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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19</title><author><name sortKey="Ghaffari, Samad" sort="Ghaffari, Samad" uniqKey="Ghaffari S" first="Samad" last="Ghaffari">Samad Ghaffari</name><affiliation><nlm:aff id="aff1">Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Roshanravan, Neda" sort="Roshanravan, Neda" uniqKey="Roshanravan N" first="Neda" last="Roshanravan">Neda Roshanravan</name><affiliation><nlm:aff id="aff1">Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Tutunchi, Helda" sort="Tutunchi, Helda" uniqKey="Tutunchi H" first="Helda" last="Tutunchi">Helda Tutunchi</name><affiliation><nlm:aff id="aff2">Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Ostadrahimi, Alireza" sort="Ostadrahimi, Alireza" uniqKey="Ostadrahimi A" first="Alireza" last="Ostadrahimi">Alireza Ostadrahimi</name><affiliation><nlm:aff id="aff2">Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Pouraghaei, Mahboub" sort="Pouraghaei, Mahboub" uniqKey="Pouraghaei M" first="Mahboub" last="Pouraghaei">Mahboub Pouraghaei</name><affiliation><nlm:aff id="aff3">Emergency Medicine Research Team, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Kafil, Behnam" sort="Kafil, Behnam" uniqKey="Kafil B" first="Behnam" last="Kafil">Behnam Kafil</name><affiliation><nlm:aff id="aff2">Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32327293</idno><idno type="pmc">7158763</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158763</idno><idno type="RBID">PMC:7158763</idno><idno type="doi">10.1016/j.arcmed.2020.04.006</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000868</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000868</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19</title><author><name sortKey="Ghaffari, Samad" sort="Ghaffari, Samad" uniqKey="Ghaffari S" first="Samad" last="Ghaffari">Samad Ghaffari</name><affiliation><nlm:aff id="aff1">Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Roshanravan, Neda" sort="Roshanravan, Neda" uniqKey="Roshanravan N" first="Neda" last="Roshanravan">Neda Roshanravan</name><affiliation><nlm:aff id="aff1">Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Tutunchi, Helda" sort="Tutunchi, Helda" uniqKey="Tutunchi H" first="Helda" last="Tutunchi">Helda Tutunchi</name><affiliation><nlm:aff id="aff2">Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Ostadrahimi, Alireza" sort="Ostadrahimi, Alireza" uniqKey="Ostadrahimi A" first="Alireza" last="Ostadrahimi">Alireza Ostadrahimi</name><affiliation><nlm:aff id="aff2">Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Pouraghaei, Mahboub" sort="Pouraghaei, Mahboub" uniqKey="Pouraghaei M" first="Mahboub" last="Pouraghaei">Mahboub Pouraghaei</name><affiliation><nlm:aff id="aff3">Emergency Medicine Research Team, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author><author><name sortKey="Kafil, Behnam" sort="Kafil, Behnam" uniqKey="Kafil B" first="Behnam" last="Kafil">Behnam Kafil</name><affiliation><nlm:aff id="aff2">Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran</nlm:aff></affiliation></author></analytic><series><title level="j">Archives of Medical Research</title><idno type="ISSN">0188-4409</idno><idno type="eISSN">1873-5487</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The current outbreak of COVID-19 (coronavirus) has been identified by World Health Organization (WHO) as a global pandemic. With the emergence of the COVID-19 virus and considering the lack of effective pharmaceutical treatment for it, there is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard. Bioactive lipids with an array of known health-promoting properties can be suggested as effective agents in alleviating acute respiratory stress induced by virus. The bioactive lipid amide, oleoylethanolamide (OEA), due to several distinctive homeostatic properties, including anti-inflammatory activities, modulation of immune response, and anti-oxidant effects can be considered as a novel potential pharmacological alternative for the management of COVID-19.</p></div></front></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Arch Med Res</journal-id><journal-id journal-id-type="iso-abbrev">Arch. Med. Res</journal-id><journal-title-group><journal-title>Archives of Medical Research</journal-title></journal-title-group><issn pub-type="ppub">0188-4409</issn><issn pub-type="epub">1873-5487</issn><publisher><publisher-name>Published by Elsevier Inc. on behalf of IMSS.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32327293</article-id><article-id pub-id-type="pmc">7158763</article-id><article-id pub-id-type="publisher-id">S0188-4409(20)30475-6</article-id><article-id pub-id-type="doi">10.1016/j.arcmed.2020.04.006</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Ghaffari</surname><given-names>Samad</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Roshanravan</surname><given-names>Neda</given-names></name><email>Neda.roshanravan10@gmail.com</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Tutunchi</surname><given-names>Helda</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Ostadrahimi</surname><given-names>Alireza</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au5"><name><surname>Pouraghaei</surname><given-names>Mahboub</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au6"><name><surname>Kafil</surname><given-names>Behnam</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</aff><aff id="aff2"><label>b</label>Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran</aff><aff id="aff3"><label>c</label>Emergency Medicine Research Team, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author: Neda Roshanravan, Dr., Cardiovascular Research Center, Tabriz University of Medical Sciences, Pstal Code 5166615573, Tabriz, Iran; Phone and Fax: (0098) (41) 33373919; <email>Neda.roshanravan10@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>15</day><month>4</month><year>2020</year></pub-date><history><date date-type="received"><day>5</day><month>4</month><year>2020</year></date><date date-type="rev-recd"><day>8</day><month>4</month><year>2020</year></date><date date-type="accepted"><day>10</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Published by Elsevier Inc. on behalf of IMSS.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><p>The current outbreak of COVID-19 (coronavirus) has been identified by World Health Organization (WHO) as a global pandemic. With the emergence of the COVID-19 virus and considering the lack of effective pharmaceutical treatment for it, there is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard. Bioactive lipids with an array of known health-promoting properties can be suggested as effective agents in alleviating acute respiratory stress induced by virus. The bioactive lipid amide, oleoylethanolamide (OEA), due to several distinctive homeostatic properties, including anti-inflammatory activities, modulation of immune response, and anti-oxidant effects can be considered as a novel potential pharmacological alternative for the management of COVID-19.</p></abstract><abstract abstract-type="author-highlights" id="abs0015"><title>Highlights</title><p><list list-type="simple" id="ulist0010"><list-item id="u0010"><label>•</label><p id="p0010">Outbreak of COVID-19 (coronavirus) has been identified by World Health Organization as a global pandemic.</p></list-item><list-item id="u0015"><label>•</label><p id="p0015">There is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard.</p></list-item><list-item id="u0020"><label>•</label><p id="p0020">Oleoylethanolamide (OEA) may be considered as a novel potential adjuvant pharmacological alternative for the management of COVID-19.</p></list-item><list-item id="u0025"><label>•</label><p id="p0025">OEA via its antioxidant and anti-inflammatory properties may be effective in the management of coronavirus infected subjects.</p></list-item></list></p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>Bioactive lipids</kwd><kwd>Coronavirus</kwd><kwd>COVID-19</kwd><kwd>OEA</kwd><kwd>Oleoylethanolamide</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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