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Progressive loss of cardiac sympathetic innervation in Parkinson's disease

Identifieur interne : 002B98 ( Main/Merge ); précédent : 002B97; suivant : 002B99

Progressive loss of cardiac sympathetic innervation in Parkinson's disease

Auteurs : Sheng-Ting Li [États-Unis] ; Raghuveer Dendi [États-Unis] ; Courtney Holmes [États-Unis] ; David S. Goldstein [États-Unis]

Source :

RBID : ISTEX:1F509D66619F60632488A8C87E4EAA0247D2CABC

English descriptors

Abstract

This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6‐[18F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6‐[18F]fluorodopamine‐derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying‐back mechanism.

Url:
DOI: 10.1002/ana.10236

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<term>Abnormal</term>
<term>Abnormal peak</term>
<term>Abnormality</term>
<term>Accession number</term>
<term>Acta neurol scand</term>
<term>Acute ischemic lesions</term>
<term>Additional families</term>
<term>Address correspondence</term>
<term>Adie syndrome</term>
<term>Adrenocortical insufficiency</term>
<term>Adrenoleukodystrophy</term>
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<term>Aldp</term>
<term>Alzheimer disease</term>
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<term>Animal experiments</term>
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<term>Febrile episodes</term>
<term>Fetal</term>
<term>Fetal brain</term>
<term>Fibers innervating sweat glands</term>
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<term>First child</term>
<term>First scan</term>
<term>First scans</term>
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<term>Hepatocerebral mitochondrial</term>
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<term>Heterozygous women</term>
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<term>Homozygous nonsense mutation</term>
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<term>Human antibodies reactive</term>
<term>Human antibody</term>
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<term>Human chromosome</term>
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<term>Hyperhidrotic side</term>
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<term>Idiopathic disease</term>
<term>Imaging</term>
<term>Immunoglobulin</term>
<term>Impairment</term>
<term>Inactivation</term>
<term>Inborn error</term>
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<term>Intravenous immunoglobulin</term>
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<term>Ischemic</term>
<term>Istituto nazionale neurologico</term>
<term>Ivig</term>
<term>Ivig preparations</term>
<term>Ivig treatment</term>
<term>Kinase</term>
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<term>Late complication</term>
<term>Late opacification</term>
<term>Lateral</term>
<term>Lateral ventricles</term>
<term>Lateral wall</term>
<term>Lateral wall radioactivity</term>
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<term>Lesion</term>
<term>Liver biopsies</term>
<term>Liver failure</term>
<term>Long chain</term>
<term>Lower thoracic</term>
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<term>Maternal uncles</term>
<term>Mental impairment</term>
<term>Mental retardation</term>
<term>Metabolism</term>
<term>Methyltransferase</term>
<term>Mitochondrial</term>
<term>Modest reduction</term>
<term>Molecular analysis</term>
<term>Morphometric analysis</term>
<term>Mosaic expression</term>
<term>Moser</term>
<term>Motor fluctuations</term>
<term>Motor system</term>
<term>Mouse model</term>
<term>Mtdna</term>
<term>Mtdna depletion</term>
<term>Mtdna levels</term>
<term>Multiple system atrophy</term>
<term>Muscle nerve</term>
<term>Muscle sodium channel</term>
<term>Muscle weakness</term>
<term>Mutation</term>
<term>Mutation analysis</term>
<term>Mutational analysis</term>
<term>Myelinated</term>
<term>Myelinated fiber density</term>
<term>Myelinated fibers</term>
<term>Myocardial radioactivity</term>
<term>Myocardial scintigraphy</term>
<term>Myotonic discharge</term>
<term>National institute</term>
<term>National institutes</term>
<term>Neonatal giant cell hepatitis</term>
<term>Neonate</term>
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<term>Nerve conduction studies</term>
<term>Nerve endings</term>
<term>Nerve fascicle</term>
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<term>Neurol neurosurg psychiatry</term>
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<term>Neurological examinations</term>
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<term>Neurology</term>
<term>Neuromuscul disord</term>
<term>Neuron</term>
<term>Neuropathy</term>
<term>Nonconsanguineous german parents</term>
<term>Nonsense mutation</term>
<term>Normal epidermal</term>
<term>Normal ranges</term>
<term>Normokpp</term>
<term>Normokpp families</term>
<term>Novel mutation</term>
<term>Novel mutations</term>
<term>Ntrk1</term>
<term>Ondrug state</term>
<term>Online</term>
<term>Online mendelian inheritance</term>
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<term>Original family</term>
<term>Original normokpp family</term>
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<term>Painful stimuli</term>
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<term>Parkinsonian patients</term>
<term>Pathogenic mutation</term>
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<term>Peptide</term>
<term>Percentage decrease</term>
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<term>Periodic paralyses</term>
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<term>Philipps university</term>
<term>Physical examination</term>
<term>Positron</term>
<term>Positron emission tomography scanning</term>
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<term>Prenatal</term>
<term>Present findings</term>
<term>Proc natl acad</term>
<term>Progressive loss</term>
<term>Progressive supranuclear palsy</term>
<term>Putative mutation</term>
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<term>Receptor</term>
<term>Receptor tyrosine kinase</term>
<term>Renal cortex</term>
<term>Renal pelvis</term>
<term>Resonance imaging</term>
<term>Resonance spectroscopic imaging</term>
<term>Retrograde flow</term>
<term>Right cerebellar hemisphere</term>
<term>Right hemisphere</term>
<term>Right side</term>
<term>Right subclavian artery</term>
<term>Ross syndrome</term>
<term>Royal victoria infirmary</term>
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<term>Second scan</term>
<term>Second scans</term>
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<term>Segmental anhidrosis</term>
<term>Segmental hyperhidrosis</term>
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<term>Selective loss</term>
<term>Sequence analysis</term>
<term>Severe delay</term>
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<term>Severe reduction</term>
<term>Shunt</term>
<term>Signal alterations</term>
<term>Significant change</term>
<term>Significant decrease</term>
<term>Significant difference</term>
<term>Skin biopsies</term>
<term>Skin biopsy</term>
<term>Small myelinated fibers</term>
<term>Sodium channel gene</term>
<term>Sodium chloride</term>
<term>Soroka university</term>
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<term>Sural nerve</term>
<term>Sural nerve biopsy</term>
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<term>Sweat glands</term>
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<term>Sympathetic innervation</term>
<term>Sympathetic skin response</term>
<term>Sympathetic terminals</term>
<term>Symptom</term>
<term>Syndrome</term>
<term>Synthetic graft</term>
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<term>Term neonates</term>
<term>Tetralogy</term>
<term>Third type</term>
<term>Tibial nerves</term>
<term>Tissue concentrations</term>
<term>Tomography</term>
<term>Total repair</term>
<term>Transcranial doppler</term>
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<term>University college</term>
<term>University college london</term>
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<term>Unrelated families</term>
<term>Unremarkable</term>
<term>Updrs motor score</term>
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<term>Ventricular wall</term>
<term>Vertebral artery</term>
<term>Vertebrobasilar</term>
<term>Vertebrobasilar stroke</term>
<term>Vgam</term>
<term>White blood cells</term>
<term>White matter</term>
<term>Wiley interscience</term>
<term>Younger brother</term>
<term>Zhejiang university</term>
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<front>
<div type="abstract" xml:lang="en">This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6‐[18F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6‐[18F]fluorodopamine‐derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying‐back mechanism.</div>
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