Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus.
Identifieur interne : 000205 ( PubMed/Checkpoint ); précédent : 000204; suivant : 000206Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus.
Auteurs : Donatella Amatore ; Ignacio Celestino ; Serena Brundu ; Luca Galluzzi ; Paolo Coluccio ; Paola Checconi ; Mauro Magnani ; Anna Teresa Palamara ; Alessandra Fraternale ; Lucia NencioniSource :
- FASEB bioAdvances [ 2573-9832 ] ; 2019.
Abstract
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH derivative (GSH-C4) on the response of aged mice infected with influenza A PR8/H1N1 virus was studied through the determination of GSH concentration in organs, lung viral titer, IgA and IgG1/IgG2a production, and Th1/Th2 cytokine profile. Old mice had lower GSH than young mice in organs. Also the gene expression of endoplasmic reticulum (ER) stress markers involved in GSH metabolism and folding of proteins, that is, Nrf2 and PDI, was reduced. Following infection, GSH content remained low and neither infection nor GSH-C4 treatment affected Nrf2 expression. In contrast, PDI expression was upregulated during infection and appeared counterbalanced by GSH-C4. Moreover, the treatment with GSH-C4 increased GSH content in organs, reduced viral replication and induced a predominant Th1 response. In conclusion, GSH-C4 treatment could be used in the elderly to contrast influenza virus infection by inducing immune response, in particular the Th1 profile.
DOI: 10.1096/fba.2018-00066
PubMed: 32123833
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of Rome Rome Italy.</nlm:affiliation><wicri:noCountry code="subField">Sapienza University of Rome Rome Italy</wicri:noCountry></affiliation></author><author><name sortKey="Celestino, Ignacio" sort="Celestino, Ignacio" uniqKey="Celestino I" first="Ignacio" last="Celestino">Ignacio Celestino</name><affiliation><nlm:affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</nlm:affiliation><wicri:noCountry code="subField">Sapienza University of Rome Rome Italy</wicri:noCountry></affiliation></author><author><name sortKey="Brundu, Serena" sort="Brundu, Serena" uniqKey="Brundu S" first="Serena" last="Brundu">Serena Brundu</name><affiliation><nlm:affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</nlm:affiliation><wicri:noCountry code="no comma">Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</wicri:noCountry></affiliation></author><author><name sortKey="Galluzzi, Luca" sort="Galluzzi, Luca" uniqKey="Galluzzi L" first="Luca" last="Galluzzi">Luca Galluzzi</name><affiliation><nlm:affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</nlm:affiliation><wicri:noCountry code="no comma">Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</wicri:noCountry></affiliation></author><author><name sortKey="Coluccio, Paolo" sort="Coluccio, Paolo" uniqKey="Coluccio P" first="Paolo" last="Coluccio">Paolo Coluccio</name><affiliation><nlm:affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</nlm:affiliation><wicri:noCountry code="subField">Sapienza University of Rome Rome Italy</wicri:noCountry></affiliation></author><author><name sortKey="Checconi, Paola" sort="Checconi, Paola" uniqKey="Checconi P" first="Paola" last="Checconi">Paola Checconi</name><affiliation><nlm:affiliation>Department of Human Sciences and Promotion of the Quality of Life IRCCS San Raffaele Pisana, San Raffaele Roma Open University Rome Italy.</nlm:affiliation><wicri:noCountry code="subField">San Raffaele Roma Open University Rome Italy</wicri:noCountry></affiliation></author><author><name sortKey="Magnani, Mauro" sort="Magnani, Mauro" uniqKey="Magnani M" first="Mauro" last="Magnani">Mauro Magnani</name><affiliation><nlm:affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</nlm:affiliation><wicri:noCountry code="no comma">Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</wicri:noCountry></affiliation></author><author><name sortKey="Palamara, Anna Teresa" sort="Palamara, Anna Teresa" uniqKey="Palamara A" first="Anna Teresa" last="Palamara">Anna Teresa Palamara</name><affiliation><nlm:affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</nlm:affiliation><wicri:noCountry code="subField">Sapienza University of Rome Rome Italy</wicri:noCountry></affiliation></author><author><name sortKey="Fraternale, Alessandra" sort="Fraternale, Alessandra" uniqKey="Fraternale A" first="Alessandra" last="Fraternale">Alessandra Fraternale</name><affiliation><nlm:affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</nlm:affiliation><wicri:noCountry code="no comma">Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</wicri:noCountry></affiliation></author><author><name sortKey="Nencioni, Lucia" sort="Nencioni, Lucia" uniqKey="Nencioni L" first="Lucia" last="Nencioni">Lucia Nencioni</name><affiliation><nlm:affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</nlm:affiliation><wicri:noCountry code="subField">Sapienza University of Rome Rome Italy</wicri:noCountry></affiliation></author></analytic><series><title level="j">FASEB bioAdvances</title><idno type="eISSN">2573-9832</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH derivative (GSH-C4) on the response of aged mice infected with influenza A PR8/H1N1 virus was studied through the determination of GSH concentration in organs, lung viral titer, IgA and IgG1/IgG2a production, and Th1/Th2 cytokine profile. Old mice had lower GSH than young mice in organs. Also the gene expression of endoplasmic reticulum (ER) stress markers involved in GSH metabolism and folding of proteins, that is, Nrf2 and PDI, was reduced. Following infection, GSH content remained low and neither infection nor GSH-C4 treatment affected Nrf2 expression. In contrast, PDI expression was upregulated during infection and appeared counterbalanced by GSH-C4. Moreover, the treatment with GSH-C4 increased GSH content in organs, reduced viral replication and induced a predominant Th1 response. In conclusion, GSH-C4 treatment could be used in the elderly to contrast influenza virus infection by inducing immune response, in particular the Th1 profile.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32123833</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>05</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2573-9832</ISSN><JournalIssue CitedMedium="Internet"><Volume>1</Volume><Issue>5</Issue><PubDate><Year>2019</Year><Month>May</Month></PubDate></JournalIssue><Title>FASEB bioAdvances</Title><ISOAbbreviation>FASEB Bioadv</ISOAbbreviation></Journal><ArticleTitle>Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus.</ArticleTitle><Pagination><MedlinePgn>296-305</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1096/fba.2018-00066</ELocationID><Abstract><AbstractText>During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH derivative (GSH-C4) on the response of aged mice infected with influenza A PR8/H1N1 virus was studied through the determination of GSH concentration in organs, lung viral titer, IgA and IgG1/IgG2a production, and Th1/Th2 cytokine profile. Old mice had lower GSH than young mice in organs. Also the gene expression of endoplasmic reticulum (ER) stress markers involved in GSH metabolism and folding of proteins, that is, Nrf2 and PDI, was reduced. Following infection, GSH content remained low and neither infection nor GSH-C4 treatment affected Nrf2 expression. In contrast, PDI expression was upregulated during infection and appeared counterbalanced by GSH-C4. Moreover, the treatment with GSH-C4 increased GSH content in organs, reduced viral replication and induced a predominant Th1 response. In conclusion, GSH-C4 treatment could be used in the elderly to contrast influenza virus infection by inducing immune response, in particular the Th1 profile.</AbstractText><CopyrightInformation>© 2019 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Amatore</LastName><ForeName>Donatella</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Celestino</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brundu</LastName><ForeName>Serena</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galluzzi</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coluccio</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Checconi</LastName><ForeName>Paola</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Human Sciences and Promotion of the Quality of Life IRCCS San Raffaele Pisana, San Raffaele Roma Open University Rome Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Magnani</LastName><ForeName>Mauro</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palamara</LastName><ForeName>Anna Teresa</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Human Sciences and Promotion of the Quality of Life IRCCS San Raffaele Pisana, San Raffaele Roma Open University Rome Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraternale</LastName><ForeName>Alessandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino (PU) Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nencioni</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Deparment of Public Health and Infectious Diseases Istituto Pasteur Italia-Fondazione Cenci-Bolognetti, Sapienza University of Rome Rome Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>FASEB Bioadv</MedlineTA><NlmUniqueID>101733210</NlmUniqueID><ISSNLinking>2573-9832</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Th response</Keyword><Keyword MajorTopicYN="N">aging</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword><Keyword MajorTopicYN="N">redox state</Keyword><Keyword MajorTopicYN="N">viral infection</Keyword></KeywordList><CoiStatement>The author declare that they have no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>11</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>01</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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sortKey="Fraternale, Alessandra" sort="Fraternale, Alessandra" uniqKey="Fraternale A" first="Alessandra" last="Fraternale">Alessandra Fraternale</name><name sortKey="Galluzzi, Luca" sort="Galluzzi, Luca" uniqKey="Galluzzi L" first="Luca" last="Galluzzi">Luca Galluzzi</name><name sortKey="Magnani, Mauro" sort="Magnani, Mauro" uniqKey="Magnani M" first="Mauro" last="Magnani">Mauro Magnani</name><name sortKey="Nencioni, Lucia" sort="Nencioni, Lucia" uniqKey="Nencioni L" first="Lucia" last="Nencioni">Lucia Nencioni</name><name sortKey="Palamara, Anna Teresa" sort="Palamara, Anna Teresa" uniqKey="Palamara A" first="Anna Teresa" last="Palamara">Anna Teresa Palamara</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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