Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus.
Identifieur interne : 000205 ( PubMed/Checkpoint ); précédent : 000204; suivant : 000206Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus.
Auteurs : Donatella Amatore ; Ignacio Celestino ; Serena Brundu ; Luca Galluzzi ; Paolo Coluccio ; Paola Checconi ; Mauro Magnani ; Anna Teresa Palamara ; Alessandra Fraternale ; Lucia NencioniSource :
- FASEB bioAdvances [ 2573-9832 ] ; 2019.
Abstract
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH derivative (GSH-C4) on the response of aged mice infected with influenza A PR8/H1N1 virus was studied through the determination of GSH concentration in organs, lung viral titer, IgA and IgG1/IgG2a production, and Th1/Th2 cytokine profile. Old mice had lower GSH than young mice in organs. Also the gene expression of endoplasmic reticulum (ER) stress markers involved in GSH metabolism and folding of proteins, that is, Nrf2 and PDI, was reduced. Following infection, GSH content remained low and neither infection nor GSH-C4 treatment affected Nrf2 expression. In contrast, PDI expression was upregulated during infection and appeared counterbalanced by GSH-C4. Moreover, the treatment with GSH-C4 increased GSH content in organs, reduced viral replication and induced a predominant Th1 response. In conclusion, GSH-C4 treatment could be used in the elderly to contrast influenza virus infection by inducing immune response, in particular the Th1 profile.
DOI: 10.1096/fba.2018-00066
PubMed: 32123833
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<front><div type="abstract" xml:lang="en">During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH derivative (GSH-C4) on the response of aged mice infected with influenza A PR8/H1N1 virus was studied through the determination of GSH concentration in organs, lung viral titer, IgA and IgG1/IgG2a production, and Th1/Th2 cytokine profile. Old mice had lower GSH than young mice in organs. Also the gene expression of endoplasmic reticulum (ER) stress markers involved in GSH metabolism and folding of proteins, that is, Nrf2 and PDI, was reduced. Following infection, GSH content remained low and neither infection nor GSH-C4 treatment affected Nrf2 expression. In contrast, PDI expression was upregulated during infection and appeared counterbalanced by GSH-C4. Moreover, the treatment with GSH-C4 increased GSH content in organs, reduced viral replication and induced a predominant Th1 response. In conclusion, GSH-C4 treatment could be used in the elderly to contrast influenza virus infection by inducing immune response, in particular the Th1 profile.</div>
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<Abstract><AbstractText>During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH derivative (GSH-C4) on the response of aged mice infected with influenza A PR8/H1N1 virus was studied through the determination of GSH concentration in organs, lung viral titer, IgA and IgG1/IgG2a production, and Th1/Th2 cytokine profile. Old mice had lower GSH than young mice in organs. Also the gene expression of endoplasmic reticulum (ER) stress markers involved in GSH metabolism and folding of proteins, that is, Nrf2 and PDI, was reduced. Following infection, GSH content remained low and neither infection nor GSH-C4 treatment affected Nrf2 expression. In contrast, PDI expression was upregulated during infection and appeared counterbalanced by GSH-C4. Moreover, the treatment with GSH-C4 increased GSH content in organs, reduced viral replication and induced a predominant Th1 response. In conclusion, GSH-C4 treatment could be used in the elderly to contrast influenza virus infection by inducing immune response, in particular the Th1 profile.</AbstractText>
<CopyrightInformation>© 2019 The Authors.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Amatore</LastName>
<ForeName>Donatella</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Celestino</LastName>
<ForeName>Ignacio</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Brundu</LastName>
<ForeName>Serena</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Galluzzi</LastName>
<ForeName>Luca</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coluccio</LastName>
<ForeName>Paolo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Checconi</LastName>
<ForeName>Paola</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Human Sciences and Promotion of the Quality of Life IRCCS San Raffaele Pisana, San Raffaele Roma Open University Rome Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Magnani</LastName>
<ForeName>Mauro</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Palamara</LastName>
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<Initials>AT</Initials>
<AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Human Sciences and Promotion of the Quality of Life IRCCS San Raffaele Pisana, San Raffaele Roma Open University Rome Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fraternale</LastName>
<ForeName>Alessandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nencioni</LastName>
<ForeName>Lucia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation>
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<Month>03</Month>
<Day>13</Day>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Th response</Keyword>
<Keyword MajorTopicYN="N">aging</Keyword>
<Keyword MajorTopicYN="N">oxidative stress</Keyword>
<Keyword MajorTopicYN="N">redox state</Keyword>
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<ReferenceList><Reference><Citation>Oxid Med Cell Longev. 2016;2016:1746985</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26885246</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2010 Mar 15;184(6):2918-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20164428</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Pathol. 2016 Jul;186(7):1712-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27338106</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ageing Res Rev. 2011 Sep;10(4):422-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21315186</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Microbiol Immunol (Bp). 2015 Mar;5(1):14-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25883791</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Mol Sci. 2013 Feb 19;14(2):4148-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23429198</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Immunol. 2017 Sep 29;8:1239</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29033950</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>ScientificWorldJournal. 2011;11:1749-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22125433</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Microbiol. 2016 Nov 22;7:1841</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27920759</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Vaccine Immunol. 2006 Sep;13(9):981-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16960108</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2001 Jun 15;166(12):7381-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11390489</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Vaccine. 2012 Aug 31;30(40):5893-900</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22835738</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24833586</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Respir Res. 2009 Nov 18;10:112</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19922665</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antioxid Redox Signal. 2011 Aug 1;15(3):593-606</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21366409</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell Microbiol. 2015 Jan;17(1):131-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25154738</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Methods Enzymol. 2005;401:468-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16399403</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Physiol. 2012 Jul 16;3:263</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22934019</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Aging Cell. 2019 Apr;18(2):e12893</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30632262</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Acta Virol. 2009;53(4):233-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19941386</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FASEB J. 2003 Apr;17(6):758-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12594179</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1988 Jul 21;334(6179):255-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2456466</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Microbes Infect. 2017 Dec;19(12):626-634</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28899815</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Vaccine. 2010 Nov 10;28(48):7676-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20875491</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Front Immunol. 2018 Jul 30;9:1747</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30105026</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Mol Aspects Med. 2009 Feb-Apr;30(1-2):42-59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18601945</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2016 Jul 27;90(16):7118-7130</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27226373</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ageing Res Rev. 2005 May;4(2):288-314</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15936251</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2000 Sep;182 Suppl 1:S74-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10944487</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Free Radic Biol Med. 2011 Jul 15;51(2):444-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21549835</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Vaccine. 2011 Sep 16;29(40):6823-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21816192</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Free Radic Biol Med. 2003 Apr 1;34(7):928-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12654482</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Aging Dis. 2018 Jun 1;9(3):358-373</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29896425</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biol Chem. 2017 Feb 1;398(2):261-275</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27514076</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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<tree><noCountry><name sortKey="Amatore, Donatella" sort="Amatore, Donatella" uniqKey="Amatore D" first="Donatella" last="Amatore">Donatella Amatore</name>
<name sortKey="Brundu, Serena" sort="Brundu, Serena" uniqKey="Brundu S" first="Serena" last="Brundu">Serena Brundu</name>
<name sortKey="Celestino, Ignacio" sort="Celestino, Ignacio" uniqKey="Celestino I" first="Ignacio" last="Celestino">Ignacio Celestino</name>
<name sortKey="Checconi, Paola" sort="Checconi, Paola" uniqKey="Checconi P" first="Paola" last="Checconi">Paola Checconi</name>
<name sortKey="Coluccio, Paolo" sort="Coluccio, Paolo" uniqKey="Coluccio P" first="Paolo" last="Coluccio">Paolo Coluccio</name>
<name sortKey="Fraternale, Alessandra" sort="Fraternale, Alessandra" uniqKey="Fraternale A" first="Alessandra" last="Fraternale">Alessandra Fraternale</name>
<name sortKey="Galluzzi, Luca" sort="Galluzzi, Luca" uniqKey="Galluzzi L" first="Luca" last="Galluzzi">Luca Galluzzi</name>
<name sortKey="Magnani, Mauro" sort="Magnani, Mauro" uniqKey="Magnani M" first="Mauro" last="Magnani">Mauro Magnani</name>
<name sortKey="Nencioni, Lucia" sort="Nencioni, Lucia" uniqKey="Nencioni L" first="Lucia" last="Nencioni">Lucia Nencioni</name>
<name sortKey="Palamara, Anna Teresa" sort="Palamara, Anna Teresa" uniqKey="Palamara A" first="Anna Teresa" last="Palamara">Anna Teresa Palamara</name>
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