Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nano Research for COVID-19</title><author><name sortKey="Chan, Warren C W" sort="Chan, Warren C W" uniqKey="Chan W" first="Warren C. W." last="Chan">Warren C. W. Chan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32227916</idno><idno type="pmc">7123821</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123821</idno><idno type="RBID">PMC:7123821</idno><idno type="doi">10.1021/acsnano.0c02540</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000000</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000000</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nano Research for COVID-19</title><author><name sortKey="Chan, Warren C W" sort="Chan, Warren C W" uniqKey="Chan W" first="Warren C. W." last="Chan">Warren C. W. Chan</name></author></analytic><series><title level="j">ACS Nano</title><idno type="ISSN">1936-0851</idno><idno type="eISSN">1936-086X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X. Guan</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P. Wu</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name></author><author><name sortKey="Tong, Y" uniqKey="Tong Y">Y. Tong</name></author><author><name sortKey="Ren, R" uniqKey="Ren R">R. Ren</name></author><author><name sortKey="Leung, K S M" uniqKey="Leung K">K. S. M. Leung</name></author><author><name sortKey="Lau, E H Y" uniqKey="Lau E">E. H. Y. Lau</name></author><author><name sortKey="Wong, J Y" uniqKey="Wong J">J. Y. Wong</name></author><author><name sortKey="Xing, X" uniqKey="Xing X">X. Xing</name></author><author><name sortKey="Xiang, N" uniqKey="Xiang N">N. Xiang</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name></author><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name></author><author><name sortKey="Tu, W" uniqKey="Tu W">W. Tu</name></author><author><name sortKey="Chen, C" uniqKey="Chen C">C. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Udugama, B" uniqKey="Udugama B">B. Udugama</name></author><author><name sortKey="Kadhiresan, P" uniqKey="Kadhiresan P">P. Kadhiresan</name></author><author><name sortKey="Kozlowski, H N" uniqKey="Kozlowski H">H. N. Kozlowski</name></author><author><name sortKey="Malekjahani, A" uniqKey="Malekjahani A">A. Malekjahani</name></author><author><name sortKey="Osborne, M" uniqKey="Osborne M">M. Osborne</name></author><author><name sortKey="Li, V Y C" uniqKey="Li V">V. Y. C. Li</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Mubareka, S" uniqKey="Mubareka S">S. Mubareka</name></author><author><name sortKey="Gubbay, J B" uniqKey="Gubbay J">J. B. Gubbay</name></author><author><name sortKey="Chan, W C W" uniqKey="Chan W">W. C. W. Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, B" uniqKey="Cao B">B. Cao</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Wen, D" uniqKey="Wen D">D. Wen</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Fan, G" uniqKey="Fan G">G. Fan</name></author><author><name sortKey="Ruan, L" uniqKey="Ruan L">L. Ruan</name></author><author><name sortKey="Song, B" uniqKey="Song B">B. Song</name></author><author><name sortKey="Cai, Y" uniqKey="Cai Y">Y. Cai</name></author><author><name sortKey="Wei, M" uniqKey="Wei M">M. Wei</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Xia, J" uniqKey="Xia J">J. Xia</name></author><author><name sortKey="Chen, N" uniqKey="Chen N">N. Chen</name></author><author><name sortKey="Xiang, J" uniqKey="Xiang J">J. Xiang</name></author><author><name sortKey="Yu, T" uniqKey="Yu T">T. Yu</name></author><author><name sortKey="Bai, T" uniqKey="Bai T">T. Bai</name></author><author><name sortKey="Xie, X" uniqKey="Xie X">X. Xie</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y. Yuan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Huang, H" uniqKey="Huang H">H. Huang</name></author><author><name sortKey="Fun, C" uniqKey="Fun C">C. Fun</name></author><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Nie, H L" uniqKey="Nie H">H.-L. Nie</name></author><author><name sortKey="Wang, F B" uniqKey="Wang F">F.-B. Wang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name></author><author><name sortKey="Xia, J" uniqKey="Xia J">J. Xia</name></author><author><name sortKey="Zheng, X" uniqKey="Zheng X">X. Zheng</name></author><author><name sortKey="Zuo, X" uniqKey="Zuo X">X. Zuo</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bunje, H" uniqKey="Bunje H">H. Bunje</name></author><author><name sortKey="Glotzer, S" uniqKey="Glotzer S">S. Glotzer</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Samori, P" uniqKey="Samori P">P. Samori</name></author><author><name sortKey="Weil, T" uniqKey="Weil T">T. Weil</name></author><author><name sortKey="Shmakov, S N" uniqKey="Shmakov S">S. N. Shmakov</name></author><author><name sortKey="Weiss, P S" uniqKey="Weiss P">P. S. Weiss</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="editorial" xml:lang="EN"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">ACS Nano</journal-id><journal-id journal-id-type="iso-abbrev">ACS Nano</journal-id><journal-id journal-id-type="publisher-id">nn</journal-id><journal-id journal-id-type="coden">ancac3</journal-id><journal-title-group><journal-title>ACS Nano</journal-title></journal-title-group><issn pub-type="ppub">1936-0851</issn><issn pub-type="epub">1936-086X</issn><publisher><publisher-name>American Chemical Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32227916</article-id><article-id pub-id-type="pmc">7123821</article-id><article-id pub-id-type="doi">10.1021/acsnano.0c02540</article-id><article-categories><subj-group><subject>Editorial</subject></subj-group></article-categories><title-group><article-title>Nano Research for COVID-19</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="ath1"><name><surname>Chan</surname><given-names>Warren C. W.</given-names></name><xref rid="cor1" ref-type="other">*</xref><role>Associate Editor</role></contrib></contrib-group><author-notes><corresp id="cor1"><label>*</label>Email:
<email>warren.chan@utoronto.ca</email>.</corresp></author-notes><pub-date pub-type="epub"><day>31</day><month>03</month><year>2020</year></pub-date><elocation-id>acsnano.0c02540</elocation-id><history></history><permissions><copyright-statement>Copyright © 2020 American Chemical Society</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>American Chemical Society</copyright-holder><license license-type="open-access"><license-p>This article is made available via the PMC Open Access Subset for
unrestricted RESEARCH re-use and analyses in any form or by any
means with acknowledgement of the original source. These
permissions are granted for the duration of the World Health
Organization (WHO) declaration of COVID-19 as a global
pandemic.</license-p></license></permissions><custom-meta-group><custom-meta><meta-name>document-id-old-9</meta-name><meta-value>nn0c02540</meta-value></custom-meta><custom-meta><meta-name>document-id-new-14</meta-name><meta-value>nn0c02540</meta-value></custom-meta><custom-meta><meta-name>ccc-price</meta-name><meta-value></meta-value></custom-meta></custom-meta-group></article-meta></front><body><p id="sec1">The coronavirus infectious disease (COVID-19), which started in late 2019, was
found to be caused by the SARS-CoV-2 virus. This virus has already infected
hundreds of thousands of people and led to tens of thousands of deaths, with
the numbers still rising quickly as of this writing, affecting essentially
every country around the world.<sup><xref ref-type="bibr" rid="ref1">1</xref></sup> Initial infections were
discovered in December 2019 in the Hubei Province of China. Those infected
presented with pneumonia-like symptoms and abnormal lung computed tomography
(CT) images. Samples from infected patients were screened by the use of a
multiplex polymerase chain reaction (PCR) panel of known pathogens. It
yielded negative results. On January 10, 2020, the previously unknown
pathogen was identified through next-generation sequencing as an RNA
virus.<sup><xref ref-type="bibr" rid="ref2">2</xref></sup> Its genome sequence showed that the novel
virus was similar to SARS-CoV, the virus that caused severe acute
respiratory syndrome (SARS) in 2002–2003, and it was named
SARS-CoV-2.</p><p>The availability of the whole genome sequence enabled researchers to develop
PCR kits to diagnose patients suffering with COVID-19. Researchers have also
developed isothermal amplification tests, serological tests, and lateral
flow assays to diagnose COVID-19.<sup><xref ref-type="bibr" rid="ref3">3</xref></sup> However, regulatory
approvals of these different tests by the various health agencies vary by
country.</p><p>In parallel with diagnostic test developments, researchers are examining
different drug formulations to treat patients suffering with COVID-19. One
potential therapy currently undergoing clinical trials is the HIV drug
combination of liponavir–ritonavir. Thus far, the trials have not
shown a significant difference between patients treated with this drug
cocktail and placebo.<sup><xref ref-type="bibr" rid="ref4">4</xref></sup></p><p>Finally, on the disease prevention front, a number of vaccine candidates are
being repurposed against SARS-CoV-2, and some have recently entered phase I
clinical trials.<sup><xref ref-type="bibr" rid="ref5">5</xref></sup> A deployable vaccine is not expected
for at least 12–18 months.</p><p>If COVID-19 persists beyond this year, we must adjust our research to address
the significant stress that COVID-19 places on our healthcare systems. The
nanotechnology community can contribute significantly in the fight against
COVID-19. Nanomaterials have been used for the development of point-of-care
diagnostics, carriers for therapeutics, and vaccine development. We
recommend a number of research targets for the nanotechnology
community:<list list-type="simple"><list-item><label>(a)</label><p><bold><italic>Rapid
point-of-care diagnostics</italic></bold>. Persons
infected with SARS-CoV-2 present with a wide range of
symptoms similar to other respiratory infections
(<italic>e.g.</italic>, fever, cough, and shortness
of breath) or may be silent carriers. Communal spread of
COVID-19 is a major concern. The availability of a
cost-effective, rapid point-of-care diagnostic test
available to doctors in emergency rooms, clinics, and
community hospitals is critical. These diagnostics enable
frontline workers to triage patients simply and to prevent
further spread of the
virus.</p></list-item><list-item><label>(b)</label><p><bold><italic>Surveillance
and monitoring</italic></bold>. Diagnostics are
critical in determining the spread of an infection. Mass
surveillance with rapid diagnostics helps public health
officials monitor virus spread, proactively identify areas
with increasing infections, anticipate surge capacity
needs, and deploy needed resources to the appropriate
areas. The success of such a system hinges on clear and
transparent collaboration and communications between
federal and state/principal public health laboratories,
hospitals, government agencies, and communities. The World
Health Organization and others have argued that widespread
testing will be needed to stop this pandemic.<sup><xref ref-type="bibr" rid="ref6">6</xref></sup></p></list-item><list-item><label>(c)</label><p><bold><italic>Therapeutics</italic></bold>.
Patients may need to be treated once individuals with
COVID-19 are identified. These therapies block the
replication of the virus in the host. Basic studies of the
nano-bio interactions could be adapted to understand how
SARS-CoV-2 infects their cells (<italic>e.g.</italic>,
SARS-CoV-2 is 60–140 nm and binds to angiotensin
converting enzyme receptor 2, ACE2), which can lead to new
therapeutic agents and
design.</p></list-item><list-item><label>(d)</label><p><bold><italic>Vaccine
development</italic></bold>. Vaccines are
instrumental in preventing disease by boosting the immune
system against a pathogen. One vaccine being evaluated is
a messenger RNA (mRNA)–lipid nanoparticle vaccine
based on the previous studies of SARS-CoV and the Middle
East Respiratory Syndrome (MERS).<sup><xref ref-type="bibr" rid="ref5">5</xref></sup></p></list-item></list></p><p>Life as we knew it before this pandemic has been forever altered. In the fight
against COVID-19, research and technology development and deployment are our
best weapons. Nanotechnology tools can be adapted to detect, to treat, and
to prevent this disease. Our community has a chance to accelerate the
translation of our developments and deploy nanotechnology advances as
frontline tools. <italic>ACS Nano</italic> is here to help disseminate your
contributions and strategies for fighting the COVID-19
pandemic.<sup><xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref7">7</xref></sup> We hope that you and yours are safe and well.</p><sec id="sec1.5"><title>Announcement</title><p>As the spring European Materials Research Society meeting has been
canceled, our <italic>ACS Nano</italic> award lectures<sup><xref ref-type="bibr" rid="ref8">8</xref></sup> will be moved to a later date and venue.</p></sec></body><back><notes notes-type="disclosure" id="notes-d1e187"><p>Views expressed in this editorial are those of the author and not necessarily
the views of the ACS.</p></notes><ref-list><title>References</title><ref id="ref1"><mixed-citation publication-type="weblink" id="cit1"><source>World Health
Organization: Coronavirus Disease (COVID-19) Pandemic</source>,
<uri xlink:href="https://www.who.int/emergencies/diseases/novel-coronavirus-2019">https://www.who.int/emergencies/diseases/novel-coronavirus-2019</uri>(accessed <year>2020</year>-03-23).</mixed-citation></ref><ref id="ref2"><mixed-citation publication-type="journal" id="cit2"><name><surname>Li</surname><given-names>Q.</given-names></name>; <name><surname>Guan</surname><given-names>X.</given-names></name>; <name><surname>Wu</surname><given-names>P.</given-names></name>; <name><surname>Wang</surname><given-names>X.</given-names></name>; <name><surname>Zhou</surname><given-names>L.</given-names></name>; <name><surname>Tong</surname><given-names>Y.</given-names></name>; <name><surname>Ren</surname><given-names>R.</given-names></name>; <name><surname>Leung</surname><given-names>K. S. M.</given-names></name>; <name><surname>Lau</surname><given-names>E. H. Y.</given-names></name>; <name><surname>Wong</surname><given-names>J. Y.</given-names></name>; <name><surname>Xing</surname><given-names>X.</given-names></name>; <name><surname>Xiang</surname><given-names>N.</given-names></name>; <name><surname>Wu</surname><given-names>Y.</given-names></name>; <name><surname>Li</surname><given-names>C.</given-names></name>; <name><surname>Chen</surname><given-names>Q.</given-names></name>; <name><surname>Li</surname><given-names>D.</given-names></name>; <name><surname>Liu</surname><given-names>T.</given-names></name>; <name><surname>Zhao</surname><given-names>J.</given-names></name>; <name><surname>Liu</surname><given-names>M.</given-names></name>; <name><surname>Tu</surname><given-names>W.</given-names></name>; <name><surname>Chen</surname><given-names>C.</given-names></name><article-title>Early Transmission Dynamics in Wuhan, China, of Novel
Coronavirus-Infected Pneumonia</article-title>. <source>N. Engl. J. Med.</source><year>2020</year>, <pub-id pub-id-type="doi">10.1056/NEJMoa2001316</pub-id>.</mixed-citation></ref><ref id="ref3"><mixed-citation publication-type="journal" id="cit3"><name><surname>Udugama</surname><given-names>B.</given-names></name>; <name><surname>Kadhiresan</surname><given-names>P.</given-names></name>; <name><surname>Kozlowski</surname><given-names>H. N.</given-names></name>; <name><surname>Malekjahani</surname><given-names>A.</given-names></name>; <name><surname>Osborne</surname><given-names>M.</given-names></name>; <name><surname>Li</surname><given-names>V. Y. C.</given-names></name>; <name><surname>Chen</surname><given-names>H.</given-names></name>; <name><surname>Mubareka</surname><given-names>S.</given-names></name>; <name><surname>Gubbay</surname><given-names>J. B.</given-names></name>; <name><surname>Chan</surname><given-names>W. C. W.</given-names></name><article-title>Diagnosing COVID-19: The Disease and Tools for
Detection</article-title>. <source>ACS Nano</source><year>2020</year>, <pub-id pub-id-type="doi">10.1021/acsnano.0c02624</pub-id>.</mixed-citation></ref><ref id="ref4"><mixed-citation publication-type="journal" id="cit4"><name><surname>Cao</surname><given-names>B.</given-names></name>; <name><surname>Wang</surname><given-names>Y.</given-names></name>; <name><surname>Wen</surname><given-names>D.</given-names></name>; <name><surname>Liu</surname><given-names>W.</given-names></name>; <name><surname>Wang</surname><given-names>J.</given-names></name>; <name><surname>Fan</surname><given-names>G.</given-names></name>; <name><surname>Ruan</surname><given-names>L.</given-names></name>; <name><surname>Song</surname><given-names>B.</given-names></name>; <name><surname>Cai</surname><given-names>Y.</given-names></name>; <name><surname>Wei</surname><given-names>M.</given-names></name>; <name><surname>Li</surname><given-names>X.</given-names></name>; <name><surname>Xia</surname><given-names>J.</given-names></name>; <name><surname>Chen</surname><given-names>N.</given-names></name>; <name><surname>Xiang</surname><given-names>J.</given-names></name>; <name><surname>Yu</surname><given-names>T.</given-names></name>; <name><surname>Bai</surname><given-names>T.</given-names></name>; <name><surname>Xie</surname><given-names>X.</given-names></name>; <name><surname>Zhang</surname><given-names>L.</given-names></name>; <name><surname>Li</surname><given-names>C.</given-names></name>; <name><surname>Yuan</surname><given-names>Y.</given-names></name><article-title>A Trial of Liponavir-Ritonavir in Adults Hospitalized
with Severe Covid-19</article-title>. <source>N. Engl. J. Med.</source><year>2020</year>, <pub-id pub-id-type="doi">10.1056/NEJMoa2001282</pub-id>.</mixed-citation></ref><ref id="ref5"><mixed-citation publication-type="weblink" id="cit5"><uri xlink:href="https://clinicaltrials.gov">https://clinicaltrials.gov</uri> (NCT04283461) (accessed
<year>2020</year>-03-25).</mixed-citation></ref><ref id="ref6"><mixed-citation publication-type="weblink" id="cit6"><uri xlink:href="https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---16-march-2020">https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---16-march-2020</uri>(accessed <year>2020</year>-03-25).</mixed-citation></ref><ref id="ref7"><mixed-citation publication-type="journal" id="cit7"><name><surname>Huang</surname><given-names>H.</given-names></name>; <name><surname>Fun</surname><given-names>C.</given-names></name>; <name><surname>Li</surname><given-names>M.</given-names></name>; <name><surname>Nie</surname><given-names>H.-L.</given-names></name>; <name><surname>Wang</surname><given-names>F.-B.</given-names></name>; <name><surname>Wang</surname><given-names>H.</given-names></name>; <name><surname>Wang</surname><given-names>R.</given-names></name>; <name><surname>Xia</surname><given-names>J.</given-names></name>; <name><surname>Zheng</surname><given-names>X.</given-names></name>; <name><surname>Zuo</surname><given-names>X.</given-names></name>; <name><surname>Huang</surname><given-names>J.</given-names></name><article-title>COVID-19: A Call for Physical Scientists and
Engineers</article-title>. <source>ACS Nano</source><year>2020</year>, <pub-id pub-id-type="doi">10.1021/acsnano.0c02476</pub-id>.</mixed-citation></ref><ref id="ref8"><mixed-citation publication-type="journal" id="cit8"><name><surname>Bunje</surname><given-names>H.</given-names></name>; <name><surname>Glotzer</surname><given-names>S.</given-names></name>; <name><surname>Li</surname><given-names>Y.</given-names></name>; <name><surname>Samori</surname><given-names>P.</given-names></name>; <name><surname>Weil</surname><given-names>T.</given-names></name>; <name><surname>Shmakov</surname><given-names>S. N.</given-names></name>; <name><surname>Weiss</surname><given-names>P. S.</given-names></name><article-title>Announcing the 2020 <italic>ACS Nano</italic> Award
Lecture Laureates</article-title>. <source>ACS Nano</source><year>2020</year>, <volume>14</volume>, <fpage>1213</fpage>–<lpage>1215</lpage>. <pub-id pub-id-type="doi">10.1021/acsnano.0c01221</pub-id>.<pub-id pub-id-type="pmid">32098015</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000000 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000000 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |