Bio-inspired virus-like nanovesicle for effective vaccination.
Identifieur interne : 000378 ( PubMed/Checkpoint ); précédent : 000377; suivant : 000379Bio-inspired virus-like nanovesicle for effective vaccination.
Auteurs : Peng Mi [République populaire de Chine] ; Pengfei Zhang [République populaire de Chine] ; Gang Liu [République populaire de Chine]Source :
- Human vaccines & immunotherapeutics [ 2164-554X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Nanoparticules (administration et posologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (isolement et purification), Vaccins sous-unitaires (administration et posologie), Vaccins sous-unitaires (génétique), Vaccins sous-unitaires (immunologie), Vaccins sous-unitaires (isolement et purification), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vaccins synthétiques (isolement et purification), Vecteurs de médicaments, Vésicules extracellulaires.
- MESH :
- administration et posologie : Nanoparticules, Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- génétique : Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- immunologie : Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- isolement et purification : Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- Animaux, Vecteurs de médicaments, Vésicules extracellulaires.
English descriptors
- KwdEn :
- Animals, Drug Carriers, Extracellular Vesicles, Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza Vaccines (isolation & purification), Nanoparticles (administration & dosage), Vaccines, Subunit (administration & dosage), Vaccines, Subunit (genetics), Vaccines, Subunit (immunology), Vaccines, Subunit (isolation & purification), Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Vaccines, Synthetic (isolation & purification).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical , genetics : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical , immunology : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical , isolation & purification : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical : Drug Carriers.
- administration & dosage : Nanoparticles.
- Animals, Extracellular Vesicles.
Abstract
Developing effective vaccines is of vital importance for protecting public health by preventing potential pandemics or by controlling ongoing ones. However, there is a threshold of rapidly design and develop effective vaccines to prevent virus infection. Inspired by the natural budding processes associated with cell membrane scission when enveloped viruses invade host cells and replicate themselves, a similar strategy was applied to achieve virus-mimetic nanovesicles (VMVs). This strategy loaded genetically engineered viral antigens onto mammalian cell membranes to produce antigen-loaded vesicles, and then used surfactants to optimize their size and stability. The VMVs resemble natural viruses in size, shape and specific immune function and have protein antigens in the correct conformation on their exterior to elicit robust immunogenicity. This was confirmed in animal models against influenza A (H1N1) virus, demonstrating that VMVs could be a versatile platform for vaccine development.
DOI: 10.1080/21645515.2016.1157244
PubMed: 27141919
Affiliations:
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Zhang</name><affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen </wicri:regionArea><wicri:noRegion>Xiamen </wicri:noRegion></affiliation></author><author><name sortKey="Liu, Gang" sort="Liu, Gang" uniqKey="Liu G" first="Gang" last="Liu">Gang Liu</name><affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen </wicri:regionArea><wicri:noRegion>Xiamen </wicri:noRegion></affiliation></author></analytic><series><title level="j">Human vaccines & immunotherapeutics</title><idno type="eISSN">2164-554X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Drug Carriers</term><term>Extracellular Vesicles</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (isolation & purification)</term><term>Nanoparticles (administration & dosage)</term><term>Vaccines, Subunit (administration 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However, there is a threshold of rapidly design and develop effective vaccines to prevent virus infection. Inspired by the natural budding processes associated with cell membrane scission when enveloped viruses invade host cells and replicate themselves, a similar strategy was applied to achieve virus-mimetic nanovesicles (VMVs). This strategy loaded genetically engineered viral antigens onto mammalian cell membranes to produce antigen-loaded vesicles, and then used surfactants to optimize their size and stability. The VMVs resemble natural viruses in size, shape and specific immune function and have protein antigens in the correct conformation on their exterior to elicit robust immunogenicity. This was confirmed in animal models against influenza A (H1N1) virus, demonstrating that VMVs could be a versatile platform for vaccine development.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27141919</PMID><DateCompleted><Year>2017</Year><Month>10</Month><Day>19</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2164-554X</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>8</Issue><PubDate><Year>2016</Year><Month>08</Month><Day>02</Day></PubDate></JournalIssue><Title>Human vaccines & immunotherapeutics</Title><ISOAbbreviation>Hum Vaccin Immunother</ISOAbbreviation></Journal><ArticleTitle>Bio-inspired virus-like nanovesicle for effective vaccination.</ArticleTitle><Pagination><MedlinePgn>2090-2091</MedlinePgn></Pagination><Abstract><AbstractText>Developing effective vaccines is of vital importance for protecting public health by preventing potential pandemics or by controlling ongoing ones. However, there is a threshold of rapidly design and develop effective vaccines to prevent virus infection. Inspired by the natural budding processes associated with cell membrane scission when enveloped viruses invade host cells and replicate themselves, a similar strategy was applied to achieve virus-mimetic nanovesicles (VMVs). This strategy loaded genetically engineered viral antigens onto mammalian cell membranes to produce antigen-loaded vesicles, and then used surfactants to optimize their size and stability. The VMVs resemble natural viruses in size, shape and specific immune function and have protein antigens in the correct conformation on their exterior to elicit robust immunogenicity. This was confirmed in animal models against influenza A (H1N1) virus, demonstrating that VMVs could be a versatile platform for vaccine development.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mi</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen , China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Innovation Center of Nanomedicine (iCONM) , Kawasaki , Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Pengfei</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen , China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen , China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>d The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen , China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, 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MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014614" MajorTopicYN="N">Vaccines, Synthetic</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">antigen delivery system</Keyword><Keyword MajorTopicYN="Y">immunogenicity</Keyword><Keyword MajorTopicYN="Y">membrane vesicle</Keyword><Keyword MajorTopicYN="Y">vaccine</Keyword><Keyword MajorTopicYN="Y">virus-like particle</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27141919</ArticleId><ArticleId IdType="doi">10.1080/21645515.2016.1157244</ArticleId><ArticleId IdType="pmc">PMC4994763</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nat Biotechnol. 2006 Nov;24(11):1377-83</Citation><ArticleIdList><ArticleId IdType="pubmed">17093488</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2010 Oct;9(10):1149-76</Citation><ArticleIdList><ArticleId 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