Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.
Identifieur interne : 000297 ( PubMed/Corpus ); précédent : 000296; suivant : 000298Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.
Auteurs : Cécile Vignal ; Muriel Pichavant ; Laurent Y. Alleman ; Madjid Djouina ; Florian Dingreville ; Esperanza Perdrix ; Christophe Waxin ; Adil Ouali Alami ; Corinne Gower-Rousseau ; Pierre Desreumaux ; Mathilde Body-MalapelSource :
- Particle and fibre toxicology [ 1743-8977 ] ; 2017.
English descriptors
- KwdEn :
- Acetylcysteine (pharmacology), Air Pollutants (chemistry), Air Pollutants (toxicity), Animals, Antioxidants (pharmacology), Colon (drug effects), Colon (immunology), Colon (metabolism), Cytokines (immunology), Cytokines (metabolism), Inflammation Mediators (immunology), Inflammation Mediators (metabolism), Inhalation Exposure (adverse effects), Lung (drug effects), Lung (immunology), Lung (metabolism), Male, Mice, Inbred C57BL, Oxidative Stress (drug effects), Particle Size, Particulate Matter (chemistry), Particulate Matter (toxicity), Solubility, Solvents (chemistry), Water (chemistry).
- MESH :
- chemical , chemistry : Air Pollutants, Particulate Matter, Solvents, Water.
- chemical , immunology : Cytokines, Inflammation Mediators.
- chemical , metabolism : Cytokines, Inflammation Mediators.
- chemical , pharmacology : Acetylcysteine, Antioxidants.
- chemical , toxicity : Air Pollutants, Particulate Matter.
- adverse effects : Inhalation Exposure.
- drug effects : Colon, Lung, Oxidative Stress.
- immunology : Colon, Lung.
- metabolism : Colon, Lung.
- Animals, Male, Mice, Inbred C57BL, Particle Size, Solubility.
Abstract
Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation.
DOI: 10.1186/s12989-017-0227-z
PubMed: 29166940
Links to Exploration step
pubmed:29166940Le document en format XML
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Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ouali Alami, Adil" sort="Ouali Alami, Adil" uniqKey="Ouali Alami A" first="Adil" last="Ouali Alami">Adil Ouali Alami</name><affiliation><nlm:affiliation>Inserm U1019, CNRS UMR 8204, Institut Pasteur de Lille- CIIL - Center for Infection and Immunity of Lille, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gower Rousseau, Corinne" sort="Gower Rousseau, Corinne" uniqKey="Gower Rousseau C" first="Corinne" last="Gower-Rousseau">Corinne Gower-Rousseau</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Desreumaux, Pierre" sort="Desreumaux, Pierre" uniqKey="Desreumaux P" first="Pierre" last="Desreumaux">Pierre Desreumaux</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Body Malapel, Mathilde" sort="Body Malapel, Mathilde" uniqKey="Body Malapel M" first="Mathilde" last="Body-Malapel">Mathilde Body-Malapel</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France. mathilde.body@univ-lille2.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29166940</idno><idno type="pmid">29166940</idno><idno type="doi">10.1186/s12989-017-0227-z</idno><idno type="wicri:Area/PubMed/Corpus">000297</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000297</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.</title><author><name sortKey="Vignal, Cecile" sort="Vignal, Cecile" uniqKey="Vignal C" first="Cécile" last="Vignal">Cécile Vignal</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pichavant, Muriel" sort="Pichavant, Muriel" uniqKey="Pichavant M" first="Muriel" last="Pichavant">Muriel Pichavant</name><affiliation><nlm:affiliation>Inserm U1019, CNRS UMR 8204, Institut Pasteur de Lille- CIIL - Center for Infection and Immunity of Lille, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Alleman, Laurent Y" sort="Alleman, Laurent Y" uniqKey="Alleman L" first="Laurent Y" last="Alleman">Laurent Y. Alleman</name><affiliation><nlm:affiliation>SAGE - Département Sciences de l'Atmosphère et Génie de l'Environnement, IMT Lille Douai, Univ. Lille, 59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Djouina, Madjid" sort="Djouina, Madjid" uniqKey="Djouina M" first="Madjid" last="Djouina">Madjid Djouina</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dingreville, Florian" sort="Dingreville, Florian" uniqKey="Dingreville F" first="Florian" last="Dingreville">Florian Dingreville</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Perdrix, Esperanza" sort="Perdrix, Esperanza" uniqKey="Perdrix E" first="Esperanza" last="Perdrix">Esperanza Perdrix</name><affiliation><nlm:affiliation>SAGE - Département Sciences de l'Atmosphère et Génie de l'Environnement, IMT Lille Douai, Univ. Lille, 59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Waxin, Christophe" sort="Waxin, Christophe" uniqKey="Waxin C" first="Christophe" last="Waxin">Christophe Waxin</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ouali Alami, Adil" sort="Ouali Alami, Adil" uniqKey="Ouali Alami A" first="Adil" last="Ouali Alami">Adil Ouali Alami</name><affiliation><nlm:affiliation>Inserm U1019, CNRS UMR 8204, Institut Pasteur de Lille- CIIL - Center for Infection and Immunity of Lille, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gower Rousseau, Corinne" sort="Gower Rousseau, Corinne" uniqKey="Gower Rousseau C" first="Corinne" last="Gower-Rousseau">Corinne Gower-Rousseau</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Desreumaux, Pierre" sort="Desreumaux, Pierre" uniqKey="Desreumaux P" first="Pierre" last="Desreumaux">Pierre Desreumaux</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Body Malapel, Mathilde" sort="Body Malapel, Mathilde" uniqKey="Body Malapel M" first="Mathilde" last="Body-Malapel">Mathilde Body-Malapel</name><affiliation><nlm:affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France. mathilde.body@univ-lille2.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Particle and fibre toxicology</title><idno type="eISSN">1743-8977</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcysteine (pharmacology)</term><term>Air Pollutants (chemistry)</term><term>Air Pollutants (toxicity)</term><term>Animals</term><term>Antioxidants (pharmacology)</term><term>Colon (drug effects)</term><term>Colon (immunology)</term><term>Colon (metabolism)</term><term>Cytokines (immunology)</term><term>Cytokines (metabolism)</term><term>Inflammation Mediators (immunology)</term><term>Inflammation Mediators (metabolism)</term><term>Inhalation Exposure (adverse effects)</term><term>Lung (drug effects)</term><term>Lung (immunology)</term><term>Lung (metabolism)</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Oxidative Stress (drug effects)</term><term>Particle Size</term><term>Particulate Matter (chemistry)</term><term>Particulate Matter (toxicity)</term><term>Solubility</term><term>Solvents (chemistry)</term><term>Water (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Air Pollutants</term><term>Particulate Matter</term><term>Solvents</term><term>Water</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetylcysteine</term><term>Antioxidants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Air Pollutants</term><term>Particulate Matter</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Inhalation Exposure</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Colon</term><term>Lung</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Colon</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Colon</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Particle Size</term><term>Solubility</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29166940</PMID><DateCompleted><Year>2018</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1743-8977</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>11</Month><Day>22</Day></PubDate></JournalIssue><Title>Particle and fibre toxicology</Title><ISOAbbreviation>Part Fibre Toxicol</ISOAbbreviation></Journal><ArticleTitle>Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.</ArticleTitle><Pagination><MedlinePgn>46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12989-017-0227-z</ELocationID><Abstract><AbstractText Label="BACKGROUND">Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation.</AbstractText><AbstractText Label="RESULTS">The collected PM had classical features of urban particles and possessed oxidative potential partly attributable to their metal fraction. Bioaccessibility study confirmed the high solubility of some metals at the gastric level. Male mice were exposed to urban coarse PM in a ventilated inhalation chamber for 15 days at a concentration relevant to episodic elevation peak of air pollution. Coarse PM inhalation induced systemic oxidative stress, recruited immune cells to the lung, and increased cytokine levels in the lung and colon. Concomitant oral administration of NAC reversed all the observed effects relative to the inhalation of coarse PM.</AbstractText><AbstractText Label="CONCLUSIONS">Coarse PM-induced low-grade inflammation in the lung and colon is mediated by oxidative stress and deserves more investigation as potentiating factor for inflammatory diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vignal</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pichavant</LastName><ForeName>Muriel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Inserm U1019, CNRS UMR 8204, Institut Pasteur de Lille- CIIL - Center for Infection and Immunity of Lille, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alleman</LastName><ForeName>Laurent Y</ForeName><Initials>LY</Initials><AffiliationInfo><Affiliation>SAGE - Département Sciences de l'Atmosphère et Génie de l'Environnement, IMT Lille Douai, Univ. Lille, 59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djouina</LastName><ForeName>Madjid</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dingreville</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perdrix</LastName><ForeName>Esperanza</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>SAGE - Département Sciences de l'Atmosphère et Génie de l'Environnement, IMT Lille Douai, Univ. Lille, 59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waxin</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ouali Alami</LastName><ForeName>Adil</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Inserm U1019, CNRS UMR 8204, Institut Pasteur de Lille- CIIL - Center for Infection and Immunity of Lille, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gower-Rousseau</LastName><ForeName>Corinne</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Desreumaux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Body-Malapel</LastName><ForeName>Mathilde</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-3392-4229</Identifier><AffiliationInfo><Affiliation>Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France. mathilde.body@univ-lille2.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>11</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Part Fibre Toxicol</MedlineTA><NlmUniqueID>101236354</NlmUniqueID><ISSNLinking>1743-8977</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000393">Air Pollutants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052638">Particulate Matter</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012997">Solvents</NameOfSubstance></Chemical><Chemical><RegistryNumber>059QF0KO0R</RegistryNumber><NameOfSubstance UI="D014867">Water</NameOfSubstance></Chemical><Chemical><RegistryNumber>WYQ7N0BPYC</RegistryNumber><NameOfSubstance UI="D000111">Acetylcysteine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000111" MajorTopicYN="N">Acetylcysteine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000393" MajorTopicYN="N">Air Pollutants</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019570" MajorTopicYN="N">Inhalation Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative 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