StressCovidV1, Ncbi, Curation, bibRecord, 000258

Musashi1 RNA‐binding protein regulates oligodendrocyte lineage cell differentiation and survival

Identifieur interne : 000258 ( Ncbi/Curation ); précédent : 000257; suivant : 000259

Musashi1 RNA‐binding protein regulates oligodendrocyte lineage cell differentiation and survival

Auteurs : Nicole R. Dobson ; Yong-Xing Zhou ; Nicole C. Flint ; Regina C. Armstrong

Source :

Glia [ 0894-1491 ] ; 2007.

RBID : PMC:2663423

Abstract

Expression of Musashi1 (Msi1), an evolutionarily conserved RNA‐binding protein, in neural stem cells of the subventricular zone in the postnatal and adult CNS indicates a potential role in the generation of oligodendrocytes. We now show Msi1 expression in a subset of oligodendrocyte progenitor (OP) cells in white matter areas temporally and spatially associated with oligodendrogenesis in the postnatal CNS. Msi1 function was evaluated by infection of OP cells with retroviral transduction of Msi1 or knockdown of endogenous Msi1. Retroviral expression of Msi1 significantly reduced the proportion of mature oligodendrocytes generated from OP cells in vitro and in vivo during myelination. Msi1 transduction also promoted OP survival, particularly under conditions of challenge from oxidative stress, while Msi1 siRNA knockdown resulted in dramatic OP cell death. Furthermore, in experimental demyelination Msi1 expression was increased among cells associated with lesions, including OP cells, indicating a potential role in the generation of remyelinating oligodendrocytes. © 2007 Wiley‐Liss, Inc.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663423

DOI: 10.1002/glia.20615
PubMed: 18098125
PubMed Central: 2663423

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PMC:2663423

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<p>Expression of Musashi1 (Msi1), an evolutionarily conserved RNA‐binding protein, in neural stem cells of the subventricular zone in the postnatal and adult CNS indicates a potential role in the generation of oligodendrocytes. We now show Msi1 expression in a subset of oligodendrocyte progenitor (OP) cells in white matter areas temporally and spatially associated with oligodendrogenesis in the postnatal CNS. Msi1 function was evaluated by infection of OP cells with retroviral transduction of Msi1 or knockdown of endogenous Msi1. Retroviral expression of Msi1 significantly reduced the proportion of mature oligodendrocytes generated from OP cells <italic>in vitro</italic>
 and <italic>in vivo</italic>
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Musashi1 RNA‐binding protein regulates oligodendrocyte lineage cell differentiation and survival

Musashi1 RNA‐binding protein regulates oligodendrocyte lineage cell differentiation and survival

Source :

Abstract

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