Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
Identifieur interne : 000904 ( Ncbi/Curation ); précédent : 000903; suivant : 000905Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
Auteurs : Chong Jie [République populaire de Chine] ; Zhuo Luo [République populaire de Chine] ; Huan Chen [République populaire de Chine] ; Min Wang [République populaire de Chine] ; Chang Yan [République populaire de Chine] ; Zhong-Fu Mao [République populaire de Chine] ; Gao-Keng Xiao [République populaire de Chine] ; Hiroshi Kurihara [République populaire de Chine] ; Yi-Fang Li [République populaire de Chine] ; Rong-Rong He [République populaire de Chine]Source :
- Oncotarget [ 1949-2553 ] ; 2017.
Abstract
Isatis indigotica has a long history in treating virus infection and related symptoms in China. Nevertheless, its antivirus evidence in animal studies is not satisfactory, which might be due to the lack of appropriate animal model. Previously, we had utilized restraint stress to establish mouse H1N1 susceptibility model which was helpful in evaluating the anti-virus effect of medicines targeting host factors, such as type I interferon production. In this study, this model was employed to investigate the effect and mechanism of indirubin, a natural bisindole alkaloid from Isatis indigotica, on influenza A virus susceptibility. In the in vitro study, the stress hormone corticosterone was used to simulate restraint stress. Our results demonstrated that indirubin decreased the susceptibility to influenza virus with lowered mortality and alleviated lung damage in restraint-stressed mice model. Moreover, indirubin promoted the expression of interferon-β and interferon inducible transmembrane 3. In addition, indirubin maintained the morphology and function of mitochondria following influenza A virus infection. Further study revealed that indirubin promoted interferon-β production through promoting mitochondrial antiviral signaling pathway. Our study indicated that indirubin could be a candidate for the therapy of influenza.
DOI: 10.18632/oncotarget.22350
PubMed: 29285277
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last="Luo">Zhuo Luo</name><affiliation wicri:level="1"><nlm:affiliation>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Chen, Huan" sort="Chen, Huan" uniqKey="Chen H" first="Huan" last="Chen">Huan Chen</name><affiliation wicri:level="1"><nlm:affiliation>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 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wicri:level="1"><nlm:affiliation>Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Kurihara, Hiroshi" sort="Kurihara, Hiroshi" uniqKey="Kurihara H" first="Hiroshi" last="Kurihara">Hiroshi Kurihara</name><affiliation wicri:level="1"><nlm:affiliation>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Yi Fang" sort="Li, Yi Fang" uniqKey="Li Y" first="Yi-Fang" last="Li">Yi-Fang Li</name><affiliation wicri:level="1"><nlm:affiliation>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="He, Rong Rong" sort="He, Rong Rong" uniqKey="He R" first="Rong-Rong" last="He">Rong-Rong He</name><affiliation wicri:level="1"><nlm:affiliation>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><i>Isatis indigotica</i> has a long history in treating virus infection and related symptoms in China. Nevertheless, its antivirus evidence in animal studies is not satisfactory, which might be due to the lack of appropriate animal model. Previously, we had utilized restraint stress to establish mouse H1N1 susceptibility model which was helpful in evaluating the anti-virus effect of medicines targeting host factors, such as type I interferon production. In this study, this model was employed to investigate the effect and mechanism of indirubin, a natural bisindole alkaloid from <i>Isatis indigotica</i>, on influenza A virus susceptibility. In the <i>in vitro</i> study, the stress hormone corticosterone was used to simulate restraint stress. Our results demonstrated that indirubin decreased the susceptibility to influenza virus with lowered mortality and alleviated lung damage in restraint-stressed mice model. Moreover, indirubin promoted the expression of interferon-β and interferon inducible transmembrane 3. In addition, indirubin maintained the morphology and function of mitochondria following influenza A virus infection. Further study revealed that indirubin promoted interferon-β production through promoting mitochondrial antiviral signaling pathway. Our study indicated that indirubin could be a candidate for the therapy of influenza.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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