N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.
Identifieur interne : 000243 ( Ncbi/Curation ); précédent : 000242; suivant : 000244N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.
Auteurs : A. Garozzo [Italie] ; G. Tempera ; D. Ungheri ; R. Timpanaro ; A. CastroSource :
- International journal of immunopathology and pharmacology [ 0394-6320 ]
Descripteurs français
- KwdFr :
- MESH :
- mortalité : Infections à Orthomyxoviridae.
- pharmacologie : Acétylcystéine, Antiviraux, Oséltamivir.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- Animaux, Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C, Synergie des médicaments.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Acetylcysteine, Antiviral Agents, Oseltamivir.
- drug therapy : Orthomyxoviridae Infections.
- mortality : Orthomyxoviridae Infections.
- Animals, Disease Models, Animal, Drug Synergism, Mice, Mice, Inbred BALB C.
Abstract
Many studies have shown that oxidative stress is important in the pathogenesis of pulmonary damage during influenza virus infections. Antioxidant molecules are therefore potentially useful against viral infection. Our previous studies show that N-acetylcysteine (NAC) has a protective effect in a model of lethal influenza infection in mice. NAC administration significantly decreased the mortality in infected mice. Further studies have demonstrated that NAC enhanced survival in combination with the antiviral agent ribavirin. In the present study, we report the effect of combined treatment with NAC and Oseltamivir, clinically used in the treatment and prevention of influenza virus infection, in a murine model of lethal influenza infection. NAC was given as a single daily dose of 1000 mg/kg starting from 4 h before infection and until day 4 after infection; Oseltamivir was given twice daily at dose of 1 mg/kg/die for 5 days, starting from 4 h before infection. End-point evaluation was 21-days survival. NAC alone was slightly effective (20%), since a suboptimal treatment was used. Survival increased to 60% with Oseltamivir and to 100% with Oseltamivir and NAC used in combination. Since NAC alone does not show any antiviral action, the present findings suggest that antioxidant therapy increase survival by an improvement in host defense mechanisms, and/or by a direct antioxidant effect against oxidative stress associated with viral infection. Our studies demonstrate the effectiveness of combining agents acting through different mechanisms, such as antiviral drugs oseltamivir and the antioxidant NAC, indicating a possible advantage of combining the two treatments.
DOI: 10.1177/039463200702000215
PubMed: 17624247
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000801
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000798
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A97
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000243
Links to Exploration step
pubmed:17624247Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.</title><author><name sortKey="Garozzo, A" sort="Garozzo, A" uniqKey="Garozzo A" first="A" last="Garozzo">A. Garozzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiological and Gynaecological Sciences, University of Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Microbiological and Gynaecological Sciences, University of Catania</wicri:regionArea><wicri:noRegion>University of Catania</wicri:noRegion></affiliation></author><author><name sortKey="Tempera, G" sort="Tempera, G" uniqKey="Tempera G" first="G" last="Tempera">G. Tempera</name></author><author><name sortKey="Ungheri, D" sort="Ungheri, D" uniqKey="Ungheri D" first="D" last="Ungheri">D. Ungheri</name></author><author><name sortKey="Timpanaro, R" sort="Timpanaro, R" uniqKey="Timpanaro R" first="R" last="Timpanaro">R. Timpanaro</name></author><author><name sortKey="Castro, A" sort="Castro, A" uniqKey="Castro A" first="A" last="Castro">A. Castro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2007 Apr-Jun</MedlineDate></PubDate></date><idno type="RBID">pubmed:17624247</idno><idno type="pmid">17624247</idno><idno type="doi">10.1177/039463200702000215</idno><idno type="wicri:Area/PubMed/Corpus">000801</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000801</idno><idno type="wicri:Area/PubMed/Curation">000798</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000798</idno><idno type="wicri:Area/PubMed/Checkpoint">000A97</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A97</idno><idno type="wicri:Area/Ncbi/Merge">000243</idno><idno type="wicri:Area/Ncbi/Curation">000243</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.</title><author><name sortKey="Garozzo, A" sort="Garozzo, A" uniqKey="Garozzo A" first="A" last="Garozzo">A. Garozzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiological and Gynaecological Sciences, University of Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Microbiological and Gynaecological Sciences, University of Catania</wicri:regionArea><wicri:noRegion>University of Catania</wicri:noRegion></affiliation></author><author><name sortKey="Tempera, G" sort="Tempera, G" uniqKey="Tempera G" first="G" last="Tempera">G. Tempera</name></author><author><name sortKey="Ungheri, D" sort="Ungheri, D" uniqKey="Ungheri D" first="D" last="Ungheri">D. Ungheri</name></author><author><name sortKey="Timpanaro, R" sort="Timpanaro, R" uniqKey="Timpanaro R" first="R" last="Timpanaro">R. Timpanaro</name></author><author><name sortKey="Castro, A" sort="Castro, A" uniqKey="Castro A" first="A" last="Castro">A. Castro</name></author></analytic><series><title level="j">International journal of immunopathology and pharmacology</title><idno type="ISSN">0394-6320</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcysteine (pharmacology)</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Disease Models, Animal</term><term>Drug Synergism</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Orthomyxoviridae Infections (mortality)</term><term>Oseltamivir (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétylcystéine (pharmacologie)</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Infections à Orthomyxoviridae (mortalité)</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Modèles animaux de maladie humaine</term><term>Oséltamivir (pharmacologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Synergie des médicaments</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetylcysteine</term><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acétylcystéine</term><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Drug Synergism</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Synergie des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many studies have shown that oxidative stress is important in the pathogenesis of pulmonary damage during influenza virus infections. Antioxidant molecules are therefore potentially useful against viral infection. Our previous studies show that N-acetylcysteine (NAC) has a protective effect in a model of lethal influenza infection in mice. NAC administration significantly decreased the mortality in infected mice. Further studies have demonstrated that NAC enhanced survival in combination with the antiviral agent ribavirin. In the present study, we report the effect of combined treatment with NAC and Oseltamivir, clinically used in the treatment and prevention of influenza virus infection, in a murine model of lethal influenza infection. NAC was given as a single daily dose of 1000 mg/kg starting from 4 h before infection and until day 4 after infection; Oseltamivir was given twice daily at dose of 1 mg/kg/die for 5 days, starting from 4 h before infection. End-point evaluation was 21-days survival. NAC alone was slightly effective (20%), since a suboptimal treatment was used. Survival increased to 60% with Oseltamivir and to 100% with Oseltamivir and NAC used in combination. Since NAC alone does not show any antiviral action, the present findings suggest that antioxidant therapy increase survival by an improvement in host defense mechanisms, and/or by a direct antioxidant effect against oxidative stress associated with viral infection. Our studies demonstrate the effectiveness of combining agents acting through different mechanisms, such as antiviral drugs oseltamivir and the antioxidant NAC, indicating a possible advantage of combining the two treatments.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000243 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000243 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:17624247
|texte= N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:17624247" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |