StressCovidV1, PubMed, Corpus, bibRecord, 000323

Intensive care medicine research agenda on invasive fungal infection in critically ill patients.

Identifieur interne : 000323 ( PubMed/Corpus ); précédent : 000322; suivant : 000324

Intensive care medicine research agenda on invasive fungal infection in critically ill patients.

Auteurs : Matteo Bassetti ; Jose Garnacho-Montero ; Thierry Calandra ; Bartjan Kullberg ; George Dimopoulos ; Elie Azoulay ; Arunaloke Chakrabarti ; Daniel Kett ; Cristobal Leon ; Luis Ostrosky-Zeichner ; Maurizio Sanguinetti ; Jean-Francois Timsit ; Malcom D. Richardson ; Andrew Shorr ; Oliver A. Cornely

Source :

Intensive care medicine [ 1432-1238 ] ; 2017.

RBID : pubmed:28255613

English descriptors

KwdEn :
- Antibodies, Fungal (blood), Antifungal Agents (pharmacology), Antifungal Agents (therapeutic use), Aspergillus (immunology), Aspergillus (isolation & purification), Biomarkers (blood), Biomedical Research, Candida (immunology), Candida (isolation & purification), Candidemia (diagnosis), Candidemia (drug therapy), Candidemia (mortality), Candidemia (prevention & control), Critical Illness (mortality), Global Health, Humans, Incidence, Intensive Care Units, Invasive Fungal Infections (diagnostic imaging), Invasive Fungal Infections (drug therapy), Invasive Fungal Infections (mortality), Invasive Fungal Infections (prevention & control), Invasive Pulmonary Aspergillosis (diagnosis), Invasive Pulmonary Aspergillosis (drug therapy), Invasive Pulmonary Aspergillosis (mortality), Invasive Pulmonary Aspergillosis (prevention & control), Practice Guidelines as Topic, Randomized Controlled Trials as Topic, Risk Factors, Standard of Care (standards).
MESH :
- chemical , blood : Antibodies, Fungal, Biomarkers.
- chemical , pharmacology : Antifungal Agents.
- chemical , therapeutic use : Antifungal Agents.
- diagnosis : Candidemia, Invasive Pulmonary Aspergillosis.
- diagnostic imaging : Invasive Fungal Infections.
- drug therapy : Candidemia, Invasive Fungal Infections, Invasive Pulmonary Aspergillosis.
- immunology : Aspergillus, Candida.
- isolation & purification : Aspergillus, Candida.
- mortality : Candidemia, Critical Illness, Invasive Fungal Infections, Invasive Pulmonary Aspergillosis.
- prevention & control : Candidemia, Invasive Fungal Infections, Invasive Pulmonary Aspergillosis.
- standards : Standard of Care.
- Biomedical Research, Global Health, Humans, Incidence, Intensive Care Units, Practice Guidelines as Topic, Randomized Controlled Trials as Topic, Risk Factors.

Abstract

To describe concisely the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to Candida and Aspergillus infections in non-neutropenic patients in the ICU setting.

DOI: 10.1007/s00134-017-4731-2
PubMed: 28255613

Links to Exploration step

pubmed:28255613

Le document en format XML

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<author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name>
<affiliation><nlm:affiliation>Infectious Diseases Clinic, Santa Maria Misericordia Hospital, University of Udine, Udine, Italy. mattba@tin.it.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garnacho Montero, Jose" sort="Garnacho Montero, Jose" uniqKey="Garnacho Montero J" first="Jose" last="Garnacho-Montero">Jose Garnacho-Montero</name>
<affiliation><nlm:affiliation>Unidad Clínica de Cuidados Intensivos, Hospital Universitario Virgen Macarena and Institute of Biomedicine of Seville, IBiS/CSIC/University of Seville, seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Calandra, Thierry" sort="Calandra, Thierry" uniqKey="Calandra T" first="Thierry" last="Calandra">Thierry Calandra</name>
<affiliation><nlm:affiliation>Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kullberg, Bartjan" sort="Kullberg, Bartjan" uniqKey="Kullberg B" first="Bartjan" last="Kullberg">Bartjan Kullberg</name>
<affiliation><nlm:affiliation>Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name>
<affiliation><nlm:affiliation>Department of Critical Care, University Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Azoulay, Elie" sort="Azoulay, Elie" uniqKey="Azoulay E" first="Elie" last="Azoulay">Elie Azoulay</name>
<affiliation><nlm:affiliation>Medical Intensive Care Unit, Hôpital Saint-Louis, ECSTRA Team, Biostatistics and Clinical Epidemiology, Paris Diderot Sorbonne University, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chakrabarti, Arunaloke" sort="Chakrabarti, Arunaloke" uniqKey="Chakrabarti A" first="Arunaloke" last="Chakrabarti">Arunaloke Chakrabarti</name>
<affiliation><nlm:affiliation>Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kett, Daniel" sort="Kett, Daniel" uniqKey="Kett D" first="Daniel" last="Kett">Daniel Kett</name>
<affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, The Leonard M. Miller School of Medicine at the University of Miami, Miami, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leon, Cristobal" sort="Leon, Cristobal" uniqKey="Leon C" first="Cristobal" last="Leon">Cristobal Leon</name>
<affiliation><nlm:affiliation>Intensive Care Unit, Hospital Universitario de Valme, Universidad de Sevilla, Seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ostrosky Zeichner, Luis" sort="Ostrosky Zeichner, Luis" uniqKey="Ostrosky Zeichner L" first="Luis" last="Ostrosky-Zeichner">Luis Ostrosky-Zeichner</name>
<affiliation><nlm:affiliation>Division of Infectious Diseases, McGovern Medical School, UTHealth, Houston, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sanguinetti, Maurizio" sort="Sanguinetti, Maurizio" uniqKey="Sanguinetti M" first="Maurizio" last="Sanguinetti">Maurizio Sanguinetti</name>
<affiliation><nlm:affiliation>Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Timsit, Jean Francois" sort="Timsit, Jean Francois" uniqKey="Timsit J" first="Jean-Francois" last="Timsit">Jean-Francois Timsit</name>
<affiliation><nlm:affiliation>1UMR1137-IAMETeam 5, Decision Sciences in Infectious Disease Prevention, Control and Care, Paris Diderot University-Inserm, Sorbonne Paris Cité and 2AP-HP, Medical and Infectious Diseases ICU, Bichat Hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Richardson, Malcom D" sort="Richardson, Malcom D" uniqKey="Richardson M" first="Malcom D" last="Richardson">Malcom D. Richardson</name>
<affiliation><nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shorr, Andrew" sort="Shorr, Andrew" uniqKey="Shorr A" first="Andrew" last="Shorr">Andrew Shorr</name>
<affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine, Medstar Washington Hospital Center, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cornely, Oliver A" sort="Cornely, Oliver A" uniqKey="Cornely O" first="Oliver A" last="Cornely">Oliver A. Cornely</name>
<affiliation><nlm:affiliation>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Clinical Trials Centre Cologne (ZKS Köln), Department I of Internal Medicine, German Centre for Infection Research (DZIF), University of Cologne, Cologne, Germany.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Intensive care medicine research agenda on invasive fungal infection in critically ill patients.</title>
<author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name>
<affiliation><nlm:affiliation>Infectious Diseases Clinic, Santa Maria Misericordia Hospital, University of Udine, Udine, Italy. mattba@tin.it.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garnacho Montero, Jose" sort="Garnacho Montero, Jose" uniqKey="Garnacho Montero J" first="Jose" last="Garnacho-Montero">Jose Garnacho-Montero</name>
<affiliation><nlm:affiliation>Unidad Clínica de Cuidados Intensivos, Hospital Universitario Virgen Macarena and Institute of Biomedicine of Seville, IBiS/CSIC/University of Seville, seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Calandra, Thierry" sort="Calandra, Thierry" uniqKey="Calandra T" first="Thierry" last="Calandra">Thierry Calandra</name>
<affiliation><nlm:affiliation>Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kullberg, Bartjan" sort="Kullberg, Bartjan" uniqKey="Kullberg B" first="Bartjan" last="Kullberg">Bartjan Kullberg</name>
<affiliation><nlm:affiliation>Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name>
<affiliation><nlm:affiliation>Department of Critical Care, University Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Azoulay, Elie" sort="Azoulay, Elie" uniqKey="Azoulay E" first="Elie" last="Azoulay">Elie Azoulay</name>
<affiliation><nlm:affiliation>Medical Intensive Care Unit, Hôpital Saint-Louis, ECSTRA Team, Biostatistics and Clinical Epidemiology, Paris Diderot Sorbonne University, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chakrabarti, Arunaloke" sort="Chakrabarti, Arunaloke" uniqKey="Chakrabarti A" first="Arunaloke" last="Chakrabarti">Arunaloke Chakrabarti</name>
<affiliation><nlm:affiliation>Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kett, Daniel" sort="Kett, Daniel" uniqKey="Kett D" first="Daniel" last="Kett">Daniel Kett</name>
<affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, The Leonard M. Miller School of Medicine at the University of Miami, Miami, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leon, Cristobal" sort="Leon, Cristobal" uniqKey="Leon C" first="Cristobal" last="Leon">Cristobal Leon</name>
<affiliation><nlm:affiliation>Intensive Care Unit, Hospital Universitario de Valme, Universidad de Sevilla, Seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ostrosky Zeichner, Luis" sort="Ostrosky Zeichner, Luis" uniqKey="Ostrosky Zeichner L" first="Luis" last="Ostrosky-Zeichner">Luis Ostrosky-Zeichner</name>
<affiliation><nlm:affiliation>Division of Infectious Diseases, McGovern Medical School, UTHealth, Houston, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sanguinetti, Maurizio" sort="Sanguinetti, Maurizio" uniqKey="Sanguinetti M" first="Maurizio" last="Sanguinetti">Maurizio Sanguinetti</name>
<affiliation><nlm:affiliation>Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Timsit, Jean Francois" sort="Timsit, Jean Francois" uniqKey="Timsit J" first="Jean-Francois" last="Timsit">Jean-Francois Timsit</name>
<affiliation><nlm:affiliation>1UMR1137-IAMETeam 5, Decision Sciences in Infectious Disease Prevention, Control and Care, Paris Diderot University-Inserm, Sorbonne Paris Cité and 2AP-HP, Medical and Infectious Diseases ICU, Bichat Hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Richardson, Malcom D" sort="Richardson, Malcom D" uniqKey="Richardson M" first="Malcom D" last="Richardson">Malcom D. Richardson</name>
<affiliation><nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shorr, Andrew" sort="Shorr, Andrew" uniqKey="Shorr A" first="Andrew" last="Shorr">Andrew Shorr</name>
<affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine, Medstar Washington Hospital Center, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cornely, Oliver A" sort="Cornely, Oliver A" uniqKey="Cornely O" first="Oliver A" last="Cornely">Oliver A. Cornely</name>
<affiliation><nlm:affiliation>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Clinical Trials Centre Cologne (ZKS Köln), Department I of Internal Medicine, German Centre for Infection Research (DZIF), University of Cologne, Cologne, Germany.</nlm:affiliation>
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<series><title level="j">Intensive care medicine</title>
<idno type="eISSN">1432-1238</idno>
<imprint><date when="2017" type="published">2017</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Fungal (blood)</term>
<term>Antifungal Agents (pharmacology)</term>
<term>Antifungal Agents (therapeutic use)</term>
<term>Aspergillus (immunology)</term>
<term>Aspergillus (isolation & purification)</term>
<term>Biomarkers (blood)</term>
<term>Biomedical Research</term>
<term>Candida (immunology)</term>
<term>Candida (isolation & purification)</term>
<term>Candidemia (diagnosis)</term>
<term>Candidemia (drug therapy)</term>
<term>Candidemia (mortality)</term>
<term>Candidemia (prevention & control)</term>
<term>Critical Illness (mortality)</term>
<term>Global Health</term>
<term>Humans</term>
<term>Incidence</term>
<term>Intensive Care Units</term>
<term>Invasive Fungal Infections (diagnostic imaging)</term>
<term>Invasive Fungal Infections (drug therapy)</term>
<term>Invasive Fungal Infections (mortality)</term>
<term>Invasive Fungal Infections (prevention & control)</term>
<term>Invasive Pulmonary Aspergillosis (diagnosis)</term>
<term>Invasive Pulmonary Aspergillosis (drug therapy)</term>
<term>Invasive Pulmonary Aspergillosis (mortality)</term>
<term>Invasive Pulmonary Aspergillosis (prevention & control)</term>
<term>Practice Guidelines as Topic</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
<term>Standard of Care (standards)</term>
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<term>Biomarkers</term>
</keywords>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antifungal Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Candidemia</term>
<term>Invasive Pulmonary Aspergillosis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Invasive Fungal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Candidemia</term>
<term>Invasive Fungal Infections</term>
<term>Invasive Pulmonary Aspergillosis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aspergillus</term>
<term>Candida</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Aspergillus</term>
<term>Candida</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Candidemia</term>
<term>Critical Illness</term>
<term>Invasive Fungal Infections</term>
<term>Invasive Pulmonary Aspergillosis</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Candidemia</term>
<term>Invasive Fungal Infections</term>
<term>Invasive Pulmonary Aspergillosis</term>
</keywords>
<keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Standard of Care</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Biomedical Research</term>
<term>Global Health</term>
<term>Humans</term>
<term>Incidence</term>
<term>Intensive Care Units</term>
<term>Practice Guidelines as Topic</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
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<front><div type="abstract" xml:lang="en">To describe concisely the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to Candida and Aspergillus infections in non-neutropenic patients in the ICU setting.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28255613</PMID>
<DateCompleted><Year>2018</Year>
<Month>07</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>43</Volume>
<Issue>9</Issue>
<PubDate><Year>2017</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Intensive care medicine</Title>
<ISOAbbreviation>Intensive Care Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Intensive care medicine research agenda on invasive fungal infection in critically ill patients.</ArticleTitle>
<Pagination><MedlinePgn>1225-1238</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-017-4731-2</ELocationID>
<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To describe concisely the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to Candida and Aspergillus infections in non-neutropenic patients in the ICU setting.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A systematic review of the medical literature taking account of national and international guidelines and expert opinion.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Severe invasive fungal infections (IFIs) are becoming increasingly frequent in critically ill patients. Approximately 80% of IFIs are due to Candida spp. and 0.3-19% to Aspergillus spp. Recent observations emphasize the necessity of building a worldwide sentinel network to monitor the emergence of new fungal species and changes in susceptibility. Robust data on the attributable mortality are essential for the design of clinical studies with mortality endpoints. Although early antifungal therapy for Candida has been recommended in patients with risk factors, sepsis of unknown cause, and positive Candida serum biomarkers [β-1 → 3-D-glucan (BDG) and Candida albicans germ tube antibody (CAGTA)], its usefulness and influence on outcome need to be confirmed. Future studies may specifically address the optimal diagnostic and therapeutic strategies for patients with abdominal candidiasis. Better knowledge of the pharmacokinetics of antifungal molecules and tissue penetration is a key issue for intensivists. Regarding invasive aspergillosis, further investigation is needed to determine its incidence in the ICU, its relationship with influenza outbreaks, the clinical impact of rapid diagnosis, and the significance of combination treatment.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Fundamental questions regarding IFI have to be addressed over the next decade. The clinical studies described in this research agenda should provide a template and set priorities for the clinical investigations that need to be performed.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bassetti</LastName>
<ForeName>Matteo</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4406-962X</Identifier>
<AffiliationInfo><Affiliation>Infectious Diseases Clinic, Santa Maria Misericordia Hospital, University of Udine, Udine, Italy. mattba@tin.it.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Clinica Malattie Infettive, Azienda Sanitaria Universitaria Integrata, Presidio Ospedaliero Santa Maria della Misericordia, Piazzale S. Maria della Misericordia, n. 15, 33100, Udine, Italy. mattba@tin.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garnacho-Montero</LastName>
<ForeName>Jose</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Unidad Clínica de Cuidados Intensivos, Hospital Universitario Virgen Macarena and Institute of Biomedicine of Seville, IBiS/CSIC/University of Seville, seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calandra</LastName>
<ForeName>Thierry</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kullberg</LastName>
<ForeName>Bartjan</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dimopoulos</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care, University Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Azoulay</LastName>
<ForeName>Elie</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Medical Intensive Care Unit, Hôpital Saint-Louis, ECSTRA Team, Biostatistics and Clinical Epidemiology, Paris Diderot Sorbonne University, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chakrabarti</LastName>
<ForeName>Arunaloke</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kett</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, The Leonard M. Miller School of Medicine at the University of Miami, Miami, FL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leon</LastName>
<ForeName>Cristobal</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Hospital Universitario de Valme, Universidad de Sevilla, Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ostrosky-Zeichner</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, McGovern Medical School, UTHealth, Houston, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanguinetti</LastName>
<ForeName>Maurizio</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Timsit</LastName>
<ForeName>Jean-Francois</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>1UMR1137-IAMETeam 5, Decision Sciences in Infectious Disease Prevention, Control and Care, Paris Diderot University-Inserm, Sorbonne Paris Cité and 2AP-HP, Medical and Infectious Diseases ICU, Bichat Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Richardson</LastName>
<ForeName>Malcom D</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shorr</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine, Medstar Washington Hospital Center, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cornely</LastName>
<ForeName>Oliver A</ForeName>
<Initials>OA</Initials>
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Intensive care medicine research agenda on invasive fungal infection in critically ill patients.

Intensive care medicine research agenda on invasive fungal infection in critically ill patients.

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