Clinical, scientific and ethnographic studies of influenza in quarantine.
Identifieur interne : 000544 ( Ncbi/Curation ); précédent : 000543; suivant : 000545Clinical, scientific and ethnographic studies of influenza in quarantine.
Auteurs : John S. Oxford [Royaume-Uni] ; Juliette R. OxfordSource :
- Expert review of vaccines [ 1744-8395 ] ; 2012.
Descripteurs français
- KwdFr :
- Anthropologie culturelle (), Essais cliniques comme sujet, Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (transmission), Humains, Hôpitaux d'isolement, Lutte contre l'infection (), Lymphocytes T CD4+ (immunologie), Quarantaine, Recherche biomédicale (), Recherche biomédicale (organisation et administration), Tests d'hémagglutination (), Transduction du signal, Transmission de maladie infectieuse (), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité).
- MESH :
- immunologie : Grippe humaine, Lymphocytes T CD4+, Virus de la grippe A.
- organisation et administration : Recherche biomédicale.
- pathogénicité : Virus de la grippe A.
- Anthropologie culturelle, Essais cliniques comme sujet, Grippe humaine, Humains, Hôpitaux d'isolement, Lutte contre l'infection, Quarantaine, Recherche biomédicale, Tests d'hémagglutination, Transduction du signal, Transmission de maladie infectieuse.
English descriptors
- KwdEn :
- Anthropology, Cultural (methods), Biomedical Research (methods), Biomedical Research (organization & administration), CD4-Positive T-Lymphocytes (immunology), Clinical Trials as Topic, Disease Transmission, Infectious (prevention & control), Hemagglutination Tests (methods), Hospitals, Isolation, Humans, Infection Control (methods), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (transmission), Quarantine, Signal Transduction.
- MESH :
- immunology : CD4-Positive T-Lymphocytes, Influenza A virus, Influenza, Human.
- methods : Anthropology, Cultural, Biomedical Research, Hemagglutination Tests, Infection Control.
- organization & administration : Biomedical Research.
- pathogenicity : Influenza A virus.
- prevention & control : Disease Transmission, Infectious, Influenza, Human.
- transmission : Influenza, Human.
- Clinical Trials as Topic, Hospitals, Isolation, Humans, Quarantine, Signal Transduction.
Abstract
From the time of the Spanish influenza pandemic in 1918 to the present seclusion of volunteers in quarantine units, either modified hotels, Phase I units or specially constructed clinics, have been key in investigating new vaccines and antivirals. Carefully selected healthy, young volunteers undergo a 10-12-day sojourn under intense medical supervision. Clinical sampling includes nasal and throat washes for virus recovery, blood for clinical chemistry, analysis of B- and T-cell response and, more recently, analysis of human genes responding to infection. The authors' studies are resulting in new developments of universal influenza vaccines that could stimulate and prime CD4 and CD8 cells to shared epitopes in all influenza A viruses. Ethnographic study has noted an absence of quarantine stress in the volunteers for the first time.
DOI: 10.1586/erv.12.77
PubMed: 23002974
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pubmed:23002974Le document en format XML
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Oxford</name><affiliation wicri:level="1"><nlm:affiliation>Blizard Institute of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology Ltd, Queen Mary's BioEnterprises, Innovation Centre, 42 New Road, E1 2AX London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute of Cell and Molecular Science, Bart's and the London, and Retroscreen Virology Ltd, Queen Mary's BioEnterprises, Innovation Centre, 42 New Road, E1 2AX London</wicri:regionArea><wicri:noRegion>E1 2AX London</wicri:noRegion></affiliation></author><author><name sortKey="Oxford, Juliette R" sort="Oxford, Juliette R" uniqKey="Oxford J" first="Juliette R" last="Oxford">Juliette R. Oxford</name></author></analytic><series><title level="j">Expert review of vaccines</title><idno type="eISSN">1744-8395</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthropology, Cultural (methods)</term><term>Biomedical Research (methods)</term><term>Biomedical Research (organization & administration)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Clinical Trials as Topic</term><term>Disease Transmission, Infectious (prevention & control)</term><term>Hemagglutination Tests (methods)</term><term>Hospitals, Isolation</term><term>Humans</term><term>Infection Control (methods)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (transmission)</term><term>Quarantine</term><term>Signal Transduction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anthropologie culturelle ()</term><term>Essais cliniques comme sujet</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (transmission)</term><term>Humains</term><term>Hôpitaux d'isolement</term><term>Lutte contre l'infection ()</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Quarantaine</term><term>Recherche biomédicale ()</term><term>Recherche biomédicale (organisation et administration)</term><term>Tests d'hémagglutination ()</term><term>Transduction du signal</term><term>Transmission de maladie infectieuse ()</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Lymphocytes T CD4+</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>Influenza A virus</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Anthropology, Cultural</term><term>Biomedical Research</term><term>Hemagglutination Tests</term><term>Infection Control</term></keywords><keywords scheme="MESH" qualifier="organisation et administration" xml:lang="fr"><term>Recherche biomédicale</term></keywords><keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>Biomedical Research</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Transmission, Infectious</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term><term>Hospitals, Isolation</term><term>Humans</term><term>Quarantine</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anthropologie culturelle</term><term>Essais cliniques comme sujet</term><term>Grippe humaine</term><term>Humains</term><term>Hôpitaux d'isolement</term><term>Lutte contre l'infection</term><term>Quarantaine</term><term>Recherche biomédicale</term><term>Tests d'hémagglutination</term><term>Transduction du signal</term><term>Transmission de maladie infectieuse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From the time of the Spanish influenza pandemic in 1918 to the present seclusion of volunteers in quarantine units, either modified hotels, Phase I units or specially constructed clinics, have been key in investigating new vaccines and antivirals. Carefully selected healthy, young volunteers undergo a 10-12-day sojourn under intense medical supervision. Clinical sampling includes nasal and throat washes for virus recovery, blood for clinical chemistry, analysis of B- and T-cell response and, more recently, analysis of human genes responding to infection. The authors' studies are resulting in new developments of universal influenza vaccines that could stimulate and prime CD4 and CD8 cells to shared epitopes in all influenza A viruses. Ethnographic study has noted an absence of quarantine stress in the volunteers for the first time.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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