The influence of psychological stress on the immune response to vaccines.
Identifieur interne : 000983 ( PubMed/Checkpoint ); précédent : 000982; suivant : 000984The influence of psychological stress on the immune response to vaccines.
Auteurs : R. Glaser [États-Unis] ; J K Kiecolt-Glaser ; W B Malarkey ; J F SheridanSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 1998.
Descripteurs français
- KwdFr :
- Aidants (psychologie), Anticorps antiviraux (analyse), Humains, Interleukine-2 (biosynthèse), Lymphocytes T (métabolisme), Maladie d'Alzheimer (), Orthomyxoviridae (immunologie), Production d'anticorps (), Stress psychologique (immunologie), Stress psychologique (physiopathologie), Sujet âgé, Système immunitaire (), Vaccins antiviraux (usage thérapeutique), Virus de l'hépatite B (immunologie), Études longitudinales.
- MESH :
- analyse : Anticorps antiviraux.
- biosynthèse : Interleukine-2.
- immunologie : Orthomyxoviridae, Stress psychologique, Virus de l'hépatite B.
- métabolisme : Lymphocytes T.
- physiopathologie : Stress psychologique.
- psychologie : Aidants.
- usage thérapeutique : Vaccins antiviraux.
- Humains, Maladie d'Alzheimer, Production d'anticorps, Sujet âgé, Système immunitaire, Études longitudinales.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (therapy), Antibodies, Viral (analysis), Antibody Formation (drug effects), Caregivers (psychology), Hepatitis B virus (immunology), Humans, Immune System (drug effects), Interleukin-2 (biosynthesis), Longitudinal Studies, Orthomyxoviridae (immunology), Stress, Psychological (immunology), Stress, Psychological (physiopathology), T-Lymphocytes (metabolism), Viral Vaccines (therapeutic use).
- MESH :
- chemical , analysis : Antibodies, Viral.
- chemical , biosynthesis : Interleukin-2.
- drug effects : Antibody Formation, Immune System.
- immunology : Hepatitis B virus, Orthomyxoviridae, Stress, Psychological.
- metabolism : T-Lymphocytes.
- physiopathology : Stress, Psychological.
- psychology : Caregivers.
- chemical , therapeutic use : Viral Vaccines.
- therapy : Alzheimer Disease.
- Aged, Humans, Longitudinal Studies.
Abstract
We compared virus-specific antibody and T-cell responses to influenza virus vaccination in 32 caregivers of Alzheimer's disease (AD) patients and matched control subjects. Caregivers showed a poorer antibody response and virus-specific T-cell response following vaccination compared to the control subjects as measured by fourfold increases in antibody titers to the vaccine and lower levels of virus-induced IL-2 levels in vitro. We performed a second study in which forty-eight medical students were inoculated with a series of three injections of the hepatitis-B (HEP-B) vaccine to coincide with the third day of three, three-day examination blocks. Twelve of the 48 medical students seroconverted after the first injection; these students were characterized by falling into the lower stressed/lower anxiety group of students. Students who reported greater social support and lower anxiety and stress demonstrated a higher antibody response to the vaccine and a more vigorous T-cell response to HEP-B surface antigen at the end of the third examination experience. The differences in antibody and T-cell responses to HEP-B and influenza virus vaccinations provide a demonstration of how stress may be able to alter both the cellular and humoral immune responses to vaccines and novel pathogens in both younger and older adults.
DOI: 10.1111/j.1749-6632.1998.tb09603.x
PubMed: 9629291
Affiliations:
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Caregivers showed a poorer antibody response and virus-specific T-cell response following vaccination compared to the control subjects as measured by fourfold increases in antibody titers to the vaccine and lower levels of virus-induced IL-2 levels in vitro. We performed a second study in which forty-eight medical students were inoculated with a series of three injections of the hepatitis-B (HEP-B) vaccine to coincide with the third day of three, three-day examination blocks. Twelve of the 48 medical students seroconverted after the first injection; these students were characterized by falling into the lower stressed/lower anxiety group of students. Students who reported greater social support and lower anxiety and stress demonstrated a higher antibody response to the vaccine and a more vigorous T-cell response to HEP-B surface antigen at the end of the third examination experience. The differences in antibody and T-cell responses to HEP-B and influenza virus vaccinations provide a demonstration of how stress may be able to alter both the cellular and humoral immune responses to vaccines and novel pathogens in both younger and older adults.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9629291</PMID><DateCompleted><Year>1998</Year><Month>07</Month><Day>09</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0077-8923</ISSN><JournalIssue CitedMedium="Print"><Volume>840</Volume><PubDate><Year>1998</Year><Month>May</Month><Day>01</Day></PubDate></JournalIssue><Title>Annals of the New York Academy of Sciences</Title><ISOAbbreviation>Ann. N. Y. Acad. Sci.</ISOAbbreviation></Journal><ArticleTitle>The influence of psychological stress on the immune response to vaccines.</ArticleTitle><Pagination><MedlinePgn>649-55</MedlinePgn></Pagination><Abstract><AbstractText>We compared virus-specific antibody and T-cell responses to influenza virus vaccination in 32 caregivers of Alzheimer's disease (AD) patients and matched control subjects. Caregivers showed a poorer antibody response and virus-specific T-cell response following vaccination compared to the control subjects as measured by fourfold increases in antibody titers to the vaccine and lower levels of virus-induced IL-2 levels in vitro. We performed a second study in which forty-eight medical students were inoculated with a series of three injections of the hepatitis-B (HEP-B) vaccine to coincide with the third day of three, three-day examination blocks. Twelve of the 48 medical students seroconverted after the first injection; these students were characterized by falling into the lower stressed/lower anxiety group of students. Students who reported greater social support and lower anxiety and stress demonstrated a higher antibody response to the vaccine and a more vigorous T-cell response to HEP-B surface antigen at the end of the third examination experience. The differences in antibody and T-cell responses to HEP-B and influenza virus vaccinations provide a demonstration of how stress may be able to alter both the cellular and humoral immune responses to vaccines and novel pathogens in both younger and older adults.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Glaser</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, Ohio State University College of Medicine, Columbus 43210, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiecolt-Glaser</LastName><ForeName>J K</ForeName><Initials>JK</Initials></Author><Author ValidYN="Y"><LastName>Malarkey</LastName><ForeName>W B</ForeName><Initials>WB</Initials></Author><Author ValidYN="Y"><LastName>Sheridan</LastName><ForeName>J F</ForeName><Initials>JF</Initials></Author></AuthorList><Language>eng</Language><GrantList 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PubStatus="entrez"><Year>1998</Year><Month>6</Month><Day>18</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9629291</ArticleId><ArticleId IdType="doi">10.1111/j.1749-6632.1998.tb09603.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Kiecolt Glaser, J K" sort="Kiecolt Glaser, J K" uniqKey="Kiecolt Glaser J" first="J K" last="Kiecolt-Glaser">J K Kiecolt-Glaser</name><name sortKey="Malarkey, W B" sort="Malarkey, W B" uniqKey="Malarkey W" first="W B" last="Malarkey">W B Malarkey</name><name sortKey="Sheridan, J F" sort="Sheridan, J F" uniqKey="Sheridan J" first="J F" last="Sheridan">J F Sheridan</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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