Pre-infection of pigs with Mycoplasma hyopneumoniae induces oxidative stress that influences outcomes of a subsequent infection with a swine influenza virus of H1N1 subtype.
Identifieur interne : 000543 ( PubMed/Corpus ); précédent : 000542; suivant : 000544Pre-infection of pigs with Mycoplasma hyopneumoniae induces oxidative stress that influences outcomes of a subsequent infection with a swine influenza virus of H1N1 subtype.
Auteurs : C. Deblanc ; F. Robert ; T. Pinard ; S. Gorin ; S. Quéguiner ; A V Gautier-Bouchardon ; S. Ferré ; J M Garraud ; R. Cariolet ; M. Brack ; G. SimonSource :
- Veterinary microbiology [ 1873-2542 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Humans, Influenza A Virus, H1N1 Subtype (metabolism), Influenza, Human, Lung (virology), Mycoplasma hyopneumoniae (metabolism), Orthomyxoviridae Infections (metabolism), Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Oxidative Stress (physiology), Sus scrofa, Swine, Swine Diseases (metabolism), Swine Diseases (microbiology), Swine Diseases (virology), Virus Shedding.
- MESH :
- metabolism : Influenza A Virus, H1N1 Subtype, Mycoplasma hyopneumoniae, Orthomyxoviridae Infections, Swine Diseases.
- microbiology : Swine Diseases.
- physiology : Oxidative Stress.
- veterinary : Orthomyxoviridae Infections.
- virology : Lung, Orthomyxoviridae Infections, Swine Diseases.
- Animals, Humans, Influenza, Human, Sus scrofa, Swine, Virus Shedding.
Abstract
The severity of swine influenza is highly variable and can be exacerbated by many factors, such as a pre-infection of pigs with Mycoplasma hyopneumoniae (Mhp). The aim of this study was to investigate the oxidative stress induced by Mhp and the impact of this stress on the evolution of an infection with the European avian-like swine H1N1 influenza virus. Two experimental trials (E1 and E2), which differed only by the feed delivered to the animals, were conducted on SPF pigs. In each trial, one group of nine 6-week-old pigs was inoculated intra-tracheally with Mhp and H1N1 at 21 days intervals and a mock-infected group (8 pigs) was included. Clinical signs were observed, blood samples were collected throughout the study and pathogens were detected in nasal swabs and lung tissues. Results indicated that Mhp infection induced an oxidative stress in E1 and E2, but its level was more important in E2 than in E1 three weeks post-Mhp inoculation, before H1N1 infection. In both trials, a strong inflammatory response and a response to the oxidative stress previously induced by Mhp appeared after H1N1 infection. However, the severity of influenza disease was significantly more marked in E2 as compared to E1, as revealed by prolonged hyperthermia, stronger reduction in mean daily weight gain and earlier viral shedding. These results suggested that severity of flu syndrome and reduction in animal performance may vary depending on the level of oxidative stress at the moment of the influenza infection, and that host responses could be influenced by the feed.
DOI: 10.1016/j.vetmic.2012.11.028
PubMed: 23266108
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pubmed:23266108Le document en format XML
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Pinard</name><affiliation><nlm:affiliation>CCPA-DELTAVIT, Research and Development Service, ZA du Bois Teillay, 35150 Janzé, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gorin, S" sort="Gorin, S" uniqKey="Gorin S" first="S" last="Gorin">S. Gorin</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Queguiner, S" sort="Queguiner, S" uniqKey="Queguiner S" first="S" last="Quéguiner">S. Quéguiner</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gautier Bouchardon, A V" sort="Gautier Bouchardon, A V" uniqKey="Gautier Bouchardon A" first="A V" last="Gautier-Bouchardon">A V Gautier-Bouchardon</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Mycoplasmology Bacteriology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ferre, S" sort="Ferre, S" uniqKey="Ferre S" first="S" last="Ferré">S. 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Deblanc</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France. Electronic address: celine.deblanc@anses.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Robert, F" sort="Robert, F" uniqKey="Robert F" first="F" last="Robert">F. Robert</name><affiliation><nlm:affiliation>CCPA-DELTAVIT, Research and Development Service, ZA du Bois Teillay, 35150 Janzé, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pinard, T" sort="Pinard, T" uniqKey="Pinard T" first="T" last="Pinard">T. Pinard</name><affiliation><nlm:affiliation>CCPA-DELTAVIT, Research and Development Service, ZA du Bois Teillay, 35150 Janzé, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gorin, S" sort="Gorin, S" uniqKey="Gorin S" first="S" last="Gorin">S. Gorin</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Queguiner, S" sort="Queguiner, S" uniqKey="Queguiner S" first="S" last="Quéguiner">S. Quéguiner</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gautier Bouchardon, A V" sort="Gautier Bouchardon, A V" uniqKey="Gautier Bouchardon A" first="A V" last="Gautier-Bouchardon">A V Gautier-Bouchardon</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Mycoplasmology Bacteriology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ferre, S" sort="Ferre, S" uniqKey="Ferre S" first="S" last="Ferré">S. Ferré</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Mycoplasmology Bacteriology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Garraud, J M" sort="Garraud, J M" uniqKey="Garraud J" first="J M" last="Garraud">J M Garraud</name><affiliation><nlm:affiliation>CCPA-DELTAVIT, Research and Development Service, ZA du Bois Teillay, 35150 Janzé, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cariolet, R" sort="Cariolet, R" uniqKey="Cariolet R" first="R" last="Cariolet">R. Cariolet</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Production of Decontaminated Pigs and Testing, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brack, M" sort="Brack, M" uniqKey="Brack M" first="M" last="Brack">M. Brack</name><affiliation><nlm:affiliation>Oxidative Stress College, GIE Santé, 224 bd St. Germain, 75007 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Simon, G" sort="Simon, G" uniqKey="Simon G" first="G" last="Simon">G. Simon</name><affiliation><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Veterinary microbiology</title><idno type="eISSN">1873-2542</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (metabolism)</term><term>Influenza, Human</term><term>Lung (virology)</term><term>Mycoplasma hyopneumoniae (metabolism)</term><term>Orthomyxoviridae Infections (metabolism)</term><term>Orthomyxoviridae Infections (veterinary)</term><term>Orthomyxoviridae Infections (virology)</term><term>Oxidative Stress (physiology)</term><term>Sus scrofa</term><term>Swine</term><term>Swine Diseases (metabolism)</term><term>Swine Diseases (microbiology)</term><term>Swine Diseases (virology)</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Mycoplasma hyopneumoniae</term><term>Orthomyxoviridae Infections</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term><term>Orthomyxoviridae Infections</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Influenza, Human</term><term>Sus scrofa</term><term>Swine</term><term>Virus Shedding</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The severity of swine influenza is highly variable and can be exacerbated by many factors, such as a pre-infection of pigs with Mycoplasma hyopneumoniae (Mhp). The aim of this study was to investigate the oxidative stress induced by Mhp and the impact of this stress on the evolution of an infection with the European avian-like swine H1N1 influenza virus. Two experimental trials (E1 and E2), which differed only by the feed delivered to the animals, were conducted on SPF pigs. In each trial, one group of nine 6-week-old pigs was inoculated intra-tracheally with Mhp and H1N1 at 21 days intervals and a mock-infected group (8 pigs) was included. Clinical signs were observed, blood samples were collected throughout the study and pathogens were detected in nasal swabs and lung tissues. Results indicated that Mhp infection induced an oxidative stress in E1 and E2, but its level was more important in E2 than in E1 three weeks post-Mhp inoculation, before H1N1 infection. In both trials, a strong inflammatory response and a response to the oxidative stress previously induced by Mhp appeared after H1N1 infection. However, the severity of influenza disease was significantly more marked in E2 as compared to E1, as revealed by prolonged hyperthermia, stronger reduction in mean daily weight gain and earlier viral shedding. These results suggested that severity of flu syndrome and reduction in animal performance may vary depending on the level of oxidative stress at the moment of the influenza infection, and that host responses could be influenced by the feed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">23266108</PMID><DateCompleted><Year>2014</Year><Month>06</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>01</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2542</ISSN><JournalIssue CitedMedium="Internet"><Volume>162</Volume><Issue>2-4</Issue><PubDate><Year>2013</Year><Month>Mar</Month><Day>23</Day></PubDate></JournalIssue><Title>Veterinary microbiology</Title><ISOAbbreviation>Vet. Microbiol.</ISOAbbreviation></Journal><ArticleTitle>Pre-infection of pigs with Mycoplasma hyopneumoniae induces oxidative stress that influences outcomes of a subsequent infection with a swine influenza virus of H1N1 subtype.</ArticleTitle><Pagination><MedlinePgn>643-651</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0378-1135(12)00661-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vetmic.2012.11.028</ELocationID><Abstract><AbstractText>The severity of swine influenza is highly variable and can be exacerbated by many factors, such as a pre-infection of pigs with Mycoplasma hyopneumoniae (Mhp). The aim of this study was to investigate the oxidative stress induced by Mhp and the impact of this stress on the evolution of an infection with the European avian-like swine H1N1 influenza virus. Two experimental trials (E1 and E2), which differed only by the feed delivered to the animals, were conducted on SPF pigs. In each trial, one group of nine 6-week-old pigs was inoculated intra-tracheally with Mhp and H1N1 at 21 days intervals and a mock-infected group (8 pigs) was included. Clinical signs were observed, blood samples were collected throughout the study and pathogens were detected in nasal swabs and lung tissues. Results indicated that Mhp infection induced an oxidative stress in E1 and E2, but its level was more important in E2 than in E1 three weeks post-Mhp inoculation, before H1N1 infection. In both trials, a strong inflammatory response and a response to the oxidative stress previously induced by Mhp appeared after H1N1 infection. However, the severity of influenza disease was significantly more marked in E2 as compared to E1, as revealed by prolonged hyperthermia, stronger reduction in mean daily weight gain and earlier viral shedding. These results suggested that severity of flu syndrome and reduction in animal performance may vary depending on the level of oxidative stress at the moment of the influenza infection, and that host responses could be influenced by the feed.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deblanc</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France. Electronic address: celine.deblanc@anses.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robert</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>CCPA-DELTAVIT, Research and Development Service, ZA du Bois Teillay, 35150 Janzé, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinard</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>CCPA-DELTAVIT, Research and Development Service, ZA du Bois Teillay, 35150 Janzé, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorin</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quéguiner</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gautier-Bouchardon</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Mycoplasmology Bacteriology Unit, BP53, 22440 Ploufragan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferré</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Mycoplasmology Bacteriology Unit, BP53, 22440 Ploufragan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garraud</LastName><ForeName>J M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>CCPA-DELTAVIT, Research and Development Service, ZA du Bois Teillay, 35150 Janzé, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cariolet</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Production of Decontaminated Pigs and Testing, BP53, 22440 Ploufragan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brack</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Oxidative Stress College, GIE Santé, 224 bd St. Germain, 75007 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simon</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Anses, Ploufragan-Plouzané Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vet Microbiol</MedlineTA><NlmUniqueID>7705469</NlmUniqueID><ISSNLinking>0378-1135</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045705" MajorTopicYN="N">Mycoplasma hyopneumoniae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D034421" MajorTopicYN="N">Sus scrofa</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013553" 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