The potential danger of suboptimal antibody responses in COVID-19
Identifieur interne : 000013 ( Pmc/Curation ); précédent : 000012; suivant : 000014The potential danger of suboptimal antibody responses in COVID-19
Auteurs : Akiko Iwasaki [États-Unis] ; Yexin Yang [États-Unis]Source :
- Nature Reviews. Immunology [ 1474-1733 ] ; 2020.
Abstract
There is a desperate need for effective therapies and vaccines for SARS-CoV-2 to mitigate the growing economic crisis that has ensued from societal lockdown. Vaccines are being developed at an unprecedented speed and are already in clinical trials, without preclinical testing for safety and efficacy. Yet, safety evaluation of candidate vaccines must not be overlooked.
Url:
DOI: 10.1038/s41577-020-0321-6
PubMed: NONE
PubMed Central: 7187142
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Immunology</title><idno type="ISSN">1474-1733</idno><idno type="eISSN">1474-1741</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">There is a desperate need for effective therapies and vaccines for SARS-CoV-2 to mitigate the growing economic crisis that has ensued from societal lockdown. Vaccines are being developed at an unprecedented speed and are already in clinical trials, without preclinical testing for safety and efficacy. Yet, safety evaluation of candidate vaccines must not be overlooked.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dilillo, Dj" uniqKey="Dilillo D">DJ DiLillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yasui, F" uniqKey="Yasui F">F Yasui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Sf" uniqKey="Wang S">SF Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaume, M" uniqKey="Jaume M">M Jaume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yip, Ms" uniqKey="Yip M">MS Yip</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yasui, F" uniqKey="Yasui F">F Yasui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierson, Tc" uniqKey="Pierson T">TC Pierson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Ff" uniqKey="Yuan F">FF Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolles, M" uniqKey="Bolles M">M Bolles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z-y Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, H W" uniqKey="Jiang H">H-w Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, F" uniqKey="Wu F">F Wu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Rev Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Rev. Immunol</journal-id><journal-title-group><journal-title>Nature Reviews. Immunology</journal-title></journal-title-group><issn pub-type="ppub">1474-1733</issn><issn pub-type="epub">1474-1741</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7187142</article-id><article-id pub-id-type="publisher-id">321</article-id><article-id pub-id-type="doi">10.1038/s41577-020-0321-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Comment</subject></subj-group></article-categories><title-group><article-title>The potential danger of suboptimal antibody responses in COVID-19</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-7824-9856</contrib-id><name><surname>Iwasaki</surname><given-names>Akiko</given-names></name><address><email>akiko.iwasaki@yale.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Yexin</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000000419368710</institution-id><institution-id institution-id-type="GRID">grid.47100.32</institution-id><institution>Department of Immunobiology,</institution><institution>Yale University School of Medicine,</institution></institution-wrap>New Haven, CT USA</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2167 1581</institution-id><institution-id institution-id-type="GRID">grid.413575.1</institution-id><institution>Howard Hughes Medical Institute,</institution></institution-wrap>Chevy Chase, MD USA</aff></contrib-group><pub-date pub-type="epub"><day>21</day><month>4</month><year>2020</year></pub-date><fpage>1</fpage><lpage>3</lpage><permissions><copyright-statement>© Springer Nature Limited 2020</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1" abstract-type="Standfirst"><p id="Par1">There is a desperate need for effective therapies and vaccines for SARS-CoV-2 to mitigate the growing economic crisis that has ensued from societal lockdown. Vaccines are being developed at an unprecedented speed and are already in clinical trials, without preclinical testing for safety and efficacy. Yet, safety evaluation of candidate vaccines must not be overlooked.</p></abstract><abstract id="Abs2" abstract-type="web-summary"><p id="Par2">Here, Iwasaki and Yang highlight the potential dangers of inducing suboptimal antibody responses to SARS-CoV-2. They stress the need for proper safety evaluation of candidate vaccines for COVID-19.</p></abstract><kwd-group kwd-group-type="npg-subject"><title>Subject terms</title><kwd>SARS-CoV-2</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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