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A controlled trial on the effect of feeding dietary chestnut extract and glycerol monolaurate on liver function in newborn calves

Identifieur interne : 000700 ( Pmc/Curation ); précédent : 000699; suivant : 000701

A controlled trial on the effect of feeding dietary chestnut extract and glycerol monolaurate on liver function in newborn calves

Auteurs : M. Wieland ; B. K. Weber ; A. Hafner-Marx ; C. Sauter-Louis ; J. Bauer ; G. Knubben-Schweizer ; M. Metzner

Source :

Journal of Animal Physiology and Animal Nutrition [ 0931-2439 ] ; 2014.

RBID : PMC:7167178

Abstract

Summary

Beginning in the fall of 2010, an increasing and alarming number of cases of calves suffering from liver dystrophy were reported in the south of Germany. An epidemiological investigation was carried out by the authors between November 2010 and July 2011, leading to the implication of a commercial dietary supplement as the potential cause for this outbreak. The components of this product were first tested in a cell culture model and two of them (dietary chestnut extract and glycerol monolaurate) showed a cytotoxic effect. The objective of this study was therefore to evaluate the effect of supplemental feeding of both components alone or in combination on liver function in newborn calves on a commercial dairy farm. Ten calves were enrolled in each of the three treatment groups and the control group (group O) following a blocked design. Treatment consisted of supplementation with chestnut extract at 0.02% of birth body mass (BM) (group C), supplementation with glycerol monolaurate at 0.006% of BM (group G) or a combined treatment (group CG) for five consecutive days. The effect of treatments on liver function was evaluated clinically and by measurement of glutamate dehydrogenase (GLDH) and aspartate aminotransferase (AST) activities as well as the determination of the concentrations of glucose, L‐lactate and total bilirubin in serum. There was a significant increase in GLDH and AST activities and a significant decrease in glucose concentration in treatment groups C and CG compared with the control group (p ≤ 0.035), whereas no difference was shown for group G. Survival was significantly decreased in groups C (p = 0.029) and CG (p = 0.001) compared with both group G and the control group. These results suggest that dietary chestnut extract in an amount of 0.02% of BM alone or in combination has a toxic effect on liver function in newborn calves.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167178

DOI: 10.1111/jpn.12179
PubMed: 24605953
PubMed Central: 7167178

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ermany. An epidemiological investigation was carried out by the authors between <styled-content style="fixed-case" toggle="no">N</styled-content>
ovember 2010 and <styled-content style="fixed-case" toggle="no">J</styled-content>
uly 2011, leading to the implication of a commercial dietary supplement as the potential cause for this outbreak. The components of this product were first tested in a cell culture model and two of them (dietary chestnut extract and glycerol monolaurate) showed a cytotoxic effect. The objective of this study was therefore to evaluate the effect of supplemental feeding of both components alone or in combination on liver function in newborn calves on a commercial dairy farm. Ten calves were enrolled in each of the three treatment groups and the control group (group <styled-content style="fixed-case" toggle="no">O</styled-content>
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) or a combined treatment (group <styled-content style="fixed-case" toggle="no">CG</styled-content>
) for five consecutive days. The effect of treatments on liver function was evaluated clinically and by measurement of glutamate dehydrogenase (<styled-content style="fixed-case" toggle="no">GLDH</styled-content>
) and aspartate aminotransferase (<styled-content style="fixed-case" toggle="no">AST</styled-content>
) activities as well as the determination of the concentrations of glucose, <styled-content style="fixed-case" toggle="no">L</styled-content>
‐lactate and total bilirubin in serum. There was a significant increase in <styled-content style="fixed-case" toggle="no">GLDH</styled-content>
 and <styled-content style="fixed-case" toggle="no">AST</styled-content>
 activities and a significant decrease in glucose concentration in treatment groups <styled-content style="fixed-case" toggle="no">C</styled-content>
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. Survival was significantly decreased in groups <styled-content style="fixed-case" toggle="no">C</styled-content>
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 (p = 0.001) compared with both group <styled-content style="fixed-case" toggle="no">G</styled-content>
 and the control group. These results suggest that dietary chestnut extract in an amount of 0.02% of <styled-content style="fixed-case" toggle="no">BM</styled-content>
 alone or in combination has a toxic effect on liver function in newborn calves.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Anim Physiol Anim Nutr (Berl)</journal-id>
<journal-id journal-id-type="iso-abbrev">J Anim Physiol Anim Nutr (Berl)</journal-id>
<journal-id journal-id-type="doi">10.1111/(ISSN)1439-0396</journal-id>
<journal-id journal-id-type="publisher-id">JPN</journal-id>
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<issn pub-type="ppub">0931-2439</issn>
<issn pub-type="epub">1439-0396</issn>
<publisher><publisher-name>John Wiley and Sons Inc.</publisher-name>
<publisher-loc>Hoboken</publisher-loc>
</publisher>
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<article-categories><subj-group subj-group-type="overline"><subject>Original Article</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>A controlled trial on the effect of feeding dietary chestnut extract and glycerol monolaurate on liver function in newborn calves</article-title>
<alt-title alt-title-type="left-running-head">M. Wieland <italic>et al</italic>
.</alt-title>
</title-group>
<contrib-group><contrib id="jpn12179-cr-0001" contrib-type="author" corresp="yes"><name><surname>Wieland</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="jpn12179-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="jpn12179-cr-0002" contrib-type="author"><name><surname>Weber</surname>
<given-names>B. K.</given-names>
</name>
<xref ref-type="aff" rid="jpn12179-aff-0002"><sup>2</sup>
</xref>
</contrib>
<contrib id="jpn12179-cr-0003" contrib-type="author"><name><surname>Hafner‐Marx</surname>
<given-names>A.</given-names>
</name>
<xref ref-type="aff" rid="jpn12179-aff-0002"><sup>2</sup>
</xref>
</contrib>
<contrib id="jpn12179-cr-0004" contrib-type="author"><name><surname>Sauter‐Louis</surname>
<given-names>C.</given-names>
</name>
<xref ref-type="aff" rid="jpn12179-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="jpn12179-cr-0005" contrib-type="author"><name><surname>Bauer</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="jpn12179-aff-0003"><sup>3</sup>
</xref>
</contrib>
<contrib id="jpn12179-cr-0006" contrib-type="author"><name><surname>Knubben‐Schweizer</surname>
<given-names>G.</given-names>
</name>
<xref ref-type="aff" rid="jpn12179-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="jpn12179-cr-0007" contrib-type="author"><name><surname>Metzner</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="jpn12179-aff-0001"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="jpn12179-aff-0001"><label><sup>1</sup>
</label>
<institution>Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre of Clinical Veterinary Medicine</institution>
<institution>LMU Munich</institution>
<city>Oberschleissheim</city>
<country country="DE">Germany</country>
</aff>
<aff id="jpn12179-aff-0002"><label><sup>2</sup>
</label>
<institution>Bavarian Health and Food Safety Authority</institution>
<city>Oberschleissheim</city>
<country country="DE">Germany</country>
</aff>
<aff id="jpn12179-aff-0003"><label><sup>3</sup>
</label>
<institution>Institute of Animal Hygiene</institution>
<institution>Technische Universität</institution>
<city>München</city>
<country country="DE">Germany</country>
</aff>
<author-notes><corresp id="correspondenceTo"><label>*</label>
<bold>Correspondence</bold>
<break></break>
Dr. M. Wieland, Clinic for Ruminants with Ambulatory and Herd Health Services at the Center of Clinical Veterinary Medicine, LMU Munich, Sonnenstraße 16, 85764 Oberschleissheim, Germany. Tel: +49 89 2180 78850; Fax: +49 89 2180 78851; E‐mail: <email>m.wieland@lmu.de</email>
<break></break>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>10</day>
<month>3</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2015</year>
</pub-date>
<volume>99</volume>
<issue>1</issue>
<issue-id pub-id-type="doi">10.1111/jpn.2014.99.issue-1</issue-id>
<fpage>190</fpage>
<lpage>200</lpage>
<history><date date-type="received"><day>15</day>
<month>10</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>24</day>
<month>1</month>
<year>2014</year>
</date>
</history>
<permissions><pmc-comment> © 2015 Blackwell Verlag GmbH </pmc-comment>
        <copyright-statement content-type="article-copyright">Journal of Animal Physiology and Animal Nutrition © 2014 Blackwell Verlag GmbH</copyright-statement>
<license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="file:JPN-99-190.pdf"></self-uri>
<abstract id="jpn12179-abs-0001"><title>Summary</title>
<p>Beginning in the fall of 2010, an increasing and alarming number of cases of calves suffering from liver dystrophy were reported in the south of <styled-content style="fixed-case" toggle="no">G</styled-content>
ermany. An epidemiological investigation was carried out by the authors between <styled-content style="fixed-case" toggle="no">N</styled-content>
ovember 2010 and <styled-content style="fixed-case" toggle="no">J</styled-content>
uly 2011, leading to the implication of a commercial dietary supplement as the potential cause for this outbreak. The components of this product were first tested in a cell culture model and two of them (dietary chestnut extract and glycerol monolaurate) showed a cytotoxic effect. The objective of this study was therefore to evaluate the effect of supplemental feeding of both components alone or in combination on liver function in newborn calves on a commercial dairy farm. Ten calves were enrolled in each of the three treatment groups and the control group (group <styled-content style="fixed-case" toggle="no">O</styled-content>
) following a blocked design. Treatment consisted of supplementation with chestnut extract at 0.02% of birth body mass (<styled-content style="fixed-case" toggle="no">BM</styled-content>
) (group <styled-content style="fixed-case" toggle="no">C</styled-content>
), supplementation with glycerol monolaurate at 0.006% of <styled-content style="fixed-case" toggle="no">BM</styled-content>
 (group <styled-content style="fixed-case" toggle="no">G</styled-content>
) or a combined treatment (group <styled-content style="fixed-case" toggle="no">CG</styled-content>
) for five consecutive days. The effect of treatments on liver function was evaluated clinically and by measurement of glutamate dehydrogenase (<styled-content style="fixed-case" toggle="no">GLDH</styled-content>
) and aspartate aminotransferase (<styled-content style="fixed-case" toggle="no">AST</styled-content>
) activities as well as the determination of the concentrations of glucose, <styled-content style="fixed-case" toggle="no">L</styled-content>
‐lactate and total bilirubin in serum. There was a significant increase in <styled-content style="fixed-case" toggle="no">GLDH</styled-content>
 and <styled-content style="fixed-case" toggle="no">AST</styled-content>
 activities and a significant decrease in glucose concentration in treatment groups <styled-content style="fixed-case" toggle="no">C</styled-content>
 and <styled-content style="fixed-case" toggle="no">CG</styled-content>
 compared with the control group (p ≤ 0.035), whereas no difference was shown for group <styled-content style="fixed-case" toggle="no">G</styled-content>
. Survival was significantly decreased in groups <styled-content style="fixed-case" toggle="no">C</styled-content>
 (p = 0.029) and <styled-content style="fixed-case" toggle="no">CG</styled-content>
 (p = 0.001) compared with both group <styled-content style="fixed-case" toggle="no">G</styled-content>
 and the control group. These results suggest that dietary chestnut extract in an amount of 0.02% of <styled-content style="fixed-case" toggle="no">BM</styled-content>
 alone or in combination has a toxic effect on liver function in newborn calves.</p>
</abstract>
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<kwd id="jpn12179-kwd-0002">liver dystrophy</kwd>
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<kwd id="jpn12179-kwd-0004">intoxication</kwd>
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<funding-group><award-group id="funding-0001"><funding-source>Josera Tierernährung, Germany</funding-source>
</award-group>
<award-group id="funding-0002"><funding-source>Alce s.r.l., Bagni di Lucca, Italy</funding-source>
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<meta-value>2.0</meta-value>
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</front>
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A controlled trial on the effect of feeding dietary chestnut extract and glycerol monolaurate on liver function in newborn calves

A controlled trial on the effect of feeding dietary chestnut extract and glycerol monolaurate on liver function in newborn calves

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