Beneficial effects on H1N1-induced acute lung injury and structure characterization of anti-complementary acidic polysaccharides from Juniperus pingii var. wilsonii.
Identifieur interne : 000223 ( PubMed/Corpus ); précédent : 000222; suivant : 000224Beneficial effects on H1N1-induced acute lung injury and structure characterization of anti-complementary acidic polysaccharides from Juniperus pingii var. wilsonii.
Auteurs : Zelong Fu ; Long Xia ; Ji De ; Mengxia Zhu ; Hong Li ; Yan Lu ; Daofeng ChenSource :
- International journal of biological macromolecules [ 1879-0003 ] ; 2019.
English descriptors
- KwdEn :
- Acute Lung Injury (drug therapy), Acute Lung Injury (etiology), Acute Lung Injury (metabolism), Acute Lung Injury (pathology), Animals, Biomarkers, Complement System Proteins, Cytokines (metabolism), Disease Models, Animal, Inflammation Mediators (metabolism), Influenza A Virus, H1N1 Subtype (drug effects), Juniperus (chemistry), Male, Mice, Orthomyxoviridae Infections (complications), Orthomyxoviridae Infections (virology), Oxidative Stress (drug effects), Phytochemicals (chemistry), Phytochemicals (pharmacology), Plant Extracts (chemistry), Plant Extracts (pharmacology), Polysaccharides (chemistry), Polysaccharides (pharmacology), Spectrum Analysis.
- MESH :
- chemical , chemistry : Phytochemicals, Plant Extracts, Polysaccharides.
- chemical , metabolism : Cytokines, Inflammation Mediators.
- chemical , pharmacology : Phytochemicals, Plant Extracts, Polysaccharides.
- chemical : Biomarkers, Complement System Proteins.
- chemistry : Juniperus.
- complications : Orthomyxoviridae Infections.
- drug effects : Influenza A Virus, H1N1 Subtype, Oxidative Stress.
- drug therapy : Acute Lung Injury.
- etiology : Acute Lung Injury.
- metabolism : Acute Lung Injury.
- pathology : Acute Lung Injury.
- virology : Orthomyxoviridae Infections.
- Animals, Disease Models, Animal, Male, Mice, Spectrum Analysis.
Abstract
Juniperus pingii var. wilsonii has been traditionally used in Tibetan medicine for the treatment of inflammatory diseases. In the present study, J. pingii var. wilsonii polysaccharides (JPWP), with high content of d‑galacturonic acid, showed potent anti-complementary activity in vitro and significantly attenuated acute lung injury (ALI) induced by H1N1 influenza virus in vivo through reducing the inflammatory responses, alleviating oxidative stress and inhibiting the activation of complement. Thus, anti-complementary activity-guided fractionation of JPWP led to the isolation of an acidic homogeneous polysaccharide, JPWP-PS, whose structure was further elucidated by acid hydrolysis, PMP derivation, methylation and NMR analysis. JPWP-PS had potent anti-complementary activity with the CH50 value of 0.073 ± 0.009 mg/mL, and was characterized by the residues of T-Araf-(1→, →3)-Araf-(1→, →3,5)-Araf-(1→, →3)-Galp-(1→ and →4)-GalpA-(1→.
DOI: 10.1016/j.ijbiomac.2019.01.163
PubMed: 30708019
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pubmed:30708019Le document en format XML
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Electronic address: luyan@fudan.edu.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Daofeng" sort="Chen, Daofeng" uniqKey="Chen D" first="Daofeng" last="Chen">Daofeng Chen</name><affiliation><nlm:affiliation>Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: dfchen@shmu.edu.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of biological macromolecules</title><idno type="eISSN">1879-0003</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Lung Injury (drug therapy)</term><term>Acute Lung Injury (etiology)</term><term>Acute Lung Injury (metabolism)</term><term>Acute Lung Injury (pathology)</term><term>Animals</term><term>Biomarkers</term><term>Complement System Proteins</term><term>Cytokines (metabolism)</term><term>Disease Models, Animal</term><term>Inflammation Mediators (metabolism)</term><term>Influenza A Virus, H1N1 Subtype (drug effects)</term><term>Juniperus (chemistry)</term><term>Male</term><term>Mice</term><term>Orthomyxoviridae Infections (complications)</term><term>Orthomyxoviridae Infections (virology)</term><term>Oxidative Stress (drug effects)</term><term>Phytochemicals (chemistry)</term><term>Phytochemicals (pharmacology)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Polysaccharides (chemistry)</term><term>Polysaccharides (pharmacology)</term><term>Spectrum Analysis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Phytochemicals</term><term>Plant Extracts</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phytochemicals</term><term>Plant Extracts</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term><term>Complement System Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Juniperus</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Acute Lung Injury</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Acute Lung Injury</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acute Lung Injury</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Acute Lung Injury</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Male</term><term>Mice</term><term>Spectrum Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Juniperus pingii var. wilsonii has been traditionally used in Tibetan medicine for the treatment of inflammatory diseases. In the present study, J. pingii var. wilsonii polysaccharides (JPWP), with high content of d‑galacturonic acid, showed potent anti-complementary activity in vitro and significantly attenuated acute lung injury (ALI) induced by H1N1 influenza virus in vivo through reducing the inflammatory responses, alleviating oxidative stress and inhibiting the activation of complement. Thus, anti-complementary activity-guided fractionation of JPWP led to the isolation of an acidic homogeneous polysaccharide, JPWP-PS, whose structure was further elucidated by acid hydrolysis, PMP derivation, methylation and NMR analysis. JPWP-PS had potent anti-complementary activity with the CH<sub>50</sub> value of 0.073 ± 0.009 mg/mL, and was characterized by the residues of T-Araf-(1→, →3)-Araf-(1→, →3,5)-Araf-(1→, →3)-Galp-(1→ and →4)-GalpA-(1→.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30708019</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>24</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0003</ISSN><JournalIssue CitedMedium="Internet"><Volume>129</Volume><PubDate><Year>2019</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>International journal of biological macromolecules</Title><ISOAbbreviation>Int. J. Biol. Macromol.</ISOAbbreviation></Journal><ArticleTitle>Beneficial effects on H1N1-induced acute lung injury and structure characterization of anti-complementary acidic polysaccharides from Juniperus pingii var. wilsonii.</ArticleTitle><Pagination><MedlinePgn>246-253</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0141-8130(18)36736-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijbiomac.2019.01.163</ELocationID><Abstract><AbstractText>Juniperus pingii var. wilsonii has been traditionally used in Tibetan medicine for the treatment of inflammatory diseases. In the present study, J. pingii var. wilsonii polysaccharides (JPWP), with high content of d‑galacturonic acid, showed potent anti-complementary activity in vitro and significantly attenuated acute lung injury (ALI) induced by H1N1 influenza virus in vivo through reducing the inflammatory responses, alleviating oxidative stress and inhibiting the activation of complement. Thus, anti-complementary activity-guided fractionation of JPWP led to the isolation of an acidic homogeneous polysaccharide, JPWP-PS, whose structure was further elucidated by acid hydrolysis, PMP derivation, methylation and NMR analysis. JPWP-PS had potent anti-complementary activity with the CH<sub>50</sub> value of 0.073 ± 0.009 mg/mL, and was characterized by the residues of T-Araf-(1→, →3)-Araf-(1→, →3,5)-Araf-(1→, →3)-Galp-(1→ and →4)-GalpA-(1→.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Zelong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Long</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De</LastName><ForeName>Ji</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Science, Tibet University, Lhasa 850000, Tibet, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Mengxia</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: luyan@fudan.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Daofeng</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: dfchen@shmu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Biol Macromol</MedlineTA><NlmUniqueID>7909578</NlmUniqueID><ISSNLinking>0141-8130</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064209">Phytochemicals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011134">Polysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-36-7</RegistryNumber><NameOfSubstance UI="D003165">Complement System Proteins</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D055371" MajorTopicYN="N">Acute Lung Injury</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003165" MajorTopicYN="N">Complement System Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018653" MajorTopicYN="N">Juniperus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064209" MajorTopicYN="N">Phytochemicals</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011134" MajorTopicYN="N">Polysaccharides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013057" MajorTopicYN="N">Spectrum Analysis</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute lung injury</Keyword><Keyword MajorTopicYN="N">Complement inhibition</Keyword><Keyword MajorTopicYN="N">Juniperus pingii var. wilsonii</Keyword><Keyword MajorTopicYN="N">Polysaccharides</Keyword><Keyword MajorTopicYN="N">Structure characterization</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>01</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30708019</ArticleId><ArticleId IdType="pii">S0141-8130(18)36736-9</ArticleId><ArticleId IdType="doi">10.1016/j.ijbiomac.2019.01.163</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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