StressCovidV1, PascalFrancis, Corpus, bibRecord, 000222

A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness

Identifieur interne : 000222 ( PascalFrancis/Corpus ); précédent : 000221; suivant : 000223

A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness

Auteurs : Roel H. Derijk ; Stefan Wust ; Onno C. Meijer ; Maria-Christina Zennaro ; Ilona S. Federenko ; Dirk H. Hellhammer ; Gilberta Giacchetti ; Erno Vreugdenhil ; Frans G. Zitman ; E. Ronald De Kloet

Source :

The Journal of clinical endocrinology and metabolism [ 0021-972X ] ; 2006.

RBID : Pascal:07-0054375

Descripteurs français

Pascal (Inist)
- Minéralocorticoïde, Polymorphisme, Variabilité génétique, Génotype, Récepteur biologique, Stress, Endocrinologie.

English descriptors

KwdEn :
- Biological receptor, Endocrinology, Genetic variability, Genotype, Mineralocorticoid, Polymorphism, Stress.

Abstract

Context: Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes. Objective: The objective of the study was to investigate the role of the MR gene variant I180V in the neuroendocrine response to a psychosocial stressor and in electrolyte regulation. Design: Associations between the MRI180V and outcome variables in a healthy cohort subjected to psychosocial challenge (Trier Social Stress Test) and in a mild hypertensive cohort exposed to acute salt loading (Weinberger's test) were investigated. In vitro transactivational assays were applied to compare the effects of cortisol and aldosterone on the MRI180V. Results: Carriers of the MR180V allele showed higher saliva (P < 0.01), plasma cortisol (P < 0.01), and heart rate responses (P < 0.05) to the Trier Social Stress Test than noncarriers (MR180I). After 3 d of a normal salt diet and the Weinberger's test, no association was found with urinary sodium excretion, plasma aldosterone, and plasma renin activity or with changes in blood pressure, aldosterone, and renin responses. In vitro testing of the MR180V allele revealed a mild loss of function using cortisol as a ligand, compared with the MR180I allele. Significantly higher doses of cortisol were needed for half-maximal induction on the TAT-1 (P < 0.002), TAT-3 (P < 0.03), or mouse mammary tumor virus (P < 0.02) promoters, whereas maximal induction was not different. These differences were not observed using aldosterone as a ligand. Conclusion: The findings reveal that cortisol and heart rate responses to a psychosocial stressor are enhanced in carriers of the MR180V variant.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0021-972X`
A02	`01`			`@0 JCEMAZ`
A03		`1`		`@0 J. clin. endocrinol. metab.`
A05				`@2 91`
A06				`@2 12`
A08	`01`	`1`	`ENG`	`@1 A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness`
A11	`01`	`1`		`@1 DERIJK (Roel H.)`
A11	`02`	`1`		`@1 WUST (Stefan)`
A11	`03`	`1`		`@1 MEIJER (Onno C.)`
A11	`04`	`1`		`@1 ZENNARO (Maria-Christina)`
A11	`05`	`1`		`@1 FEDERENKO (Ilona S.)`
A11	`06`	`1`		`@1 HELLHAMMER (Dirk H.)`
A11	`07`	`1`		`@1 GIACCHETTI (Gilberta)`
A11	`08`	`1`		`@1 VREUGDENHIL (Erno)`
A11	`09`	`1`		`@1 ZITMAN (Frans G.)`
A11	`10`	`1`		`@1 DE KLOET (E. Ronald)`
A14	`01`			`@1 Division of Medical Pharmacology, Leiden University Medical Center, Leiden University @2 2300 RA Leiden @3 NLD @Z 1 aut. @Z 3 aut. @Z 8 aut. @Z 10 aut.`
A14	`02`			`@1 Leiden/Amsterdam Center for Drug Research, Department of Psychiatry, Leiden University Medical Center, Leiden University @2 2300 RA Leiden @3 NLD @Z 1 aut. @Z 9 aut.`
A14	`03`			`@1 Department of Psychobiology, University of Trier @2 54290 Trier @3 DEU @Z 2 aut. @Z 6 aut.`
A14	`04`			`@1 Institut National de la Santé et de la Recherche Médicale, U772, College de France @2 75231 Paris @3 FRA @Z 4 aut.`
A14	`05`			`@1 Department of Psychology and Social Behavior, University of California, Irvine @2 Irvine, CA 92697-7085 @3 USA @Z 5 aut.`
A14	`06`			`@1 Clinica di Endocrinologia, Universita Politecnica delle Marche @2 60131 Ancona @3 ITA @Z 7 aut.`
A20				`@1 5083-5089`
A21				`@1 2006`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 6022 @5 354000145163800570`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 40 ref.`
A47	`01`	`1`		`@0 07-0054375`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 The Journal of clinical endocrinology and metabolism`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Context: Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes. Objective: The objective of the study was to investigate the role of the MR gene variant I180V in the neuroendocrine response to a psychosocial stressor and in electrolyte regulation. Design: Associations between the MRI180V and outcome variables in a healthy cohort subjected to psychosocial challenge (Trier Social Stress Test) and in a mild hypertensive cohort exposed to acute salt loading (Weinberger's test) were investigated. In vitro transactivational assays were applied to compare the effects of cortisol and aldosterone on the MRI180V. Results: Carriers of the MR180V allele showed higher saliva (P < 0.01), plasma cortisol (P < 0.01), and heart rate responses (P < 0.05) to the Trier Social Stress Test than noncarriers (MR180I). After 3 d of a normal salt diet and the Weinberger's test, no association was found with urinary sodium excretion, plasma aldosterone, and plasma renin activity or with changes in blood pressure, aldosterone, and renin responses. In vitro testing of the MR180V allele revealed a mild loss of function using cortisol as a ligand, compared with the MR180I allele. Significantly higher doses of cortisol were needed for half-maximal induction on the TAT-1 (P < 0.002), TAT-3 (P < 0.03), or mouse mammary tumor virus (P < 0.02) promoters, whereas maximal induction was not different. These differences were not observed using aldosterone as a ligand. Conclusion: The findings reveal that cortisol and heart rate responses to a psychosocial stressor are enhanced in carriers of the MR180V variant.
C02	`01`	`X`		`@0 002B21`
C02	`02`	`X`		`@0 002A28`
C03	`01`	`X`	`FRE`	`@0 Minéralocorticoïde @5 01`
C03	`01`	`X`	`ENG`	`@0 Mineralocorticoid @5 01`
C03	`01`	`X`	`SPA`	`@0 Mineralocorticoide @5 01`
C03	`02`	`X`	`FRE`	`@0 Polymorphisme @5 02`
C03	`02`	`X`	`ENG`	`@0 Polymorphism @5 02`
C03	`02`	`X`	`SPA`	`@0 Polimorfismo @5 02`
C03	`03`	`X`	`FRE`	`@0 Variabilité génétique @5 03`
C03	`03`	`X`	`ENG`	`@0 Genetic variability @5 03`
C03	`03`	`X`	`SPA`	`@0 Variabilidad genética @5 03`
C03	`04`	`X`	`FRE`	`@0 Génotype @5 05`
C03	`04`	`X`	`ENG`	`@0 Genotype @5 05`
C03	`04`	`X`	`SPA`	`@0 Genotipo @5 05`
C03	`05`	`X`	`FRE`	`@0 Récepteur biologique @5 06`
C03	`05`	`X`	`ENG`	`@0 Biological receptor @5 06`
C03	`05`	`X`	`SPA`	`@0 Receptor biológico @5 06`
C03	`06`	`X`	`FRE`	`@0 Stress @5 08`
C03	`06`	`X`	`ENG`	`@0 Stress @5 08`
C03	`06`	`X`	`SPA`	`@0 Estrés @5 08`
C03	`07`	`X`	`FRE`	`@0 Endocrinologie @5 09`
C03	`07`	`X`	`ENG`	`@0 Endocrinology @5 09`
C03	`07`	`X`	`SPA`	`@0 Endocrinología @5 09`
N21				`@1 036`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0054375 INIST
ET :	A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness
AU :	DERIJK (Roel H.); WUST (Stefan); MEIJER (Onno C.); ZENNARO (Maria-Christina); FEDERENKO (Ilona S.); HELLHAMMER (Dirk H.); GIACCHETTI (Gilberta); VREUGDENHIL (Erno); ZITMAN (Frans G.); DE KLOET (E. Ronald)
AF :	Division of Medical Pharmacology, Leiden University Medical Center, Leiden University/2300 RA Leiden/Pays-Bas (1 aut., 3 aut., 8 aut., 10 aut.); Leiden/Amsterdam Center for Drug Research, Department of Psychiatry, Leiden University Medical Center, Leiden University/2300 RA Leiden/Pays-Bas (1 aut., 9 aut.); Department of Psychobiology, University of Trier/54290 Trier/Allemagne (2 aut., 6 aut.); Institut National de la Santé et de la Recherche Médicale, U772, College de France/75231 Paris/France (4 aut.); Department of Psychology and Social Behavior, University of California, Irvine/Irvine, CA 92697-7085/Etats-Unis (5 aut.); Clinica di Endocrinologia, Universita Politecnica delle Marche/60131 Ancona/Italie (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	The Journal of clinical endocrinology and metabolism; ISSN 0021-972X; Coden JCEMAZ; Etats-Unis; Da. 2006; Vol. 91; No. 12; Pp. 5083-5089; Bibl. 40 ref.
LA :	Anglais
EA :	Context: Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes. Objective: The objective of the study was to investigate the role of the MR gene variant I180V in the neuroendocrine response to a psychosocial stressor and in electrolyte regulation. Design: Associations between the MRI180V and outcome variables in a healthy cohort subjected to psychosocial challenge (Trier Social Stress Test) and in a mild hypertensive cohort exposed to acute salt loading (Weinberger's test) were investigated. In vitro transactivational assays were applied to compare the effects of cortisol and aldosterone on the MRI180V. Results: Carriers of the MR180V allele showed higher saliva (P < 0.01), plasma cortisol (P < 0.01), and heart rate responses (P < 0.05) to the Trier Social Stress Test than noncarriers (MR180I). After 3 d of a normal salt diet and the Weinberger's test, no association was found with urinary sodium excretion, plasma aldosterone, and plasma renin activity or with changes in blood pressure, aldosterone, and renin responses. In vitro testing of the MR180V allele revealed a mild loss of function using cortisol as a ligand, compared with the MR180I allele. Significantly higher doses of cortisol were needed for half-maximal induction on the TAT-1 (P < 0.002), TAT-3 (P < 0.03), or mouse mammary tumor virus (P < 0.02) promoters, whereas maximal induction was not different. These differences were not observed using aldosterone as a ligand. Conclusion: The findings reveal that cortisol and heart rate responses to a psychosocial stressor are enhanced in carriers of the MR180V variant.
CC :	002B21; 002A28
FD :	Minéralocorticoïde; Polymorphisme; Variabilité génétique; Génotype; Récepteur biologique; Stress; Endocrinologie
ED :	Mineralocorticoid; Polymorphism; Genetic variability; Genotype; Biological receptor; Stress; Endocrinology
SD :	Mineralocorticoide; Polimorfismo; Variabilidad genética; Genotipo; Receptor biológico; Estrés; Endocrinología
LO :	INIST-6022.354000145163800570
ID :	07-0054375

Links to Exploration step

Pascal:07-0054375

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness</title>
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<author><name sortKey="Giacchetti, Gilberta" sort="Giacchetti, Gilberta" uniqKey="Giacchetti G" first="Gilberta" last="Giacchetti">Gilberta Giacchetti</name>
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<author><name sortKey="Vreugdenhil, Erno" sort="Vreugdenhil, Erno" uniqKey="Vreugdenhil E" first="Erno" last="Vreugdenhil">Erno Vreugdenhil</name>
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<author><name sortKey="Zitman, Frans G" sort="Zitman, Frans G" uniqKey="Zitman F" first="Frans G." last="Zitman">Frans G. Zitman</name>
<affiliation><inist:fA14 i1="02"><s1>Leiden/Amsterdam Center for Drug Research, Department of Psychiatry, Leiden University Medical Center, Leiden University</s1>
<s2>2300 RA Leiden</s2>
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<author><name sortKey="De Kloet, E Ronald" sort="De Kloet, E Ronald" uniqKey="De Kloet E" first="E. Ronald" last="De Kloet">E. Ronald De Kloet</name>
<affiliation><inist:fA14 i1="01"><s1>Division of Medical Pharmacology, Leiden University Medical Center, Leiden University</s1>
<s2>2300 RA Leiden</s2>
<s3>NLD</s3>
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<series><title level="j" type="main">The Journal of clinical endocrinology and metabolism</title>
<title level="j" type="abbreviated">J. clin. endocrinol. metab.</title>
<idno type="ISSN">0021-972X</idno>
<imprint><date when="2006">2006</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological receptor</term>
<term>Endocrinology</term>
<term>Genetic variability</term>
<term>Genotype</term>
<term>Mineralocorticoid</term>
<term>Polymorphism</term>
<term>Stress</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Minéralocorticoïde</term>
<term>Polymorphisme</term>
<term>Variabilité génétique</term>
<term>Génotype</term>
<term>Récepteur biologique</term>
<term>Stress</term>
<term>Endocrinologie</term>
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<front><div type="abstract" xml:lang="en">Context: Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes. Objective: The objective of the study was to investigate the role of the MR gene variant I180V in the neuroendocrine response to a psychosocial stressor and in electrolyte regulation. Design: Associations between the MRI180V and outcome variables in a healthy cohort subjected to psychosocial challenge (Trier Social Stress Test) and in a mild hypertensive cohort exposed to acute salt loading (Weinberger's test) were investigated. In vitro transactivational assays were applied to compare the effects of cortisol and aldosterone on the MRI180V. Results: Carriers of the MR180V allele showed higher saliva (P < 0.01), plasma cortisol (P < 0.01), and heart rate responses (P < 0.05) to the Trier Social Stress Test than noncarriers (MR180I). After 3 d of a normal salt diet and the Weinberger's test, no association was found with urinary sodium excretion, plasma aldosterone, and plasma renin activity or with changes in blood pressure, aldosterone, and renin responses. In vitro testing of the MR180V allele revealed a mild loss of function using cortisol as a ligand, compared with the MR180I allele. Significantly higher doses of cortisol were needed for half-maximal induction on the TAT-1 (P < 0.002), TAT-3 (P < 0.03), or mouse mammary tumor virus (P < 0.02) promoters, whereas maximal induction was not different. These differences were not observed using aldosterone as a ligand. Conclusion: The findings reveal that cortisol and heart rate responses to a psychosocial stressor are enhanced in carriers of the MR180V variant.</div>
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<fA03 i2="1"><s0>J. clin. endocrinol. metab.</s0>
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<fA05><s2>91</s2>
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<fA06><s2>12</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness</s1>
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<fA11 i1="01" i2="1"><s1>DERIJK (Roel H.)</s1>
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<fA11 i1="02" i2="1"><s1>WUST (Stefan)</s1>
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<fA11 i1="03" i2="1"><s1>MEIJER (Onno C.)</s1>
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<fA11 i1="04" i2="1"><s1>ZENNARO (Maria-Christina)</s1>
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<fA11 i1="05" i2="1"><s1>FEDERENKO (Ilona S.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>HELLHAMMER (Dirk H.)</s1>
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<fA11 i1="07" i2="1"><s1>GIACCHETTI (Gilberta)</s1>
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<fA11 i1="08" i2="1"><s1>VREUGDENHIL (Erno)</s1>
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<fA11 i1="09" i2="1"><s1>ZITMAN (Frans G.)</s1>
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<fA11 i1="10" i2="1"><s1>DE KLOET (E. Ronald)</s1>
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<fA14 i1="01"><s1>Division of Medical Pharmacology, Leiden University Medical Center, Leiden University</s1>
<s2>2300 RA Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Leiden/Amsterdam Center for Drug Research, Department of Psychiatry, Leiden University Medical Center, Leiden University</s1>
<s2>2300 RA Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Psychobiology, University of Trier</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale, U772, College de France</s1>
<s2>75231 Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Psychology and Social Behavior, University of California, Irvine</s1>
<s2>Irvine, CA 92697-7085</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Clinica di Endocrinologia, Universita Politecnica delle Marche</s1>
<s2>60131 Ancona</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>5083-5089</s1>
</fA20>
<fA21><s1>2006</s1>
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<fA23 i1="01"><s0>ENG</s0>
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<fA60><s1>P</s1>
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<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>The Journal of clinical endocrinology and metabolism</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Context: Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes. Objective: The objective of the study was to investigate the role of the MR gene variant I180V in the neuroendocrine response to a psychosocial stressor and in electrolyte regulation. Design: Associations between the MRI180V and outcome variables in a healthy cohort subjected to psychosocial challenge (Trier Social Stress Test) and in a mild hypertensive cohort exposed to acute salt loading (Weinberger's test) were investigated. In vitro transactivational assays were applied to compare the effects of cortisol and aldosterone on the MRI180V. Results: Carriers of the MR180V allele showed higher saliva (P < 0.01), plasma cortisol (P < 0.01), and heart rate responses (P < 0.05) to the Trier Social Stress Test than noncarriers (MR180I). After 3 d of a normal salt diet and the Weinberger's test, no association was found with urinary sodium excretion, plasma aldosterone, and plasma renin activity or with changes in blood pressure, aldosterone, and renin responses. In vitro testing of the MR180V allele revealed a mild loss of function using cortisol as a ligand, compared with the MR180I allele. Significantly higher doses of cortisol were needed for half-maximal induction on the TAT-1 (P < 0.002), TAT-3 (P < 0.03), or mouse mammary tumor virus (P < 0.02) promoters, whereas maximal induction was not different. These differences were not observed using aldosterone as a ligand. Conclusion: The findings reveal that cortisol and heart rate responses to a psychosocial stressor are enhanced in carriers of the MR180V variant.</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Minéralocorticoïde</s0>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Mineralocorticoid</s0>
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<fC03 i1="02" i2="X" l="SPA"><s0>Polimorfismo</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Variabilité génétique</s0>
<s5>03</s5>
</fC03>
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<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Variabilidad genética</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Génotype</s0>
<s5>05</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Genotype</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Genotipo</s0>
<s5>05</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Récepteur biologique</s0>
<s5>06</s5>
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<fC03 i1="05" i2="X" l="ENG"><s0>Biological receptor</s0>
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<s5>08</s5>
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<s5>08</s5>
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<s5>09</s5>
</fC03>
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<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Endocrinología</s0>
<s5>09</s5>
</fC03>
<fN21><s1>036</s1>
</fN21>
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<server><NO>PASCAL 07-0054375 INIST</NO>
<ET>A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness</ET>
<AU>DERIJK (Roel H.); WUST (Stefan); MEIJER (Onno C.); ZENNARO (Maria-Christina); FEDERENKO (Ilona S.); HELLHAMMER (Dirk H.); GIACCHETTI (Gilberta); VREUGDENHIL (Erno); ZITMAN (Frans G.); DE KLOET (E. Ronald)</AU>
<AF>Division of Medical Pharmacology, Leiden University Medical Center, Leiden University/2300 RA Leiden/Pays-Bas (1 aut., 3 aut., 8 aut., 10 aut.); Leiden/Amsterdam Center for Drug Research, Department of Psychiatry, Leiden University Medical Center, Leiden University/2300 RA Leiden/Pays-Bas (1 aut., 9 aut.); Department of Psychobiology, University of Trier/54290 Trier/Allemagne (2 aut., 6 aut.); Institut National de la Santé et de la Recherche Médicale, U772, College de France/75231 Paris/France (4 aut.); Department of Psychology and Social Behavior, University of California, Irvine/Irvine, CA 92697-7085/Etats-Unis (5 aut.); Clinica di Endocrinologia, Universita Politecnica delle Marche/60131 Ancona/Italie (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The Journal of clinical endocrinology and metabolism; ISSN 0021-972X; Coden JCEMAZ; Etats-Unis; Da. 2006; Vol. 91; No. 12; Pp. 5083-5089; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Context: Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes. Objective: The objective of the study was to investigate the role of the MR gene variant I180V in the neuroendocrine response to a psychosocial stressor and in electrolyte regulation. Design: Associations between the MRI180V and outcome variables in a healthy cohort subjected to psychosocial challenge (Trier Social Stress Test) and in a mild hypertensive cohort exposed to acute salt loading (Weinberger's test) were investigated. In vitro transactivational assays were applied to compare the effects of cortisol and aldosterone on the MRI180V. Results: Carriers of the MR180V allele showed higher saliva (P < 0.01), plasma cortisol (P < 0.01), and heart rate responses (P < 0.05) to the Trier Social Stress Test than noncarriers (MR180I). After 3 d of a normal salt diet and the Weinberger's test, no association was found with urinary sodium excretion, plasma aldosterone, and plasma renin activity or with changes in blood pressure, aldosterone, and renin responses. In vitro testing of the MR180V allele revealed a mild loss of function using cortisol as a ligand, compared with the MR180I allele. Significantly higher doses of cortisol were needed for half-maximal induction on the TAT-1 (P < 0.002), TAT-3 (P < 0.03), or mouse mammary tumor virus (P < 0.02) promoters, whereas maximal induction was not different. These differences were not observed using aldosterone as a ligand. Conclusion: The findings reveal that cortisol and heart rate responses to a psychosocial stressor are enhanced in carriers of the MR180V variant.</EA>
<CC>002B21; 002A28</CC>
<FD>Minéralocorticoïde; Polymorphisme; Variabilité génétique; Génotype; Récepteur biologique; Stress; Endocrinologie</FD>
<ED>Mineralocorticoid; Polymorphism; Genetic variability; Genotype; Biological receptor; Stress; Endocrinology</ED>
<SD>Mineralocorticoide; Polimorfismo; Variabilidad genética; Genotipo; Receptor biológico; Estrés; Endocrinología</SD>
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A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness

A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness

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