A novel COVID-19 and its effects on cardiovascular disease
Identifieur interne : 000087 ( Pmc/Corpus ); précédent : 000086; suivant : 000088A novel COVID-19 and its effects on cardiovascular disease
Auteurs : Arumugam Paramasivam ; Jayaseelan Vijayashree Priyadharsini ; Subramanian Raghunandhakumar ; Perumal ElumalaiSource :
- Hypertension Research [ 0916-9636 ] ; 2020.
Url:
DOI: 10.1038/s41440-020-0461-x
PubMed: NONE
PubMed Central: 7191131
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A novel COVID-19 and its effects on cardiovascular disease</title><author><name sortKey="Paramasivam, Arumugam" sort="Paramasivam, Arumugam" uniqKey="Paramasivam A" first="Arumugam" last="Paramasivam">Arumugam Paramasivam</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 045X</institution-id><institution-id institution-id-type="GRID">grid.412431.1</institution-id><institution>BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS],</institution><institution>Saveetha University,</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author><author><name sortKey="Priyadharsini, Jayaseelan Vijayashree" sort="Priyadharsini, Jayaseelan Vijayashree" uniqKey="Priyadharsini J" first="Jayaseelan Vijayashree" last="Priyadharsini">Jayaseelan Vijayashree Priyadharsini</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 045X</institution-id><institution-id institution-id-type="GRID">grid.412431.1</institution-id><institution>BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS],</institution><institution>Saveetha University,</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author><author><name sortKey="Raghunandhakumar, Subramanian" sort="Raghunandhakumar, Subramanian" uniqKey="Raghunandhakumar S" first="Subramanian" last="Raghunandhakumar">Subramanian Raghunandhakumar</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 045X</institution-id><institution-id institution-id-type="GRID">grid.412431.1</institution-id><institution>BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS],</institution><institution>Saveetha University,</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author><author><name sortKey="Elumalai, Perumal" sort="Elumalai, Perumal" uniqKey="Elumalai P" first="Perumal" last="Elumalai">Perumal Elumalai</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1756 0397</institution-id><institution-id institution-id-type="GRID">grid.444359.b</institution-id><institution>Central Research Laboratory, Meenakshi Medical College Hospital & Research Institute,</institution><institution>Meenakshi Academy of Higher Education and Research (MAHER),</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7191131</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191131</idno><idno type="RBID">PMC:7191131</idno><idno type="doi">10.1038/s41440-020-0461-x</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000087</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000087</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A novel COVID-19 and its effects on cardiovascular disease</title><author><name sortKey="Paramasivam, Arumugam" sort="Paramasivam, Arumugam" uniqKey="Paramasivam A" first="Arumugam" last="Paramasivam">Arumugam Paramasivam</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 045X</institution-id><institution-id institution-id-type="GRID">grid.412431.1</institution-id><institution>BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS],</institution><institution>Saveetha University,</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author><author><name sortKey="Priyadharsini, Jayaseelan Vijayashree" sort="Priyadharsini, Jayaseelan Vijayashree" uniqKey="Priyadharsini J" first="Jayaseelan Vijayashree" last="Priyadharsini">Jayaseelan Vijayashree Priyadharsini</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 045X</institution-id><institution-id institution-id-type="GRID">grid.412431.1</institution-id><institution>BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS],</institution><institution>Saveetha University,</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author><author><name sortKey="Raghunandhakumar, Subramanian" sort="Raghunandhakumar, Subramanian" uniqKey="Raghunandhakumar S" first="Subramanian" last="Raghunandhakumar">Subramanian Raghunandhakumar</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 045X</institution-id><institution-id institution-id-type="GRID">grid.412431.1</institution-id><institution>BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS],</institution><institution>Saveetha University,</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author><author><name sortKey="Elumalai, Perumal" sort="Elumalai, Perumal" uniqKey="Elumalai P" first="Perumal" last="Elumalai">Perumal Elumalai</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1756 0397</institution-id><institution-id institution-id-type="GRID">grid.444359.b</institution-id><institution>Central Research Laboratory, Meenakshi Medical College Hospital & Research Institute,</institution><institution>Meenakshi Academy of Higher Education and Research (MAHER),</institution></institution-wrap>Chennai, India</nlm:aff></affiliation></author></analytic><series><title level="j">Hypertension Research</title><idno 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Hypertens Res</journal-id><journal-id journal-id-type="iso-abbrev">Hypertens. Res</journal-id><journal-title-group><journal-title>Hypertension Research</journal-title></journal-title-group><issn pub-type="ppub">0916-9636</issn><issn pub-type="epub">1348-4214</issn><publisher><publisher-name>Springer Singapore</publisher-name><publisher-loc>Singapore</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7191131</article-id><article-id pub-id-type="publisher-id">461</article-id><article-id pub-id-type="doi">10.1038/s41440-020-0461-x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Correspondence</subject></subj-group></article-categories><title-group><article-title>A novel COVID-19 and its effects on cardiovascular disease</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Paramasivam</surname><given-names>Arumugam</given-names></name><address><email>paramasivam0103@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Priyadharsini</surname><given-names>Jayaseelan Vijayashree</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Raghunandhakumar</surname><given-names>Subramanian</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Elumalai</surname><given-names>Perumal</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 045X</institution-id><institution-id institution-id-type="GRID">grid.412431.1</institution-id><institution>BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS],</institution><institution>Saveetha University,</institution></institution-wrap>Chennai, India</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1756 0397</institution-id><institution-id institution-id-type="GRID">grid.444359.b</institution-id><institution>Central Research Laboratory, Meenakshi Medical College Hospital & Research Institute,</institution><institution>Meenakshi Academy of Higher Education and Research (MAHER),</institution></institution-wrap>Chennai, India</aff></contrib-group><pub-date pub-type="epub"><day>30</day><month>4</month><year>2020</year></pub-date><fpage>1</fpage><lpage>2</lpage><history><date date-type="received"><day>8</day><month>4</month><year>2020</year></date><date date-type="rev-recd"><day>10</day><month>4</month><year>2020</year></date><date date-type="accepted"><day>12</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© The Japanese Society of Hypertension 2020</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions></article-meta></front><body><p id="Par1">Coronavirus disease (COVID-19) is a novel infectious disease caused by a newly discovered severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR2">2</xref>]. COVID-19 spread rapidly from China, reaching a pandemic and putting the world on alert. SARS-CoV-2 has been reported in 211 countries, areas or territories, and >1,200,000 cases have been confirmed, with an estimated mortality risk of ~5.5% (<ext-link ext-link-type="uri" xlink:href="https://www.who.int/emergencies/diseases/novel-coronavirus-2019">https://www.who.int/emergencies/diseases/novel-coronavirus-2019</ext-link>). In India, ~5000 patients were confirmed with SARS-CoV-2, with an estimated mortality risk of ~2.5% and an escalating incidence rate increasing daily. Unfortunately, there are no specific vaccines or treatments for COVID-19 at this time, and current management includes travel restrictions, patient isolation, and supportive medical care. However, scientists are endeavoring to discover drugs and vaccines for COVID-19, but a better understanding of the underlying pathobiology is required.</p><p id="Par2">More recent research has suggested that older people and people with chronic health conditions, including cardiovascular disease (CVD), are at higher risk for mortality and morbidity related to COVID-19 than the average population [<xref ref-type="bibr" rid="CR2">2</xref>]. In a case series of 21 patients with COVID-19, congestive heart failure was the second most common baseline comorbidity (42.9%) [<xref ref-type="bibr" rid="CR3">3</xref>]. A new study reported that COVID-19 can cause heart injury, even in people without underlying heart issues [<xref ref-type="bibr" rid="CR2">2</xref>]. However, while the clinical manifestations of COVID-19 are dominated by respiratory symptoms, cardiovascular involvement can occur through several other mechanisms [<xref ref-type="bibr" rid="CR4">4</xref>]. Acute cardiac injury is the most frequently reported cardiovascular abnormality in COVID-19, and it occurs in ~8–12% of all patients [<xref ref-type="bibr" rid="CR5">5</xref>]. The presence of underlying CVD and/or development of acute cardiac injury might confer an increased risk of death (Table <xref rid="Tab1" ref-type="table">1</xref>).<table-wrap id="Tab1"><label>Table 1</label><caption><p>Cardiovascular complications in COVID-19</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Clinical manifestation</th><th>Incidence</th><th>Reference</th></tr></thead><tbody><tr><td>Cardiovascular abnormality (increased cardiac troponin I)</td><td>8–12%</td><td>[<xref ref-type="bibr" rid="CR5">5</xref>]</td></tr><tr><td>Heart failure</td><td>52% in those who died and 12% in those who recovered</td><td>[<xref ref-type="bibr" rid="CR6">6</xref>]</td></tr><tr><td>Acute cardiac injury</td><td>59% in those who died and 1% in those who recovered</td><td>[<xref ref-type="bibr" rid="CR6">6</xref>]</td></tr><tr><td>Arrhythmia</td><td>16.7%</td><td>[<xref ref-type="bibr" rid="CR8">8</xref>]</td></tr><tr><td>Acute cardiac injury</td><td>7.2%</td><td>[<xref ref-type="bibr" rid="CR8">8</xref>]</td></tr></tbody></table></table-wrap></p><p id="Par3">A recent study reported the importance of cardiac injury in patients with COVID-19; in these patients, 10.6% had coronary heart disease, 4.1% had heart failure, and 5.3% had cerebrovascular disease. Approximately 20% of patients had cardiac injury. A similar study demonstrated factors associated with outcomes in 187 patients with COVID-19. They showed that 35% had underlying CVD (hypertension, coronary heart disease, or cardiomyopathy), and 28% showed evidence of acute myocardial injury (defined as elevated troponin T). Furthermore, mortality was significantly higher in individuals with high troponin T levels than in those with normal troponin T levels. In addition, patients with high troponin T levels were older and had more comorbidities, including hypertension, coronary heart disease, cardiomyopathy, and chronic kidney disease [<xref ref-type="bibr" rid="CR2">2</xref>].</p><p id="Par4">Another study showed that the incidence of acute heart failure was 23% (44 out of 191 patients with COVID-19) and that multiple precipitating etiologies, including acute coronary syndrome, cardiac arrhythmias, stress-induced cardiomyopathy, and fulminant myocarditis, might result in acute heart failure or cardiogenic shock in patients with COVID-19 [<xref ref-type="bibr" rid="CR6">6</xref>]. Lactate dehydrogenase (LDH), creatine kinase (CK) and their isoenzymes as well as the protein troponin I (TnI), which exhibited better cardiac specificity, are linked with injury of the heart muscle. Chen et al. reported that among the 99 confirmed COVID-19 patients, 13 (13%) presented elevated CK, and 75 (76%) showed elevated LDH [<xref ref-type="bibr" rid="CR7">7</xref>]. Wang et al. revealed the clinical characteristics of 138 hospitalized COVID-19 patients, showing elevated TnI in 10 (7.2%), whereas 23 (16.7%) had arrhythmia [<xref ref-type="bibr" rid="CR8">8</xref>]. In addition, Guan et al. demonstrated that 13.7% of COVID-19 patients showed elevated CK levels, and 37.2% showed increased LDH levels [<xref ref-type="bibr" rid="CR9">9</xref>]. Although SARS-CoV-2 potentially invades alveolar epithelial cells, resulting in an acute systemic inflammatory response [<xref ref-type="bibr" rid="CR4">4</xref>, <xref ref-type="bibr" rid="CR6">6</xref>], the exact etiology and mechanisms of elevation of cardiac biomarkers among patients with COVID-19 have not yet been reported. The identification of angiotensin-converting enzyme 2 (ACE2) as a functional receptor for coronaviruses, including SARS-CoV and SARS-CoV-2, provides clues about their indirect association with cardiovascular pathology. The ACE2 receptor, the binding point for SARS-CoV-2, is abundantly found in myocytes. Therefore, myocyte damage from a direct viral attack could very well be the predominant mechanism.</p><p id="Par5">ACE2 is a membrane-bound aminopeptidase that is highly expressed in the heart and lungs, and has a vital role in the cardiovascular and immune systems in normal health as well as in various disease conditions [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR10">10</xref>]. ACE2 is also involved in heart function and the development of hypertension and diabetes mellitus. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury. COVID-19 is more severe in patients with CVD, which might be associated with increased secretion of ACE2 in these patients compared with healthy individuals [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR10">10</xref>].</p><p id="Par6">In conclusion, there seems to be a unique interplay between SARS-CoV-2 and CVDs. Although COVID-19 is predominantly a respiratory illness, a large number of patients with COVID-19 present with preexisting CVD or develop new-onset cardiac dysfunction during the course of the illness. Therefore, understanding the CVD caused by SARS-CoV-2 and the underlying mechanisms is of the greatest importance, and during treatment for COVID-19, careful attention should be given to cardiovascular protection.</p></body><back><fn-group><fn><p><bold>Publisher’s note</bold> Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p></fn></fn-group><notes notes-type="ethics"><title>Compliance with ethical standards</title><notes notes-type="COI-statement"><title>Conflict of interest</title><p id="Par7">The authors declare that they have no conflicts of interest.</p></notes></notes><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="journal"><person-group 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