
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Di Fiume 447, 34149 Trieste, Italy. marco.confalonieri@aots.sanita.fvg.it</nlm:affiliation></affiliation></author><author><name sortKey="Cifaldi, Rossella" sort="Cifaldi, Rossella" uniqKey="Cifaldi R" first="Rossella" last="Cifaldi">Rossella Cifaldi</name></author><author><name sortKey="Dreas, Lorella" sort="Dreas, Lorella" uniqKey="Dreas L" first="Lorella" last="Dreas">Lorella Dreas</name></author><author><name sortKey="Viviani, Marino" sort="Viviani, Marino" uniqKey="Viviani M" first="Marino" last="Viviani">Marino Viviani</name></author><author><name sortKey="Biolo, Marco" sort="Biolo, Marco" uniqKey="Biolo M" first="Marco" last="Biolo">Marco Biolo</name></author><author><name sortKey="Gabrielli, Marco" sort="Gabrielli, Marco" uniqKey="Gabrielli M" first="Marco" last="Gabrielli">Marco Gabrielli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20639272</idno><idno type="pmid">20639272</idno><idno type="doi">10.1177/1753465810376951</idno><idno type="wicri:Area/PubMed/Corpus">000680</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000680</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Methylprednisolone infusion for life-threatening H1N1-virus infection.</title><author><name sortKey="Confalonieri, Marco" sort="Confalonieri, Marco" uniqKey="Confalonieri M" first="Marco" last="Confalonieri">Marco Confalonieri</name><affiliation><nlm:affiliation>Pneumology Department, University Hospital of Cattinara, Str. Di Fiume 447, 34149 Trieste, Italy. marco.confalonieri@aots.sanita.fvg.it</nlm:affiliation></affiliation></author><author><name sortKey="Cifaldi, Rossella" sort="Cifaldi, Rossella" uniqKey="Cifaldi R" first="Rossella" last="Cifaldi">Rossella Cifaldi</name></author><author><name sortKey="Dreas, Lorella" sort="Dreas, Lorella" uniqKey="Dreas L" first="Lorella" last="Dreas">Lorella Dreas</name></author><author><name sortKey="Viviani, Marino" sort="Viviani, Marino" uniqKey="Viviani M" first="Marino" last="Viviani">Marino Viviani</name></author><author><name sortKey="Biolo, Marco" sort="Biolo, Marco" uniqKey="Biolo M" first="Marco" last="Biolo">Marco Biolo</name></author><author><name sortKey="Gabrielli, Marco" sort="Gabrielli, Marco" uniqKey="Gabrielli M" first="Marco" last="Gabrielli">Marco Gabrielli</name></author></analytic><series><title level="j">Therapeutic advances in respiratory disease</title><idno type="eISSN">1753-4666</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiviral Agents (therapeutic use)</term><term>Bronchoalveolar Lavage (methods)</term><term>Combined Modality Therapy</term><term>Extracorporeal Membrane Oxygenation</term><term>Female</term><term>Glucocorticoids (administration & dosage)</term><term>Glucocorticoids (therapeutic use)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (therapy)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Methylprednisolone (administration & dosage)</term><term>Methylprednisolone (therapeutic use)</term><term>Middle Aged</term><term>Oseltamivir (therapeutic use)</term><term>Respiration, Artificial (methods)</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Glucocorticoids</term><term>Methylprednisolone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Glucocorticoids</term><term>Methylprednisolone</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Bronchoalveolar Lavage</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Combined Modality Therapy</term><term>Extracorporeal Membrane Oxygenation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During winter 2009 we treated with prolonged corticosteroid infusion eight consecutive patients affected by H1N1-virus infection and severe pneumonia. The most severe patient was a previously healthy 30-year-old man admitted to hospital because of bilateral pneumonia and severe acute respiratory failure.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20639272</PMID><DateCompleted><Year>2010</Year><Month>11</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1753-4666</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>4</Issue><PubDate><Year>2010</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Therapeutic advances in respiratory disease</Title><ISOAbbreviation>Ther Adv Respir Dis</ISOAbbreviation></Journal><ArticleTitle>Methylprednisolone infusion for life-threatening H1N1-virus infection.</ArticleTitle><Pagination><MedlinePgn>233-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/1753465810376951</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">During winter 2009 we treated with prolonged corticosteroid infusion eight consecutive patients affected by H1N1-virus infection and severe pneumonia. The most severe patient was a previously healthy 30-year-old man admitted to hospital because of bilateral pneumonia and severe acute respiratory failure.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">H1N1-virus infection was detected by broncho-alveolar lavage performed on day 1. After some days following admission the patient was still in a life-threatening state, not responding to oseltamivir, protective mechanical ventilation and veno-arterial extracorporeal membrane oxygenation (ECMO).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The addition of methylprednisolone infusion at a stress dose (1 mg/kg/24 h) as rescue therapy significantly and rapidly improved the clinical condition. Weaning from ECMO and invasive mechanical ventilation was possible within a relatively few days.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">According to the literature reports more than 34% of H1N1-virus severe infections were treated with corticosteroids. This report and our experience may suggest a possible life-saving use of corticosteroids at a stress dose in severely ill patients with an H1N1-virus infection that is not responding to the most advanced treatments.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Confalonieri</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pneumology Department, University Hospital of Cattinara, Str. Di Fiume 447, 34149 Trieste, Italy. marco.confalonieri@aots.sanita.fvg.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cifaldi</LastName><ForeName>Rossella</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Dreas</LastName><ForeName>Lorella</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Viviani</LastName><ForeName>Marino</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Biolo</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gabrielli</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>07</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ther Adv Respir Dis</MedlineTA><NlmUniqueID>101316317</NlmUniqueID><ISSNLinking>1753-4658</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical><Chemical><RegistryNumber>X4W7ZR7023</RegistryNumber><NameOfSubstance UI="D008775">Methylprednisolone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018893" MajorTopicYN="N">Bronchoalveolar Lavage</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015199" MajorTopicYN="N">Extracorporeal Membrane Oxygenation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008775" MajorTopicYN="N">Methylprednisolone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053139" 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