StressCovidV1, Ncbi, Merge, bibRecord, 000537

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.

Identifieur interne : 000537 ( Ncbi/Merge ); précédent : 000536; suivant : 000538

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.

Auteurs : Koji Onomoto [Japon] ; Michihiko Jogi ; Ji-Seung Yoo ; Ryo Narita ; Shiho Morimoto ; Azumi Takemura ; Suryaprakash Sambhara ; Atushi Kawaguchi ; Suguru Osari ; Kyosuke Nagata ; Tomoh Matsumiya ; Hideo Namiki ; Mitsutoshi Yoneyama ; Takashi Fujita

Source :

PloS one [ 1932-6203 ] ; 2012.

RBID : pubmed:22912779

Descripteurs français

English descriptors

KwdEn :
- Animals, Antibodies, Viral (immunology), Chlorocebus aethiops, Cytoplasmic Granules (immunology), DEAD Box Protein 58, DEAD-box RNA Helicases (immunology), DEAD-box RNA Helicases (metabolism), Fibroblasts, HeLa Cells, Humans, Immunity, Innate (immunology), Immunohistochemistry, Influenza A virus (immunology), Interferon Type I (immunology), Mice, Mice, Knockout, Orthomyxoviridae Infections (immunology), RNA, Viral (metabolism), Vero Cells, eIF-2 Kinase (immunology), eIF-2 Kinase (metabolism).
MESH :
- chemical , immunology : Antibodies, Viral, DEAD-box RNA Helicases, Interferon Type I, eIF-2 Kinase.
- immunology : Cytoplasmic Granules, Immunity, Innate, Influenza A virus, Orthomyxoviridae Infections.
- chemical , metabolism : DEAD-box RNA Helicases, RNA, Viral, eIF-2 Kinase.
- Animals, Chlorocebus aethiops, DEAD Box Protein 58, Fibroblasts, HeLa Cells, Humans, Immunohistochemistry, Mice, Mice, Knockout, Vero Cells.

Abstract

Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) function as cytoplasmic sensors for viral RNA to initiate antiviral responses including type I interferon (IFN) production. It has been unclear how RIG-I encounters and senses viral RNA. To address this issue, we examined intracellular localization of RIG-I in response to viral infection using newly generated anti-RIG-I antibody. Immunohistochemical analysis revealed that RLRs localized in virus-induced granules containing stress granule (SG) markers together with viral RNA and antiviral proteins. Because of similarity in morphology and components, we termed these aggregates antiviral stress granules (avSGs). Influenza A virus (IAV) deficient in non-structural protein 1 (NS1) efficiently generated avSGs as well as IFN, however IAV encoding NS1 produced little. Inhibition of avSGs formation by removal of either the SG component or double-stranded RNA (dsRNA)-dependent protein kinase (PKR) resulted in diminished IFN production and concomitant enhancement of viral replication. Furthermore, we observed that transfection of dsRNA resulted in IFN production in an avSGs-dependent manner. These results strongly suggest that the avSG is the locus for non-self RNA sensing and the orchestration of multiple proteins is critical in the triggering of antiviral responses.

DOI: 10.1371/journal.pone.0043031
PubMed: 22912779

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000560
to stream PubMed, to step Curation: 000558
to stream PubMed, to step Checkpoint: 000586

Links to Exploration step

pubmed:22912779

Le document en format XML

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<front><div type="abstract" xml:lang="en">Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) function as cytoplasmic sensors for viral RNA to initiate antiviral responses including type I interferon (IFN) production. It has been unclear how RIG-I encounters and senses viral RNA. To address this issue, we examined intracellular localization of RIG-I in response to viral infection using newly generated anti-RIG-I antibody. Immunohistochemical analysis revealed that RLRs localized in virus-induced granules containing stress granule (SG) markers together with viral RNA and antiviral proteins. Because of similarity in morphology and components, we termed these aggregates antiviral stress granules (avSGs). Influenza A virus (IAV) deficient in non-structural protein 1 (NS1) efficiently generated avSGs as well as IFN, however IAV encoding NS1 produced little. Inhibition of avSGs formation by removal of either the SG component or double-stranded RNA (dsRNA)-dependent protein kinase (PKR) resulted in diminished IFN production and concomitant enhancement of viral replication. Furthermore, we observed that transfection of dsRNA resulted in IFN production in an avSGs-dependent manner. These results strongly suggest that the avSG is the locus for non-self RNA sensing and the orchestration of multiple proteins is critical in the triggering of antiviral responses.</div>
</front>
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<Abstract><AbstractText>Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) function as cytoplasmic sensors for viral RNA to initiate antiviral responses including type I interferon (IFN) production. It has been unclear how RIG-I encounters and senses viral RNA. To address this issue, we examined intracellular localization of RIG-I in response to viral infection using newly generated anti-RIG-I antibody. Immunohistochemical analysis revealed that RLRs localized in virus-induced granules containing stress granule (SG) markers together with viral RNA and antiviral proteins. Because of similarity in morphology and components, we termed these aggregates antiviral stress granules (avSGs). Influenza A virus (IAV) deficient in non-structural protein 1 (NS1) efficiently generated avSGs as well as IFN, however IAV encoding NS1 produced little. Inhibition of avSGs formation by removal of either the SG component or double-stranded RNA (dsRNA)-dependent protein kinase (PKR) resulted in diminished IFN production and concomitant enhancement of viral replication. Furthermore, we observed that transfection of dsRNA resulted in IFN production in an avSGs-dependent manner. These results strongly suggest that the avSG is the locus for non-self RNA sensing and the orchestration of multiple proteins is critical in the triggering of antiviral responses.</AbstractText>
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Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.

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