Proinflammatory effects of the hemagglutinin protein of the avian influenza A (H7N9) virus and microRNA‑mediated homeostasis response in THP‑1 cells.
Identifieur interne : 000732 ( Ncbi/Merge ); précédent : 000731; suivant : 000733Proinflammatory effects of the hemagglutinin protein of the avian influenza A (H7N9) virus and microRNA‑mediated homeostasis response in THP‑1 cells.
Auteurs : Shaobo Zhang [République populaire de Chine] ; Dayong Gu [République populaire de Chine] ; Xiaoxi Ouyang [République populaire de Chine] ; Weidong Xie [République populaire de Chine]Source :
- Molecular medicine reports [ 1791-3004 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Homéostasie, Humains, Interleukine-1 alpha (immunologie), Interleukine-1 bêta (immunologie), Interleukine-6 (immunologie), Lignée cellulaire tumorale, Protéines virales (métabolisme), Récepteur de type Toll-4 (métabolisme), Régulation de l'expression des gènes, Sous-type H7N9 du virus de la grippe A, Stress physiologique, Techniques de knock-down de gènes, microARN (génétique), microARN (métabolisme).
- MESH :
- génétique : ARN messager, microARN.
- immunologie : Interleukine-1 alpha, Interleukine-1 bêta, Interleukine-6.
- métabolisme : ARN messager, Glycoprotéine hémagglutinine du virus influenza, Protéines virales, Récepteur de type Toll-4, microARN.
- Homéostasie, Humains, Lignée cellulaire tumorale, Régulation de l'expression des gènes, Sous-type H7N9 du virus de la grippe A, Stress physiologique, Techniques de knock-down de gènes.
English descriptors
- KwdEn :
- Cell Line, Tumor, Gene Expression Regulation, Gene Knockdown Techniques, Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Homeostasis, Humans, Influenza A Virus, H7N9 Subtype, Interleukin-1alpha (immunology), Interleukin-1beta (immunology), Interleukin-6 (immunology), MicroRNAs (genetics), MicroRNAs (metabolism), RNA, Messenger (genetics), RNA, Messenger (metabolism), Stress, Physiological, Toll-Like Receptor 4 (metabolism), Viral Proteins (metabolism).
- MESH :
- chemical , genetics : MicroRNAs, RNA, Messenger.
- chemical , immunology : Interleukin-1alpha, Interleukin-1beta, Interleukin-6.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, MicroRNAs, RNA, Messenger, Toll-Like Receptor 4, Viral Proteins.
- Cell Line, Tumor, Gene Expression Regulation, Gene Knockdown Techniques, Homeostasis, Humans, Influenza A Virus, H7N9 Subtype, Stress, Physiological.
Abstract
The pathology and immunological responses to hemagglutinin (HA) from H7N9 avian influenza viruses in humans remain unclear. The present study aimed to investigate the proinflammatory activity of the HA protein obtained from H7N9 viruses and the mechanisms underlying the homeostasis of microRNAs (miRNAs) in response to inflammatory stimuli. The expression of proinflammatory factors and miRNAs was assayed in the THP‑1 cells using reverse transcription‑quantitative polymerase chain reaction. Results showed that HA significantly increased the expression of interleukin (IL)‑1α, IL‑1β and IL‑6 in the THP‑1 cells. Furthermore, HA and lipopolysaccharide exhibited synergic effects on the expression of IL‑1α, IL‑1β and IL‑6 in the THP‑1 cells. Let‑7e can target IL‑6 and inhibit its expression. Notably, HA significantly increased let‑7e expression in THP‑1 cells and decreased the let‑7e levels in the medium. However, the knockdown of toll‑like receptor 4 (TLR4) significantly attenuated the effects of HA. These results indicate that the HA can induce inflammatory stress and may trigger an miRNA‑mediated homeostasis response to this stress. The effects of HA appeared to be mediated by the TLR4 pathway.
DOI: 10.3892/mmr.2015.4142
PubMed: 26238163
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000411
- to stream PubMed, to step Curation: 000410
- to stream PubMed, to step Checkpoint: 000398
Links to Exploration step
pubmed:26238163Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proinflammatory effects of the hemagglutinin protein of the avian influenza A (H7N9) virus and microRNA‑mediated homeostasis response in THP‑1 cells.</title><author><name sortKey="Zhang, Shaobo" sort="Zhang, Shaobo" uniqKey="Zhang S" first="Shaobo" last="Zhang">Shaobo Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055</wicri:regionArea><wicri:noRegion>Guangdong 518055</wicri:noRegion></affiliation></author><author><name sortKey="Gu, Dayong" sort="Gu, Dayong" uniqKey="Gu D" first="Dayong" last="Gu">Dayong Gu</name><affiliation wicri:level="1"><nlm:affiliation>Central Laboratory of Health Quarantine, International Travel Health Care Center, Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, Guangdong 518033, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory of Health Quarantine, International Travel Health Care Center, Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, Guangdong 518033</wicri:regionArea><wicri:noRegion>Guangdong 518033</wicri:noRegion></affiliation></author><author><name sortKey="Ouyang, Xiaoxi" sort="Ouyang, Xiaoxi" uniqKey="Ouyang X" first="Xiaoxi" last="Ouyang">Xiaoxi Ouyang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Inspection and Quarantine, School of Public Health, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Health Inspection and Quarantine, School of Public Health, Sun Yat‑Sen University, Guangzhou, Guangdong 510080</wicri:regionArea><wicri:noRegion>Guangdong 510080</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Weidong" sort="Xie, Weidong" uniqKey="Xie W" first="Weidong" last="Xie">Weidong Xie</name><affiliation wicri:level="1"><nlm:affiliation>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055</wicri:regionArea><wicri:noRegion>Guangdong 518055</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26238163</idno><idno type="pmid">26238163</idno><idno type="doi">10.3892/mmr.2015.4142</idno><idno type="wicri:Area/PubMed/Corpus">000411</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000411</idno><idno type="wicri:Area/PubMed/Curation">000410</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000410</idno><idno type="wicri:Area/PubMed/Checkpoint">000398</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000398</idno><idno type="wicri:Area/Ncbi/Merge">000732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Proinflammatory effects of the hemagglutinin protein of the avian influenza A (H7N9) virus and microRNA‑mediated homeostasis response in THP‑1 cells.</title><author><name sortKey="Zhang, Shaobo" sort="Zhang, Shaobo" uniqKey="Zhang S" first="Shaobo" last="Zhang">Shaobo Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055</wicri:regionArea><wicri:noRegion>Guangdong 518055</wicri:noRegion></affiliation></author><author><name sortKey="Gu, Dayong" sort="Gu, Dayong" uniqKey="Gu D" first="Dayong" last="Gu">Dayong Gu</name><affiliation wicri:level="1"><nlm:affiliation>Central Laboratory of Health Quarantine, International Travel Health Care Center, Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, Guangdong 518033, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory of Health Quarantine, International Travel Health Care Center, Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, Guangdong 518033</wicri:regionArea><wicri:noRegion>Guangdong 518033</wicri:noRegion></affiliation></author><author><name sortKey="Ouyang, Xiaoxi" sort="Ouyang, Xiaoxi" uniqKey="Ouyang X" first="Xiaoxi" last="Ouyang">Xiaoxi Ouyang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Inspection and Quarantine, School of Public Health, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Health Inspection and Quarantine, School of Public Health, Sun Yat‑Sen University, Guangzhou, Guangdong 510080</wicri:regionArea><wicri:noRegion>Guangdong 510080</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Weidong" sort="Xie, Weidong" uniqKey="Xie W" first="Weidong" last="Xie">Weidong Xie</name><affiliation wicri:level="1"><nlm:affiliation>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055</wicri:regionArea><wicri:noRegion>Guangdong 518055</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular medicine reports</title><idno type="eISSN">1791-3004</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line, Tumor</term><term>Gene Expression Regulation</term><term>Gene Knockdown Techniques</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Homeostasis</term><term>Humans</term><term>Influenza A Virus, H7N9 Subtype</term><term>Interleukin-1alpha (immunology)</term><term>Interleukin-1beta (immunology)</term><term>Interleukin-6 (immunology)</term><term>MicroRNAs (genetics)</term><term>MicroRNAs (metabolism)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Stress, Physiological</term><term>Toll-Like Receptor 4 (metabolism)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term><term>Homéostasie</term><term>Humains</term><term>Interleukine-1 alpha (immunologie)</term><term>Interleukine-1 bêta (immunologie)</term><term>Interleukine-6 (immunologie)</term><term>Lignée cellulaire tumorale</term><term>Protéines virales (métabolisme)</term><term>Récepteur de type Toll-4 (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Sous-type H7N9 du virus de la grippe A</term><term>Stress physiologique</term><term>Techniques de knock-down de gènes</term><term>microARN (génétique)</term><term>microARN (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MicroRNAs</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interleukin-1alpha</term><term>Interleukin-1beta</term><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>MicroRNAs</term><term>RNA, Messenger</term><term>Toll-Like Receptor 4</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>microARN</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interleukine-1 alpha</term><term>Interleukine-1 bêta</term><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Protéines virales</term><term>Récepteur de type Toll-4</term><term>microARN</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Gene Expression Regulation</term><term>Gene Knockdown Techniques</term><term>Homeostasis</term><term>Humans</term><term>Influenza A Virus, H7N9 Subtype</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Homéostasie</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Régulation de l'expression des gènes</term><term>Sous-type H7N9 du virus de la grippe A</term><term>Stress physiologique</term><term>Techniques de knock-down de gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathology and immunological responses to hemagglutinin (HA) from H7N9 avian influenza viruses in humans remain unclear. The present study aimed to investigate the proinflammatory activity of the HA protein obtained from H7N9 viruses and the mechanisms underlying the homeostasis of microRNAs (miRNAs) in response to inflammatory stimuli. The expression of proinflammatory factors and miRNAs was assayed in the THP‑1 cells using reverse transcription‑quantitative polymerase chain reaction. Results showed that HA significantly increased the expression of interleukin (IL)‑1α, IL‑1β and IL‑6 in the THP‑1 cells. Furthermore, HA and lipopolysaccharide exhibited synergic effects on the expression of IL‑1α, IL‑1β and IL‑6 in the THP‑1 cells. Let‑7e can target IL‑6 and inhibit its expression. Notably, HA significantly increased let‑7e expression in THP‑1 cells and decreased the let‑7e levels in the medium. However, the knockdown of toll‑like receptor 4 (TLR4) significantly attenuated the effects of HA. These results indicate that the HA can induce inflammatory stress and may trigger an miRNA‑mediated homeostasis response to this stress. The effects of HA appeared to be mediated by the TLR4 pathway.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26238163</PMID><DateCompleted><Year>2016</Year><Month>07</Month><Day>21</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1791-3004</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Molecular medicine reports</Title><ISOAbbreviation>Mol Med Rep</ISOAbbreviation></Journal><ArticleTitle>Proinflammatory effects of the hemagglutinin protein of the avian influenza A (H7N9) virus and microRNA‑mediated homeostasis response in THP‑1 cells.</ArticleTitle><Pagination><MedlinePgn>6241-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3892/mmr.2015.4142</ELocationID><Abstract><AbstractText>The pathology and immunological responses to hemagglutinin (HA) from H7N9 avian influenza viruses in humans remain unclear. The present study aimed to investigate the proinflammatory activity of the HA protein obtained from H7N9 viruses and the mechanisms underlying the homeostasis of microRNAs (miRNAs) in response to inflammatory stimuli. The expression of proinflammatory factors and miRNAs was assayed in the THP‑1 cells using reverse transcription‑quantitative polymerase chain reaction. Results showed that HA significantly increased the expression of interleukin (IL)‑1α, IL‑1β and IL‑6 in the THP‑1 cells. Furthermore, HA and lipopolysaccharide exhibited synergic effects on the expression of IL‑1α, IL‑1β and IL‑6 in the THP‑1 cells. Let‑7e can target IL‑6 and inhibit its expression. Notably, HA significantly increased let‑7e expression in THP‑1 cells and decreased the let‑7e levels in the medium. However, the knockdown of toll‑like receptor 4 (TLR4) significantly attenuated the effects of HA. These results indicate that the HA can induce inflammatory stress and may trigger an miRNA‑mediated homeostasis response to this stress. The effects of HA appeared to be mediated by the TLR4 pathway.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Shaobo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Dayong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Central Laboratory of Health Quarantine, International Travel Health Care Center, Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, Guangdong 518033, P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ouyang</LastName><ForeName>Xiaoxi</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Health Inspection and Quarantine, School of Public Health, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Weidong</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Shenzhen Key Lab of Health Science and Technology, Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R. China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Greece</Country><MedlineTA>Mol Med Rep</MedlineTA><NlmUniqueID>101475259</NlmUniqueID><ISSNLinking>1791-2997</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508584">IL1A protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508585">IL1B protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053582">Interleukin-1alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D035683">MicroRNAs</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495345">TLR4 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C109963">hemagglutinin, avian influenza A virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C487931">mirnlet7 microRNA, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055785" MajorTopicYN="N">Gene Knockdown Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="Y">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064766" MajorTopicYN="Y">Influenza A Virus, H7N9 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053582" MajorTopicYN="N">Interleukin-1alpha</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D035683" MajorTopicYN="N">MicroRNAs</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26238163</ArticleId><ArticleId IdType="doi">10.3892/mmr.2015.4142</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Shaobo" sort="Zhang, Shaobo" uniqKey="Zhang S" first="Shaobo" last="Zhang">Shaobo Zhang</name></noRegion><name sortKey="Gu, Dayong" sort="Gu, Dayong" uniqKey="Gu D" first="Dayong" last="Gu">Dayong Gu</name><name sortKey="Ouyang, Xiaoxi" sort="Ouyang, Xiaoxi" uniqKey="Ouyang X" first="Xiaoxi" last="Ouyang">Xiaoxi Ouyang</name><name sortKey="Xie, Weidong" sort="Xie, Weidong" uniqKey="Xie W" first="Weidong" last="Xie">Weidong Xie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000732 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000732 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:26238163
|texte= Proinflammatory effects of the hemagglutinin protein of the avian influenza A (H7N9) virus and microRNA‑mediated homeostasis response in THP‑1 cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:26238163" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |