Caregiving, repetitive thought, and immune response to vaccination in older adults.
Identifieur interne : 000260 ( Ncbi/Curation ); précédent : 000259; suivant : 000261Caregiving, repetitive thought, and immune response to vaccination in older adults.
Auteurs : Suzanne C. Segerstrom [États-Unis] ; Lindsey J. Schipper ; Richard N. GreenbergSource :
- Brain, behavior, and immunity [ 1090-2139 ] ; 2008.
Descripteurs français
- KwdFr :
- Aidants (psychologie), Analyse de régression, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Attitude envers la santé, Cognition (physiologie), Démence (immunologie), Démence (psychologie), Démence (soins infirmiers), Dépression (immunologie), Dépression (psychologie), Dépression (soins infirmiers), Enquêtes et questionnaires, Femelle, Grippe humaine (immunologie), Humains, Immunité (immunologie), Immunité (physiologie), Interleukine-6 (biosynthèse), Interleukine-6 (immunologie), Interleukine-6 (sang), Mâle, Pensée (activité mentale) (physiologie), Prestations des soins de santé (), Stress psychologique (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Test ELISA, Vaccination, Vaccins antigrippaux (immunologie), Vieillissement (immunologie), Vieillissement (psychologie).
- MESH :
- biosynthèse : Interleukine-6.
- immunologie : Anticorps antiviraux, Démence, Dépression, Grippe humaine, Immunité, Interleukine-6, Stress psychologique, Vaccins antigrippaux, Vieillissement.
- physiologie : Cognition, Immunité, Pensée (activité mentale).
- psychologie : Aidants, Démence, Dépression, Vieillissement.
- sang : Anticorps antiviraux, Interleukine-6.
- soins infirmiers : Démence, Dépression.
- Analyse de régression, Attitude envers la santé, Enquêtes et questionnaires, Femelle, Humains, Mâle, Prestations des soins de santé, Sujet âgé, Sujet âgé de 80 ans ou plus, Test ELISA, Vaccination.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Aging (immunology), Aging (psychology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Attitude to Health, Caregivers (psychology), Cognition (physiology), Delivery of Health Care (methods), Dementia (immunology), Dementia (nursing), Dementia (psychology), Depression (immunology), Depression (nursing), Depression (psychology), Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunity (immunology), Immunity (physiology), Influenza Vaccines (immunology), Influenza, Human (immunology), Interleukin-6 (biosynthesis), Interleukin-6 (blood), Interleukin-6 (immunology), Male, Regression Analysis, Stress, Psychological (immunology), Surveys and Questionnaires, Thinking (physiology), Vaccination.
- MESH :
- chemical , biosynthesis : Interleukin-6.
- chemical , blood : Antibodies, Viral, Interleukin-6.
- immunology : Aging, Antibodies, Viral, Dementia, Depression, Immunity, Influenza Vaccines, Influenza, Human, Interleukin-6, Stress, Psychological.
- methods : Delivery of Health Care.
- nursing : Dementia, Depression.
- physiology : Cognition, Immunity, Thinking.
- psychology : Aging, Caregivers, Dementia, Depression.
- Aged, Aged, 80 and over, Attitude to Health, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Regression Analysis, Surveys and Questionnaires, Vaccination.
Abstract
Chronic stressors such as caregiving have been associated with reduced antibody production after vaccination and elevated interleukin (IL)-6 in older adults. However, individual differences in repetitive thought, that is, frequent or prolonged thought about oneself and one's world, can modify perception and effects of stress. For example, worry during stressful circumstances has been associated with poorer immune outcomes, whereas cognitive processing has been associated with better outcomes. The present study tested the relationship of caregiving and two types of repetitive thought, negative (e.g., worry) and neutral (e.g., reflection), to pre- and post-influenza vaccine antibody and IL-6. Dementia caregivers (n=14) and controls (n=30) were interviewed and had blood drawn pre- and post-vaccine in a multi-wave study. Multi-level models found that caregivers had higher IL-6 than controls after vaccination (t(23)=2.36, p<.05). There were several interactions between caregiver status and repetitive thought in predicting both depression and immune responses to vaccination. Among caregivers, negative repetitive thought predicted more depression and lower antibody titers, whereas neutral repetitive thought predicted less depression and higher antibody titers, but also higher post-vaccination IL-6. Among controls, negative repetitive thought predicted more depression but higher antibody titers, whereas neutral repetitive thought predicted less depression and lower post-vaccination IL-6. In mediational tests, depression did not account for the effects of repetitive thought. Results generally support beneficial effects of neutral repetitive thought and detrimental effects of negative repetitive thought, but those effects may be reduced or even reversed depending on life circumstances.
DOI: 10.1016/j.bbi.2007.11.004
PubMed: 18166335
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pubmed:18166335Le document en format XML
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However, individual differences in repetitive thought, that is, frequent or prolonged thought about oneself and one's world, can modify perception and effects of stress. For example, worry during stressful circumstances has been associated with poorer immune outcomes, whereas cognitive processing has been associated with better outcomes. The present study tested the relationship of caregiving and two types of repetitive thought, negative (e.g., worry) and neutral (e.g., reflection), to pre- and post-influenza vaccine antibody and IL-6. Dementia caregivers (n=14) and controls (n=30) were interviewed and had blood drawn pre- and post-vaccine in a multi-wave study. Multi-level models found that caregivers had higher IL-6 than controls after vaccination (t(23)=2.36, p<.05). There were several interactions between caregiver status and repetitive thought in predicting both depression and immune responses to vaccination. Among caregivers, negative repetitive thought predicted more depression and lower antibody titers, whereas neutral repetitive thought predicted less depression and higher antibody titers, but also higher post-vaccination IL-6. Among controls, negative repetitive thought predicted more depression but higher antibody titers, whereas neutral repetitive thought predicted less depression and lower post-vaccination IL-6. In mediational tests, depression did not account for the effects of repetitive thought. Results generally support beneficial effects of neutral repetitive thought and detrimental effects of negative repetitive thought, but those effects may be reduced or even reversed depending on life circumstances.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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