The Preventive Effect of the Traditional Japanese Herbal Medicine, Hochuekkito, against Influenza A Virus via Autophagy in vitro.
Identifieur interne : 000301 ( PubMed/Checkpoint ); précédent : 000300; suivant : 000302The Preventive Effect of the Traditional Japanese Herbal Medicine, Hochuekkito, against Influenza A Virus via Autophagy in vitro.
Auteurs : Keita Takanashi [Japon] ; Katsuaki Dan ; Sho Kanzaki ; Hideki Hasegawa ; Kenji Watanabe ; Kaoru OgawaSource :
- Pharmacology [ 1423-0313 ] ; 2017.
Descripteurs français
- KwdFr :
- Agents protecteurs (pharmacologie), Animaux, Autophagie (), Autophagie (physiologie), Cellules rénales canines Madin-Darby, Chiens, Médicaments issus de plantes chinoises (pharmacologie), Poulets, Science des plantes médicinales, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (physiologie).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Drugs, Chinese Herbal, Protective Agents.
- drug effects : Autophagy, Influenza A Virus, H1N1 Subtype.
- physiology : Autophagy, Influenza A Virus, H1N1 Subtype.
- Animals, Chickens, Dogs, Herbal Medicine, Madin Darby Canine Kidney Cells.
Abstract
Hochuekkito (HKT), a traditional Japanese herbal medicine, enhances the immunity of elderly or weak individuals. It is also known to have preventive effects against influenza clinically. However, the detailed mechanisms of the preventive effects have not been clarified. We examined the relationship between the preventive effects of HKT and autophagy, a known stress response and quality control mechanism, using Madin-Darby canine kidney cells and influenza A/PR/8/34 (H1N1) virus.
DOI: 10.1159/000452474
PubMed: 27788517
Affiliations:
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sort="Kanzaki, Sho" uniqKey="Kanzaki S" first="Sho" last="Kanzaki">Sho Kanzaki</name></author><author><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name></author><author><name sortKey="Watanabe, Kenji" sort="Watanabe, Kenji" uniqKey="Watanabe K" first="Kenji" last="Watanabe">Kenji Watanabe</name></author><author><name sortKey="Ogawa, Kaoru" sort="Ogawa, Kaoru" uniqKey="Ogawa K" first="Kaoru" last="Ogawa">Kaoru Ogawa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27788517</idno><idno type="pmid">27788517</idno><idno type="doi">10.1159/000452474</idno><idno type="wicri:Area/PubMed/Corpus">000339</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000339</idno><idno type="wicri:Area/PubMed/Curation">000338</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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Kantō</region></placeName></affiliation></author><author><name sortKey="Dan, Katsuaki" sort="Dan, Katsuaki" uniqKey="Dan K" first="Katsuaki" last="Dan">Katsuaki Dan</name></author><author><name sortKey="Kanzaki, Sho" sort="Kanzaki, Sho" uniqKey="Kanzaki S" first="Sho" last="Kanzaki">Sho Kanzaki</name></author><author><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name></author><author><name sortKey="Watanabe, Kenji" sort="Watanabe, Kenji" uniqKey="Watanabe K" first="Kenji" last="Watanabe">Kenji Watanabe</name></author><author><name sortKey="Ogawa, Kaoru" sort="Ogawa, Kaoru" uniqKey="Ogawa K" first="Kaoru" last="Ogawa">Kaoru Ogawa</name></author></analytic><series><title level="j">Pharmacology</title><idno type="eISSN">1423-0313</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autophagy (drug effects)</term><term>Autophagy (physiology)</term><term>Chickens</term><term>Dogs</term><term>Drugs, Chinese Herbal (pharmacology)</term><term>Herbal Medicine</term><term>Influenza A Virus, H1N1 Subtype (drug effects)</term><term>Influenza A Virus, H1N1 Subtype (physiology)</term><term>Madin Darby Canine Kidney Cells</term><term>Protective Agents (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents protecteurs (pharmacologie)</term><term>Animaux</term><term>Autophagie ()</term><term>Autophagie (physiologie)</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Médicaments issus de plantes chinoises (pharmacologie)</term><term>Poulets</term><term>Science des plantes médicinales</term><term>Sous-type H1N1 du virus de la grippe A ()</term><term>Sous-type H1N1 du virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Drugs, Chinese Herbal</term><term>Protective Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents protecteurs</term><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Autophagie</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chickens</term><term>Dogs</term><term>Herbal Medicine</term><term>Madin Darby Canine Kidney Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Poulets</term><term>Science des plantes médicinales</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hochuekkito (HKT), a traditional Japanese herbal medicine, enhances the immunity of elderly or weak individuals. It is also known to have preventive effects against influenza clinically. However, the detailed mechanisms of the preventive effects have not been clarified. We examined the relationship between the preventive effects of HKT and autophagy, a known stress response and quality control mechanism, using Madin-Darby canine kidney cells and influenza A/PR/8/34 (H1N1) virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27788517</PMID><DateCompleted><Year>2017</Year><Month>03</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>03</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1423-0313</ISSN><JournalIssue CitedMedium="Internet"><Volume>99</Volume><Issue>3-4</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Pharmacology</Title><ISOAbbreviation>Pharmacology</ISOAbbreviation></Journal><ArticleTitle>The Preventive Effect of the Traditional Japanese Herbal Medicine, Hochuekkito, against Influenza A Virus via Autophagy in vitro.</ArticleTitle><Pagination><MedlinePgn>99-105</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000452474</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Hochuekkito (HKT), a traditional Japanese herbal medicine, enhances the immunity of elderly or weak individuals. It is also known to have preventive effects against influenza clinically. However, the detailed mechanisms of the preventive effects have not been clarified. We examined the relationship between the preventive effects of HKT and autophagy, a known stress response and quality control mechanism, using Madin-Darby canine kidney cells and influenza A/PR/8/34 (H1N1) virus.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The effect of HKT on autophagy in influenza A virus (IAV)-infected cells was assessed by Western blotting and fluorescence microscopy using an RFP-GFP-LC3B sensor kit.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In Western blotting, treatment with HKT before IAV infection (pre-HKT) tended to induce autophagy in IAV-infected cells at an early stage of infection, eventually suppressing IAV-induced autophagy. Moreover, several autolysosomes, indicative of normal autophagosome-lysosome fusion, were observed in Pre-HKT cells transduced with RFP-GFP-LC3B but not in untreated IAV-infected cells.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings indicated that IAV-mediated inhibition of the fusion of autophagosomes with lysosomes was prevented by HKT treatment before infection. According to these results, we propose that this phenomenon is one of the preventive effects of HKT against IAV.</AbstractText><CopyrightInformation>© 2016 S. Karger AG, Basel.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Takanashi</LastName><ForeName>Keita</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dan</LastName><ForeName>Katsuaki</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kanzaki</LastName><ForeName>Sho</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hasegawa</LastName><ForeName>Hideki</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>Kenji</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Ogawa</LastName><ForeName>Kaoru</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Pharmacology</MedlineTA><NlmUniqueID>0152016</NlmUniqueID><ISSNLinking>0031-7012</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020011">Protective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C402943">bu-zhong-yi-qi-tang</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029001" MajorTopicYN="N">Herbal Medicine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061985" MajorTopicYN="N">Madin Darby Canine Kidney Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020011" MajorTopicYN="N">Protective Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27788517</ArticleId><ArticleId IdType="pii">000452474</ArticleId><ArticleId IdType="doi">10.1159/000452474</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Dan, Katsuaki" sort="Dan, Katsuaki" uniqKey="Dan K" first="Katsuaki" last="Dan">Katsuaki Dan</name><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name><name sortKey="Kanzaki, Sho" sort="Kanzaki, Sho" uniqKey="Kanzaki S" first="Sho" last="Kanzaki">Sho Kanzaki</name><name sortKey="Ogawa, Kaoru" sort="Ogawa, Kaoru" uniqKey="Ogawa K" first="Kaoru" last="Ogawa">Kaoru Ogawa</name><name sortKey="Watanabe, Kenji" sort="Watanabe, Kenji" uniqKey="Watanabe K" first="Kenji" last="Watanabe">Kenji Watanabe</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Takanashi, Keita" sort="Takanashi, Keita" uniqKey="Takanashi K" first="Keita" last="Takanashi">Keita Takanashi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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