StressCovidV1, PascalFrancis, Corpus, bibRecord, 000195

Relation of lifetime trauma and depressive symptoms to mortality in HIV

Identifieur interne : 000195 ( PascalFrancis/Corpus ); précédent : 000194; suivant : 000196

Relation of lifetime trauma and depressive symptoms to mortality in HIV

Auteurs : Jane Leserman ; Brian Wells Pence ; Kathryn Whetten ; Michael J. Mugavero ; Nathan M. Thielman ; Marvin S. Swartz ; Dalene Stangl

Source :

The American journal of psychiatry [ 0002-953X ] ; 2007.

RBID : Francis:08-0002966

Descripteurs français

Pascal (Inist)
- Durée vie, Traumatisme, Symptomatologie, Etat dépressif, Mortalité, SIDA, Virus immunodéficience humaine.

English descriptors

KwdEn :
- AIDS, Depression, Human immunodeficiency virus, Lifetime, Mortality, Symptomatology, Trauma.

Abstract

Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0002-953X`
A02	`01`			`@0 AJPSAO`
A03		`1`		`@0 Am. j. psychiatr.`
A05				`@2 164`
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A08	`01`	`1`	`ENG`	`@1 Relation of lifetime trauma and depressive symptoms to mortality in HIV`
A11	`01`	`1`		`@1 LESERMAN (Jane)`
A11	`02`	`1`		`@1 WELLS PENCE (Brian)`
A11	`03`	`1`		`@1 WHETTEN (Kathryn)`
A11	`04`	`1`		`@1 MUGAVERO (Michael J.)`
A11	`05`	`1`		`@1 THIELMAN (Nathan M.)`
A11	`06`	`1`		`@1 SWARTZ (Marvin S.)`
A11	`07`	`1`		`@1 STANGL (Dalene)`
A14	`01`			`@1 Department of Psychiatry and Medicine, University of North Carolina at Chapel Hill @3 USA`
A14	`02`			`@1 Health Inequalities Program, Center for Health Policy and Terry Sanford Institute of Public Policy, Duke University @2 Durham, NC @3 USA`
A14	`03`			`@1 Department of Community and Family Medicine, Division of Infectious Diseases, Duke University @2 Durham, NC @3 USA`
A14	`04`			`@1 Department of Medicine, and Institute of Statistics and Decision Sciences, Duke University @2 Durham, NC @3 USA`
A14	`05`			`@1 Department of Medicine, University of Alabama at Birmingham @2 Birmingham @3 USA`
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A21				`@1 2007`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 39 ref.`
A47	`01`	`1`		`@0 08-0002966`
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A61				`@0 A`
A64	`01`	`1`		`@0 The American journal of psychiatry`
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C01	`01`		`ENG`	@0 Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.
C02	`01`	`X`		`@0 770D03G01 @1 IV`
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C03	`01`	`X`	`ENG`	`@0 Lifetime @5 01`
C03	`01`	`X`	`SPA`	`@0 Tiempo vida @5 01`
C03	`02`	`X`	`FRE`	`@0 Traumatisme @5 02`
C03	`02`	`X`	`ENG`	`@0 Trauma @5 02`
C03	`02`	`X`	`SPA`	`@0 Traumatismo @5 02`
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C03	`03`	`X`	`ENG`	`@0 Symptomatology @5 03`
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C03	`04`	`X`	`SPA`	`@0 Estado depresivo @5 04`
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C03	`05`	`X`	`ENG`	`@0 Mortality @5 05`
C03	`05`	`X`	`SPA`	`@0 Mortalidad @5 05`
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C07	`01`	`X`	`SPA`	`@0 Virosis`
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C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
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C07	`03`	`X`	`ENG`	`@0 Lentivirus @2 NW`
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C07	`08`	`X`	`SPA`	`@0 Inmunopatología @5 40`
N21				`@1 007`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	FRANCIS 08-0002966 INIST
ET :	Relation of lifetime trauma and depressive symptoms to mortality in HIV
AU :	LESERMAN (Jane); WELLS PENCE (Brian); WHETTEN (Kathryn); MUGAVERO (Michael J.); THIELMAN (Nathan M.); SWARTZ (Marvin S.); STANGL (Dalene)
AF :	Department of Psychiatry and Medicine, University of North Carolina at Chapel Hill/Etats-Unis; Health Inequalities Program, Center for Health Policy and Terry Sanford Institute of Public Policy, Duke University/Durham, NC/Etats-Unis; Department of Community and Family Medicine, Division of Infectious Diseases, Duke University/Durham, NC/Etats-Unis; Department of Medicine, and Institute of Statistics and Decision Sciences, Duke University/Durham, NC/Etats-Unis; Department of Medicine, University of Alabama at Birmingham/Birmingham/Etats-Unis
DT :	Publication en série; Niveau analytique
SO :	The American journal of psychiatry; ISSN 0002-953X; Coden AJPSAO; Etats-Unis; Da. 2007; Vol. 164; No. 11; Pp. 1707-1713; Bibl. 39 ref.
LA :	Anglais
EA :	Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.
CC :	770D03G01
FD :	Durée vie; Traumatisme; Symptomatologie; Etat dépressif; Mortalité; SIDA; Virus immunodéficience humaine
FG :	Virose; Infection; Lentivirus; Retroviridae; Virus; Trouble de l'humeur; Immunodéficit; Immunopathologie
ED :	Lifetime; Trauma; Symptomatology; Depression; Mortality; AIDS; Human immunodeficiency virus
EG :	Viral disease; Infection; Lentivirus; Retroviridae; Virus; Mood disorder; Immune deficiency; Immunopathology
SD :	Tiempo vida; Traumatismo; Sintomatología; Estado depresivo; Mortalidad; SIDA; Human immunodeficiency virus
LO :	INIST-3283.354000173512310150
ID :	08-0002966

Links to Exploration step

Francis:08-0002966

Le document en format XML

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<affiliation><inist:fA14 i1="03"><s1>Department of Community and Family Medicine, Division of Infectious Diseases, Duke University</s1>
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<affiliation><inist:fA14 i1="03"><s1>Department of Community and Family Medicine, Division of Infectious Diseases, Duke University</s1>
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<s2>Durham, NC</s2>
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<affiliation><inist:fA14 i1="05"><s1>Department of Medicine, University of Alabama at Birmingham</s1>
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<author><name sortKey="Thielman, Nathan M" sort="Thielman, Nathan M" uniqKey="Thielman N" first="Nathan M." last="Thielman">Nathan M. Thielman</name>
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<author><name sortKey="Swartz, Marvin S" sort="Swartz, Marvin S" uniqKey="Swartz M" first="Marvin S." last="Swartz">Marvin S. Swartz</name>
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<term>Trauma</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Durée vie</term>
<term>Traumatisme</term>
<term>Symptomatologie</term>
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<front><div type="abstract" xml:lang="en">Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.</div>
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<fA14 i1="01"><s1>Department of Psychiatry and Medicine, University of North Carolina at Chapel Hill</s1>
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<fA14 i1="02"><s1>Health Inequalities Program, Center for Health Policy and Terry Sanford Institute of Public Policy, Duke University</s1>
<s2>Durham, NC</s2>
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<fA14 i1="03"><s1>Department of Community and Family Medicine, Division of Infectious Diseases, Duke University</s1>
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<fA14 i1="04"><s1>Department of Medicine, and Institute of Statistics and Decision Sciences, Duke University</s1>
<s2>Durham, NC</s2>
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<fA14 i1="05"><s1>Department of Medicine, University of Alabama at Birmingham</s1>
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<fC01 i1="01" l="ENG"><s0>Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.</s0>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Sintomatología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Etat dépressif</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Depression</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Estado depresivo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Mortalité</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Mortality</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Mortalidad</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>SIDA</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>AIDS</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>SIDA</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Virus immunodéficience humaine</s0>
<s2>NW</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>07</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Lentivirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Retroviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble de l'humeur</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Mood disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno humor</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Immunodéficit</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Immune deficiency</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Inmunodeficiencia</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>007</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>FRANCIS 08-0002966 INIST</NO>
<ET>Relation of lifetime trauma and depressive symptoms to mortality in HIV</ET>
<AU>LESERMAN (Jane); WELLS PENCE (Brian); WHETTEN (Kathryn); MUGAVERO (Michael J.); THIELMAN (Nathan M.); SWARTZ (Marvin S.); STANGL (Dalene)</AU>
<AF>Department of Psychiatry and Medicine, University of North Carolina at Chapel Hill/Etats-Unis; Health Inequalities Program, Center for Health Policy and Terry Sanford Institute of Public Policy, Duke University/Durham, NC/Etats-Unis; Department of Community and Family Medicine, Division of Infectious Diseases, Duke University/Durham, NC/Etats-Unis; Department of Medicine, and Institute of Statistics and Decision Sciences, Duke University/Durham, NC/Etats-Unis; Department of Medicine, University of Alabama at Birmingham/Birmingham/Etats-Unis</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of psychiatry; ISSN 0002-953X; Coden AJPSAO; Etats-Unis; Da. 2007; Vol. 164; No. 11; Pp. 1707-1713; Bibl. 39 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: In an era of highly active anti-retroviral therapies, the authors needed to confirm previous findings showing that stress and depression have an impact on HIV disease progression. The goal of the current study was to examine the effects of lifetime trauma, recent stressful events, and depression on all-cause and AIDS-related mortality among HIV-infected men and women. The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality. Method: The authors consecutively sampled HIV-infected men and women who received care at one of eight infectious diseases clinics in five Southeastern states. The sample included 490 patients who were followed by interview for 27 months and followed with their medical records for up to 41 months. Results: There were 29 deaths; 16 were AIDS-related. More lifetime trauma and antigenic marker on helper/inducer T cells (CD4) <200 significantly predicted faster all-cause and AIDS-related mortality. For those at or above the median in trauma, the all-cause death rate was 3.54 per 100 person-years, compared to 1.72 for those below the median. For those at or above the median in trauma, the AIDS-related death rate was 2.13 per 100 person-years, compared to 0.77 for those below the median. Depressive symptoms and higher baseline viral load were significantly related to greater risk of AIDS-related mortality. Conclusions: Further research is needed to determine if interventions to address trauma and depression can modify these detrimental effects on HIV.</EA>
<CC>770D03G01</CC>
<FD>Durée vie; Traumatisme; Symptomatologie; Etat dépressif; Mortalité; SIDA; Virus immunodéficience humaine</FD>
<FG>Virose; Infection; Lentivirus; Retroviridae; Virus; Trouble de l'humeur; Immunodéficit; Immunopathologie</FG>
<ED>Lifetime; Trauma; Symptomatology; Depression; Mortality; AIDS; Human immunodeficiency virus</ED>
<EG>Viral disease; Infection; Lentivirus; Retroviridae; Virus; Mood disorder; Immune deficiency; Immunopathology</EG>
<SD>Tiempo vida; Traumatismo; Sintomatología; Estado depresivo; Mortalidad; SIDA; Human immunodeficiency virus</SD>
<LO>INIST-3283.354000173512310150</LO>
<ID>08-0002966</ID>
</server>
</inist>
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Relation of lifetime trauma and depressive symptoms to mortality in HIV

Relation of lifetime trauma and depressive symptoms to mortality in HIV

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