Epidemiology of cleft lip and palate. An attempt to rule out chance correlations.
Identifieur interne : 000605 ( Ncbi/Checkpoint ); précédent : 000604; suivant : 000606Epidemiology of cleft lip and palate. An attempt to rule out chance correlations.
Auteurs : I. SaxénSource :
- British journal of preventive & social medicine [ 0007-1242 ] ; 1975.
Descripteurs français
- KwdFr :
- Antihistaminiques des récepteurs H1 (effets indésirables), Bec-de-lièvre (épidémiologie), Bec-de-lièvre (étiologie), Classe sociale, Complications de la grossesse et maladies infectieuses, Consommation d'alcool, Femelle, Fente palatine (épidémiologie), Fente palatine (étiologie), Finlande, Fièvre (), Grippe humaine (), Grossesse, Humains, Malformations dues aux médicaments et aux drogues, Menace d'avortement, Mâle, Nouveau-né, Pelvis (imagerie diagnostique), Prématuré, Radiographie, Saisons, Stress physiologique, Tabagisme.
- MESH :
- effets indésirables : Antihistaminiques des récepteurs H1.
- imagerie diagnostique : Pelvis.
- épidémiologie : Bec-de-lièvre, Fente palatine.
- étiologie : Bec-de-lièvre, Fente palatine.
- Classe sociale, Complications de la grossesse et maladies infectieuses, Consommation d'alcool, Femelle, Finlande, Fièvre, Grippe humaine, Grossesse, Humains, Malformations dues aux médicaments et aux drogues, Menace d'avortement, Mâle, Nouveau-né, Prématuré, Radiographie, Saisons, Stress physiologique, Tabagisme.
English descriptors
- KwdEn :
- Abnormalities, Drug-Induced, Abortion, Threatened, Alcohol Drinking, Cleft Lip (epidemiology), Cleft Lip (etiology), Cleft Palate (epidemiology), Cleft Palate (etiology), Female, Fever (complications), Finland, Histamine H1 Antagonists (adverse effects), Humans, Infant, Newborn, Infant, Premature, Influenza, Human (complications), Male, Pelvis (diagnostic imaging), Pregnancy, Pregnancy Complications, Infectious, Radiography, Seasons, Smoking, Social Class, Stress, Physiological.
- MESH :
- chemical , adverse effects : Histamine H1 Antagonists.
- complications : Fever, Influenza, Human.
- diagnostic imaging : Pelvis.
- epidemiology : Cleft Lip, Cleft Palate.
- etiology : Cleft Lip, Cleft Palate.
- Abnormalities, Drug-Induced, Abortion, Threatened, Alcohol Drinking, Female, Finland, Humans, Infant, Newborn, Infant, Premature, Male, Pregnancy, Pregnancy Complications, Infectious, Radiography, Seasons, Smoking, Social Class, Stress, Physiological.
Abstract
The findings of a previous epidemiological study on oral clefts (599 children) were tested in an independent sample of 194 children, using the same source as for the previous study (Finnish Register of Congenital Malformations). Several of the earlier results--such as seasonal variation and associations between clefts and parental age, social factors, and emotional stress--were not reproduced. It is concluded that chance correlations introduce a marked problem to epidemiological studies. The findings of both studies show that there is an exceptionally high incidence of cleft palate in Finland. Significant geographical variations and associations between clefts and prematurity, threatened abortion during the first and second trimesters, maternal drug consumption during the first trimester, and influenza and fever during the first trimester were found. The possible role of these findings in the aetiology of oral clefts is discussed, and particular attention is paid to the possible teratogenicity of salicylates.
PubMed: 241446
Affiliations:
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An attempt to rule out chance correlations.</title><author><name sortKey="Saxen, I" sort="Saxen, I" uniqKey="Saxen I" first="I" last="Saxén">I. Saxén</name></author></analytic><series><title level="j">British journal of preventive & social medicine</title><idno type="ISSN">0007-1242</idno><imprint><date when="1975" type="published">1975</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abnormalities, Drug-Induced</term><term>Abortion, Threatened</term><term>Alcohol Drinking</term><term>Cleft Lip (epidemiology)</term><term>Cleft Lip (etiology)</term><term>Cleft Palate (epidemiology)</term><term>Cleft Palate (etiology)</term><term>Female</term><term>Fever (complications)</term><term>Finland</term><term>Histamine H1 Antagonists (adverse effects)</term><term>Humans</term><term>Infant, Newborn</term><term>Infant, Premature</term><term>Influenza, Human (complications)</term><term>Male</term><term>Pelvis (diagnostic imaging)</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious</term><term>Radiography</term><term>Seasons</term><term>Smoking</term><term>Social Class</term><term>Stress, Physiological</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antihistaminiques des récepteurs H1 (effets indésirables)</term><term>Bec-de-lièvre (épidémiologie)</term><term>Bec-de-lièvre (étiologie)</term><term>Classe sociale</term><term>Complications de la grossesse et maladies infectieuses</term><term>Consommation d'alcool</term><term>Femelle</term><term>Fente palatine (épidémiologie)</term><term>Fente palatine (étiologie)</term><term>Finlande</term><term>Fièvre ()</term><term>Grippe humaine ()</term><term>Grossesse</term><term>Humains</term><term>Malformations dues aux médicaments et aux drogues</term><term>Menace d'avortement</term><term>Mâle</term><term>Nouveau-né</term><term>Pelvis (imagerie diagnostique)</term><term>Prématuré</term><term>Radiographie</term><term>Saisons</term><term>Stress physiologique</term><term>Tabagisme</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Histamine H1 Antagonists</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Fever</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Pelvis</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antihistaminiques des récepteurs H1</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cleft Lip</term><term>Cleft Palate</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cleft Lip</term><term>Cleft Palate</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Pelvis</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Bec-de-lièvre</term><term>Fente palatine</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Bec-de-lièvre</term><term>Fente palatine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Abnormalities, Drug-Induced</term><term>Abortion, Threatened</term><term>Alcohol Drinking</term><term>Female</term><term>Finland</term><term>Humans</term><term>Infant, Newborn</term><term>Infant, Premature</term><term>Male</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious</term><term>Radiography</term><term>Seasons</term><term>Smoking</term><term>Social Class</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Classe sociale</term><term>Complications de la grossesse et maladies infectieuses</term><term>Consommation d'alcool</term><term>Femelle</term><term>Finlande</term><term>Fièvre</term><term>Grippe humaine</term><term>Grossesse</term><term>Humains</term><term>Malformations dues aux médicaments et aux drogues</term><term>Menace d'avortement</term><term>Mâle</term><term>Nouveau-né</term><term>Prématuré</term><term>Radiographie</term><term>Saisons</term><term>Stress physiologique</term><term>Tabagisme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The findings of a previous epidemiological study on oral clefts (599 children) were tested in an independent sample of 194 children, using the same source as for the previous study (Finnish Register of Congenital Malformations). Several of the earlier results--such as seasonal variation and associations between clefts and parental age, social factors, and emotional stress--were not reproduced. It is concluded that chance correlations introduce a marked problem to epidemiological studies. The findings of both studies show that there is an exceptionally high incidence of cleft palate in Finland. Significant geographical variations and associations between clefts and prematurity, threatened abortion during the first and second trimesters, maternal drug consumption during the first trimester, and influenza and fever during the first trimester were found. The possible role of these findings in the aetiology of oral clefts is discussed, and particular attention is paid to the possible teratogenicity of salicylates.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Saxen, I" sort="Saxen, I" uniqKey="Saxen I" first="I" last="Saxén">I. Saxén</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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