[A thermodynamic analysis of oxidative inactivation of influenza virus and lipid peroxidation of viral envelope lipids].
Identifieur interne : 003B09 ( Main/Merge ); précédent : 003B08; suivant : 003B10[A thermodynamic analysis of oxidative inactivation of influenza virus and lipid peroxidation of viral envelope lipids].
Auteurs : V D PoryvaevSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Membrane Lipids, Viral Envelope Proteins.
- chemical : Fluorescent Dyes.
- Influenza A virus, Lipid Peroxidation, Oxidative Stress, Thermodynamics.
Abstract
The "activation energy" values for virus inactivation (22.2 kcal/mol) calculated using Arrenius formula and the levels of accumulation of the final product of lipid peroxidation, fluorescent pigment (21.2 kcal/mol), in virus envelopes were found to be in good correlation for purified influenza A/PR8/34 virus suspensions stored at temperatures from 6 to 37 degrees C. A "lipid" mechanism of inactivation of enveloped viruses is proposed, permitting, together with the "nucleic" and "protein" mechanisms, a satisfactory interpretation of the relationship between the stability of viral material and the medium composition, lipid composition of virus envelopes, and other factors.
PubMed: 8686266
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pubmed:8686266Le document en format XML
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