Immune regulation of the unfolded protein response at the mucosal barrier in viral infection
Identifieur interne : 000891 ( Pmc/Curation ); précédent : 000890; suivant : 000892Immune regulation of the unfolded protein response at the mucosal barrier in viral infection
Auteurs : Ran Wang ; Md. Moniruzzaman ; Eric Shuffle ; Rohan Lourie ; Sumaira Z. HasnainSource :
- Clinical & Translational Immunology [ 2050-0068 ] ; 2018.
Abstract
Protein folding in the endoplasmic reticulum (
Url:
DOI: 10.1002/cti2.1014
PubMed: 29632667
PubMed Central: 5881172
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Moniruzzaman</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="cti21014-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Shuffle, Eric" sort="Shuffle, Eric" uniqKey="Shuffle E" first="Eric" last="Shuffle">Eric Shuffle</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Lourie, Rohan" sort="Lourie, Rohan" uniqKey="Lourie R" first="Rohan" last="Lourie">Rohan Lourie</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="cti21014-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Hasnain, Sumaira Z" sort="Hasnain, Sumaira Z" uniqKey="Hasnain S" first="Sumaira Z" last="Hasnain">Sumaira Z. Hasnain</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="cti21014-aff-0002"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29632667</idno><idno type="pmc">5881172</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881172</idno><idno type="RBID">PMC:5881172</idno><idno type="doi">10.1002/cti2.1014</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000891</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000891</idno><idno type="wicri:Area/Pmc/Curation">000891</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000891</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immune regulation of the unfolded protein response at the mucosal barrier in viral infection</title><author><name sortKey="Wang, Ran" sort="Wang, Ran" uniqKey="Wang R" first="Ran" last="Wang">Ran Wang</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="cti21014-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Moniruzzaman, Md" sort="Moniruzzaman, Md" uniqKey="Moniruzzaman M" first="Md." last="Moniruzzaman">Md. Moniruzzaman</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="cti21014-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Shuffle, Eric" sort="Shuffle, Eric" uniqKey="Shuffle E" first="Eric" last="Shuffle">Eric Shuffle</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Lourie, Rohan" sort="Lourie, Rohan" uniqKey="Lourie R" first="Rohan" last="Lourie">Rohan Lourie</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="cti21014-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Hasnain, Sumaira Z" sort="Hasnain, Sumaira Z" uniqKey="Hasnain S" first="Sumaira Z" last="Hasnain">Sumaira Z. Hasnain</name><affiliation><nlm:aff id="cti21014-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="cti21014-aff-0002"></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical & Translational Immunology</title><idno type="eISSN">2050-0068</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Protein folding in the endoplasmic reticulum (<styled-content style="fixed-case" toggle="no">ER</styled-content>) is subject to stringent quality control. When protein secretion demand exceeds the protein folding capacity of the <styled-content style="fixed-case" toggle="no">ER</styled-content>, the unfolded protein response (<styled-content style="fixed-case" toggle="no">UPR</styled-content>) is triggered as a consequence of <styled-content style="fixed-case" toggle="no">ER</styled-content> stress. Due to the secretory function of epithelial cells, <styled-content style="fixed-case" toggle="no">UPR</styled-content> plays an important role in maintaining epithelial barrier function at mucosal sites. <styled-content style="fixed-case" toggle="no">ER</styled-content> stress and activation of the <styled-content style="fixed-case" toggle="no">UPR</styled-content> are natural mechanisms by which mucosal epithelial cells combat viral infections. In this review, we discuss the important role of <styled-content style="fixed-case" toggle="no">UPR</styled-content> in regulating mucosal epithelium homeostasis. In addition, we review current insights into how the <styled-content style="fixed-case" toggle="no">UPR</styled-content> is involved in viral infection at mucosal barriers and potential therapeutic strategies that restore epithelial cell integrity following acute viral infections via cytokine and cellular stress manipulation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Transl Immunology</journal-id><journal-id journal-id-type="iso-abbrev">Clin Transl Immunology</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)2050-0068</journal-id><journal-id journal-id-type="publisher-id">CTI2</journal-id><journal-title-group><journal-title>Clinical & Translational Immunology</journal-title></journal-title-group><issn pub-type="epub">2050-0068</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29632667</article-id><article-id pub-id-type="pmc">5881172</article-id><article-id pub-id-type="doi">10.1002/cti2.1014</article-id><article-id pub-id-type="publisher-id">CTI21014</article-id><article-categories><subj-group subj-group-type="overline"><subject>Special Feature Review</subject></subj-group><subj-group subj-group-type="heading"><subject>Special Feature Reviews</subject></subj-group></article-categories><title-group><article-title>Immune regulation of the unfolded protein response at the mucosal barrier in viral infection</article-title><alt-title alt-title-type="left-running-head">R Wang <italic>et al</italic>.</alt-title></title-group><contrib-group><contrib id="cti21014-cr-0001" contrib-type="author"><name><surname>Wang</surname><given-names>Ran</given-names></name><xref ref-type="aff" rid="cti21014-aff-0001"><sup>1</sup></xref><xref ref-type="aff" rid="cti21014-aff-0002"><sup>2</sup></xref></contrib><contrib id="cti21014-cr-0002" contrib-type="author"><name><surname>Moniruzzaman</surname><given-names>Md.</given-names></name><xref ref-type="aff" rid="cti21014-aff-0001"><sup>1</sup></xref><xref ref-type="aff" rid="cti21014-aff-0002"><sup>2</sup></xref></contrib><contrib id="cti21014-cr-0003" contrib-type="author"><name><surname>Shuffle</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="cti21014-aff-0001"><sup>1</sup></xref></contrib><contrib id="cti21014-cr-0004" contrib-type="author"><name><surname>Lourie</surname><given-names>Rohan</given-names></name><xref ref-type="aff" rid="cti21014-aff-0001"><sup>1</sup></xref><xref ref-type="aff" rid="cti21014-aff-0003"><sup>3</sup></xref></contrib><contrib id="cti21014-cr-0005" contrib-type="author" corresp="yes"><name><surname>Hasnain</surname><given-names>Sumaira Z</given-names></name><xref ref-type="aff" rid="cti21014-aff-0001"><sup>1</sup></xref><xref ref-type="aff" rid="cti21014-aff-0002"><sup>2</sup></xref><address><email>sumaira.hasnain@mater.uq.edu.au</email></address></contrib></contrib-group><aff id="cti21014-aff-0001"><label><sup>1</sup></label><named-content content-type="organisation-division">Translational Research Institute</named-content><institution>Immunopathology Group at Mater Research Institute – The University of Queensland</institution><city>Brisbane</city><named-content content-type="country-part">QLD</named-content><country country="AU">Australia</country></aff><aff id="cti21014-aff-0002"><label><sup>2</sup></label><named-content content-type="organisation-division">Faculty of Medicine</named-content><institution>The University of Queensland</institution><city>Brisbane</city><named-content content-type="country-part">QLD</named-content><country country="AU">Australia</country></aff><aff id="cti21014-aff-0003"><label><sup>3</sup></label><named-content content-type="organisation-division">Translational Research Institute</named-content><institution>Inflammatory Bowel Disease Group at Mater Research Institute – The University of Queensland</institution><city>Brisbane</city><named-content content-type="country-part">QLD</named-content><country country="AU">Australia</country></aff><author-notes><corresp id="correspondenceTo"><label>*</label><bold>Correspondence</bold><break></break>SZ Hasnain, Translational Research Institute, Level 4/37 Kent St, Woolloongabba, Brisbane, QLD 4102, Australia.<break></break>E‐mail: <email>sumaira.hasnain@mater.uq.edu.au</email><break></break></corresp></author-notes><pub-date pub-type="epub"><day>03</day><month>4</month><year>2018</year></pub-date><pub-date pub-type="collection"><year>2018</year></pub-date><volume>7</volume><issue>4</issue><issue-id pub-id-type="doi">10.1002/cti2.2018.7.issue-4</issue-id><elocation-id>e1014</elocation-id><history><date date-type="received"><day>04</day><month>12</month><year>2017</year></date><date date-type="rev-recd"><day>28</day><month>2</month><year>2018</year></date><date date-type="accepted"><day>01</day><month>3</month><year>2018</year></date></history><permissions><pmc-comment> © 2018 Australasian Society for Immunology Inc. </pmc-comment>
<copyright-statement content-type="article-copyright">© 2018 The Authors. <italic>Clinical & Translational Immunology</italic> published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc.</copyright-statement><license license-type="creativeCommonsBy"><license-p>This is an open access article under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link> License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="file:CTI2-7-e1014.pdf"></self-uri><abstract id="cti21014-abs-0001"><title>Abstract</title><p>Protein folding in the endoplasmic reticulum (<styled-content style="fixed-case" toggle="no">ER</styled-content>) is subject to stringent quality control. When protein secretion demand exceeds the protein folding capacity of the <styled-content style="fixed-case" toggle="no">ER</styled-content>, the unfolded protein response (<styled-content style="fixed-case" toggle="no">UPR</styled-content>) is triggered as a consequence of <styled-content style="fixed-case" toggle="no">ER</styled-content> stress. Due to the secretory function of epithelial cells, <styled-content style="fixed-case" toggle="no">UPR</styled-content> plays an important role in maintaining epithelial barrier function at mucosal sites. <styled-content style="fixed-case" toggle="no">ER</styled-content> stress and activation of the <styled-content style="fixed-case" toggle="no">UPR</styled-content> are natural mechanisms by which mucosal epithelial cells combat viral infections. In this review, we discuss the important role of <styled-content style="fixed-case" toggle="no">UPR</styled-content> in regulating mucosal epithelium homeostasis. In addition, we review current insights into how the <styled-content style="fixed-case" toggle="no">UPR</styled-content> is involved in viral infection at mucosal barriers and potential therapeutic strategies that restore epithelial cell integrity following acute viral infections via cytokine and cellular stress manipulation.</p></abstract><abstract abstract-type="graphical" id="cti21014-abs-0002"><p>We review current insights into how the UPR is involved in viral infection at mucosal barriers and potential therapeutic strategies that restore epithelial cell integrity following acute viral infections via cytokine and cellular stress manipulation.<boxed-text position="anchor" content-type="graphic" id="cti21014-blkfxd-0001" orientation="portrait"><graphic xlink:href="CTI2-7-e1014-g006.jpg" position="anchor" id="nlm-graphic-1" orientation="portrait"></graphic></boxed-text></p></abstract><kwd-group kwd-group-type="author-generated"><kwd id="cti21014-kwd-0001">endoplasmic reticulum stress</kwd><kwd id="cti21014-kwd-0002">epithelial cells</kwd><kwd id="cti21014-kwd-0003">mucosal barrier</kwd><kwd id="cti21014-kwd-0004">unfolded protein response</kwd><kwd id="cti21014-kwd-0005">viral infection</kwd></kwd-group><funding-group><award-group id="funding-0001"><funding-source>Mater Foundation</funding-source></award-group><award-group id="funding-0002"><funding-source><institution-wrap><institution>University of Queensland Postdoctoral Fellowship </institution><institution-id institution-id-type="open-funder-registry">10.13039/501100001794</institution-id></institution-wrap></funding-source></award-group><award-group id="funding-0003"><funding-source>Foundation of Research Excellence Grant</funding-source></award-group></funding-group><counts><fig-count count="5"></fig-count><table-count count="1"></table-count><page-count count="15"></page-count><word-count count="8299"></word-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>2018</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:16.04.2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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