Immunomodulatory activity of red ginseng against influenza A virus infection.
Identifieur interne : 000488 ( PubMed/Corpus ); précédent : 000487; suivant : 000489Immunomodulatory activity of red ginseng against influenza A virus infection.
Auteurs : Jong Seok Lee ; Hye Suk Hwang ; Eun-Ju Ko ; Yu-Na Lee ; Young-Man Kwon ; Min-Chul Kim ; Sang-Moo KangSource :
- Nutrients [ 2072-6643 ] ; 2014.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Antiviral Agents (pharmacology), Bronchoalveolar Lavage Fluid (chemistry), Cell Line, Disease Models, Animal, Epithelial Cells (drug effects), Epithelial Cells (metabolism), Female, Humans, Immunomodulation, Influenza A virus (drug effects), Lung (cytology), Lung (drug effects), Mice, Mice, Inbred BALB C, Microbial Viability (drug effects), Orthomyxoviridae Infections (drug therapy), Oxidative Stress (drug effects), Panax (chemistry), Plant Extracts (pharmacology), Pneumonia (drug therapy), Pneumonia (virology), Reactive Oxygen Species.
- MESH :
- chemical , pharmacology : Antiviral Agents, Plant Extracts.
- chemistry : Bronchoalveolar Lavage Fluid, Panax.
- cytology : Lung.
- drug effects : Epithelial Cells, Influenza A virus, Lung, Microbial Viability, Oxidative Stress.
- drug therapy : Orthomyxoviridae Infections, Pneumonia.
- metabolism : Epithelial Cells.
- virology : Pneumonia.
- Administration, Oral, Animals, Cell Line, Disease Models, Animal, Female, Humans, Immunomodulation, Mice, Mice, Inbred BALB C, Reactive Oxygen Species.
Abstract
Ginseng herbal medicine has been known to have beneficial effects on improving human health. We investigated whether red ginseng extract (RGE) has preventive effects on influenza A virus infection in vivo and in vitro. RGE was found to improve survival of human lung epithelial cells upon influenza virus infection. Also, RGE treatment reduced the expression of pro-inflammatory genes (IL-6, IL-8) probably in part through interference with the formation of reactive oxygen species by influenza A virus infection. Long-term oral administration of mice with RGE showed multiple immunomodulatory effects such as stimulating antiviral cytokine IFN-γ production after influenza A virus infection. In addition, RGE administration in mice inhibited the infiltration of inflammatory cells into the bronchial lumens. Therefore, RGE might have the potential beneficial effects on preventing influenza A virus infections via its multiple immunomodulatory functions.
DOI: 10.3390/nu6020517
PubMed: 24473234
Links to Exploration step
pubmed:24473234Le document en format XML
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Ko</name><affiliation><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. ej.ko226@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Yu Na" sort="Lee, Yu Na" uniqKey="Lee Y" first="Yu-Na" last="Lee">Yu-Na Lee</name><affiliation><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. mistybluerain7@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Kwon, Young Man" sort="Kwon, Young Man" uniqKey="Kwon Y" first="Young-Man" last="Kwon">Young-Man Kwon</name><affiliation><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. ymankwon@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Min Chul" sort="Kim, Min Chul" uniqKey="Kim M" first="Min-Chul" last="Kim">Min-Chul Kim</name><affiliation><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. mckim001@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name><affiliation><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. kangsm8@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nutrients</title><idno type="eISSN">2072-6643</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Bronchoalveolar Lavage Fluid (chemistry)</term><term>Cell Line</term><term>Disease Models, Animal</term><term>Epithelial Cells (drug effects)</term><term>Epithelial Cells (metabolism)</term><term>Female</term><term>Humans</term><term>Immunomodulation</term><term>Influenza A virus (drug effects)</term><term>Lung (cytology)</term><term>Lung (drug effects)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Microbial Viability (drug effects)</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Oxidative Stress (drug effects)</term><term>Panax (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Pneumonia (drug therapy)</term><term>Pneumonia (virology)</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Bronchoalveolar Lavage Fluid</term><term>Panax</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Epithelial Cells</term><term>Influenza A virus</term><term>Lung</term><term>Microbial Viability</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Cell Line</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Immunomodulation</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Reactive Oxygen Species</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ginseng herbal medicine has been known to have beneficial effects on improving human health. We investigated whether red ginseng extract (RGE) has preventive effects on influenza A virus infection in vivo and in vitro. RGE was found to improve survival of human lung epithelial cells upon influenza virus infection. Also, RGE treatment reduced the expression of pro-inflammatory genes (IL-6, IL-8) probably in part through interference with the formation of reactive oxygen species by influenza A virus infection. Long-term oral administration of mice with RGE showed multiple immunomodulatory effects such as stimulating antiviral cytokine IFN-γ production after influenza A virus infection. In addition, RGE administration in mice inhibited the infiltration of inflammatory cells into the bronchial lumens. Therefore, RGE might have the potential beneficial effects on preventing influenza A virus infections via its multiple immunomodulatory functions. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24473234</PMID><DateCompleted><Year>2014</Year><Month>09</Month><Day>18</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2072-6643</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Jan</Month><Day>27</Day></PubDate></JournalIssue><Title>Nutrients</Title><ISOAbbreviation>Nutrients</ISOAbbreviation></Journal><ArticleTitle>Immunomodulatory activity of red ginseng against influenza A virus infection.</ArticleTitle><Pagination><MedlinePgn>517-29</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/nu6020517</ELocationID><Abstract><AbstractText>Ginseng herbal medicine has been known to have beneficial effects on improving human health. We investigated whether red ginseng extract (RGE) has preventive effects on influenza A virus infection in vivo and in vitro. RGE was found to improve survival of human lung epithelial cells upon influenza virus infection. Also, RGE treatment reduced the expression of pro-inflammatory genes (IL-6, IL-8) probably in part through interference with the formation of reactive oxygen species by influenza A virus infection. Long-term oral administration of mice with RGE showed multiple immunomodulatory effects such as stimulating antiviral cytokine IFN-γ production after influenza A virus infection. In addition, RGE administration in mice inhibited the infiltration of inflammatory cells into the bronchial lumens. Therefore, RGE might have the potential beneficial effects on preventing influenza A virus infections via its multiple immunomodulatory functions. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jong Seok</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. jongseoklee78@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Hye Suk</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. hshwang33@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ko</LastName><ForeName>Eun-Ju</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. ej.ko226@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Yu-Na</ForeName><Initials>YN</Initials><AffiliationInfo><Affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. mistybluerain7@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Young-Man</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. ymankwon@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Min-Chul</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. mckim001@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Sang-Moo</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. kangsm8@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI093772</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI105170</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI093772</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI105170</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Nutrients</MedlineTA><NlmUniqueID>101521595</NlmUniqueID><ISSNLinking>2072-6643</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen 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