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Therapeutic spectrum of interferon‐β in ischemic stroke

Identifieur interne : 000974 ( Ncbi/Merge ); précédent : 000973; suivant : 000975

Therapeutic spectrum of interferon‐β in ischemic stroke

Auteurs : Madhuri Wanve ; Harpreet Kaur ; Deepaneeta Sarmah ; Jackson Saraf ; Kanta Pravalika ; Kanchan Vats ; Kiran Kalia ; Anupom Borah ; Dileep R. Yavagal ; Kunjan R. Dave ; Pallab Bhattacharya

Source :

RBID : PMC:7167007

Abstract

Abstract

Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US‐FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon‐beta (IFN‐β), an endogenous cytokine and a key anti‐inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN‐β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN‐β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN‐β therapy that may be helpful in improving stroke outcome are also discussed.


Url:
DOI: 10.1002/jnr.24333
PubMed: 30320448
PubMed Central: 7167007

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PMC:7167007

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<sup>1</sup>
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<sup>1</sup>
</xref>
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<name>
<surname>Sarmah</surname>
<given-names>Deepaneeta</given-names>
</name>
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<sup>1</sup>
</xref>
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<sup>1</sup>
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<sup>1</sup>
</xref>
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<sup>3</sup>
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<sup>3</sup>
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<named-content content-type="organisation-division">Department of Pharmacology and Toxicology</named-content>
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<city>Gandhinagar</city>
<country country="IN">India</country>
</aff>
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<label>
<sup>2</sup>
</label>
<named-content content-type="organisation-division">Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics</named-content>
<institution>Assam University</institution>
<city>Silchar</city>
<country country="IN">India</country>
</aff>
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<label>
<sup>3</sup>
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<named-content content-type="organisation-division">Department of Neurology and Neurosurgery</named-content>
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<break></break>
Pallab Bhattacharya, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Palaj, Gandhinagar 382355, Gujarat, India.
<break></break>
Email:
<email>pallab.bhu@gmail.com</email>
;
<email>pallab.bhattacharya@niperahm.ac.in</email>
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<p>Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US‐FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon‐beta (IFN‐β), an endogenous cytokine and a key anti‐inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN‐β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN‐β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN‐β therapy that may be helpful in improving stroke outcome are also discussed.</p>
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,
<string-name>
<surname>Kaur</surname>
<given-names>H</given-names>
</string-name>
,
<string-name>
<surname>Sarmah</surname>
<given-names>D</given-names>
</string-name>
, et al.
<article-title>Therapeutic spectrum of interferon‐β in ischemic stroke</article-title>
.
<source xml:lang="en">J Neuro Res</source>
.
<year>2019</year>
;
<volume>97</volume>
:
<fpage>116</fpage>
<lpage>127</lpage>
.
<pub-id pub-id-type="doi">10.1002/jnr.24333</pub-id>
</mixed-citation>
</p>
<fn-group>
<fn id="jnr24333-note-0001">
<p>
<bold>Funding Information</bold>
Science and Engineering Research Board, Grant/Award Number: SB/YS/LS‐196/2014; NIPER‐Ahmedabad; Department of Pharmaceuticals, Ministry of Chemical and Fertilizers; International Society for Neurochemistry</p>
</fn>
</fn-group>
</notes>
</front>
</pmc>
<affiliations>
<list></list>
<tree>
<noCountry>
<name sortKey="Bhattacharya, Pallab" sort="Bhattacharya, Pallab" uniqKey="Bhattacharya P" first="Pallab" last="Bhattacharya">Pallab Bhattacharya</name>
<name sortKey="Borah, Anupom" sort="Borah, Anupom" uniqKey="Borah A" first="Anupom" last="Borah">Anupom Borah</name>
<name sortKey="Dave, Kunjan R" sort="Dave, Kunjan R" uniqKey="Dave K" first="Kunjan R." last="Dave">Kunjan R. Dave</name>
<name sortKey="Kalia, Kiran" sort="Kalia, Kiran" uniqKey="Kalia K" first="Kiran" last="Kalia">Kiran Kalia</name>
<name sortKey="Kaur, Harpreet" sort="Kaur, Harpreet" uniqKey="Kaur H" first="Harpreet" last="Kaur">Harpreet Kaur</name>
<name sortKey="Pravalika, Kanta" sort="Pravalika, Kanta" uniqKey="Pravalika K" first="Kanta" last="Pravalika">Kanta Pravalika</name>
<name sortKey="Saraf, Jackson" sort="Saraf, Jackson" uniqKey="Saraf J" first="Jackson" last="Saraf">Jackson Saraf</name>
<name sortKey="Sarmah, Deepaneeta" sort="Sarmah, Deepaneeta" uniqKey="Sarmah D" first="Deepaneeta" last="Sarmah">Deepaneeta Sarmah</name>
<name sortKey="Vats, Kanchan" sort="Vats, Kanchan" uniqKey="Vats K" first="Kanchan" last="Vats">Kanchan Vats</name>
<name sortKey="Wanve, Madhuri" sort="Wanve, Madhuri" uniqKey="Wanve M" first="Madhuri" last="Wanve">Madhuri Wanve</name>
<name sortKey="Yavagal, Dileep R" sort="Yavagal, Dileep R" uniqKey="Yavagal D" first="Dileep R." last="Yavagal">Dileep R. Yavagal</name>
</noCountry>
</tree>
</affiliations>
</record>

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