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Risk factors for gastroschisis: A case-control study in a Brazilian population.

Identifieur interne : 000B21 ( Ncbi/Merge ); précédent : 000B20; suivant : 000B22

Risk factors for gastroschisis: A case-control study in a Brazilian population.

Auteurs : Amanda B. Freitas [Brésil] ; Sandra F. Centofanti [Brésil] ; Gilmar S. Osmundo-Junior [Brésil] ; Agatha S. Rodrigues [Brésil] ; Rossana P V. Francisco [Brésil] ; Maria L. Brizot [Brésil]

Source :

RBID : pubmed:32115707

Abstract

To evaluate risk factors associated with fetal gastroschisis.

DOI: 10.1002/ijgo.13135
PubMed: 32115707

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<title level="j">International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics</title>
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<div type="abstract" xml:lang="en">To evaluate risk factors associated with fetal gastroschisis.</div>
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<Month>04</Month>
<Day>01</Day>
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<Year>2020</Year>
<Month>Mar</Month>
<Day>02</Day>
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<Title>International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics</Title>
<ISOAbbreviation>Int J Gynaecol Obstet</ISOAbbreviation>
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<ArticleTitle>Risk factors for gastroschisis: A case-control study in a Brazilian population.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/ijgo.13135</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate risk factors associated with fetal gastroschisis.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">As a secondary aim of a larger case-control study, pregnant women attending the Fetal Medicine Unit at the Department of Obstetrics and Gynecology at Hospital das Clinicas, Sao Paulo University Medical School between July 1, 2013, and July 31, 2015, were allocated into either the gastroschisis group, where the woman was carrying a fetus with gastroschisis, or the control group, where the fetus was normal. Patients in the control group were matched at study entry for maternal age, preconception body mass index and weeks of gestation. In-person interviews were conducted during pregnancy to obtain data on demographic, medical, and social characteristics; exposure to substances; pregnancy history; the presence of chronic disease, urinary tract infections (UTIs), influenza, and fever; and the occurrence of stress events between the month before the last menstrual period and the first trimester of pregnancy.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 171 women included in the study, 57 were allocated to the gastroschisis group and 114 to the control group. There were significant associations between gastroschisis and maternal UTI (P=0.011), tobacco use (P=0.001), alcohol consumption (P≤0.001), and illicit drug use (P=0.012). After analysis by standard logistic regression, the remaining significant factors were UTI, tobacco use, and alcohol consumption.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">UTI and exposure to tobacco or alcohol just before conception and during early pregnancy were associated with an increase in the likelihood of fetal gastroschisis.</AbstractText>
<CopyrightInformation>© 2020 International Federation of Gynecology and Obstetrics.</CopyrightInformation>
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<LastName>Freitas</LastName>
<ForeName>Amanda B</ForeName>
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<Affiliation>Department of Obstetrics and Gynecology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.</Affiliation>
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<ForeName>Sandra F</ForeName>
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<Affiliation>Department of Obstetrics and Gynecology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.</Affiliation>
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<LastName>Osmundo-Junior</LastName>
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<Affiliation>Department of Obstetrics and Gynecology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Statistics, Institute of Mathematics and Statistics, Sao Paulo University, Sao Paulo, SP, Brazil.</Affiliation>
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<Affiliation>Department of Obstetrics and Gynecology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.</Affiliation>
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<Agency>Sao Paulo Research Foundation (FAPESP)</Agency>
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<Keyword MajorTopicYN="N">Alcohol consumption</Keyword>
<Keyword MajorTopicYN="N">Epidemiology</Keyword>
<Keyword MajorTopicYN="N">Gastroschisis</Keyword>
<Keyword MajorTopicYN="N">Habits</Keyword>
<Keyword MajorTopicYN="N">Lifestyle</Keyword>
<Keyword MajorTopicYN="N">Risk factor</Keyword>
<Keyword MajorTopicYN="N">Tobacco use</Keyword>
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</Reference>
<Reference>
<Citation>Rittler M, Campana H, Ermini ML, et al. Gastroschisis and young mothers: What makes them different from other mothers of the same age? Birth Defects Res Part A Clin Mol Teratol. 2015;103:536-543.</Citation>
</Reference>
<Reference>
<Citation>Souther C, Puapong DP, Woo R, Johnson SM. Possible etiologies of increased incidence of gastroschisis. Pediatr Surg Int. 2017;33:1209-1213.</Citation>
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<name sortKey="Freitas, Amanda B" sort="Freitas, Amanda B" uniqKey="Freitas A" first="Amanda B" last="Freitas">Amanda B. Freitas</name>
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<name sortKey="Brizot, Maria L" sort="Brizot, Maria L" uniqKey="Brizot M" first="Maria L" last="Brizot">Maria L. Brizot</name>
<name sortKey="Centofanti, Sandra F" sort="Centofanti, Sandra F" uniqKey="Centofanti S" first="Sandra F" last="Centofanti">Sandra F. Centofanti</name>
<name sortKey="Francisco, Rossana P V" sort="Francisco, Rossana P V" uniqKey="Francisco R" first="Rossana P V" last="Francisco">Rossana P V. Francisco</name>
<name sortKey="Osmundo Junior, Gilmar S" sort="Osmundo Junior, Gilmar S" uniqKey="Osmundo Junior G" first="Gilmar S" last="Osmundo-Junior">Gilmar S. Osmundo-Junior</name>
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