The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study
Identifieur interne : 000F60 ( Ncbi/Merge ); précédent : 000F59; suivant : 000F61The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study
Auteurs : Jinping Zhang [République populaire de Chine] ; Peng Liu [République populaire de Chine] ; Morong Wang [République populaire de Chine] ; Jie Wang [République populaire de Chine] ; Jie Chen [République populaire de Chine] ; Wenling Yuan [République populaire de Chine] ; Mei Li [République populaire de Chine] ; Zhijuan Xie [République populaire de Chine] ; Wangping Dong [République populaire de Chine] ; Hongye Li [République populaire de Chine] ; Yan Zhao [République populaire de Chine] ; Lun Wan [République populaire de Chine] ; Tian Chu [République populaire de Chine] ; Lu Wang [République populaire de Chine] ; Hui Zhang [République populaire de Chine] ; Ting Tao [République populaire de Chine] ; Jing Ma [République populaire de Chine]Source :
- Zeitschrift Fur Gesundheitswissenschaften [ 2198-1833 ] ; 2020.
Abstract
The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment.
A retrospective analysis of the clinical manifestation and auxiliary examination of 19 patients with COVID-19 from the Liyuan Hospital intensive care unit (ICU) between January 16, 2020 and February 20, 2020 was undertaken.
There were 11 male and 8 female cases among the patients. The median (range) age was 73 (38–91) years. Of these patients, 8 (42.1%) had died and the median duration from ICU admission to death was 2 (interquartile range (IQR): 1–10.75) days. Seven of these 8 patients had underlying diseases. The auxiliary examination showed fever (68.4%), dry cough (15.8%), dyspnea (10.5%), and diarrhea (5.3%). All 19 cases showed ground-glass changes on chest computed tomography. Serum hypersensitive C-reactive protein (hs-CRP) and serum amylase A (SAA) were clearly increased in all of the cases. Among the 19 cases, there were 16 (84.2%) cases in which the total number of lymphocytes decreased, 12 cases (63%) had reduced liver function, and 11 cases (58%) had deviant results for fibrinogen (FIB) and D-dimer, in particular, the D-dimer level was significantly higher in the non-survivors compared with the survivors.
There were more men than women among critically ill patients. All of the cases showed ground-glass changes on chest computed tomography and the vast majority of patients displayed fever and dry cough. The clinical laboratory indices change significantly, especially the D-dimer level among non-survivors.
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DOI: 10.1007/s10389-020-01291-2
PubMed: 32318325
PubMed Central: 7171052
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Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Morong" sort="Wang, Morong" uniqKey="Wang M" first="Morong" last="Wang">Morong Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.33199.31</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 7223</institution-id><institution>ICU, Liyuan Hospital affiliated to Tongji Medical College,</institution><institution>Huazhong University of Science and Technology,</institution></institution-wrap>Wuhan, 430071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jie" sort="Wang, Jie" uniqKey="Wang J" first="Jie" last="Wang">Jie Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id 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id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.33199.31</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 7223</institution-id><institution>ICU, Liyuan Hospital affiliated to Tongji Medical College,</institution><institution>Huazhong University of Science and Technology,</institution></institution-wrap>Wuhan, 430071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Lu" sort="Wang, Lu" uniqKey="Wang L" first="Lu" last="Wang">Lu Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.33199.31</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 7223</institution-id><institution>ICU, Liyuan Hospital affiliated to Tongji Medical College,</institution><institution>Huazhong University of Science and Technology,</institution></institution-wrap>Wuhan, 430071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hui" sort="Zhang, Hui" uniqKey="Zhang H" first="Hui" last="Zhang">Hui Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.33199.31</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 7223</institution-id><institution>ICU, Liyuan Hospital affiliated to Tongji Medical College,</institution><institution>Huazhong University of Science and Technology,</institution></institution-wrap>Wuhan, 430071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Tao, Ting" sort="Tao, Ting" uniqKey="Tao T" first="Ting" last="Tao">Ting Tao</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.33199.31</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 7223</institution-id><institution>ICU, Liyuan Hospital affiliated to Tongji Medical College,</institution><institution>Huazhong University of Science and Technology,</institution></institution-wrap>Wuhan, 430071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.33199.31</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 7223</institution-id><institution>ICU, Liyuan Hospital affiliated to Tongji Medical College,</institution><institution>Huazhong University of Science and Technology,</institution></institution-wrap>Wuhan, 430071 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Zeitschrift Fur Gesundheitswissenschaften</title><idno type="ISSN">2198-1833</idno><idno type="eISSN">1613-2238</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment.</p></sec><sec><title>Methods</title><p id="Par2">A retrospective analysis of the clinical manifestation and auxiliary examination of 19 patients with COVID-19 from the Liyuan Hospital intensive care unit (ICU) between January 16, 2020 and February 20, 2020 was undertaken.</p></sec><sec><title>Results</title><p id="Par3">There were 11 male and 8 female cases among the patients. The median (range) age was 73 (38–91) years. Of these patients, 8 (42.1%) had died and the median duration from ICU admission to death was 2 (interquartile range (IQR): 1–10.75) days. Seven of these 8 patients had underlying diseases. The auxiliary examination showed fever (68.4%), dry cough (15.8%), dyspnea (10.5%), and diarrhea (5.3%). All 19 cases showed ground-glass changes on chest computed tomography. Serum hypersensitive C-reactive protein (hs-CRP) and serum amylase A (SAA) were clearly increased in all of the cases. Among the 19 cases, there were 16 (84.2%) cases in which the total number of lymphocytes decreased, 12 cases (63%) had reduced liver function, and 11 cases (58%) had deviant results for fibrinogen (FIB) and D-dimer, in particular, the D-dimer level was significantly higher in the non-survivors compared with the survivors.</p></sec><sec><title>Conclusion</title><p id="Par4">There were more men than women among critically ill patients. All of the cases showed ground-glass changes on chest computed tomography and the vast majority of patients displayed fever and dry cough. The clinical laboratory indices change significantly, especially the D-dimer level among non-survivors.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, N" uniqKey="Chen N">N Chen</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name></author><author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, M" uniqKey="Chung M">M Chung</name></author><author><name sortKey="Bernheim, A" uniqKey="Bernheim A">A Bernheim</name></author><author><name sortKey="Mei, X" uniqKey="Mei X">X Mei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, J" uniqKey="Cui J">J Cui</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Shi, Zl" uniqKey="Shi Z">ZL Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holshue, Ml" uniqKey="Holshue M">ML Holshue</name></author><author><name sortKey="Debolt, C" uniqKey="Debolt C">C DeBolt</name></author><author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S Lindquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honce, R" uniqKey="Honce R">R Honce</name></author><author><name sortKey="Schultz Cherry, S" uniqKey="Schultz Cherry S">S Schultz-Cherry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Saw, Pe" uniqKey="Saw P">PE Saw</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Z Gesundh Wiss</journal-id><journal-id journal-id-type="iso-abbrev">Z Gesundh Wiss</journal-id><journal-title-group><journal-title>Zeitschrift Fur Gesundheitswissenschaften</journal-title></journal-title-group><issn pub-type="ppub">2198-1833</issn><issn pub-type="epub">1613-2238</issn><publisher><publisher-name>Springer Berlin Heidelberg</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32318325</article-id><article-id pub-id-type="pmc">7171052</article-id><article-id pub-id-type="publisher-id">1291</article-id><article-id pub-id-type="doi">10.1007/s10389-020-01291-2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name><surname>Zhang</surname><given-names>Jinping</given-names></name><address><email>zhangjinping0425@163.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Liu</surname><given-names>Peng</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Morong</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Wenling</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Mei</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Xie</surname><given-names>Zhijuan</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dong</surname><given-names>Wangping</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Hongye</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Yan</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wan</surname><given-names>Lun</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Tian</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Lu</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tao</surname><given-names>Ting</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Ma</surname><given-names>Jing</given-names></name><address><email>jiaositang@163.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.33199.31</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 7223</institution-id><institution>ICU, Liyuan Hospital affiliated to Tongji Medical College,</institution><institution>Huazhong University of Science and Technology,</institution></institution-wrap>Wuhan, 430071 China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.49470.3e</institution-id><institution-id institution-id-type="ISNI">0000 0001 2331 6153</institution-id><institution>State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases,</institution><institution>Department of Immunology, Wuhan University School of Basic Medical Sciences,</institution></institution-wrap>Wuhan, 430071 China</aff></contrib-group><pub-date pub-type="epub"><day>21</day><month>4</month><year>2020</year></pub-date><fpage>1</fpage><lpage>4</lpage><history><date date-type="received"><day>15</day><month>3</month><year>2020</year></date><date date-type="accepted"><day>2</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© Springer-Verlag GmbH Germany, part of Springer Nature 2020</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment.</p></sec><sec><title>Methods</title><p id="Par2">A retrospective analysis of the clinical manifestation and auxiliary examination of 19 patients with COVID-19 from the Liyuan Hospital intensive care unit (ICU) between January 16, 2020 and February 20, 2020 was undertaken.</p></sec><sec><title>Results</title><p id="Par3">There were 11 male and 8 female cases among the patients. The median (range) age was 73 (38–91) years. Of these patients, 8 (42.1%) had died and the median duration from ICU admission to death was 2 (interquartile range (IQR): 1–10.75) days. Seven of these 8 patients had underlying diseases. The auxiliary examination showed fever (68.4%), dry cough (15.8%), dyspnea (10.5%), and diarrhea (5.3%). All 19 cases showed ground-glass changes on chest computed tomography. Serum hypersensitive C-reactive protein (hs-CRP) and serum amylase A (SAA) were clearly increased in all of the cases. Among the 19 cases, there were 16 (84.2%) cases in which the total number of lymphocytes decreased, 12 cases (63%) had reduced liver function, and 11 cases (58%) had deviant results for fibrinogen (FIB) and D-dimer, in particular, the D-dimer level was significantly higher in the non-survivors compared with the survivors.</p></sec><sec><title>Conclusion</title><p id="Par4">There were more men than women among critically ill patients. All of the cases showed ground-glass changes on chest computed tomography and the vast majority of patients displayed fever and dry cough. The clinical laboratory indices change significantly, especially the D-dimer level among non-survivors.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Coronavirus disease 2019</kwd><kwd>Clinical manifestations</kwd><kwd>Epidemiology</kwd><kwd>Retrospective</kwd><kwd>D-dimer</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Jinping" sort="Zhang, Jinping" uniqKey="Zhang J" first="Jinping" last="Zhang">Jinping Zhang</name></noRegion><name sortKey="Chen, Jie" sort="Chen, Jie" uniqKey="Chen J" first="Jie" last="Chen">Jie Chen</name><name sortKey="Chu, Tian" sort="Chu, Tian" uniqKey="Chu T" first="Tian" last="Chu">Tian Chu</name><name sortKey="Dong, Wangping" sort="Dong, Wangping" uniqKey="Dong W" first="Wangping" last="Dong">Wangping Dong</name><name sortKey="Li, Hongye" sort="Li, Hongye" uniqKey="Li H" first="Hongye" last="Li">Hongye Li</name><name sortKey="Li, Mei" sort="Li, Mei" uniqKey="Li M" first="Mei" last="Li">Mei Li</name><name sortKey="Liu, Peng" sort="Liu, Peng" uniqKey="Liu P" first="Peng" last="Liu">Peng Liu</name><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><name sortKey="Tao, Ting" sort="Tao, Ting" uniqKey="Tao T" first="Ting" last="Tao">Ting Tao</name><name sortKey="Wan, Lun" sort="Wan, Lun" uniqKey="Wan L" first="Lun" last="Wan">Lun Wan</name><name sortKey="Wang, Jie" sort="Wang, Jie" uniqKey="Wang J" first="Jie" last="Wang">Jie Wang</name><name sortKey="Wang, Lu" sort="Wang, Lu" uniqKey="Wang L" first="Lu" last="Wang">Lu Wang</name><name sortKey="Wang, Morong" sort="Wang, Morong" uniqKey="Wang M" first="Morong" last="Wang">Morong Wang</name><name sortKey="Xie, Zhijuan" sort="Xie, Zhijuan" uniqKey="Xie Z" first="Zhijuan" last="Xie">Zhijuan Xie</name><name sortKey="Yuan, Wenling" sort="Yuan, Wenling" uniqKey="Yuan W" first="Wenling" last="Yuan">Wenling Yuan</name><name sortKey="Zhang, Hui" sort="Zhang, Hui" uniqKey="Zhang H" first="Hui" last="Zhang">Hui Zhang</name><name sortKey="Zhao, Yan" sort="Zhao, Yan" uniqKey="Zhao Y" first="Yan" last="Zhao">Yan Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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