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Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

Identifieur interne : 000C63 ( Ncbi/Merge ); précédent : 000C62; suivant : 000C64

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

Auteurs : Andrew M. South [États-Unis] ; Laurie Tomlinson [Royaume-Uni] ; Daniel Edmonston [États-Unis] ; Swapnil Hiremath ; Matthew A. Sparks [États-Unis]

Source :

RBID : PMC:7118703

Abstract

The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-CoV-2 — gains entry to host cells via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship between the virus and the renin–angiotensin system (RAS) and how this might be affected by RAS inhibitors.


Url:
DOI: 10.1038/s41581-020-0279-4
PubMed: 32246101
PubMed Central: 7118703

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PMC:7118703

Le document en format XML

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<pub-date pub-type="epub">
<day>3</day>
<month>4</month>
<year>2020</year>
</pub-date>
<fpage>1</fpage>
<lpage>3</lpage>
<permissions>
<copyright-statement>© Springer Nature Limited 2020</copyright-statement>
<license>
<license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1" abstract-type="Standfirst">
<p id="Par1">The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-CoV-2 — gains entry to host cells via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship between the virus and the renin–angiotensin system (RAS) and how this might be affected by RAS inhibitors.</p>
</abstract>
<kwd-group kwd-group-type="npg-subject">
<title>Subject terms</title>
<kwd>Molecular biology</kwd>
<kwd>Hypertension</kwd>
<kwd>Infection</kwd>
<kwd>Nephrology</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region>
<li>Caroline du Nord</li>
</region>
</list>
<tree>
<noCountry>
<name sortKey="Hiremath, Swapnil" sort="Hiremath, Swapnil" uniqKey="Hiremath S" first="Swapnil" last="Hiremath">Swapnil Hiremath</name>
</noCountry>
<country name="États-Unis">
<region name="Caroline du Nord">
<name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name>
</region>
<name sortKey="Edmonston, Daniel" sort="Edmonston, Daniel" uniqKey="Edmonston D" first="Daniel" last="Edmonston">Daniel Edmonston</name>
<name sortKey="Edmonston, Daniel" sort="Edmonston, Daniel" uniqKey="Edmonston D" first="Daniel" last="Edmonston">Daniel Edmonston</name>
<name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name>
<name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name>
<name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name>
<name sortKey="Sparks, Matthew A" sort="Sparks, Matthew A" uniqKey="Sparks M" first="Matthew A." last="Sparks">Matthew A. Sparks</name>
</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Tomlinson, Laurie" sort="Tomlinson, Laurie" uniqKey="Tomlinson L" first="Laurie" last="Tomlinson">Laurie Tomlinson</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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