Effect of influenza vaccination on oxidative stress products in breath.
Identifieur interne : 000644 ( PubMed/Corpus ); précédent : 000643; suivant : 000645Effect of influenza vaccination on oxidative stress products in breath.
Auteurs : Michael Phillips ; Renee N. Cataneo ; Anirudh Chaturvedi ; Patrick J. Danaher ; Anantrai Devadiga ; David A. Legendre ; Kim L. Nail ; Peter Schmitt ; James WaiSource :
- Journal of breath research [ 1752-7163 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Influenza Vaccines.
- chemical : Biomarkers.
- drug effects : Oxidative Stress.
- metabolism : Influenza, Human.
- Adult, Breath Tests, Female, Humans, Male.
Abstract
Viral infections cause increased oxidative stress, so a breath test for oxidative stress biomarkers (alkanes and alkane derivatives) might provide a new tool for early diagnosis. We studied 33 normal healthy human subjects receiving scheduled treatment with live attenuated influenza vaccine (LAIV). Each subject was his or her own control, since they were studied on day 0 prior to vaccination, and then on days 2, 7 and 14 following vaccination. Breath volatile organic compounds (VOCs) were collected with a breath collection apparatus, then analyzed by automated thermal desorption with gas chromatography and mass spectroscopy. A Monte Carlo simulation technique identified non-random VOC biomarkers of infection based on their C-statistic values (area under curve of receiver operating characteristic). Treatment with LAIV was followed by non-random changes in the abundance of breath VOCs. 2, 8-Dimethyl-undecane and other alkane derivatives were observed on all days. Conservative multivariate models identified vaccinated subjects on day 2 (C-statistic = 0.82, sensitivity = 63.6% and specificity = 88.5%); day 7 (C-statistic = 0.94, sensitivity = 88.5% and specificity = 92.3%); and day 14 (C-statistic = 0.95, sensitivity = 92.3% and specificity = 92.3%). The altered breath VOCs were not detected in live attenuated influenza vaccine, excluding artifactual contamination. LAIV vaccination in healthy humans elicited a prompt and sustained increase in breath biomarkers of oxidative stress. A breath test for these VOCs could potentially identify humans who are acutely infected with influenza, but who have not yet developed clinical symptoms or signs of disease.
DOI: 10.1088/1752-7155/4/2/026001
PubMed: 21383469
Links to Exploration step
pubmed:21383469Le document en format XML
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Danaher</name></author><author><name sortKey="Devadiga, Anantrai" sort="Devadiga, Anantrai" uniqKey="Devadiga A" first="Anantrai" last="Devadiga">Anantrai Devadiga</name></author><author><name sortKey="Legendre, David A" sort="Legendre, David A" uniqKey="Legendre D" first="David A" last="Legendre">David A. Legendre</name></author><author><name sortKey="Nail, Kim L" sort="Nail, Kim L" uniqKey="Nail K" first="Kim L" last="Nail">Kim L. Nail</name></author><author><name sortKey="Schmitt, Peter" sort="Schmitt, Peter" uniqKey="Schmitt P" first="Peter" last="Schmitt">Peter Schmitt</name></author><author><name sortKey="Wai, James" sort="Wai, James" uniqKey="Wai J" first="James" last="Wai">James Wai</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:21383469</idno><idno type="pmid">21383469</idno><idno type="doi">10.1088/1752-7155/4/2/026001</idno><idno type="wicri:Area/PubMed/Corpus">000644</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000644</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of influenza vaccination on oxidative stress products in breath.</title><author><name sortKey="Phillips, Michael" sort="Phillips, Michael" uniqKey="Phillips M" first="Michael" last="Phillips">Michael Phillips</name><affiliation><nlm:affiliation>Menssana Research Inc., Fort Lee, NJ 07024-6510, USA. mphillips@menssanaresearch.com</nlm:affiliation></affiliation></author><author><name sortKey="Cataneo, Renee N" sort="Cataneo, Renee N" uniqKey="Cataneo R" first="Renee N" last="Cataneo">Renee N. Cataneo</name></author><author><name sortKey="Chaturvedi, Anirudh" sort="Chaturvedi, Anirudh" uniqKey="Chaturvedi A" first="Anirudh" last="Chaturvedi">Anirudh Chaturvedi</name></author><author><name sortKey="Danaher, Patrick J" sort="Danaher, Patrick J" uniqKey="Danaher P" first="Patrick J" last="Danaher">Patrick J. Danaher</name></author><author><name sortKey="Devadiga, Anantrai" sort="Devadiga, Anantrai" uniqKey="Devadiga A" first="Anantrai" last="Devadiga">Anantrai Devadiga</name></author><author><name sortKey="Legendre, David A" sort="Legendre, David A" uniqKey="Legendre D" first="David A" last="Legendre">David A. Legendre</name></author><author><name sortKey="Nail, Kim L" sort="Nail, Kim L" uniqKey="Nail K" first="Kim L" last="Nail">Kim L. Nail</name></author><author><name sortKey="Schmitt, Peter" sort="Schmitt, Peter" uniqKey="Schmitt P" first="Peter" last="Schmitt">Peter Schmitt</name></author><author><name sortKey="Wai, James" sort="Wai, James" uniqKey="Wai J" first="James" last="Wai">James Wai</name></author></analytic><series><title level="j">Journal of breath research</title><idno type="eISSN">1752-7163</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Biomarkers</term><term>Breath Tests</term><term>Female</term><term>Humans</term><term>Influenza Vaccines (pharmacology)</term><term>Influenza, Human (metabolism)</term><term>Male</term><term>Oxidative Stress (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Breath Tests</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viral infections cause increased oxidative stress, so a breath test for oxidative stress biomarkers (alkanes and alkane derivatives) might provide a new tool for early diagnosis. We studied 33 normal healthy human subjects receiving scheduled treatment with live attenuated influenza vaccine (LAIV). Each subject was his or her own control, since they were studied on day 0 prior to vaccination, and then on days 2, 7 and 14 following vaccination. Breath volatile organic compounds (VOCs) were collected with a breath collection apparatus, then analyzed by automated thermal desorption with gas chromatography and mass spectroscopy. A Monte Carlo simulation technique identified non-random VOC biomarkers of infection based on their C-statistic values (area under curve of receiver operating characteristic). Treatment with LAIV was followed by non-random changes in the abundance of breath VOCs. 2, 8-Dimethyl-undecane and other alkane derivatives were observed on all days. Conservative multivariate models identified vaccinated subjects on day 2 (C-statistic = 0.82, sensitivity = 63.6% and specificity = 88.5%); day 7 (C-statistic = 0.94, sensitivity = 88.5% and specificity = 92.3%); and day 14 (C-statistic = 0.95, sensitivity = 92.3% and specificity = 92.3%). The altered breath VOCs were not detected in live attenuated influenza vaccine, excluding artifactual contamination. LAIV vaccination in healthy humans elicited a prompt and sustained increase in breath biomarkers of oxidative stress. A breath test for these VOCs could potentially identify humans who are acutely infected with influenza, but who have not yet developed clinical symptoms or signs of disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21383469</PMID><DateCompleted><Year>2011</Year><Month>08</Month><Day>02</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1752-7163</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of breath research</Title><ISOAbbreviation>J Breath Res</ISOAbbreviation></Journal><ArticleTitle>Effect of influenza vaccination on oxidative stress products in breath.</ArticleTitle><Pagination><MedlinePgn>026001</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1088/1752-7155/4/2/026001</ELocationID><Abstract><AbstractText>Viral infections cause increased oxidative stress, so a breath test for oxidative stress biomarkers (alkanes and alkane derivatives) might provide a new tool for early diagnosis. We studied 33 normal healthy human subjects receiving scheduled treatment with live attenuated influenza vaccine (LAIV). Each subject was his or her own control, since they were studied on day 0 prior to vaccination, and then on days 2, 7 and 14 following vaccination. Breath volatile organic compounds (VOCs) were collected with a breath collection apparatus, then analyzed by automated thermal desorption with gas chromatography and mass spectroscopy. A Monte Carlo simulation technique identified non-random VOC biomarkers of infection based on their C-statistic values (area under curve of receiver operating characteristic). Treatment with LAIV was followed by non-random changes in the abundance of breath VOCs. 2, 8-Dimethyl-undecane and other alkane derivatives were observed on all days. Conservative multivariate models identified vaccinated subjects on day 2 (C-statistic = 0.82, sensitivity = 63.6% and specificity = 88.5%); day 7 (C-statistic = 0.94, sensitivity = 88.5% and specificity = 92.3%); and day 14 (C-statistic = 0.95, sensitivity = 92.3% and specificity = 92.3%). The altered breath VOCs were not detected in live attenuated influenza vaccine, excluding artifactual contamination. LAIV vaccination in healthy humans elicited a prompt and sustained increase in breath biomarkers of oxidative stress. A breath test for these VOCs could potentially identify humans who are acutely infected with influenza, but who have not yet developed clinical symptoms or signs of disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Menssana Research Inc., Fort Lee, NJ 07024-6510, USA. mphillips@menssanaresearch.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cataneo</LastName><ForeName>Renee N</ForeName><Initials>RN</Initials></Author><Author ValidYN="Y"><LastName>Chaturvedi</LastName><ForeName>Anirudh</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Danaher</LastName><ForeName>Patrick J</ForeName><Initials>PJ</Initials></Author><Author ValidYN="Y"><LastName>Devadiga</LastName><ForeName>Anantrai</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Legendre</LastName><ForeName>David A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>Nail</LastName><ForeName>Kim L</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Wai</LastName><ForeName>James</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>01</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Breath Res</MedlineTA><NlmUniqueID>101463871</NlmUniqueID><ISSNLinking>1752-7155</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001944" MajorTopicYN="Y">Breath Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21383469</ArticleId><ArticleId IdType="pii">S1752-7155(10)34354-0</ArticleId><ArticleId IdType="doi">10.1088/1752-7155/4/2/026001</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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