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Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) infection

Identifieur interne : 001389 ( Ncbi/Merge ); précédent : 001388; suivant : 001390

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) infection

Auteurs : Livan Delgado-Roche [Mexique] ; Fernando Mesta [Mexique]

Source :

RBID : PMC:7190501

Abstract

The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV), the pathogenic agent of Covid-19, represent a serious health problem worldwide. Respiratory viral infections are, in general, associated with cytokine production, inflammation, cell death, and other pathophysiological processes, which could be link with a redox imbalance or oxidative stress. These phenomena are substantially increased during aging. Actually, severity and mortality risk of SARS-CoV-2 infection or Covid-19 disease have been associated with the age. The aim of the present work was to contribute with the understanding of the possible link between oxidative stress and the pathogenesis, severity and mortality risk in patients affected by SARS-CoV infection.


Url:
DOI: 10.1016/j.arcmed.2020.04.019
PubMed: NONE
PubMed Central: 7190501

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PMC:7190501

Le document en format XML

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<p>The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV), the pathogenic agent of Covid-19, represent a serious health problem worldwide. Respiratory viral infections are, in general, associated with cytokine production, inflammation, cell death, and other pathophysiological processes, which could be link with a redox imbalance or oxidative stress. These phenomena are substantially increased during aging. Actually, severity and mortality risk of SARS-CoV-2 infection or Covid-19 disease have been associated with the age. The aim of the present work was to contribute with the understanding of the possible link between oxidative stress and the pathogenesis, severity and mortality risk in patients affected by SARS-CoV infection.</p>
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<email>ldelgadoroche@gmail.com</email>
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Gerencia de Investigación Clínica, Dirección Médica, Laboratorios Liomont S.A. de C.V., Ciudad de México, México</aff>
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Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Guillermo Massieu, Ciudad de México, México</aff>
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Address reprint requests to: Livan Delgado-Roche, Dr., Ph.D. Gerencia de Investigación Clínica, Dirección Médica, Laboratorios Liomont S.A. de C.V., Carretera México Toluca, 5420, Colonia El Yaqui, Alcaldía Cuajimalpa de Morelos, 05320, Ciudad de México, México. Phone: (+52) (55) 5814-1510; FAX: (+52) (55) 5814-1200;
<email>ldelgadoroche@gmail.com</email>
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<copyright-statement>© 2020 Published by Elsevier Inc. on behalf of IMSS.</copyright-statement>
<copyright-year>2020</copyright-year>
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<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
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<abstract id="abs0010">
<p>The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV), the pathogenic agent of Covid-19, represent a serious health problem worldwide. Respiratory viral infections are, in general, associated with cytokine production, inflammation, cell death, and other pathophysiological processes, which could be link with a redox imbalance or oxidative stress. These phenomena are substantially increased during aging. Actually, severity and mortality risk of SARS-CoV-2 infection or Covid-19 disease have been associated with the age. The aim of the present work was to contribute with the understanding of the possible link between oxidative stress and the pathogenesis, severity and mortality risk in patients affected by SARS-CoV infection.</p>
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<p id="p0010">Oxidative stress is associated with SARS-CoV pathogenesis</p>
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<label>-</label>
<p id="p0015">Inflammation and oxidative stress contribute with SARS-CoV infection</p>
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<p id="p0020">Covid-19 in aging patients could be associated with oxidative stress</p>
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<title>Key Words</title>
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