Progressive loss of cardiac sympathetic innervation in Parkinson's disease
Identifieur interne : 002B98 ( Main/Merge ); précédent : 002B97; suivant : 002B99Progressive loss of cardiac sympathetic innervation in Parkinson's disease
Auteurs : Sheng-Ting Li [États-Unis] ; Raghuveer Dendi [États-Unis] ; Courtney Holmes [États-Unis] ; David S. Goldstein [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2002-08.
English descriptors
- Teeft :
- Abnormal, Abnormal peak, Abnormality, Accession number, Acta neurol scand, Acute ischemic lesions, Additional families, Address correspondence, Adie syndrome, Adrenocortical insufficiency, Adrenoleukodystrophy, Agat defects, Aldp, Alzheimer disease, Amyloid, Amyloid deposition, Anhidrosis, Anhidrotic, Anhidrotic areas, Anhidrotic side, Animal experiments, Antegrade flow, Antibody, Antibody concentration, Aortic arch, Arch neurol, Areflexia, Arteriovenous malformation, August, Autistic behavior, Autonomic failure, Autonomic neuropathy, Autonomic neuropathy type, Autosomal recessive, Average value, Axial sections, Beer sheva, Beneficial effect, Biopsy, Birth weight, Blood flow, Body temperature, Body weight, Bone marrow transplant, Bone marrow transplantation, Botulinum toxin, Brain creatine, Brain damage, Brain involvement, Brain lesions, Brain parenchyma, Brain spectroscopy, Bruce rappaport faculty, Cardiac, Cardiac uptake, Carotid artery, Case report, Central processing, Centrum semiovale, Cerebellar, Cerebellar infarct, Cerebral forms, Cerebral involvement, Cerebrospinal fluid, Cerebrovascular, Cerebrovascular disease, Cholinergic, Cholinergic fibers, Cholinergic sweat gland innervation, Choroidal arteries, Chromosome, Chronic stimulation, Clin, Clinical features, Clinical neurology, Clinical neurosciences, Clinical symptoms, Coding region, Congenital, Congenital indifference, Congenital insensitivity, Consecutive days, Contralateral side, Control subjects, Cortical liquoral spaces, Creatine, Creatine biosynthesis, Creatine deficiency, Creatine deficiency syndrome, Creatine deficiency syndromes, Creatine levels, Creatine metabolism, Creatine peak, Creatine signal, Creatine supplementation, Creatine transport, Creatine transporter defect, Creatine transporter gene, Cultured skin, Cultured skin fibroblasts, Current address, Cytogenetic, Cytogenetic studies, Defect, Defective creatine transport, Degeneration, Deletion, Denervation, Deoxyguanosine, Deoxyguanosine kinase, Deoxyguanosine kinase gene, Depletion, Depletion syndrome, Desensitizing effect, Dguok, Dguok gene, Dguok protein product, Diffuse loss, Diffusion tensor, Direct effect, Dopaminergic, Dopaminergic drugs, Doppler ultrasonography, Dorsal root ganglia, Dysfunction, Dyskinesia, Dyskinesia score, Early detection, Electron microscopy, Encoding, Environmental conditions, Epidermal, Epidermal innervation, European origin, Exon, Extrapyramidal features, Fallot, Family history, Favourable response, Febrile episodes, Fetal, Fetal brain, Fibers innervating sweat glands, Fibroblast, First child, First scan, First scans, Fluctuation, Force overflow, Force regulation, Further studies, Galen, Galen arteriovenous malformation, Gamt, Gamt deficiency, Gene, Gene encoding, Genet, German patient, Gfpeak, Glycine amidinotransferase, Gray matter, Grip force, Guanidinoacetate, Guanidinoacetate methyltransferase deficiency, Harlequin syndrome, Heart rate variability, Heat intolerance, Hepatocerebral, Hepatocerebral mitochondrial, Hepatocerebral mtdna depletion, Hereditary, Heterozygote, Heterozygous, Heterozygous women, Homozygous mutation, Homozygous nonsense mutation, Human antibodies, Human antibodies reactive, Human antibody, Human brain, Human chromosome, Hyperhidrosis, Hyperhidrotic, Hyperhidrotic area, Hyperhidrotic side, Hyperkpp, Hypotension, Idiopathic disease, Imaging, Immunoglobulin, Impairment, Inactivation, Inborn error, Index case, Indiana university school, Inferior cerebellar artery, Inferior cerebellar artery territory, Innervation, Insensitivity, Interscience, Interventricular septum, Intravenous, Intravenous immunoglobulin, Intravenous immunoglobulin treatment, Ischemia, Ischemic, Istituto nazionale neurologico, Ivig, Ivig preparations, Ivig treatment, Kinase, Language delay, Late complication, Late opacification, Lateral, Lateral ventricles, Lateral wall, Lateral wall radioactivity, Ledd, Lesion, Liver biopsies, Liver failure, Long chain, Lower thoracic, Magnetic resonance imaging, Malformation, Maternal uncles, Mental impairment, Mental retardation, Metabolism, Methyltransferase, Mitochondrial, Modest reduction, Molecular analysis, Morphometric analysis, Mosaic expression, Moser, Motor fluctuations, Motor system, Mouse model, Mtdna, Mtdna depletion, Mtdna levels, Multiple system atrophy, Muscle nerve, Muscle sodium channel, Muscle weakness, Mutation, Mutation analysis, Mutational analysis, Myelinated, Myelinated fiber density, Myelinated fibers, Myocardial radioactivity, Myocardial scintigraphy, Myotonic discharge, National institute, National institutes, Neonatal giant cell hepatitis, Neonate, Nerve, Nerve biopsy, Nerve conduction studies, Nerve endings, Nerve fascicle, Nerve fibers, Nerve growth factor, Neurol, Neurol neurosurg psychiatry, Neurological, Neurological disorders, Neurological examinations, Neurologische klinik, Neurology, Neuromuscul disord, Neuron, Neuropathy, Nonconsanguineous german parents, Nonsense mutation, Normal epidermal, Normal ranges, Normokpp, Normokpp families, Novel mutation, Novel mutations, Ntrk1, Ondrug state, Online, Online mendelian inheritance, Oral creatine monohydrate supplementation, Original family, Original normokpp family, Orthostatic, Orthostatic hypotension, Pain sensation, Painful stimuli, Parkinson disease, Parkinsonian patients, Pathogenic mutation, Peak grip force, Pediatr, Pediatr neurol, Peptide, Percentage decrease, Periodic muscle weakness, Periodic paralyses, Periodic paralysis, Periventricular leukomalacia, Phenotype, Philipps university, Physical examination, Positron, Positron emission tomography scanning, Poskanzer, Precision grip, Prenatal, Present findings, Proc natl acad, Progressive loss, Progressive supranuclear palsy, Putative mutation, Radioactivity, Receptor, Receptor tyrosine kinase, Renal cortex, Renal pelvis, Resonance imaging, Resonance spectroscopic imaging, Retrograde flow, Right cerebellar hemisphere, Right hemisphere, Right side, Right subclavian artery, Ross syndrome, Royal victoria infirmary, Salivary glands, Salomon, Scan, Scn4a, Second scan, Second scans, Secretory responsiveness, Segmental anhidrosis, Segmental hyperhidrosis, Selective degeneration, Selective loss, Sequence analysis, Severe delay, Severe phenotype, Severe reduction, Shunt, Signal alterations, Significant change, Significant decrease, Significant difference, Skin biopsies, Skin biopsy, Small myelinated fibers, Sodium channel gene, Sodium chloride, Soroka university, Standard deviation, Standard error, Subclavian, Subclavian artery, Subthalamic, Subthalamic nucleus, Subtraction angiography, Sudomotor, Sudomotor fibers, Supplementation, Sural, Sural nerve, Sural nerve biopsy, Sweat gland innervation, Sweat glands, Sympathetic denervation, Sympathetic innervation, Sympathetic skin response, Sympathetic terminals, Symptom, Syndrome, Synthetic graft, Temporal lobe, Term neonates, Tetralogy, Third type, Tibial nerves, Tissue concentrations, Tomography, Total repair, Transcranial doppler, Transporter, Transporter defect, Treatment conditions, Trka, Trka gene, University college, University college london, Unknown origin, Unmyelinated, Unmyelinated fibers, Unrelated families, Unremarkable, Updrs motor score, Urine, Vacuo dilatation, Valsalva maneuver, Ventricular, Ventricular myocardium, Ventricular wall, Vertebral artery, Vertebrobasilar, Vertebrobasilar stroke, Vgam, White blood cells, White matter, Wiley interscience, Younger brother, Zhejiang university.
Abstract
This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6‐[18F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6‐[18F]fluorodopamine‐derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying‐back mechanism.
Url:
DOI: 10.1002/ana.10236
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<term>Abnormality</term>
<term>Accession number</term>
<term>Acta neurol scand</term>
<term>Acute ischemic lesions</term>
<term>Additional families</term>
<term>Address correspondence</term>
<term>Adie syndrome</term>
<term>Adrenocortical insufficiency</term>
<term>Adrenoleukodystrophy</term>
<term>Agat defects</term>
<term>Aldp</term>
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<term>Amyloid</term>
<term>Amyloid deposition</term>
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<term>Creatine deficiency syndrome</term>
<term>Creatine deficiency syndromes</term>
<term>Creatine levels</term>
<term>Creatine metabolism</term>
<term>Creatine peak</term>
<term>Creatine signal</term>
<term>Creatine supplementation</term>
<term>Creatine transport</term>
<term>Creatine transporter defect</term>
<term>Creatine transporter gene</term>
<term>Cultured skin</term>
<term>Cultured skin fibroblasts</term>
<term>Current address</term>
<term>Cytogenetic</term>
<term>Cytogenetic studies</term>
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<term>Deoxyguanosine</term>
<term>Deoxyguanosine kinase</term>
<term>Deoxyguanosine kinase gene</term>
<term>Depletion</term>
<term>Depletion syndrome</term>
<term>Desensitizing effect</term>
<term>Dguok</term>
<term>Dguok gene</term>
<term>Dguok protein product</term>
<term>Diffuse loss</term>
<term>Diffusion tensor</term>
<term>Direct effect</term>
<term>Dopaminergic</term>
<term>Dopaminergic drugs</term>
<term>Doppler ultrasonography</term>
<term>Dorsal root ganglia</term>
<term>Dysfunction</term>
<term>Dyskinesia</term>
<term>Dyskinesia score</term>
<term>Early detection</term>
<term>Electron microscopy</term>
<term>Encoding</term>
<term>Environmental conditions</term>
<term>Epidermal</term>
<term>Epidermal innervation</term>
<term>European origin</term>
<term>Exon</term>
<term>Extrapyramidal features</term>
<term>Fallot</term>
<term>Family history</term>
<term>Favourable response</term>
<term>Febrile episodes</term>
<term>Fetal</term>
<term>Fetal brain</term>
<term>Fibers innervating sweat glands</term>
<term>Fibroblast</term>
<term>First child</term>
<term>First scan</term>
<term>First scans</term>
<term>Fluctuation</term>
<term>Force overflow</term>
<term>Force regulation</term>
<term>Further studies</term>
<term>Galen</term>
<term>Galen arteriovenous malformation</term>
<term>Gamt</term>
<term>Gamt deficiency</term>
<term>Gene</term>
<term>Gene encoding</term>
<term>Genet</term>
<term>German patient</term>
<term>Gfpeak</term>
<term>Glycine amidinotransferase</term>
<term>Gray matter</term>
<term>Grip force</term>
<term>Guanidinoacetate</term>
<term>Guanidinoacetate methyltransferase deficiency</term>
<term>Harlequin syndrome</term>
<term>Heart rate variability</term>
<term>Heat intolerance</term>
<term>Hepatocerebral</term>
<term>Hepatocerebral mitochondrial</term>
<term>Hepatocerebral mtdna depletion</term>
<term>Hereditary</term>
<term>Heterozygote</term>
<term>Heterozygous</term>
<term>Heterozygous women</term>
<term>Homozygous mutation</term>
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<term>Human antibodies</term>
<term>Human antibodies reactive</term>
<term>Human antibody</term>
<term>Human brain</term>
<term>Human chromosome</term>
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<term>Hyperhidrotic</term>
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<term>Hyperkpp</term>
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<term>Immunoglobulin</term>
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<term>Index case</term>
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<term>Intravenous immunoglobulin treatment</term>
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<term>Ischemic</term>
<term>Istituto nazionale neurologico</term>
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<term>Ivig preparations</term>
<term>Ivig treatment</term>
<term>Kinase</term>
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<term>Late complication</term>
<term>Late opacification</term>
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<term>Lateral ventricles</term>
<term>Lateral wall</term>
<term>Lateral wall radioactivity</term>
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<term>Lesion</term>
<term>Liver biopsies</term>
<term>Liver failure</term>
<term>Long chain</term>
<term>Lower thoracic</term>
<term>Magnetic resonance imaging</term>
<term>Malformation</term>
<term>Maternal uncles</term>
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<term>Mental retardation</term>
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<term>Mtdna levels</term>
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<term>Mutational analysis</term>
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<term>Myelinated fiber density</term>
<term>Myelinated fibers</term>
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<term>Myocardial scintigraphy</term>
<term>Myotonic discharge</term>
<term>National institute</term>
<term>National institutes</term>
<term>Neonatal giant cell hepatitis</term>
<term>Neonate</term>
<term>Nerve</term>
<term>Nerve biopsy</term>
<term>Nerve conduction studies</term>
<term>Nerve endings</term>
<term>Nerve fascicle</term>
<term>Nerve fibers</term>
<term>Nerve growth factor</term>
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<term>Neurol neurosurg psychiatry</term>
<term>Neurological</term>
<term>Neurological disorders</term>
<term>Neurological examinations</term>
<term>Neurologische klinik</term>
<term>Neurology</term>
<term>Neuromuscul disord</term>
<term>Neuron</term>
<term>Neuropathy</term>
<term>Nonconsanguineous german parents</term>
<term>Nonsense mutation</term>
<term>Normal epidermal</term>
<term>Normal ranges</term>
<term>Normokpp</term>
<term>Normokpp families</term>
<term>Novel mutation</term>
<term>Novel mutations</term>
<term>Ntrk1</term>
<term>Ondrug state</term>
<term>Online</term>
<term>Online mendelian inheritance</term>
<term>Oral creatine monohydrate supplementation</term>
<term>Original family</term>
<term>Original normokpp family</term>
<term>Orthostatic</term>
<term>Orthostatic hypotension</term>
<term>Pain sensation</term>
<term>Painful stimuli</term>
<term>Parkinson disease</term>
<term>Parkinsonian patients</term>
<term>Pathogenic mutation</term>
<term>Peak grip force</term>
<term>Pediatr</term>
<term>Pediatr neurol</term>
<term>Peptide</term>
<term>Percentage decrease</term>
<term>Periodic muscle weakness</term>
<term>Periodic paralyses</term>
<term>Periodic paralysis</term>
<term>Periventricular leukomalacia</term>
<term>Phenotype</term>
<term>Philipps university</term>
<term>Physical examination</term>
<term>Positron</term>
<term>Positron emission tomography scanning</term>
<term>Poskanzer</term>
<term>Precision grip</term>
<term>Prenatal</term>
<term>Present findings</term>
<term>Proc natl acad</term>
<term>Progressive loss</term>
<term>Progressive supranuclear palsy</term>
<term>Putative mutation</term>
<term>Radioactivity</term>
<term>Receptor</term>
<term>Receptor tyrosine kinase</term>
<term>Renal cortex</term>
<term>Renal pelvis</term>
<term>Resonance imaging</term>
<term>Resonance spectroscopic imaging</term>
<term>Retrograde flow</term>
<term>Right cerebellar hemisphere</term>
<term>Right hemisphere</term>
<term>Right side</term>
<term>Right subclavian artery</term>
<term>Ross syndrome</term>
<term>Royal victoria infirmary</term>
<term>Salivary glands</term>
<term>Salomon</term>
<term>Scan</term>
<term>Scn4a</term>
<term>Second scan</term>
<term>Second scans</term>
<term>Secretory responsiveness</term>
<term>Segmental anhidrosis</term>
<term>Segmental hyperhidrosis</term>
<term>Selective degeneration</term>
<term>Selective loss</term>
<term>Sequence analysis</term>
<term>Severe delay</term>
<term>Severe phenotype</term>
<term>Severe reduction</term>
<term>Shunt</term>
<term>Signal alterations</term>
<term>Significant change</term>
<term>Significant decrease</term>
<term>Significant difference</term>
<term>Skin biopsies</term>
<term>Skin biopsy</term>
<term>Small myelinated fibers</term>
<term>Sodium channel gene</term>
<term>Sodium chloride</term>
<term>Soroka university</term>
<term>Standard deviation</term>
<term>Standard error</term>
<term>Subclavian</term>
<term>Subclavian artery</term>
<term>Subthalamic</term>
<term>Subthalamic nucleus</term>
<term>Subtraction angiography</term>
<term>Sudomotor</term>
<term>Sudomotor fibers</term>
<term>Supplementation</term>
<term>Sural</term>
<term>Sural nerve</term>
<term>Sural nerve biopsy</term>
<term>Sweat gland innervation</term>
<term>Sweat glands</term>
<term>Sympathetic denervation</term>
<term>Sympathetic innervation</term>
<term>Sympathetic skin response</term>
<term>Sympathetic terminals</term>
<term>Symptom</term>
<term>Syndrome</term>
<term>Synthetic graft</term>
<term>Temporal lobe</term>
<term>Term neonates</term>
<term>Tetralogy</term>
<term>Third type</term>
<term>Tibial nerves</term>
<term>Tissue concentrations</term>
<term>Tomography</term>
<term>Total repair</term>
<term>Transcranial doppler</term>
<term>Transporter</term>
<term>Transporter defect</term>
<term>Treatment conditions</term>
<term>Trka</term>
<term>Trka gene</term>
<term>University college</term>
<term>University college london</term>
<term>Unknown origin</term>
<term>Unmyelinated</term>
<term>Unmyelinated fibers</term>
<term>Unrelated families</term>
<term>Unremarkable</term>
<term>Updrs motor score</term>
<term>Urine</term>
<term>Vacuo dilatation</term>
<term>Valsalva maneuver</term>
<term>Ventricular</term>
<term>Ventricular myocardium</term>
<term>Ventricular wall</term>
<term>Vertebral artery</term>
<term>Vertebrobasilar</term>
<term>Vertebrobasilar stroke</term>
<term>Vgam</term>
<term>White blood cells</term>
<term>White matter</term>
<term>Wiley interscience</term>
<term>Younger brother</term>
<term>Zhejiang university</term>
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<front><div type="abstract" xml:lang="en">This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6‐[18F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6‐[18F]fluorodopamine‐derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying‐back mechanism.</div>
</front>
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