StressCovidV1, PascalFrancis, Corpus, bibRecord, 000160

The impact of environmental risk factors on HIV-associated cognitive decline in children

Identifieur interne : 000160 ( PascalFrancis/Corpus ); précédent : 000159; suivant : 000161

The impact of environmental risk factors on HIV-associated cognitive decline in children

Auteurs : C. J. Hochhauser ; S. Gaur ; R. Marone ; M. Lewis

Source :

AIDS Care : (Print) [ 0954-0121 ] ; 2008.

RBID : Pascal:08-0415028

Descripteurs français

Pascal (Inist)
- Facteur milieu, Santé et environnement, Facteur risque, SIDA, Virus immunodéficience humaine, Détérioration intellectuelle, Trouble cognitif, Stress, Rétrospective, Santé publique, Santé mentale, Environnement social, Etats-Unis, Enfant, Age préscolaire, Age scolaire, Adolescent.

English descriptors

KwdEn :
- AIDS, Adolescent, Child, Cognitive disorder, Environmental factor, Health and environment, Human immunodeficiency virus, Intellectual deterioration, Mental health, Preschool age, Public health, Retrospective, Risk factor, School age, Social environment, Stress, United States.

Abstract

Both the human immunodeficiency virus (HIV) and environmental stress have been independently associated with decreased cognitive functioning in children. Given that they are also known to have a strong relationship with each other, the present study sought to test the hypothesis that children in conditions of high environmental risk would be at greater risk for the cognitive complications related to immunosuppression. A retrospective review was conducted to examine the records of 141 children treated at a large pediatric AIDS clinic from 1993 to 2000. CD4 + lymphocyte levels were recorded from laboratory results and IQ scores were recorded from routine psychological evaluations. Key indicators of environmental risk were collected and combined into one measure of overall environmental risk. Pearson product moment correlations were conducted to examine the relationship between environmental risk, age-adjusted CD4 and IQ. Results indicated a significant correlation between CD4 and IQ, with higher levels of immunocompetence predicting higher IQ scores. When subjects were dichotomized based on their environmental risk score, there was no relationship between CD4 count and IQ in the low environmental risk group. In contrast, CD4 was positively associated with IQ in the high environmental risk group. It is proposed that this may be due to gpl20 levels in immunocompromised children being particularly toxic to the hippocampus and cortex under conditions of high stress but not so under conditions of low stress.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 08-0415028 INIST
ET :	The impact of environmental risk factors on HIV-associated cognitive decline in children
AU :	HOCHHAUSER (C. J.); GAUR (S.); MARONE (R.); LEWIS (M.)
AF :	University of Medicine and Dentistry of NJ, Institute for the Study of Child Development/New Brunswick/Etats-Unis (1 aut., 4 aut.); University of Medicine and Dentistry of NJ, Pediatric Allergy, Immunology and Infectious Disease/New Brunswick/Etats-Unis (2 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	AIDS Care : (Print); ISSN 0954-0121; Royaume-Uni; Da. 2008; Vol. 20; No. 6; Pp. 692-699; Bibl. 2 p.1/2
LA :	Anglais
EA :	Both the human immunodeficiency virus (HIV) and environmental stress have been independently associated with decreased cognitive functioning in children. Given that they are also known to have a strong relationship with each other, the present study sought to test the hypothesis that children in conditions of high environmental risk would be at greater risk for the cognitive complications related to immunosuppression. A retrospective review was conducted to examine the records of 141 children treated at a large pediatric AIDS clinic from 1993 to 2000. CD4 + lymphocyte levels were recorded from laboratory results and IQ scores were recorded from routine psychological evaluations. Key indicators of environmental risk were collected and combined into one measure of overall environmental risk. Pearson product moment correlations were conducted to examine the relationship between environmental risk, age-adjusted CD4 and IQ. Results indicated a significant correlation between CD4 and IQ, with higher levels of immunocompetence predicting higher IQ scores. When subjects were dichotomized based on their environmental risk score, there was no relationship between CD4 count and IQ in the low environmental risk group. In contrast, CD4 was positively associated with IQ in the high environmental risk group. It is proposed that this may be due to gpl20 levels in immunocompromised children being particularly toxic to the hippocampus and cortex under conditions of high stress but not so under conditions of low stress.
CC :	002B30A02; 002B05C02D; 002B18D10
FD :	Facteur milieu; Santé et environnement; Facteur risque; SIDA; Virus immunodéficience humaine; Détérioration intellectuelle; Trouble cognitif; Stress; Rétrospective; Santé publique; Santé mentale; Environnement social; Etats-Unis; Enfant; Age préscolaire; Age scolaire; Adolescent
FG :	Virose; Infection; Lentivirus; Retroviridae; Virus; Amérique du Nord; Amérique; Homme; Immunodéficit; Immunopathologie
ED :	Environmental factor; Health and environment; Risk factor; AIDS; Human immunodeficiency virus; Intellectual deterioration; Cognitive disorder; Stress; Retrospective; Public health; Mental health; Social environment; United States; Child; Preschool age; School age; Adolescent
EG :	Viral disease; Infection; Lentivirus; Retroviridae; Virus; North America; America; Human; Immune deficiency; Immunopathology
SD :	Factor medio; Salud y medio ambiente; Factor riesgo; SIDA; Human immunodeficiency virus; Deterioro intelectual; Trastorno cognitivo; Estrés; Retrospectiva; Salud pública; Salud mental; Contexto social; Estados Unidos; Niño; Edad preescolar; Edad escolar; Adolescente
LO :	INIST-22096.354000200293860100
ID :	08-0415028

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Pascal:08-0415028

Le document en format XML

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<front><div type="abstract" xml:lang="en">Both the human immunodeficiency virus (HIV) and environmental stress have been independently associated with decreased cognitive functioning in children. Given that they are also known to have a strong relationship with each other, the present study sought to test the hypothesis that children in conditions of high environmental risk would be at greater risk for the cognitive complications related to immunosuppression. A retrospective review was conducted to examine the records of 141 children treated at a large pediatric AIDS clinic from 1993 to 2000. CD4 + lymphocyte levels were recorded from laboratory results and IQ scores were recorded from routine psychological evaluations. Key indicators of environmental risk were collected and combined into one measure of overall environmental risk. Pearson product moment correlations were conducted to examine the relationship between environmental risk, age-adjusted CD4 and IQ. Results indicated a significant correlation between CD4 and IQ, with higher levels of immunocompetence predicting higher IQ scores. When subjects were dichotomized based on their environmental risk score, there was no relationship between CD4 count and IQ in the low environmental risk group. In contrast, CD4 was positively associated with IQ in the high environmental risk group. It is proposed that this may be due to gpl20 levels in immunocompromised children being particularly toxic to the hippocampus and cortex under conditions of high stress but not so under conditions of low stress.</div>
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<fC02 i1="02" i2="X"><s0>002B05C02D</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B18D10</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Facteur milieu</s0>
<s5>01</s5>
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<s5>01</s5>
</fC03>
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<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Santé et environnement</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Health and environment</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Salud y medio ambiente</s0>
<s5>02</s5>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Risk factor</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Factor riesgo</s0>
<s5>03</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s5>04</s5>
</fC03>
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<s2>NW</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>05</s5>
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<fC03 i1="05" i2="X" l="SPA"><s0>Human immunodeficiency virus</s0>
<s2>NW</s2>
<s5>05</s5>
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<s5>06</s5>
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<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Deterioro intelectual</s0>
<s5>06</s5>
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<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Cognitive disorder</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Trastorno cognitivo</s0>
<s5>07</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Stress</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Stress</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Estrés</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Rétrospective</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Retrospective</s0>
<s5>09</s5>
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<fC03 i1="09" i2="X" l="SPA"><s0>Retrospectiva</s0>
<s5>09</s5>
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<fC03 i1="10" i2="X" l="FRE"><s0>Santé publique</s0>
<s5>10</s5>
</fC03>
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<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Salud pública</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Santé mentale</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Mental health</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Salud mental</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Environnement social</s0>
<s5>12</s5>
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<fC03 i1="12" i2="X" l="ENG"><s0>Social environment</s0>
<s5>12</s5>
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<fC03 i1="12" i2="X" l="SPA"><s0>Contexto social</s0>
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<s5>13</s5>
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<fC03 i1="13" i2="X" l="ENG"><s0>United States</s0>
<s2>NG</s2>
<s5>13</s5>
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<fC03 i1="13" i2="X" l="SPA"><s0>Estados Unidos</s0>
<s2>NG</s2>
<s5>13</s5>
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<fC03 i1="14" i2="X" l="FRE"><s0>Enfant</s0>
<s5>18</s5>
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<fC03 i1="14" i2="X" l="ENG"><s0>Child</s0>
<s5>18</s5>
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<s5>18</s5>
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<s5>19</s5>
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<fC03 i1="15" i2="X" l="ENG"><s0>Preschool age</s0>
<s5>19</s5>
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<s5>19</s5>
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<s5>20</s5>
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<s5>20</s5>
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<s5>20</s5>
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<s5>21</s5>
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<s5>21</s5>
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<s5>21</s5>
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<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
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<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
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<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
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<fC07 i1="03" i2="X" l="FRE"><s0>Lentivirus</s0>
<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<fC07 i1="04" i2="X" l="ENG"><s0>Retroviridae</s0>
<s2>NW</s2>
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<fC07 i1="04" i2="X" l="SPA"><s0>Retroviridae</s0>
<s2>NW</s2>
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<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
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<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Amérique du Nord</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>North America</s0>
<s2>NG</s2>
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<fC07 i1="06" i2="X" l="SPA"><s0>America del norte</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Amérique</s0>
<s2>NG</s2>
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<fC07 i1="07" i2="X" l="ENG"><s0>America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Immunodéficit</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Immune deficiency</s0>
<s5>37</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Inmunodeficiencia</s0>
<s5>37</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>39</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>39</s5>
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<fN21><s1>266</s1>
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<server><NO>PASCAL 08-0415028 INIST</NO>
<ET>The impact of environmental risk factors on HIV-associated cognitive decline in children</ET>
<AU>HOCHHAUSER (C. J.); GAUR (S.); MARONE (R.); LEWIS (M.)</AU>
<AF>University of Medicine and Dentistry of NJ, Institute for the Study of Child Development/New Brunswick/Etats-Unis (1 aut., 4 aut.); University of Medicine and Dentistry of NJ, Pediatric Allergy, Immunology and Infectious Disease/New Brunswick/Etats-Unis (2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>AIDS Care : (Print); ISSN 0954-0121; Royaume-Uni; Da. 2008; Vol. 20; No. 6; Pp. 692-699; Bibl. 2 p.1/2</SO>
<LA>Anglais</LA>
<EA>Both the human immunodeficiency virus (HIV) and environmental stress have been independently associated with decreased cognitive functioning in children. Given that they are also known to have a strong relationship with each other, the present study sought to test the hypothesis that children in conditions of high environmental risk would be at greater risk for the cognitive complications related to immunosuppression. A retrospective review was conducted to examine the records of 141 children treated at a large pediatric AIDS clinic from 1993 to 2000. CD4 + lymphocyte levels were recorded from laboratory results and IQ scores were recorded from routine psychological evaluations. Key indicators of environmental risk were collected and combined into one measure of overall environmental risk. Pearson product moment correlations were conducted to examine the relationship between environmental risk, age-adjusted CD4 and IQ. Results indicated a significant correlation between CD4 and IQ, with higher levels of immunocompetence predicting higher IQ scores. When subjects were dichotomized based on their environmental risk score, there was no relationship between CD4 count and IQ in the low environmental risk group. In contrast, CD4 was positively associated with IQ in the high environmental risk group. It is proposed that this may be due to gpl20 levels in immunocompromised children being particularly toxic to the hippocampus and cortex under conditions of high stress but not so under conditions of low stress.</EA>
<CC>002B30A02; 002B05C02D; 002B18D10</CC>
<FD>Facteur milieu; Santé et environnement; Facteur risque; SIDA; Virus immunodéficience humaine; Détérioration intellectuelle; Trouble cognitif; Stress; Rétrospective; Santé publique; Santé mentale; Environnement social; Etats-Unis; Enfant; Age préscolaire; Age scolaire; Adolescent</FD>
<FG>Virose; Infection; Lentivirus; Retroviridae; Virus; Amérique du Nord; Amérique; Homme; Immunodéficit; Immunopathologie</FG>
<ED>Environmental factor; Health and environment; Risk factor; AIDS; Human immunodeficiency virus; Intellectual deterioration; Cognitive disorder; Stress; Retrospective; Public health; Mental health; Social environment; United States; Child; Preschool age; School age; Adolescent</ED>
<EG>Viral disease; Infection; Lentivirus; Retroviridae; Virus; North America; America; Human; Immune deficiency; Immunopathology</EG>
<SD>Factor medio; Salud y medio ambiente; Factor riesgo; SIDA; Human immunodeficiency virus; Deterioro intelectual; Trastorno cognitivo; Estrés; Retrospectiva; Salud pública; Salud mental; Contexto social; Estados Unidos; Niño; Edad preescolar; Edad escolar; Adolescente</SD>
<LO>INIST-22096.354000200293860100</LO>
<ID>08-0415028</ID>
</server>
</inist>
</record>

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The impact of environmental risk factors on HIV-associated cognitive decline in children

The impact of environmental risk factors on HIV-associated cognitive decline in children

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