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Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

Identifieur interne : 000850 ( Ncbi/Merge ); précédent : 000849; suivant : 000851

Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

Auteurs : Derek A. Pociask [États-Unis] ; Keven M. Robinson [États-Unis] ; Kong Chen [États-Unis] ; Kevin J. Mchugh [États-Unis] ; Michelle E. Clay [États-Unis] ; Grace T. Huang [États-Unis] ; Panayiotis V. Benos [États-Unis] ; Yvonne M W. Janssen-Heininger [États-Unis] ; Jay K. Kolls [États-Unis] ; Vikas Anathy [États-Unis] ; John F. Alcorn [États-Unis]

Source :

RBID : pubmed:28193481

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English descriptors

Abstract

Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild-to-moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models; however, little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days after infection. Influenza induced persistent parenchymal lung inflammation, alveolar epithelial metaplasia, and epithelial endoplasmic reticulum stress that were evident after the clearance of virus and resolution of morbidity. Influenza infection induced robust changes in the lung transcriptome, including a significant impact on inflammatory and extracellular matrix protein expression. Despite the robust changes in lung gene expression, preceding influenza (21 days) did not exacerbate secondary Staphylococcus aureus infection. Finally, we examined the impact of influenza on miRNA expression in the lung and found an increase in miR-155. miR-155 knockout mice recovered from influenza infection faster than controls and had decreased lung inflammation and endoplasmic reticulum stress. These data illuminate the dynamic molecular changes in the lung in the weeks after influenza infection and characterize the repair process, identifying a novel role for miR-155.

DOI: 10.1016/j.ajpath.2016.12.012
PubMed: 28193481

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<div type="abstract" xml:lang="en">Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild-to-moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models; however, little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days after infection. Influenza induced persistent parenchymal lung inflammation, alveolar epithelial metaplasia, and epithelial endoplasmic reticulum stress that were evident after the clearance of virus and resolution of morbidity. Influenza infection induced robust changes in the lung transcriptome, including a significant impact on inflammatory and extracellular matrix protein expression. Despite the robust changes in lung gene expression, preceding influenza (21 days) did not exacerbate secondary Staphylococcus aureus infection. Finally, we examined the impact of influenza on miRNA expression in the lung and found an increase in miR-155. miR-155 knockout mice recovered from influenza infection faster than controls and had decreased lung inflammation and endoplasmic reticulum stress. These data illuminate the dynamic molecular changes in the lung in the weeks after influenza infection and characterize the repair process, identifying a novel role for miR-155.</div>
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<AbstractText>Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild-to-moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models; however, little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days after infection. Influenza induced persistent parenchymal lung inflammation, alveolar epithelial metaplasia, and epithelial endoplasmic reticulum stress that were evident after the clearance of virus and resolution of morbidity. Influenza infection induced robust changes in the lung transcriptome, including a significant impact on inflammatory and extracellular matrix protein expression. Despite the robust changes in lung gene expression, preceding influenza (21 days) did not exacerbate secondary Staphylococcus aureus infection. Finally, we examined the impact of influenza on miRNA expression in the lung and found an increase in miR-155. miR-155 knockout mice recovered from influenza infection faster than controls and had decreased lung inflammation and endoplasmic reticulum stress. These data illuminate the dynamic molecular changes in the lung in the weeks after influenza infection and characterize the repair process, identifying a novel role for miR-155.</AbstractText>
<CopyrightInformation>Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Pociask</LastName>
<ForeName>Derek A</ForeName>
<Initials>DA</Initials>
<AffiliationInfo>
<Affiliation>Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, Louisiana; Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</Affiliation>
</AffiliationInfo>
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<LastName>Robinson</LastName>
<ForeName>Keven M</ForeName>
<Initials>KM</Initials>
<AffiliationInfo>
<Affiliation>Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chen</LastName>
<ForeName>Kong</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</Affiliation>
</AffiliationInfo>
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<LastName>McHugh</LastName>
<ForeName>Kevin J</ForeName>
<Initials>KJ</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Clay</LastName>
<ForeName>Michelle E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y">
<LastName>Huang</LastName>
<ForeName>Grace T</ForeName>
<Initials>GT</Initials>
<AffiliationInfo>
<Affiliation>Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania; PhD Program in Computational Biology, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, Pennsylvania.</Affiliation>
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<LastName>Benos</LastName>
<ForeName>Panayiotis V</ForeName>
<Initials>PV</Initials>
<AffiliationInfo>
<Affiliation>Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.</Affiliation>
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<LastName>Janssen-Heininger</LastName>
<ForeName>Yvonne M W</ForeName>
<Initials>YMW</Initials>
<AffiliationInfo>
<Affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</Affiliation>
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<LastName>Kolls</LastName>
<ForeName>Jay K</ForeName>
<Initials>JK</Initials>
<AffiliationInfo>
<Affiliation>Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</Affiliation>
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<LastName>Anathy</LastName>
<ForeName>Vikas</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</Affiliation>
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<LastName>Alcorn</LastName>
<ForeName>John F</ForeName>
<Initials>JF</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania. Electronic address: john.alcorn@chp.edu.</Affiliation>
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<ArticleIdList>
<ArticleId IdType="pubmed">28193481</ArticleId>
<ArticleId IdType="pii">S0002-9440(17)30062-7</ArticleId>
<ArticleId IdType="doi">10.1016/j.ajpath.2016.12.012</ArticleId>
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</ArticleIdList>
<ReferenceList>
<Reference>
<Citation>Semin Respir Crit Care Med. 2016 Aug;37(4):487-500</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">27486731</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell. 2011 Oct 28;147(3):525-38</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22036562</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Respir Res. 2009 Nov 12;10:107</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19909524</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Annu Rev Pathol. 2008;3:499-522</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18039138</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Immunol. 2013 Nov 15;191(10):5153-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24089191</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>MBio. 2011 Nov 15;2(6):null</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22086488</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am Rev Respir Dis. 1961 Feb;83(2)Pt 2:84-97</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">13713780</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Respir Res. 2015 Feb 05;16:10</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25651926</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cancer Inform. 2008;6:389-421</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19259419</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Infect Dis. 2014 Mar;209(6):865-75</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24072844</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Infect Immun. 2015 Oct;83(10):3764-70</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">26216421</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11400-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17600087</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Respir Crit Care Med. 2010 Jul 15;182(2):220-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20395557</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Pathol. 2013 Apr;182(4):1286-96</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23490254</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1;307(5):L395-406</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25038188</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>BMC Genomics. 2014 Jul 11;15:587</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25015185</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S75-82</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21342903</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Acta Pathol Jpn. 1972 Nov;22(4):859-76</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">4350609</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cancer Res. 2007 Aug 15;67(16):7713-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17699775</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biomed Opt. 2013 Apr;18(4):046001</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23545853</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Respir Cell Mol Biol. 2012 May;46(5):573-81</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21799120</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2014 Dec 19;289(51):35246-63</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25339175</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biochem Cell Biol. 2015 Apr;93(2):129-37</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25557625</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Immunol. 1977 Oct;33(2):423-36</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">303150</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2014 Nov 14;9(11):e111520</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25398128</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am Rev Respir Dis. 1983 Oct;128(4):730-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">6625351</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2010 Mar;84(6):3023-32</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20071585</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Immunol. 2009 Oct 15;183(8):5301-10</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19783685</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2012;7(4):e34638</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22514650</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Immunol. 2011 Feb 1;186(3):1666-74</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21178015</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Med. 2008 Mar;14(3):275-81</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18264110</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Lancet. 1958 Nov 29;2(7057):1141-3</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">13612141</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L465-75</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">26589478</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2010 Jul 14;5(7):e11601</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20644650</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Respir Cell Mol Biol. 2011 Sep;45(3):489-97</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21131445</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2008 Dec 18;456(7224):980-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19043405</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Transl Res. 2011 Apr;157(4):191-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21420029</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2007 Apr 27;316(5824):608-11</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17463290</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nucleic Acids Res. 2011 Jul;39(Web Server issue):W416-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21558324</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Exp Med. 2010 Aug 2;207(8):1589-97</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20643828</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Influenza Other Respir Viruses. 2013 Sep;7(5):872-86</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23331969</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Curr Opin Immunol. 2015 Jun;34:59-67</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25723597</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Respir Cell Mol Biol. 2016 Oct;55(4):613-615</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">27689795</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Respir Cell Mol Biol. 2011 Aug;45(2):287-94</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20971881</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Mol Life Sci. 2015 Aug;72(15):2973-88</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25809161</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am Rev Respir Dis. 1990 Aug;142(2):374-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">2166456</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Thorac Dis. 2015 Dec;7(12):E672-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">26793388</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2010 Dec 31;285(53):41328-36</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21036908</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2009 Aug 24;4(8):e6718</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19701459</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2009 Oct 23;284(43):29514-25</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19706597</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L158-67</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">26001778</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2015 Jan 29;517(7536):621-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25533958</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Mar 15;8(6):843-52</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19221491</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2015 Jan 29;517(7536):616-20</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25383540</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Immunol. 2013 Jun;14 (6):593-602</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23603793</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2013 Sep 16;8(9):e74190</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24066118</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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<name sortKey="Benos, Panayiotis V" sort="Benos, Panayiotis V" uniqKey="Benos P" first="Panayiotis V" last="Benos">Panayiotis V. Benos</name>
<name sortKey="Chen, Kong" sort="Chen, Kong" uniqKey="Chen K" first="Kong" last="Chen">Kong Chen</name>
<name sortKey="Clay, Michelle E" sort="Clay, Michelle E" uniqKey="Clay M" first="Michelle E" last="Clay">Michelle E. Clay</name>
<name sortKey="Huang, Grace T" sort="Huang, Grace T" uniqKey="Huang G" first="Grace T" last="Huang">Grace T. Huang</name>
<name sortKey="Janssen Heininger, Yvonne M W" sort="Janssen Heininger, Yvonne M W" uniqKey="Janssen Heininger Y" first="Yvonne M W" last="Janssen-Heininger">Yvonne M W. Janssen-Heininger</name>
<name sortKey="Kolls, Jay K" sort="Kolls, Jay K" uniqKey="Kolls J" first="Jay K" last="Kolls">Jay K. Kolls</name>
<name sortKey="Mchugh, Kevin J" sort="Mchugh, Kevin J" uniqKey="Mchugh K" first="Kevin J" last="Mchugh">Kevin J. Mchugh</name>
<name sortKey="Robinson, Keven M" sort="Robinson, Keven M" uniqKey="Robinson K" first="Keven M" last="Robinson">Keven M. Robinson</name>
</country>
</tree>
</affiliations>
</record>

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